Drug Clearance MANIK

Written By
Department of Pharmacy
University of Rajshahi
Rajshahi-6205, Bangladesh

-~•..
Cou~~E No. 30'1
--;
t;llA21t
Md.
Imran
Nur
Manik

-- ----- ----- ,_.,_
-- -
/(
I
I
I. I
I
(p. ClT ';:: k.Cf· Vp
·~ ~#.}£= t:.Vv/-@.
'If Cir ; ~ ~~ ~1 ·lo·l~f ,,,.II _i~~ t!.l·MM11M pr·l'('':::M :it~,)t, .. ~r·cj>' .in~IL•dn'll 1•lc11rt111<'~
·lhr11v0h '" ~/, ·tc!~j_cJ~t:t'~ric) l~ &.- it~, Hi.en,
CJr ':: ~~Vo t k.ev'D rf- k.,,VD
'W'anl-1 ~i -Y( Ut!U1:),
t>P, Cl T :::.,Vb ( K~ + kJ. +km)
,', eT ~ YD.k {
I
. i
!
·lo .*1e. fJr~ ~ckto (~he·li(!e.) e.Umi>u·lr(ln .• ~I~ , .
v. = 'D0.
D Lp
l.
!bro ~ Bo7 dru.n con"+~rAl1~
VD .._ Volume. oF di~/rih0}f<1Yl r'~
. ____;----:~ ~
cl 1) ---- .
• .~. -alt = K'De :a 1<q,.v,, - - ®
1~·0tt'l. '(D s. ® , IJ<? hAV{
~ _ d'DsL:il_
~p
or, £lilrlina.~T11n rJl ~ -= 'r Cir - ®·~
'"f r/,.~-~ deat--ane e t1 ''~ /~.%1~.(..,,·//111.J -· ·u , ., -~
Eli ttllll""'IOl t1A-t~~~ -··--
• 'Pl<'.~ma con('f.n~Akon (Cp)
-~ .
.·,,_ft..
/
~ Shor.a lt,~ flt!/11.l<on$hif kfw~cn-
(O ~·1'1~-~~v/Fotr ·
Md.
Imran
Nur
Manik

.. ·'
l
· Cl.:·m·,~n('~ tn~ ~ c~leol~d .fop ao/ ot-n~ti Jriwlv~d .1? 1'1e· ir,,.e.wrsih}<! r--<!!!_oYJ
d1·•D ~o~ lh• b<+. 'M~/ D"n""5 ln JJ,,_ W; J...v~. !h· e•rjk 1;,,. d!"Q
;,,.,.,,.,jr"". tnelod-11 dj ,..,.,,re)rori L b;ot..;[:;:,:,tr:1r., J~;Jny,~· FL /;'!9'-
i
-, I
rntr1t 17 <~H'(J1tl rlt•lla d:ai·.~:•tt•,. ~
' .
•
c.fr -=- VD· k -© W'1er.e., I< :i,1 ihe eli'tninA.J;a-q ~a.fe
Cl'n6fant
: I
Yo =- App,;(ren~ vo}i.im~ of J;~fri:~u/i::m
$0, U1< el~~e ~ e~ ·Ju ih~ r,tiodu<!J of e/~Tna/i'Crn l"et.-b em16~nl- and
tik~ Vo ~ lu~v
krnv,, r: Hep~Jtc. II
Md.
Imran
Nur
Manik

II
I
I, ~.? i1le.~ {foiJ
<'..<.· = 1h'°'°1 droJ c'"",
C~: ~ Ou~9or7lj clr4 con~..
EliJYl01ho.·li0t1 t?.c.v
ora~n
1f ·II"~ I~ ,.,,.;~:•t'~ft]rcr11 }11 ·llr-c Llcod (en.) c11/~~l·IH "~· 't'''lj}.t_l~ttl~j u•·i·.:th·1· U11t1 I
11•• ~·~o t~n,,,,J.....Jr"" ~ bboct ~v) 6)"r"~"· 1~... ~"'"~" .fft;"1••3 1,., J,..,"
,. ,,.l'f,I~·~ Jr 1'1t: o~~ . i . ·
I
I
' .t
I
I
_. f.f,,, at'( t"'W'"'' ~1t<~r-tt>1<'e =r h"' tJe.f1n~d r:.1i'• Jl,(!'(E~flf,n t~.j' ~~ ...
,·,:;bi"1'0 ,J.035 {Ml .fl•W"· lh••tll~ J~< ·~~~2:_~''.';,.,l~,~2-:·~ /;,.,..·
fop ~hi~ J¢f;11Tlit1h : l1l~n~e jo ·fh.·~ f>f .,,,,,. MNrl fJ(ll.,I (4) fo H1t' o,~,. t.1ncJ JJ,~·.
~·lh·~<'lran ~1lt> trz). ~-e ER ;s lht. {~~~ran ·~ cl,.,~ e~l Jy lh< ot~ a~ ~
r({t',t't?~, 1ii1~tnh. .
,3 :-...... ,
- --
Md.
Imran
Nur
Manik

