Lan Capsules (Generic Lansoprazole Capsules)

Lan Capsules (Generic Lansoprazole Capsules)
© The Swiss Pharmacy

Lan (Generic Lansoprazole Capsules) is used for
treatment of indigestion, heartburn, duodenal
ulcer, gastric ulcer, Gastroesophageal Reflux
Disease (GERD or reflux esophagitis), erosive
esophagitis, and Pathological Hypersecretory
Conditions including Zollinger-Ellison syndrome.

Lan Capsules are manufactured by Intas
Pharmaceuticals Limited, India in the strengths of 15 mg
and 30 mg.

Chemical Structure

The active ingredient contained in Lan
capsules is Lansoprazole.
Each Lan capsule contains 15 mg or 30
mg of Lansoprazole.

Uses of Lan 15 mg and 30 mg Capsules:
Lan Capsules (Lansoprazole) is used to treat certain conditions where
there is too much acid in the stomach. It is used to treat indigestion,
heartburn, duodenal and stomach ulcers, stomach ulcers caused by
NSAID use, reflux disease, erosive esophagitis, and
gastroesophageal reflux disease (GERD).
GERD is a condition wherein the acid in the stomach washes back up
into the esophagus. Sometimes lansoprazole is used in combination
with antibiotics (eg, Amoxicillin, Clarithromycin) to treat ulcers
associated with an infection caused by H. pylori bacteria.
Lansoprazole is also used to treat Zollinger-Ellison syndrome (ZES),
which is a condition where the stomach produces too much acid.
Lansoprazole is a proton pump inhibitor (PPI). It works by decreasing
the amount of acid produced by the stomach.

Short-Term Treatment of Active Duodenal Ulcer: Lan (Generic Lansoprazole
Capsules) are indicated for short-term treatment (for four weeks) for healing and
symptom relief of active duodenal ulcer.
H. pylori Eradication to Reduce the Risk of Duodenal Ulcer Recurrence:
Triple Therapy (Lansoprazole/Amoxicillin/Clarithromycin): Lansoprazole capsules in
combination with Amoxicillin plus Clarithromycin as triple therapy are indicated for
the treatment of patients with H. pylori infection and duodenal ulcer disease (active
or one-year history of a duodenal ulcer) to eradicate H. pylori. Eradication of H. pylori
has been shown to reduce the risk of duodenal ulcer recurrence.
Dual Therapy (Lansoprazole/Amoxicillin): Lansoprazole capsules in combination
with amoxicillin as dual therapy are indicated for the treatment of patients with H.
pylori infection and duodenal ulcer disease (active or one-year history of a duodenal
ulcer) who are either allergic or intolerant to Clarithromycin or in whom resistance to
Clarithromycin is known or suspected. Eradication of H. pylori has been shown to
reduce the risk of duodenal ulcer recurrence.
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Maintenance of Healed Duodenal Ulcers: Lan (Generic Lansoprazole
Capsules) are used to maintain healing of duodenal ulcers. Controlled
studies do not extend beyond 12 months.
Short-Term Treatment of Active Benign Gastric Ulcer: Lansoprazole
capsules are indicated for short-term treatment (up to eight weeks) for
healing and symptom relief of active benign gastric ulcer.
Healing of NSAID-Associated Gastric Ulcer: Lansoprazole capsules are used
for the treatment of NSAID-associated gastric ulcer in patients who continue
NSAID use. Controlled studies did not extend beyond eight weeks.
Risk Reduction of NSAID-Associated Gastric Ulcer: Lansoprazole capsules
are used for reducing the risk of NSAID-associated gastric ulcers in patients
with a history of a documented gastric ulcer who require the use of an
NSAID. Controlled studies did not extend beyond 12 weeks.

Short-Term Treatment of Symptomatic GERD: Lan (Generic Lansoprazole Capsules)
are used for the treatment of heartburn and other symptoms associated with GERD
for up to eight weeks.
Short-Term Treatment of Erosive Esophagitis: Lansoprazole capsules are used for
short-term treatment (up to eight weeks) for healing and symptom relief of all grades
of erosive esophagitis. For patients who do not heal with Lansoprazole capsules for
eight weeks (5% to 10%), it may be helpful to give an additional eight weeks of
treatment. In case there is a recurrence of erosive esophagitis an additional eight
week course of Lansoprazole capsules may be considered.
Maintenance of Healing of Erosive Esophagitis (EE): Lansoprazole capsules are used
to maintain healing of erosive esophagitis. Controlled studies did not extend beyond
12 months.
Pathological Hypersecretory Conditions Including Zollinger-Ellison Syndrome (ZES):
Lansoprazole capsules are used for the long-term treatment of pathological
hypersecretory conditions, including Zollinger-Ellison syndrome.

Recommended Adult Dosage
The dose of Lan Capsules (Generic Lansoprazole Capsules) for
various indications is given below:
Reflux Oesophagitis: 30 mg Lan (Generic Lansoprazole Capsules) once
daily for 4 weeks. The majority of patients will be healed after the first
course. For patients who have not fully healed within this time, a further
4 weeks’ treatment using the same dosage regimen is indicated. For
long-term management, a maintenance dose of 15 mg or 30 mg once
daily can be used dependent upon patient response.
Duodenal Ulcer: 30 mg Lansoprazole once daily for 4 weeks. For the
prevention of relapse, the recommended maintenance dose is 15 mg
once daily.

