SlideShare a Scribd company logo
Preparation # 5
Aspirin Capsules
Compiled by: Ivy Rose C. Orozco,RPh
PHARMACEUTICS1L – Pharmaceutical Dosage Forms, Drug Delivery
Systems and Medical Devices
Aspirin Capsules
● Category: Non-steroidal Anti-inflammatory
drug
● Synonym: Acetyl salicylic acid
● Final Product: transparent capsule containing
finely divided powders of acetyl salicylic acid
● Uses: to reduce pain, fever, and/or
inflammation, used as antithrombotic.
● Label: White label for internal use, taken orally
● Container: blister pack, foil or may be
packaged in amber bottle, protected from
light, and tightly sealed container
Capsules
• Capsules are solid dosage
forms in which medicinal
agents and/or inert substances
are enclosed in a small shell of
gelatin.
• Gelatin capsule shells may be
hard (2-piece capsules) or soft
(One-piece capsule),
depending on the composition.
• Shells – body and cap
Capsules
• Hard-gelatin capsules – clinical trials,
extemporaneous compounding
• Empty capsule – gelatin, sugar and
water (clear, colorless, tasteless)
• Titanium dioxide – opaquant
• Gelatin – obtained by partial
hydrolysis of collagen obtained from
the skin, white connective tissues,
and bones of animals; soluble in
water and gastric fluid, digested by
proteolytic enzymes
Capsules
• Capsule parts:
• Capsule body and short cap -
locked
Preparation of Filled Hard Gelatin Capsule
1. Developing and preparing the
formulation and selecting the
capsule size
2. Filling the capsule shells
3. Capsule sealing (optional)
4. Cleaning and polishing the capsule
Soft Gelatin Capsule
• Made of gelatin, glycerin, sorbitol
• Contain more moisture, w/
preservative (methylparaben,
propylparaben)
• Oblong, round, oval shaped
• Single-colored,two-toned with or
w/o imprinting
• Hermetically seal liquids,
suspensions and pasty materials
• Pharmaceutically elegant and easier
to swallow
Preparation of Soft Gelatin Capsule
• Plate process – warm sheet of plain
colored gelatin plate at the bottom
of the mold, pour the medication
containing liquid, second sheet of
gelatin plate is placed on top
• Pressure is applied to seal
Uses of Soft Gelatin Capsule
1. For water-immiscible volatile and
non-volatile liquids
2. Water-miscible non-volatile liquids
3. Water-miscible and relatively
nonvolatile compounds
Compendial Requirements for Capsules
1. Added substances must be inert, do
not exceed the minimum amount
required to provide intended effects,
do not impair product bioavailability,
do not interfere with requisite
compendial assays/tests
2. Containers must be light resistant,
tight or well-closed (combination)
3. Must pass the disintegration test
4. Must pass the dissolution test
5. Weight variation test must also be
Compendial Requirements for Capsules
6. Must pass the Content uniformity
test
7. Content labeling
8. Stability Testing
9. Moisture permeation test
End of Discussion

More Related Content

Similar to Preparation # 5.pptx

Capsules, Types, Gelatin , Preparation of capsules presentation.pptx
Capsules, Types, Gelatin , Preparation of capsules presentation.pptxCapsules, Types, Gelatin , Preparation of capsules presentation.pptx
Capsules, Types, Gelatin , Preparation of capsules presentation.pptx
kaiteyworkaddress1
 
Soft gelatin capsules
Soft gelatin capsulesSoft gelatin capsules
Soft gelatin capsules
Teny Thomas
 
Capsulesfinalppt
Capsulesfinalppt Capsulesfinalppt
Capsulesfinalppt
DWARIKANATH3
 
Capsules
CapsulesCapsules
Capsules
CapsulesCapsules
Capsules
ceutics1315
 
Capsule
CapsuleCapsule
DRUG NUTRIENT INTERACTION - CAPSULES
DRUG NUTRIENT INTERACTION - CAPSULESDRUG NUTRIENT INTERACTION - CAPSULES
DRUG NUTRIENT INTERACTION - CAPSULES
sanjnamathew1
 
Presentation2Non Sterile manufacturing Process Technology Capsules(hard & sof...
Presentation2Non Sterile manufacturing Process Technology Capsules(hard & sof...Presentation2Non Sterile manufacturing Process Technology Capsules(hard & sof...
Presentation2Non Sterile manufacturing Process Technology Capsules(hard & sof...
AjayGhuge9
 