i
I
I.1
·~ J"'ff ~uma #-vol. 7k kid11ey p j<,,./~ of J.."fl e~~teJ in
., · : ihe. urine
~!B )< Cp :=_ Qtl )< Cu .
. ' mVmi; >< .A-5/ml. = ml/ttifn )< fig/ml
. ~~et"? . 11.a ._ h _. _I I ·
. ' '--'~ - Keno..t ~~t1t>anr~.
c, = 'P~~m~ dT'UO e»tJ ('('n~t·tdlan . ,
~n ~ Rtfe 4 vrln-e .f/w.
Cv = lJ~-e ~·clroo 6!Jn~e;;lr"'}1'0t1.
~ • c:urel~J· fo ~k c.1nln~ •
~
. l'1ort ~iu7),Y- , t·"~-' t'!,4!&tJ'dl'1(9~ jd de·f.·11<:•d &10 }l1·c. l•t·•it ;~t•y r_4>'U~ e'ft.<'t~f!·/r'-'n t><ilt
J..lvlJ.,.I 7 ·lh~ 7/••m• .J"'fJ conrn~Jron .1~ I< deh.t.J Cr ('/~~
/rlR ~- ,,t:"~~~1r°" = dW
F•~ "'/Y J,."8. cj...rd #iv°"{j~ ihe. 14.cl.,,. /he©• I~. J,"3 'f"'-ssc• llr~~
tA ~ ('4"'. ~lk,.#otl, r~~rr-lim ~nd/o~ acUYl · ~~t!~ekm1) ~V@t~i~< t-4e of :
11.~ . p~lol•,fe.J "Pl•ch -J, "/......"i ,;l.ovJIJ lh.l "1••r•11M J.re,J• "' 11,.
~1ltcd -rlor.o .t2;fe ~ ilie ~bi'!fl ~.f +lte fk(J~t'I ·-~ e/rminie . dr:~ , t«Jhe""~d 1h~. <!ler~51c.,,I
JJ~lron& 0 r deA~oe io ~ A • Col16t.n~ fuokm. •f 1/.,~Jn ..,/Je/., 1~'-
~"i+- coribtn_~ .f~ t-etn"'V'~J r: tJYU., be ~ /h~ ei11rri.
/, --T'. ' I ' •
b t'enA c: ~"Mn(!~ wflh ;~ ,; ni~'co.n~ jn hro ·.httttma t:euhcs
~ ..: ~t't4,. dt<'.i(t'4n<''l I elia j6 denned ~ ik~ of pl~!Sn{A . 'ff1t'-I ;~ c1~"1rl?cl tt{ cl)1lv.
p·~,-J·/ ~[: ·lrme ~hr~vo~ ih~(Efd~, i·~'I t"- «!on6fanl ·fr"-cfr of /he. Vt> 1'l wl;<!I, ··
{i.,e ch·Ltl ·, d~~J id i!SJ.~.1.t~ ~ li,i! kr~ny. ~ uhi/- of ·Ji~·,
' .. ~-2.
Md.
Imran
Nur
Manik

·• ~
·;):( f<c!n~I o k~ar~t1C'-"' etytttl.l ·1® 1ncli("lli?6 W1"'-l ·ll1f! drt'(J 1~ -"{·.f(~f,~~
:.·.:,;J,~,;~~ th ·h~ t'('n~I 4ubtJ~r (!ell .
. ···------ Y.lJ;(' ~nttl c!learan~ Dt t_ rlri() r.ieJt,.+ive- ·/o <§~ ft•ovide~ jnf,,hrHo.·lit'1
m1 ~~ ~anf6~ of t:enJ_ ~relrm . For e~mp~, -
·--·~·---·- .
Yi<e.-o:J (!/€t{_r~n~~ v~lue6 :e~ee ir rnl min ~..,~ jndfcrt.iive <'{
· p~ular c§(!rtl®>. .e.·~ ~::§_ 0':0 mVmin) · -]-~
y. Rt?rio.l t!JL~r~n£'¢ w.fo~fJ Hz~J- ~re. (~:£~)_§m0ni11 a~ inJ1~~:lrv~
/r .1,.t'.~,taG~~~. eff ·, ~~n (~ rnVtnm).
, . . /.1f t ~n..) ek"r"'noe ! :id~ ·l<i .!1Q_ 1nl/mm j ·•. 11., 4'tJ •
~1~(;~pl~~rn~ pt~o~e~-k~_!;d S- indi'"~~ ·t~+ fJw. Atit'D i<l ,,J;n,;n(·~J fr nl~m,.,,,,~
~4H"',li"'1 -1" ·111~ <'J>9e, 6 · ,,'.1} ~k ren ...l q/"""""<!e Df j,,u/in i6 .......'1,,--
:n1e~e·t f'f ·6'fRt·
~ ~ f,~n~ ci~rAnt?e :
/.1JknCl~ inv•l"'f.l <&r1a> ;r~~- il •niy he ~m1bJl•<I 1;r e:
ttd.,~i~o·l~A·lian cf- t-tn~n§J.)~IJch ~t>~Je ~·lh ih~ dn~ . ~3 ~h~ pMbenecfd
.IL r•,-6) tlf'e e•r•Cl>~.t:en·l7 ~""mi6f.wl . 1""'~<! cld bj,,('/('$ Ih• -lul:vlaI' ~ecr Jr"'1
oY ~~ ~1 .mu1r-t•·lr·~ r.tf u,~ ltWt1iel' Ltur1ir~ BH~. .
, /wt,,~, i;l,a. inve~ @16iv~ Ji/Tu§, 'ii '''QY k ~r-n/1•0/1,c/ ~
t11ttki•f " ah.~.. Jri(t}f:. vrlne6.
'l! ~k ~ ~ o.clcl..i~ s- -+~""- ~ u mo.Id... o..lJ~~:~,~
- • o~ ~j,¥Tl.;~ .. ~
lft "'1t...a.- u na.. • '-f-W.."'- '"'n.L dn.u.~ ~
:J . > -u; I -1... +,_ ~,,
..e.xe.nt.-kd · (20.{'idti. 2J -u..cle 0
t»tt-- ; :_J'""""'~
~ ~rfisi~ . ....,,
Md.
Imran
Nur
Manik

..13
JDu/df
~
r
.f<enc:-f t!l~Y'atK~ '6 dilermi'~d t;~h~ of ·fh_:e_ ~Uf!Ve obWn~d 7 pf,fl,;.9
Hti: t·tti~ of- dt>ud e~t!t·~~r.n in utine ~ Du/t.ll) "'OcU'ua-1 . ~
dr'._Ua eone!enl!'~·hen.
~~.= ~~ere:lt6ri . ,,-.t
. *~""°' ~t>nt! •
lk ~e1o~ ~rcJ (!i~r~n~e of~ dt-"8 i~ ~{fh~r~'r ohpihed ~ dr1-iec-r
tn~tl6ore~ni. 1~~ d~~~ ~Iv~ .fop 1hf!. J~ i.~ ~-~ iW- of iii< 6~t>Ja,,,d
pc{et'l!n~e , ~~ ~~· wiv~h ~ de~~J · ccmyleJel ·fhr-e19'1 ·[he. /<1'Jn7 7'~
m~ul~ti ~llro.~r"° &) -th~ t!J~a~rx!'?- t<'~oe, ~~~ ihe.e._~. of rettoJ ~:x.~re-
I
. !
. . • I
F1Hr1-~"iM r11.fe + ~4!rdion ! ~ah - R-t!"'b~1·e.ft,,n '°~·. I. •
Cp !
r1111r"n~r,,.lrrn.___ ____..I
, - -
• <!l(ca.r,;1.nce r(lffo . L.... ·1 , a..ios-orz.p~
~~"""n~ tncy-·b~ c.ondidend ~ 1k t'~O. cffJ14! ~otn·of fh.e. nlo~r«:'/ar {ilfrp./i'cn
1
rH•cl 1'.e~ive ~ecrdion ti~ftg I~ ff,~ ~etAb9'>~r'~ ,.,J~ divrd(!J_jz_ih-c pl~~tnt J~,tt~
Md.
Imran
Nur
Manik