Gastric Ulcer: 30 mg Lansoprazole once daily for 8 weeks.
Patients whose gastric or duodenal ulcer is not associated with
ingestion of non-steroidal anti-inflammatory drugs require
treatment with antimicrobial agents in addition to
antisecretory drugs whether on first presentation or on
recurrence.
Acid-Related Dyspepsia: Lansoprazole 15 mg or 30 mg once
daily for 2 to 4 weeks, depending on the severity and
persistence of symptoms. Patients who do not respond after 4
weeks, or who relapse shortly afterwards, should be
investigated.

Eradication Of H. Pylori To Reduce The Risk Of Duodenal Ulcer
Recurrence: The following combinations have been shown to
be effective when used for 10 or 14 days: Lansoprazole 30 mg
twice daily plus two of the following antibiotics: Amoxycillin 1 g
twice daily for 10 or 14 days and Clarithromycin 500 mg twice
daily for 10 or 14 days.

Contraindications
➔
Lan capsules are contraindicated in patients with a known
hypersensitivity to Lansoprazole, other proton pump inhibitors or
any component of the tablet.
➔
Administration of Lan capsules is contraindicated in patients
with severe hepatic impairment.
➔
Concomitant use with Atazanavir. Lansoprazole should not be
coadministered with Atazanavir due to a significant reduction in
Atazanavir exposure.

Storage Instructions
Lan Capsules (Generic Lansoprazole Capsules) have
to be stored at controlled room temperature i.e. from
20°C to 25°C (68°F to 77°F) with excursions permitted
between 15° to 30°C (59° to 86°F).
Keep this as well as all other medicines away from
children and pets.

Warnings
Gastric Malignancy: In adults, symptomatic response with Lansoprazole
capsules (Lan) does not preclude the presence of gastric malignancy.
Consider additional follow-up and diagnostic testing.
Acute Interstitial Nephritis: Acute interstitial nephritis has been observed in
patients taking PPIs.
Clostridium difficile-Associated Diarrhea: PPI therapy may be associated with
increased risk of Clostridium-difficile associated diarrhea.
Bone Fracture: Long-term and multiple daily dose PPI therapy may be
associated with an increased risk for osteoporosis-related fractures of the hip,
wrist or spine.
Cutaneous and Systemic Lupus Erythematosus: Mostly cutaneous; new onset
or exacerbation of existing disease; discontinue Lansoprazole capsules (Lan)
and refer to specialist for evaluation.

Warnings
Cyanocobalamin (Vitamin B12) Deficiency: Daily long-term use (e.g., longer
than 3 years) may lead to malabsorption or a deficiency of
cyanocobalamin.
Hypomagnesemia: Hypomagnesemia has been reported rarely with
prolonged treatment with PPIs.
Interactions with Investigations for Neuroendocrine Tumors: Increases in
intragastric pH may result in hypergastrinemia and enterochromaffin-like
cell hyperplasia and increased chromogranin A levels which may interfere
with diagnostic investigations for neuroendocrine tumors.
Interaction with Methotrexate: Concomitant use with PPIs may elevate
and/or prolong serum concentrations of methotrexate and/or its
metabolite, possibly leading to toxicity. With high-dose methotrexate
administration, consider a temporary withdrawal of Lan capsules.

Warnings
Patients with Phenylketonuria: Each 15 mg Lansoprazole capsules
contains 2.5 mg and each 30 mg Lansoprazole capsules contains 5.1
mg of phenylalanine.
Lansoprazole is metabolized substantially by the liver. The results
of clinical trials in adult patients with liver disease indicate that the
metabolism of Lansoprazole is prolonged in patients with
severehepatic impairment. Consider dose adjustment in patients
with severe hepatic impairment.

Lan Capsules and Alcohol
Yes, you can drink alcohol with Lansoprazole (Lan Capsules).
Although drinking alcohol is not contraindicated when using
Lansoprazole, it's best not to drink too much, because drinking
alcohol makes your stomach produce more acid than normal.
This can irritate your stomach lining and make your symptoms
worse.

Possible Side Effects
Most common Lansoprazole capsules (Lan) side effects with
an incidence rate of greater than or equal to 1% are diarrhea,
abdominal pain, nausea and constipation.

Possible Side Effects
The following are the possible serious side effects of Lansoprazole
capsules (Lan): Acute Interstitial Nephritis, Clostridium difficile-
Associated Diarrhea, Bone Fracture, Cutaneous and Systemic
Lupus Erythematosus, Cyanocobalamin (Vitamin B12) Deficiency,
Hypomagnesemia and Fundic Gland Polyps.

Lan Capsules Overdosage
Lansoprazole is not removed from the circulation by
hemodialysis. In one reported overdose, a patient consumed 600
mg of lansoprazole with no adverse reaction.
Oral Lansoprazole doses up to 5000 mg/kg in rats
[approximately 1300 times the 30 mg human dose based on
body surface area (BSA)] and in mice (about 675.7 times the 30
mg human dose based on BSA) did not produce deaths or any
clinical signs.
In the event of overdose, treatment should be symptomatic and
supportive.

Lan Capsules During Pregnancy
Lansoprazole capsules (Lan) has been classified by the US FDA as
Pregnancy Category B.
Reproduction studies have been performed in pregnant rats at oral
doses up to 40 times the recommended human dose and in pregnant
rabbits at oral doses up to 16 times the recommended human dose
and have revealed no evidence of impaired fertility or harm to the fetus
due to Lansoprazole.
There are, however, no adequate or well-controlled studies in
pregnant women.
Because animal reproduction studies are not always predictive of
human response, this drug should be used during pregnancy only if
clearly needed.

Lan Capsules (Generic Lansoprazole Capsules) are
manufactured by Intas Pharmaceuticals Limited, India.

Lan Capsules (Generic Lansoprazole Capsules)

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