Non Sterile manufacturing Process Technology Capsules(hard & soft).pptx
Non Sterile manufacturing Process Technology Capsules(hard & soft).pptxNon Sterile manufacturing Process Technology Capsules(hard & soft).pptx
Non Sterile manufacturing Process Technology Capsules(hard & soft).pptx
AjayGhuge9
 
529704272-Capsules.pdf
529704272-Capsules.pdf529704272-Capsules.pdf
529704272-Capsules.pdf
GATWECHDECHRUT
 
529704272-Capsules.pdf
529704272-Capsules.pdf529704272-Capsules.pdf
529704272-Capsules.pdf
GATWECHDECHRUT
 
Capsule in industrial
Capsule in industrialCapsule in industrial
Capsule in industrial
Indraj Saini
 
Processing of capsule
Processing of capsuleProcessing of capsule
Processing of capsule
sumitpingale89
 
Hard Gelatin Capsules.pptx
Hard Gelatin Capsules.pptxHard Gelatin Capsules.pptx
Hard Gelatin Capsules.pptx
Poonam Patil
 
Capsules
CapsulesCapsules
Capsules
shivalisingla5
 
10-180712154020.pptx
10-180712154020.pptx10-180712154020.pptx
10-180712154020.pptx
MariyambibiMandarawa1
 
Capsules
CapsulesCapsules
Capsules
PRABU12345678
 
capsules
capsulescapsules
Recent advances in capsule
Recent advances in capsule Recent advances in capsule
Recent advances in capsule
Tirupati Rasala
 
capsule-191011092034.pdf
capsule-191011092034.pdfcapsule-191011092034.pdf
capsule-191011092034.pdf
SridharA50
 

Similar to Preparation # 5.pptx (20)

Capsules, Types, Gelatin , Preparation of capsules presentation.pptx
Capsules, Types, Gelatin , Preparation of capsules presentation.pptxCapsules, Types, Gelatin , Preparation of capsules presentation.pptx
Capsules, Types, Gelatin , Preparation of capsules presentation.pptx
 
Soft gelatin capsules
Soft gelatin capsulesSoft gelatin capsules
Soft gelatin capsules
 
Capsulesfinalppt
Capsulesfinalppt Capsulesfinalppt
Capsulesfinalppt
 
Capsules
CapsulesCapsules
Capsules
 
Capsules
CapsulesCapsules
Capsules
 
Capsule
CapsuleCapsule
Capsule
 
DRUG NUTRIENT INTERACTION - CAPSULES
DRUG NUTRIENT INTERACTION - CAPSULESDRUG NUTRIENT INTERACTION - CAPSULES
DRUG NUTRIENT INTERACTION - CAPSULES
 
Presentation2Non Sterile manufacturing Process Technology Capsules(hard & sof...
Presentation2Non Sterile manufacturing Process Technology Capsules(hard & sof...Presentation2Non Sterile manufacturing Process Technology Capsules(hard & sof...
Presentation2Non Sterile manufacturing Process Technology Capsules(hard & sof...
 
Non Sterile manufacturing Process Technology Capsules(hard & soft).pptx
Non Sterile manufacturing Process Technology Capsules(hard & soft).pptxNon Sterile manufacturing Process Technology Capsules(hard & soft).pptx
Non Sterile manufacturing Process Technology Capsules(hard & soft).pptx
 
529704272-Capsules.pdf
529704272-Capsules.pdf529704272-Capsules.pdf
529704272-Capsules.pdf
 
529704272-Capsules.pdf
529704272-Capsules.pdf529704272-Capsules.pdf
529704272-Capsules.pdf
 
Capsule in industrial
Capsule in industrialCapsule in industrial
Capsule in industrial
 
Processing of capsule
Processing of capsuleProcessing of capsule
Processing of capsule
 
Hard Gelatin Capsules.pptx
Hard Gelatin Capsules.pptxHard Gelatin Capsules.pptx
Hard Gelatin Capsules.pptx
 
Capsules
CapsulesCapsules
Capsules
 
10-180712154020.pptx
10-180712154020.pptx10-180712154020.pptx
10-180712154020.pptx
 