---··-·'-··-···"--"'-.:..•.__:
-- .. -
I
' II
I
A ar-rh !G I~ plo·lkd 0t <!um__ula.·k Jr~ e~~kJ in ur~ wr~ug fhe_ Au~.
Cl('apant"e )9 obJ~tl"ct {tJTrf' 1h~t>f 1Jie <!Ot•ve. • /ILIC <"ctri t><' t:.!lHh1(f.-r/ l7 IJ1<
/r~f~~ci;JJ ~k or "f •i~~r m~agur~ment 1n~·th.cl6.
.ffta~· d Du = ct~. ~r. ~ll ~ ©
o/ .;.,J"e'>ttltva ·Ii.~ ~av~'"r} ~
~ t
· :r~Du ~ Cl~JCp.dl
0 ,;;; 0
Vu l
""' ;f)uJo :: el~. ~uc]o - ~
· .:H lt 1~ yof.,tne tf c/J6lrr~o1iim Vo tt "~ dirnin"'1i(1n el!lnt1/i!rrf
:, --- I ~?'.'::
e.l"t1r·Anc-e · c~n k.. c~l~vlea.f-~J rfJ.~ ~U&'-"t(1i ecyu.Jrm - · .·.•
I
·1 ej~ = ~.Vp ]-.@
.: .
".f,..,. ,. ,:., , ('(. • ·r · ,.,., n·.·~ r,,,...11.•t!
. I
I
''[Au(.]: --~
·,
-. ..,.,,t -, ,,
~ ~-',.., ...
Md.
Imran
Nur
Manik

/ctH t: KmVD -@
., . . ' . ' .
. .. TolAI. ,_b.J/ ll•ar""7 (cir) i' ~uo! ~ .lk .;,utn ,~f r•n.J <'f.a.r•we <lnd
~..pxbe eb.t><n<'<! and ill h.aeJ ari U-e_ O>nc'?r} Uvd fJ,.. ,.,.J;,,.,_ Wt ."''~ "11 "
"'1t·n el~AH1'8 1'en( .
ctr ~ C1~ t e.JJt - tD
d. ('learonl'e <!t?n e c!a. eultttiJ .frn>m ~".ff«l rr"'me~et•!). t.f ·lfi~ vo(um.:__1_d;t'J/r;J,.,/,~
a,J eh•,,;""lbti corn1·~iJ 5 .ilt'<' I<~"'n, t:.17 d"'"""""(Clr), renal d•.iM ne"-~I~)a ,,J
, h,.r""~Te clear•n•: (clu) tan be e;.leu!.ifaJ; a.~ r<f-1J- ./nfii ./'./Ir~"tf e"f""~i.m;•
Air t: kVt> · -4)
' '
I
I.
r-··
Md.
Imran
Nur
Manik

-
. .... - ---·-~---.-
I
I
I
. '
l
~t ()J>t.. ~he e~cf or prolem !,;nJ,· ori l'~no.l deo.ranl!E! ~
'H1t:t/ein kvr1d d1·to~ ttre no elfm;Mfecl r0/om.qv/aF
f,·U11p.Jib11 •• /T,t:to~[or>e fh~ ecvu"'-11611
J'~tR :: f~r~~ron r~:I~ = dDt/<I~ _ <!)
n~ftnt.t. ~on<'. tr i .. . ·• ,.,..
·for H1e ~"'(~llf,,.f;tm of t>e,p"1 ~JM~'ml'e tril.1e/· he. mrxlif!!_cl, ~~,,uGe. lJnjz /h@
dt·ua. . .i(, ~:re~~,j' ~ o: (;pear froc(!Q.; • 'fhe€t1J. J..,':':g'>re. ~l~UP-.~ ex~retfJ 7
@!five. ~ecrel§) +o1r~1'8 ca.r-d~ {jnJpd f<~e~c5. Cleett'ttnl'{? i ~/ueG fct> 11:i~ r)'>Ol('in
l~und. dr16 ttf'~ 1'1e~e{ot7~ ~J~u/,J~ ~J, ilie ~(I~, ecyttt;J;~ .
_ ... -~&tk of-J§bo.unh~ -_ excre/il'n , ; _
Clrt • ~n<«nk~on of~ dr~. Jn~~.~ - ~
. '.f,1 r-J'i-a., ilJ~ e~bYI )9 rd eaii)r "~d k~~ ~J,.,_ ,.,.J" •f dr!lO
' .,~<!Tl j4• usualf de'1;mi~ @fo.,llei+'g Uri~" ""''WfiJ·7he. J,,~ &<r.jed
. jn -~J,e ~±_e. j6 ~lte <E5)if ~"tt0 ~~~J f ~ ·1L•l11.1le?r ~,e"r~~~ncJ b;'
~"'.''"' 310.-u/Ar fl'H~~. However, i~ ;.,.~ f'9'ibf._ -I• cirt.1mquieh 1i." "mht!rll
of, b,~J ~ rt~lrv~y ~t.J .j;.om jh<' <lrt74UMf Dt d~~ R->e~!".rieJ r3/omerv-
lllr . ttHr~~wn · .
•1
"•;
-~I! -~-.,,,. ~
l<Vo ::: f<~Vp+ ~'"Vo -- (V
r Vp ,. •n b··I~ .sld6 o{ "'Vt.t."/,••,
1 k =-~et ~:J
---~------------
Md.
Imran
Nur
Manik

