samsamni vati is an ayurvedic preparation mentioned by AFI it is indicated in all types of jwara its can be use as rasayan too

1. Department of
Rasasatra evam
Bhaishajyakalpana
Topic : Phalatrikadi kwath
(Sha.Sam.Ma.Kha.Kwatha Kalpana)
Name : Kapadiya bhargav
Roll No. : 22
Guided by Dr. Nasir parmar sir
Dr. Trupti yenurkar mam

2. OBJECTIVES :
● Introduction
● Definition
● Ingredients
● Method of preparation
● Dose
● Indication
● Therapeutic properties
● Anupana
● Pathya Apathya
● Sevan Kala
● Pharmacodynamics and pharmacokinetics
● Research updates

3. INTRODUCTION :
पानीयं षोडशगुणं क्षुण्णे द्रव्यपले क्षक्षपेत्।
मृत्पात्रे क्वाथयेद् ग्राह्यमष्टमांशावशेक्षषतम्
तज्जलं पाययेद् धीमान् कोष्णं मृद्वक्षिसाक्षधतम्
(Sa. Ma. Kha. 2/1-2)
1 pal dravya and 16 parts of water boiled and
reduced to 1/8th part, filtered and used.

4. Phalatrikadi
kwath

5. INGREDIENTS :
1. Amalaki
2. Bibhitaki
3. Haritaki
4. Guduci
5. Vasa
6. Kalmegha
7. Nimba
8. Katuki

6. Method of
preparation

8. 1 pal dravya and 16 parts of water, boiled and reduced to 1/4th part, filtered and
used.

9. DOSE :
10-20 ml, once or twice a day before or after
food

10. INDICATIONS :
● Kamala (Jaundice)
● Pandu Roga (Anaemia)
● liver diseases
● loss of appetite

11. ANUPANA :
Equal Quantity Of Water

12. THERAPEUTIC
PROPERTIES :
● Rasa – पञ्च रस (अलावण, तिक्त, काशय
प्रधान)
● Guna – लघु, रुक्ष, गुरु, तिग्ध
● Vipaka - मधुर/ कटु
● Virya – अनुष्ण- शीि

13. PATHYA :
● Old sali rice
● Bringle
● Bitter melon
● Patol
● Jivanti
APATHYA :
● Watermelon
● Fish
● Dahi
● Guru dravya
● Kshar padarth

14. SEVANA KALA :
● Early in the morning and at night
for Rasayan purpose .
● Empty stomach in case of jwara.
( Reference : charak chiksa sthan )

15. CHEMICAL COMPOSITION :
1. **Tinosporaside:** This is a major active constituent in
Guduchi known for its immunomodulatory effects.
2. **Berberine:** An alkaloid with antimicrobial and anti-
inflammatory properties, berberine is found in various medicinal
plants, including Guduchi.
3. **Cordifolioside A, B, and C:** These are glycosides with
potential immunomodulatory and antioxidant activities.
4. **Tinocordiside:** Another glycoside with reported anti-
inflammatory properties.

16. 5. **Tinocordifolin:** A flavonoid with
antioxidant and anti-inflammatory
properties.
6. **Giloin and Giloinsin:** These
compounds are reported to have
hepatoprotective effects.
7. **Tinosporin:** An alkaloid with
antioxidant properties.
8. **β-Sitosterol:** A phytosterol with
potential anti-inflammatory effects.

17. 1. Immunomodulation: Guduchi is known for its
Immunomodulatory effects. It may Influence various Immune cells,
enhancing the Immune response to Infections and promoting overall
immune system balance.
2. Anti-inflammatory Properties: Guduchi exhibits anti-
inflammatory effects, potentially inhibiting Inflammatory pathways in the
body. This property may be beneficial for conditions involving Inflammation.
3. Antioxidant Activity: The herb possesses antioxidant
properties, helping to neutralize harmful free radicals in the body. This
antioxidant activity may contribute to Guduchi's role in promoting overall
health and well-being.
PHARMACODYNAMIC
S :

18. 4. Adaptogenic Effects : Guduchi is considered an
adaptogen, meaning it may help the body adapt to stressors. This
adaptogenic quality could contribute to its traditional use as a tonic for
vitality and resilience.
5. Hepatoprotective : Some studies suggest that Guduchi may
have hepatoprotective effects, supporting the health of the liver and
potentially aiding in liver detoxification processes.
6. Antidiabetic Potential : Research has explored Guduchi's
possible antidiabetic effects, including its impact on glucose metabolism
and insulin sensitivity.

19. PHARMACOKINETICS :
1. Absorption: The absorption of active compounds from Guduchi
Ghana can vary based on factors such as the formulation, dosage form,
and individual characteristics of the person taking it. Herbal extracts are
often a complex mixture of compounds, and the absorption may involve
different pathways in the gastrointestinal tract.
2. Distribution: After absorption, the distribution of Guduchi
compounds throughout the body occurs. The active constituents of
Guduchi may be distributed to various tissues, and their concentrations
may vary in different organs.
3. Metabolism: The metabolism of Guduchi compounds, particularly
in the liver, plays a role in transforming them into metabolites. The specific
enzymes involved in this process and the nature of the metabolites can
depend on the individual components of the herbal extract.

20. 4. Excretion: Elimination of Guduchi compounds and their
metabolites from the body typically involves excretion through urine and, to
a lesser extent, through feces. The elimination half-life and clearance of
Guduchi components may vary.

21. RESEARCH UPDATES
Aim:
● To determine the clinical efficacy and safety of an Ayurveda intervention
(Guduchighana Vati) in asymptomatic and mild-to-moderate cases of COVID-19.

22. Materials and methods:
● sample size of 30 participants (15 in each arm). The participants were
asymptomatic or mild to moderate cases of COVID-19. Guduchighana Vati 500
mg twice daily for 10 days was administered in the study group and
Hydroxychloroquine for 5 days in the control group. Paracetamol, Vitamin C,
Multivitamin, and Zinc were also provided in the control group. The main
outcome measures were to negative real-time reverse transcription–
polymerase chain reaction (RT-PCR) assay for COVID-19, proportion of
participants with negative RT-PCR for COVID-19 at 5th and 10th day,
proportion of participants with clinical recovery, improvement in laboratory
parameters, and incidence of adverse drug reaction/adverse event (ADR/AE).
The results of RT-PCR and clinical recovery were compared between groups
using Chi-square test.

23. Results:
● The proportion of participants with negative RT-PCR for
COVID-19 in the Guduchighana Vati group (93.3%)
was better as compared to the control group (66.6%) till
10th day of the study period.
Conclusion:
● In this study on asymptomatic and mild to moderate
cases of COVID-19, Guduchighana Vati
showed numerically better proportion of participants
with negative RT-PCR assay for COVID-19 and
reduced time to clinical improvement.

24. 1. Dr. Umesh sukla
2. Dr. Nitin ujjaliya
3. Dr. Pankaj gupta
4. Dr. Vivek Khare
5. Dr. Babita yadav
6. Dr. Amitkumar rai
7. Dr. Hetalben Amin
8. Dr. Rakesh rana
9. Dr. Arunabh tripathi
10. Dr. Shruti khanduri
11. Dr. Bhagvan sahay sharma
12. Dr. Bhogavalli chandrashekhar rao
13. Dr. Narayanam Srikanth
14. Dr. Kartar singh dhiman
Author :

25. अनुगृहीिोऽस्मि !