Capsules
CapsulesCapsules
Capsules
 
capsules
capsulescapsules
capsules
 
Recent advances in capsule
Recent advances in capsule Recent advances in capsule
Recent advances in capsule
 
capsule-191011092034.pdf
capsule-191011092034.pdfcapsule-191011092034.pdf
capsule-191011092034.pdf
 

More from IvyRoseOrozco1

Preparation # 10 Sulfur Ointment.pptx
Preparation # 10 Sulfur Ointment.pptxPreparation # 10 Sulfur Ointment.pptx
Preparation # 10 Sulfur Ointment.pptx
IvyRoseOrozco1
 
Preparation # 12 Peppermint Water.pptx
Preparation # 12 Peppermint Water.pptxPreparation # 12 Peppermint Water.pptx
Preparation # 12 Peppermint Water.pptx
IvyRoseOrozco1
 
Preparation #3.pptx
Preparation #3.pptxPreparation #3.pptx
Preparation #3.pptx
IvyRoseOrozco1
 
Preparation #2.pptx
Preparation #2.pptxPreparation #2.pptx
Preparation #2.pptx
IvyRoseOrozco1
 
Preparation #1.pptx
Preparation #1.pptxPreparation #1.pptx
Preparation #1.pptx
IvyRoseOrozco1
 
Preparation #4.pptx
Preparation #4.pptxPreparation #4.pptx
Preparation #4.pptx
IvyRoseOrozco1
 

More from IvyRoseOrozco1 (6)

Preparation # 10 Sulfur Ointment.pptx
Preparation # 10 Sulfur Ointment.pptxPreparation # 10 Sulfur Ointment.pptx
Preparation # 10 Sulfur Ointment.pptx
 
Preparation # 12 Peppermint Water.pptx
Preparation # 12 Peppermint Water.pptxPreparation # 12 Peppermint Water.pptx
Preparation # 12 Peppermint Water.pptx
 
Preparation #3.pptx
Preparation #3.pptxPreparation #3.pptx
Preparation #3.pptx
 
Preparation #2.pptx
Preparation #2.pptxPreparation #2.pptx
Preparation #2.pptx
 
Preparation #1.pptx
Preparation #1.pptxPreparation #1.pptx
Preparation #1.pptx
 
Preparation #4.pptx
Preparation #4.pptxPreparation #4.pptx
Preparation #4.pptx
 

Recently uploaded

2001_Book_HumanChromosomes - Genéticapdf
2001_Book_HumanChromosomes - Genéticapdf2001_Book_HumanChromosomes - Genéticapdf
2001_Book_HumanChromosomes - Genéticapdf
lucianamillenium
 
Delhi Call Girls ✓WhatsApp 9999965857 🔝Top Class Call Girl Service Available
Delhi Call Girls ✓WhatsApp 9999965857 🔝Top Class Call Girl Service AvailableDelhi Call Girls ✓WhatsApp 9999965857 🔝Top Class Call Girl Service Available
Delhi Call Girls ✓WhatsApp 9999965857 🔝Top Class Call Girl Service Available
kk090568
 
The Limited Role of the Streaming Instability during Moon and Exomoon Formation
The Limited Role of the Streaming Instability during Moon and Exomoon FormationThe Limited Role of the Streaming Instability during Moon and Exomoon Formation
The Limited Role of the Streaming Instability during Moon and Exomoon Formation
Sérgio Sacani
 
Rodents, Birds and locust_Pests of crops.pdf
Rodents, Birds and locust_Pests of crops.pdfRodents, Birds and locust_Pests of crops.pdf
Rodents, Birds and locust_Pests of crops.pdf
PirithiRaju
 
Module_1.In autotrophic nutrition ORGANISM
Module_1.In autotrophic nutrition ORGANISMModule_1.In autotrophic nutrition ORGANISM
Module_1.In autotrophic nutrition ORGANISM
rajeshwexl
 
Evaluation and Identification of J'BaFofi the Giant Spider of Congo and Moke...
Evaluation and Identification of J'BaFofi the Giant  Spider of Congo and Moke...Evaluation and Identification of J'BaFofi the Giant  Spider of Congo and Moke...
Evaluation and Identification of J'BaFofi the Giant Spider of Congo and Moke...
MrSproy
 