"'''"''''·'-'·~~-.•···-·~·""=··... :.· __-.. _~_:::;_..__~>--'-.:- :_ :_-::~-: -- - - - :...... -
--- ~-~---· - -~ _. - - ---·=:_-;._- ..:- . ~;:-.:~~-='.::- ::. ·.·-=.-~--: :--:--:.-:-..'!.-:"·---~--~
·,
'
' .
·rt•• <fE.f~ eliny...J;..,, n-ie. (!•n~t<nl(E}t6 "- ~$e(u I · m~asu•~~·mf {or J~
elirnh'ei{ion in ~ ® ;J!YlfArhnenr mDdizf • Tn mv/~ef.im~.etr/m-en/. tntJ~/e,, ~v~rJ
tnr"lhn~~ .f"r fhe e~lim~J~~f r{~~M~ ~t·t> J)()!5;!_h/e . lT1(' 0'-;'-"•~1' .rlimi11"·Jr,.,, ,.~It (Y>t1t.~'m1
~ r>eft'f'_,enfi; elirnm:d'll!Yl forn ·I~ ~t"'1 <-""trifu~1t.oen/- .. ancf f"/ttJ. body demvm~e js
. I
· ·l,~ f~~~~ oF k ~~ t~ v11lu~ of)he.,_ ~enta.f ~omrwlm~flt-, V.r. Al/6-ruj_~,;c!~,. 1
. . ·~~ . . . M
·lo~"' t.:,?jr (!ka~~nre rn7 b_e e6·~·mA~d atrorJFro -h,,ft,J/~iicr fA/uJIYl ~" /h~ rroJU(!~
i1 ·H~ e~n~~TM ra:l" r!tn~~nt b 4:.-n~ vt¥7>. ·"lk!& /11.ilei· mdli(IC.~ u;vet, ·If,~ ~me v~f11<.
fr ~leAN.nee. 01i,,,, rnetl.,d6 ¥r ;,,J~ol"-lmtJ ..,./..J ht<?/€•Mooe co~J,k. eiU"''' ins ·
~t1n~~ne~v5. ~lt~l'd~e. Ot' S.~u!y-~1'J~ cle~tl~ .dern.:Lma Ot1 1tJIJl'h Vo~''°~ 0{
d;~Jrj -
. . , . .
bvho_T) Js <~~tt. flir· Iii(!~ ~1'hner1f moJt!I da•ua. ho<y !icat!tAi1te.:· ~t?n l>e'·~"'/L!Lt··-
1~tcl t0Hh ~h~ .f1>Jl&wi1(1_ e~tl~~ilttl •
. ,.
f?.krmi~ ·.(!l. €0./~ftin of b,,d
rer . mo:o· J~ eludie6 , ih-e_ l~a Jr,'11 cer1eer/r1-/;tm (f~~(!_ 1'1u5
1,~,,d +-8) a11 l'f"'J in d~,.,,.,~.~ cA/wl..krm. f(a~tnA. .,..•i,,r,, l:lnJ, A~7 '
ldH" -<.ffe~l "n ·IJ,•. l"enca.f ~Je~p,.flt'.!e 0P-[~~Jr-1e!J ~N-t•r#_1 c·~,,.~-~wh.·~~. r:·•S"i/kn.
f,,~ jl,..,_ ~r.. ·jh.- f,,,,~ ·~ .f.,,.dr"'1 jt. f;Jlet><J .J- ·II,... o!•"l,<tt~arf ,,,t,,.,,.,,,~ ~~"
'rl•in boon.I ,J...fl "'f1'f"i'S ~be. ~Ed ~ lt.. bm~~s AnJ ...Jr~·!>' see-
pt"fed )nlo ~h~.. t7enJ ·/tjl)I~ . - S~p ~ 1~ ~ ' .·: ! ;
I
i
C.'
p J'
. 11-e~
E"ltte•JMJ ti ):$ ~t6o · ~ .in 1k. c!"-/~u/1.kori o~~ c"nc~nl~~·l1"tni
, 11i{/,c f~a. "'''~'" tJ:._ jd ./lie. .f,.adr'"' rf~r"8 ..''""~ 1~ls f~.. f.,±,
. nf(E)clN)tl •
I ,:
1
Md.
Imran
Nur
Manik

/
'i
. I.. ,
'. t
l11 ~ bV~ .,-@
' ' 1;. ebl..M 'er1.J .,i,...,,,.nee .j'... dr11.;s d<!mOtl.<l /,... ~· '(J Lwo e",,r r/..~~'. J(;,~
I
·lieb tc.Mh 1nel~bolism a,,d e~re:li"'" ... i~'- folJow'hV. ~t"'·lr"~ jG t r-"'d.
_ o- e!} ~;=K~vr] .
~' .... ~m•M 1he ~~fon wkn .fr,.c/Mri:;;...-- ' . . . ;•
~A. fha• tn"7 roa~. ·th~ ·lo·l,..f ~m01>~ . ~ 'ff, ~xe,..eteJ j,., ~h4..
ttt>1n"- JYl'/' p~ e b~necl bl' diNe~ tt'iS~/~; .lh~ P~fio v:,~·l·h~ ft'ac~7M "t -/he cla~e
~b6orbeJ. ~~ , i~ ~''~: ~ 1h<! ~ttdrtN'} ,,F dtaua ~tte1~ v!!~naecJ .in I~ vrine_
f;_ i~ €P/~ -It l<;Jk .
1 ~ •·«:
Md.
Imran
Nur
Manik

