Plant growth-promoting rhizobacteria (PGPR) offer a sustainable and eco-friendly approach to combatting plant diseases. These beneficial bacteria colonize plant roots and employ diverse strategies to shield plants from harmful pathogens. They directly compete with pathogens for resources, produce antimicrobial compounds like antibiotics, and even deprive them of essential nutrients like iron. Additionally, PGPR trigger the plant's own defense mechanisms, priming it for rapid response against future attacks. This induced systemic resistance (ISR) enhances plant resilience and reduces disease severity. Research suggests PGPR can effectively control a wide range of plant diseases caused by bacteria, fungi, and even viruses. As concerns about chemical pesticide overuse rise, PGPR hold immense potential for sustainable agriculture, promoting healthy crops and safeguarding global food security.