20240610_INSIGHT_PartnerProfile-02_Tampere.pdf
20240610_INSIGHT_PartnerProfile-02_Tampere.pdf20240610_INSIGHT_PartnerProfile-02_Tampere.pdf
20240610_INSIGHT_PartnerProfile-02_Tampere.pdf
Steffi Friedrichs
 
GBSN - Microbiology (Unit 2) Antimicrobial agents
GBSN - Microbiology (Unit 2) Antimicrobial agentsGBSN - Microbiology (Unit 2) Antimicrobial agents
GBSN - Microbiology (Unit 2) Antimicrobial agents
Areesha Ahmad
 
gastroretentive drug delivery system-PPT.pptx
gastroretentive drug delivery system-PPT.pptxgastroretentive drug delivery system-PPT.pptx
gastroretentive drug delivery system-PPT.pptx
Shekar Boddu
 
حبوب الاجهاض الامارات | 00971547952044 | حبوب اجهاض امارات للبيع
حبوب الاجهاض الامارات | 00971547952044 | حبوب اجهاض امارات للبيعحبوب الاجهاض الامارات | 00971547952044 | حبوب اجهاض امارات للبيع
حبوب الاجهاض الامارات | 00971547952044 | حبوب اجهاض امارات للبيع
حبوب الاجهاض الامارات حبوب سايتوتك الامارات
 
一比一原版美国佩斯大学毕业证如何办理
一比一原版美国佩斯大学毕业证如何办理一比一原版美国佩斯大学毕业证如何办理
一比一原版美国佩斯大学毕业证如何办理
gyhwyo
 
Discovery of Merging Twin Quasars at z=6.05
Discovery of Merging Twin Quasars at z=6.05Discovery of Merging Twin Quasars at z=6.05
Discovery of Merging Twin Quasars at z=6.05
Sérgio Sacani
 
Explainable Deepfake Image/Video Detection
Explainable Deepfake Image/Video DetectionExplainable Deepfake Image/Video Detection
Explainable Deepfake Image/Video Detection
VasileiosMezaris
 
Mites,Slug,Snail_Infesting agricultural crops.pdf
Mites,Slug,Snail_Infesting agricultural crops.pdfMites,Slug,Snail_Infesting agricultural crops.pdf
Mites,Slug,Snail_Infesting agricultural crops.pdf
PirithiRaju
 
22PH503 - Astronomy and Astrophysics - Unit 2 - Spectral Classification of Stars
22PH503 - Astronomy and Astrophysics - Unit 2 - Spectral Classification of Stars22PH503 - Astronomy and Astrophysics - Unit 2 - Spectral Classification of Stars
22PH503 - Astronomy and Astrophysics - Unit 2 - Spectral Classification of Stars
RDhivya6
 
Premuim Call Girls Pune 🔥 7014168258 🔥 Real Fun With Sexual Girl Available 24...
Premuim Call Girls Pune 🔥 7014168258 🔥 Real Fun With Sexual Girl Available 24...Premuim Call Girls Pune 🔥 7014168258 🔥 Real Fun With Sexual Girl Available 24...
Premuim Call Girls Pune 🔥 7014168258 🔥 Real Fun With Sexual Girl Available 24...
$A19
 
seed production, Nursery & Gardening.pdf
seed production, Nursery & Gardening.pdfseed production, Nursery & Gardening.pdf
seed production, Nursery & Gardening.pdf
Nistarini College, Purulia (W.B) India
 
Roles and skills of administration-MON.pptx
Roles and skills of administration-MON.pptxRoles and skills of administration-MON.pptx
Roles and skills of administration-MON.pptx
DawThantMonPaing
 
GBSN - Biochemistry (Unit 12) Hormones
GBSN - Biochemistry (Unit 12) HormonesGBSN - Biochemistry (Unit 12) Hormones
GBSN - Biochemistry (Unit 12) Hormones
Areesha Ahmad
 
GBSN - Microbiology (Unit 2) Susceptibility of Microbial agents
GBSN - Microbiology (Unit 2) Susceptibility of Microbial agentsGBSN - Microbiology (Unit 2) Susceptibility of Microbial agents
GBSN - Microbiology (Unit 2) Susceptibility of Microbial agents
Areesha Ahmad
 

Recently uploaded (20)