. ---. -:._- ._:: ..
- -
·-,--:~,..:;-_.. :.-.:,,.~..= _::.,_~·.::-=-~~."'-.-;'::.,...:=c~.;_~·;,..c_--==-..;-~,__-~ .....,.~- -.. -..-- --
., ,_.,-,-.-·-_.- -
.,·
"""'
~'
I.
~
....__..,
. Tu .ef{~ eJ,ow, 4W il.e f;r.13/- ord12r r..f.. C't>h•-Ja.,f@J in 1he (om·
~rlr11e-if rnoJel'j6 e.yt.U!..{erJ -/o -/o/1_ b<idy efe,.,.anC"<!, fae/i~ •f c/r~hso,.kJ
_ "f~renf vokm1e •f d16lribuJr"'1 • 'In .JJ.r~ 't.«!5e, U,e <!:(~Jfen·tiiJ._ co~nf is
I!·•~ r.1hLc i-~"'1'-f.m ~"!'"" (f) ""~ 6iFT?.
·I.
fr:>0iY1 (P s:~, ~ (W1 ~rif-e ,
KR.v,.c,, s: CJR{j-.fr).c,
' ~, k~ i!: Ct~(t_::fr) . :- {ff)
~ Vo
.~ '
[.~ . , ·. Cp = flagrn,. d~un """"~,J,.jr,..1 •.
'$· ,' .· Clp.. '=- ~eha/ t!l~n~ , ..
~ 1 ·· F~rn © s. ~~~D~::~~::~p , 01>, k~'~ ~
.~ : . l!IR = k,,Y1.>! -® . llo
. ·~ !'or o: J~'(j !01lh 1-[t><!,,.C,60rf1'1"" fot~k.J] o~J;, 11.e dr"ft
~A.-·ff,G. e.v~@ ;,s ""'"t"ld ~ foll~'
.dJl_ ,;;.Cl~ ~- f.).l'f -0)
a, ii;~ rttte of drLl(j ~re~ u6~ {plj,Y61ol~are mi!di/ft~ill be -
41f = Cll! .Cr - @ [. · .L<,._ • Vt> .,,. "-J~]
,... ,...,--
Md.
Imran
Nur
Manik

·····-·-.- -----~-=------ .- --·:--_----..."... _.
-- ~- .
- - ·--· ·--- .-~---·--
• I '
tl '1 == Hf.p~Jrt e~rttn~ ,
cR e E)'.J~c·lion ro.~ict...'~..
()_ z: .0/tt§d .ff,,,., .
J;..,., ih· "''~an ;{ i~ ·l•ar ./h..-1 • ~h., dn.•u6 io,i/~ 6£).,.,/,-q,,,·Mu ,...L-,,
i~· t>ernoved '; 1~(Jfi)~~t ~~ ~ri"!z'"~a6 ~h~ 1.11~tAn, is ~fu~ed hl bl~J
jn tJ~l~h ·fk. J.,,,8 ls <!on.J.;ned, ; ·
(J. (t,.-ev)
Cl~ ---;~.. (',.
==- ~. (E~)
. ~a. :r C"nc t., of dr~ i-n a!fe;r ,.
~v • Cen~, ;e.f, d11'(J in ~in .·• ..,..
l"~~'o ·pl"/~ ari 1m;r~QJ ~Je Jn Jrit,t~ ebln1m1/1'dn:
!J·. An 4!:x../rae~i(1() ~"':Wo "'7 be e~~~J .:t6 !~ox of tre dr~ ~~· ?he. liv~r
I h tJ,~ reWi've. ~onc-Tnfr,~~&o t"h"') ~f clra ~kl- fo rewoval 7 ~he l~. j.<?:,
c~-l'v
·:f R,, ::: C" Her~.,
f-~~ 1--&
CA-tv .·
~~
1r.:.. Tur-~1"ne~-~ El)'..~riae~fon
.',, ..
~n"1t1 I
. . 0,n. 1~~ 011te'I' ).and,' ~~~t'elrttn of' lnd rt!Ai~ -/J,e ~/rmintX./i&n tif- dpf.{a by
I .
·~"'I,."" ih• .,(;1'Tl"~"'1· -Ja ltwr t1.J ~ is n'J~/,,J. Ss, ~o me,.~ore
dro3 e~min~kio: Vil"'. of~ rn""e re,mn..bk 1han .,,.,_!,-;,,, ,,..1..i
4·.t''""l de/bu me~n '1·· e~/""'clron t>o../to of- an t>t• _tn? /•'.lh'4: . ;~ j/6 im 01> ~u~e. it'
ctt'Vg eJ;"';"" Pon .
e%<"J'~ ~ I' ;_ 0 n~ J..u ? I
I ' • I i ., . . .
A. 1)""0 js eh'l'l1MA~~J ·lrom .H1~ bt.1cjr rnttinty ~ t'enJ e,t~l"e. rtfr'I • Bor ~Omte. druoB are
•15• e/i.,;,;J;d, fro1n l~~ liwr vfa bif.. P,e".' /u~~ &•/o.~ d~v3;). So,j f we '"" nl ~o . .
· "'t'tt~ure dro.d ~limin~frttn ·fr.om en/tr~ '°'9f~~~ hllv.e. ·/v C!6n~i'de?t> 1'1~ elimi'neJrdYI ~ f
d•"(19 .f-. ~.,..~ ; I<~dn7 6.- lu')16 , Dr'W- cit".:..nee j,z ~""~ Jrre cf tn""~orernenl- me •
·,
-H,od.
Md.
Imran
Nur
Manik