2001_Book_HumanChromosomes - Genéticapdf
2001_Book_HumanChromosomes - Genéticapdf2001_Book_HumanChromosomes - Genéticapdf
2001_Book_HumanChromosomes - Genéticapdf
 
Delhi Call Girls ✓WhatsApp 9999965857 🔝Top Class Call Girl Service Available
Delhi Call Girls ✓WhatsApp 9999965857 🔝Top Class Call Girl Service AvailableDelhi Call Girls ✓WhatsApp 9999965857 🔝Top Class Call Girl Service Available
Delhi Call Girls ✓WhatsApp 9999965857 🔝Top Class Call Girl Service Available
 
The Limited Role of the Streaming Instability during Moon and Exomoon Formation
The Limited Role of the Streaming Instability during Moon and Exomoon FormationThe Limited Role of the Streaming Instability during Moon and Exomoon Formation
The Limited Role of the Streaming Instability during Moon and Exomoon Formation
 
Rodents, Birds and locust_Pests of crops.pdf
Rodents, Birds and locust_Pests of crops.pdfRodents, Birds and locust_Pests of crops.pdf
Rodents, Birds and locust_Pests of crops.pdf
 
Module_1.In autotrophic nutrition ORGANISM
Module_1.In autotrophic nutrition ORGANISMModule_1.In autotrophic nutrition ORGANISM
Module_1.In autotrophic nutrition ORGANISM
 
Evaluation and Identification of J'BaFofi the Giant Spider of Congo and Moke...
Evaluation and Identification of J'BaFofi the Giant  Spider of Congo and Moke...Evaluation and Identification of J'BaFofi the Giant  Spider of Congo and Moke...
Evaluation and Identification of J'BaFofi the Giant Spider of Congo and Moke...
 
20240610_INSIGHT_PartnerProfile-02_Tampere.pdf
20240610_INSIGHT_PartnerProfile-02_Tampere.pdf20240610_INSIGHT_PartnerProfile-02_Tampere.pdf
20240610_INSIGHT_PartnerProfile-02_Tampere.pdf
 
GBSN - Microbiology (Unit 2) Antimicrobial agents
GBSN - Microbiology (Unit 2) Antimicrobial agentsGBSN - Microbiology (Unit 2) Antimicrobial agents
GBSN - Microbiology (Unit 2) Antimicrobial agents
 
gastroretentive drug delivery system-PPT.pptx
gastroretentive drug delivery system-PPT.pptxgastroretentive drug delivery system-PPT.pptx
gastroretentive drug delivery system-PPT.pptx
 
حبوب الاجهاض الامارات | 00971547952044 | حبوب اجهاض امارات للبيع
حبوب الاجهاض الامارات | 00971547952044 | حبوب اجهاض امارات للبيعحبوب الاجهاض الامارات | 00971547952044 | حبوب اجهاض امارات للبيع
حبوب الاجهاض الامارات | 00971547952044 | حبوب اجهاض امارات للبيع
 
一比一原版美国佩斯大学毕业证如何办理
一比一原版美国佩斯大学毕业证如何办理一比一原版美国佩斯大学毕业证如何办理
一比一原版美国佩斯大学毕业证如何办理
 
Discovery of Merging Twin Quasars at z=6.05
Discovery of Merging Twin Quasars at z=6.05Discovery of Merging Twin Quasars at z=6.05
Discovery of Merging Twin Quasars at z=6.05
 
Explainable Deepfake Image/Video Detection
Explainable Deepfake Image/Video DetectionExplainable Deepfake Image/Video Detection
Explainable Deepfake Image/Video Detection
 
Mites,Slug,Snail_Infesting agricultural crops.pdf
Mites,Slug,Snail_Infesting agricultural crops.pdfMites,Slug,Snail_Infesting agricultural crops.pdf
Mites,Slug,Snail_Infesting agricultural crops.pdf
 
22PH503 - Astronomy and Astrophysics - Unit 2 - Spectral Classification of Stars
22PH503 - Astronomy and Astrophysics - Unit 2 - Spectral Classification of Stars22PH503 - Astronomy and Astrophysics - Unit 2 - Spectral Classification of Stars
22PH503 - Astronomy and Astrophysics - Unit 2 - Spectral Classification of Stars
 
Premuim Call Girls Pune 🔥 7014168258 🔥 Real Fun With Sexual Girl Available 24...
Premuim Call Girls Pune 🔥 7014168258 🔥 Real Fun With Sexual Girl Available 24...Premuim Call Girls Pune 🔥 7014168258 🔥 Real Fun With Sexual Girl Available 24...
Premuim Call Girls Pune 🔥 7014168258 🔥 Real Fun With Sexual Girl Available 24...
 
seed production, Nursery & Gardening.pdf
seed production, Nursery & Gardening.pdfseed production, Nursery & Gardening.pdf
seed production, Nursery & Gardening.pdf
 
Roles and skills of administration-MON.pptx
Roles and skills of administration-MON.pptxRoles and skills of administration-MON.pptx
Roles and skills of administration-MON.pptx
 
GBSN - Biochemistry (Unit 12) Hormones
GBSN - Biochemistry (Unit 12) HormonesGBSN - Biochemistry (Unit 12) Hormones
GBSN - Biochemistry (Unit 12) Hormones
 
GBSN - Microbiology (Unit 2) Susceptibility of Microbial agents
GBSN - Microbiology (Unit 2) Susceptibility of Microbial agentsGBSN - Microbiology (Unit 2) Susceptibility of Microbial agents
GBSN - Microbiology (Unit 2) Susceptibility of Microbial agents
 

Preparation # 5.pptx

  • 1. Preparation # 5 Aspirin Capsules Compiled by: Ivy Rose C. Orozco,RPh PHARMACEUTICS1L – Pharmaceutical Dosage Forms, Drug Delivery Systems and Medical Devices
  • 2. Aspirin Capsules ● Category: Non-steroidal Anti-inflammatory drug ● Synonym: Acetyl salicylic acid ● Final Product: transparent capsule containing finely divided powders of acetyl salicylic acid ● Uses: to reduce pain, fever, and/or inflammation, used as antithrombotic. ● Label: White label for internal use, taken orally ● Container: blister pack, foil or may be packaged in amber bottle, protected from light, and tightly sealed container
  • 3. Capsules • Capsules are solid dosage forms in which medicinal agents and/or inert substances are enclosed in a small shell of gelatin. • Gelatin capsule shells may be hard (2-piece capsules) or soft (One-piece capsule), depending on the composition. • Shells – body and cap
  • 4. Capsules • Hard-gelatin capsules – clinical trials, extemporaneous compounding • Empty capsule – gelatin, sugar and water (clear, colorless, tasteless) • Titanium dioxide – opaquant • Gelatin – obtained by partial hydrolysis of collagen obtained from the skin, white connective tissues, and bones of animals; soluble in water and gastric fluid, digested by proteolytic enzymes
  • 5. Capsules • Capsule parts: • Capsule body and short cap - locked
  • 6. Preparation of Filled Hard Gelatin Capsule 1. Developing and preparing the formulation and selecting the capsule size 2. Filling the capsule shells 3. Capsule sealing (optional) 4. Cleaning and polishing the capsule
  • 7. Soft Gelatin Capsule • Made of gelatin, glycerin, sorbitol • Contain more moisture, w/ preservative (methylparaben, propylparaben) • Oblong, round, oval shaped • Single-colored,two-toned with or w/o imprinting • Hermetically seal liquids, suspensions and pasty materials • Pharmaceutically elegant and easier to swallow
  • 8. Preparation of Soft Gelatin Capsule • Plate process – warm sheet of plain colored gelatin plate at the bottom of the mold, pour the medication containing liquid, second sheet of gelatin plate is placed on top • Pressure is applied to seal
  • 9. Uses of Soft Gelatin Capsule 1. For water-immiscible volatile and non-volatile liquids 2. Water-miscible non-volatile liquids 3. Water-miscible and relatively nonvolatile compounds
  • 10. Compendial Requirements for Capsules 1. Added substances must be inert, do not exceed the minimum amount required to provide intended effects, do not impair product bioavailability, do not interfere with requisite compendial assays/tests 2. Containers must be light resistant, tight or well-closed (combination) 3. Must pass the disintegration test 4. Must pass the dissolution test 5. Weight variation test must also be
  • 11. Compendial Requirements for Capsules 6. Must pass the Content uniformity test 7. Content labeling 8. Stability Testing 9. Moisture permeation test