I
. !
G11 W~ f"e.1uf fs ~nct>ea~ hltn)d fl{'to Jn~ ~h~ ofom~11ulus.1,
' '
('~ :rion~nt~l~· ~+·lh~. rra-.(!ul~dens~,
' . ·-
(1.:~ ob
~: .~ na l,fr.roJ .fl,,,,, tti eu.t ore. u a. ~ , fl1 f>~ rt'-'~;"11: ·/Jir !riu/ bf~ ffN..; t ~nit1in
1:;:_r
rk no.r~.,.J 1ew1 d~ 't.nlJ .....bl~ .,J.,'Oe Jn 11K @'fn"J ri?3 i< c<>lkl~~"~
t·e3ul~ffut1 .of- rren"" b/~ t/~.fk Pen"'I h{01>J tltJw }5 au1'1t>enulo.1ed ,., //1e ~l/zr~ff'(T
~~. ;, .
'yl( fl{~nt aP1eriokP v~odr/,:~or· fet:I ~C?K t:net.?hAn~m :'
I : ' ' :; '• I
i !. .• • +
. . !fl Joo liHk blaod'·ft~~ hflo t1en"1 4oht,lts .~au.s~_s c/e.!!'~d-' N~8-
,.
'
--···-,,
I
I
_·__ .~.~~e .mec~niGrrl: ·. j
,- I
. - · l,vhen1 a.rtt~TJ re~so~ e i/ s~~J1<4 iJ1~ w"/I ,_,f 1'1< at'1~,..r"1e
Jil•h "~~· .1-,c•nJ•7 <!Pnlmok011 tf arl•~./~ '"'~ ,,.,.J. b/eocl .(/ow 40-
'"''«:11 nor>mJ • . - . -. : . i
• • c ~onw~~. "'¥". r~"~'@.an "ftQ,;,I, '!'Y"O~"r" ""·l,!Jfl~"
llntll5 ·lhe a·~ry; J~· A11~·~,- and -~h~re'/we ·~. t>en~I biOod -(/t:td.•.
..... :r 7. . i
vU-~o,Y,,'- D""'(j Qi<.~°"' o>i>-- ~rr-ovatl ~ lh.+..tl +« Non-v1>(~"- 9
,,_ --.;..,7 -e"'~ -r ·~ ~,,..,.,, ,,, pn>~ .},... . .vU"-"-+c»: •
~~:r~L;~~ ~4;-:€_:J~~T~k7;;
.-rf-1.-. ~ Vb~~ ""1.0- ~ vi.. ~ ~I> f...ro €¥-f>IY-d ~. '
. *4;fer111."1.:k<»>:~ 13, T. .;.., "". p-o<M.~ h7 .~. ~ ~ ·.. ~.,..,;,~:
O'l'W~ -fo "'- ~ -eu« ft> ~ htfJ;-· di- "> L1J.rtz".(7" ."1--n dV>~ 7""9J-1<!
pro'!L'h· ~·· ~('NILS ~~v.,.fv& P,... ~ hib-'lrl<hV>,:fo..,'""'''':H~ &}- ,
1
~ /i.~JJ ~';7 tn li(Q))__. ~ -+:~... ~a.. l<.J~ ~
» ~ '~H.,,,1 % l'6'J<L+. c>Jc...o 61n.fcU... · e:r ~ r ~ :. . ...J.i j
~·- JltA__ ~~ 6t- tJfo~ {st{fy-4 ~T~ ·~ ~' .941 ·;.}
, ~~ 4 __b~cc; ... ~}f::z.~.~~-~--~~-~~~~'Z- ~-.-- -~-~::_·.-.·.~~:-~Y__._ ""~~:., -;-··.'!:·-~::.--·- ~-- ... :·.:....· .. ~-~-' ~;
Md.
Imran
Nur
Manik

- -~~--~~ - :::;;.._
-· --- ···-- -···- ---·-····-·.
__... -·
---·- ... - ---·--··-
- - -·· -- -- -~·'. -:·-------:-.:-::: -- -:.·_- ..-_
---~ --~, ... ,. . ·~
...,
_.,.
. '1 ~ Mpt "" ~ .• ll-'(1uo..-1-}. ff ~:::J~ is . <elI>.=5 .... -,.u._, ~~~
i ·~ ~~~f,Qf~e,.:l'Tl..-
:tl,f,.I" ~n rno.t.nto.kl"q ..h (l<;mo{ic. <,1f9.l~uns, .,.,_ lot>od l. -'.<:.> ... ~ •
" " '' fl,..._ 1(1~ -i>.L _§ loo.,d Jm<LS5.'._1na.- Juru'.a ~'°""i;,_ n..
C,,n Jtt,_~ e."""(j""'C<!;hrzna~ ~y,,.~"""'--ho...
11J.X-to.(1°YnRllllp.~ . Of>"ttnbts . . . ~ . . '
/@ 11:. ·h..p• .0 m~"'~.,_ ·~ nort,.,,.,.L ;T ~=· _11ood~ llul<l< &;> 4.<..l;n.L~lv
,..@ H~ps -ln" rn.inl?>n.. tl•b lo~rct- fr*"'-i,,od~ ~ ~"""(r f OJJm~ ~.
/ @ • ~ • " th>- cyi""'-'""- !.O'l~· B'- (!J)n.op.i"'L. ~n<1;~enf;< .
~ ID1ood-. c~rn.oa;t'a" fr ~eve.. ~~son-p-"';L)
(ii) 11:: 63 d~~/ 9. lnN.tru.• :9"'1~ .SU.lo<¥"""' jn•m fi,...1::j.
G '.l'I:: d§..q~~ <!.D.n.~ ...... no.';;:, ~uJos~en - NH:?>, ..ffpp"ri£"- acld ~
:-~i<
lno'(j an.le. .· ~ol . fJ ~ -t..lps in f "'~"i""/k add - lo<v.l"' .Q..~J.,oluM. ·
- . •. ·~
d Rm<t"' _§- k.ia ~: _
(0 ft ~ WM~ :J°"?c:iud:5, sp~ucJ.~ 4h.L
•1U::,,.~"-""'l-S . £'< .S ....(pho.o.- eont!l)n1..,a. e.rvd ~nodu~b
•
•
Md.
Imran
Nur
Manik

. - -· -- --····-· -··- ---- ,_ .. ------
i .
. · ~l<tn == ~mA 1- l<me +-~Inc+ ..... · + J<,,'T -- @
lte' rJtJ.·licm~IJr in 1~i~ etywx/i'crn a14urnen.1J,,:.f, ·lh~ rO(f'~ ~r~tti]9
~ .. ;~ @it'· ot>~ tfnd ihJ ~h~ ~vh~tr~e @l'uq) ~DIK'enlt"~lrdtl i6 ver>l /oc_1' ,
·' . . ··.. . . I .
~"'ee,-ih~$¬ ~+~s_ o~~ are Cl)~ickrecl ~ o~oe!<'~S.
. .
ih~ F~nt~e. ~f l~~1 -~r~ me1o.holr~l1' .: I he toiind 'J'ihe io/lht~mg- arr~6ia1J.
'./•. ,).p"ff rne~i,.,/;3..d " .·-'ff >< 180 , ~
V-'ht>J ~on J*on <!"-USe. 11,e "~--~f r:YJt!}~boJitJm ..~f!~mtd bt: er'O order pflo~e~~ 1
~p.Ju~~h Oc!~l' 1 »: ... _ ....· . .
l. lll~. pro~s· 6f ~lo/r~n~r~b-n ~t' t~l"bolitJm ?~ i~ ~-.~-1l-m__..~=t~.~<!.-C-fln-~-
f .<7-- d~ -/cl ~·::: irfe1~boLit; }~n {lh~ kij'. -fltf- rnepbo~c. enax_lfle ~on~nJr~1FoY1 {s
. ,~ .. • ! ~~ ~
~~~!~~})~~ tc ff'~n ~i~«' and 1h~ dtiua ~t,~~,,«li C!~n~~#¥~~ '..rn~. ~"~n
,. dr'fj eon~+"lrm i!l<!§f/.._f....-lo lh<>. efia,lmi • ~b6<"e;..Jr~P"m,·IJ.,.,re ~...,,
.,.,,:J.,.f '"Tiitrlt'$ ·I~1i91'1<> l'eA'dl>il '.rt,.c1 .,,,., t-cil. ..f rnel•'>•1i.1m 3,, "
1101 011ckr '1'3 .
: . ~ermine fhe. '~"Y'uo.Jlon # 'j¬ r~01/- o/- dru rn-ef·..ho·l1'5111 ~
y... ~ · . '~ ~ tm!Yltt· 1~rH> .m~· · . ,.ud·" ·f;irm1 ihe· bod,Y jhVl'>l'A?G ih~ f''ofc~~ rif t;.,tl-i tnd~ bt'I;.,,.,-,
cnic~ ~~'"re·litin. 1J;~ r~·te '~1m~~nt l!'f ~~minalr~n (!<) ~ fJ"" 5l'tn t'l.f ·fh~ ffr·t;~ ord"'r t;a.1~. ...,_._ ~
C!'nf')~nf ·for m~~bc(~tl1 (K~, and lhe ~~ wckr ~fa ~o,ns~J for erxcreHon ~e) .
•• • ~ cl l<e +l<m . ~@ : -
.. . . ""'~'°0 UM! J_ .
0eeo.lJSe ~ d~ rmJ k biolr~n~r;;;:i -le ~~. rne/..bokl•s (rnd ..b./ile11.
In" h,,,ill~,~me~"bolile$:__..el".,),.'fk '1W'J..~h'9m Pi'te ""~J;,nf ~ is 2~"',~L_
.r,~ t·~e c!en~/"nf~ {or 1~, .formo.lion eJf ~ae!h .,m~fe..~~/jl~ · · ,···~-~·
l
Md.
Imran
Nur
Manik

...:..-:--_
R.'* of ··jnJ·ermedr'J~ [_Eo] for~·I~ ~ k1 [E]fv]
fZtt~e- ~f ~t1l~rmeJ.·~~ ~DJ _ckcomro~illdn z: l<i_ [Eb] + I<~ [ED]
rv-- . I --
' I
d ~D]/lt ~ k1 [_t][D] - ~ [_EoJ .. ~.9 ~DJ
=--
-e, K1 [EJ[o] -Q~ +~~~DJ - @
(1J] "' 'f)~(} : [E] "' En.rme l ~DJ ~. ·r>•'"J r:,,ll("'" Jnlci• .,.,,/r.l' :
U'l ~ ft·odotd- .,to' metAb" (;~ ; KJ I Jc,). ,r.,P_, ~ f11•r.1 ,,,.,,,.,. ,.,,_f.t. l'nnr:f;.,J!l . ···~
__ K_in_d7~~ (JenePA)r ~8n!>rckred IW~ f!E dr>Lw :rn/erad6 id,,, ~ mok
~· e.~o/''" lo {or"1 "" . ••1Jlre _J""8 jn/e.!:_mec/l,./t • '/)ie "'1;Jf"le -Jr~ i'!ni<•medJ..JH
~·l!,,iJ,(r J•t!ttef~ ~lo 7iel~ "' t>ead~~ Ot' ~ d,..ugc§:·/"bt1@. '/i1e ~le 1JY7o~~
.fn., dr·ua . mel"'boli~rn iu cktScr.ihecl :?' I1~ Mi'<!l1"elis t·le1 t~'tl C'1t<-dtc11 I ,(,,JJ(.t' vt11Vtn(5
' Jl.._I ihe.EE)f ..n "",-Y""'~k: ret<elrm J6 ~nf '1/"'" l/ie@Mrlf"'ffe;W o{
.... ~
·~·H1 .,l~e enaytl'le trr.J 1h~ Jriu.0 .
Eacl, ..,~r~ crinil~n~ ;., ~9vr~ ;f3 "'~ reac/,·~n ,.,4~ e,,r>G/~nf- .
•f jh<o e~<> D<-'<'U!?G ~hen fh.,_ clr'(J ~OIK'ell};A'./j<J'f) 'fr. ~ ',
~Jl ~fl)e. 1narm.e rntl}<'cJ~ be~D tflt' teJn fle!Xec-1 CL'ifh d'i] ~ g_ iJ1'° P~ctdil'n J'el. t( .5 .
a J (1 ~ ; ·Jh~ r~1~ T'~<.-~~s ~heri he~e~ " ~ro cpc~r proe~'f!Y. lhe ''
, jn1o?hli"1' ~'€0.~·fjt:r(l rJe ~ knewn &~ th-e. V~, ~nd ·Jhe; !Jt'b.1l1·~~t. N' dru0 c"c1Yl<'Pn-.
• ~Y't'-~fl'11 (ll WtJ<!J1 lh€. reete..litm "e_<.'Ut't; t:Ltf;jl)lh-e ma~ilJTlVh1 ~tt.te j6' f<.nown ~'J.ce
Md.
Imran
Nur
Manik

--) @)
·• ~
, '
Solved io)' i?E]
[_E DJ "- [Ii!)[DJ
. J.bJ +Km
et1J1'1n-<t.
Fron,@)
, ,,.,h.e~ k.,, =~ ..,J~ c!m5/ar>I
. :lrt :;eifuro..~hn t!(J)tdJlrm of ·.
. Let,
I -
. ·. . . I
.. ~;_<¬ff.td;:~~'.He /}:o] ton~m/.,.jm, i~ (cn~/;.nt 1Pifh t"'5f"'"I lo
1~-mr ,bdtW~e. "~" ....t~ of f..rm...ffen ·fire J~ua <'n~/fn" int<!rm..liafi e't'~
to' ih« ~ •f nde(!llrne±~tlfl of th.. J,,,_ en~z- J!ei·m:_dl..h . Thl){J ,
~ anL:', 6.~ kifrhJ·~D~J· -(_F.,,_-fK5J[_E'?J
. 1<1 [ElJ ft>J = ~D] [t<~Lbl +~2t r<~J!
[l) [b] i: (!!DJ}IPJ + l<.?.~I<~ J:. -@
5l>btJ~iltJI~ th~ ~Iv~ of Jr}_ ·).n etyLtAfo,.,_gJ
I '··
· · · d lfl?Jj.11 = K1[LM-J.EJ~11>J -Q<ztir~ LEoJ
Md.
Imran
Nur
Manik

- . ··- . .. - ··-·· - - -- --- . - - . -·
, Km, is J,~neJ ot!> lh• (ftt1/r:..JV con(Y~t'"-JIM wkt1 1~... velo-
,~3.u,._ rea.elr4'1_ ~ .~~ -lo ~ ma,;j~ wlu•ity _.,., O• 5' V1114"',
"The. ~m i' a' ~ef~I ip~~~m~i~r ~tt~f Y,ewa/~ ~J,e ~(errlmi_try of ·/he ~u~§·lw..Je'
.._1 "').;..~ ~l,e l"<''J...1r.., •ecoM ,,_J ""'f v,,,.,.,_ . r.. D••"'"'I. r~.." drt•o I~ lh "'
ltir(1€ l<'m, ~ qr~'fir Cl!Jn«!ctn~r~l1art ~ifl be 0~ <!~t;~UtrY , hefore ~·lorcJim lB
-ti - (J - I · e-r-
r~ac~J,
. i
lhl~ ~'lv.tt~im Je,crlb~ ih<t.@of- tlte·~"'bo/rle .(011mt.lrt111 N· -fJ!<
· Mi~J,~eli~ '- t1~nfen ecyu.Ji(!(I ·
c==;=:::: .. --
Md.
Imran
Nur
Manik

_..,.,.,,·,·.~~·--.<:.=.~·-"-'-'• __ ;.... -··-·-·~--··-·--~---:-~·--·····-·------.·· - .
'fer rncof bro.Jr~,,~ formei1Jron t'ea.~./ron~, fil.e 1ndt(be-ie ~f fl,e JN~ i~ '!!~
fl:Y~n 11'~ ro~ri~ ~fnrl)LJnd • lhe. ~nWr6im of l'I. druu +' more ro/4tr rne1~'1Dlile
'~~b~g· ti~ d,,,, .Jn k e/irrru~ ~re ~w(!l<'f iliAn if ihe d11iv remo.ined llprJ
;o)~k. A h!'1~ . ~olubl. <lr~ ero!l!<'6 tell 1nernb"'11<:1 a.J ""1iJt t>eabsorl:..J h;
l~e t'en~I /uboJar c-~Jf, ~o ~em~hi jn ~he 6';17. Th c•on/~aql-, ·Hie mote pb/,,_r m~1t>.'""'
;!~ J~~ Cro9' "'1 If ~mJ,l"~n~ <2a'5Ji Js .f,/PY.,J '')h.,.~luj, s: nlonm>ulos,
je3' ~.,,,._a~ .!'LAk_tlf'.b.J ...J ii; m~~ rrc1z ~<!l'e~ Jn //,(! ~ • fi,r ~
r~B, blo-lr-~11~~1(.{·hm t1~~tJ/fD in 11ie ~11~ffm t1f ().. mflf?e f"/'1,., rne:l1<balife
,,,~ j('.; ~rrnAt!olotJ'~',!l:~~ anJ is dlmin~I~ 1~p1J't ··/'1at1 fh~ (p:t•~·1d dt·L~ •
,.. ,;ow dr"O~· -jf,-e ~~t,.J,.li/e I t._ 1""'rw~l·gi'""l!r ""~.,,., Cf• r;· /..,.iC
ffec·fo · ·
. fr•J,.~<> ·Ih,,j al''- 'fria<t.Jrve . mu~ I b< blo/1"'Mfo_r·,~,./ j n II1• bn'fr ·lo
elA~_,~·~e6 ih~f h1."(('. rl~r~~lloofc.. ~c~'yjl;t. · :· . .
~ tl'l n1<2nr:
. / i. lhe Mf~h"el;G Men~n -f'tyu~lr'1YI a.~su~~-~ J'1~f@/_r47 mo/(<'J1t.
_ir, ~til~!rrJeJ ~~tyu~.n·Jt"Jy r@~n¥me ~- f>. ·~'~e. l/otVeWY', ~m7 ~AJA-
2:2l mr>r~ ·l~n V_!le. J,.,~ tnole~vle. aJ ~ lime .
z. J~ 14 b.frdr~3 ~ k~ 7 E?nD(m"1i• ,,,.,e{wi1s -lo
one or m•r-'~ onl 'f ~ "./'-lk un.J,.,nqed ~ v;.. 11.e k;J,,.l.
~fDlr«nsJ;,r1n .../lon I~ d " ~/- ~ofe. e<elron '.'.... %&/if . ·
d · -flit! k,,,_.J;(! hTol,.,~n~{orh1ea.·Jtm e.n¥me~ fl"j' ,.,,, :b;1fv1;/,_,,,/· t•o/e f~,. ft; ~
~ lrv.,lrori)ernd <1vl.ie"V"'rj-~!ml.,,,./to!i) of drvf6 · for fl.<>!k · c/r·•3~· sv~h M _1b•J~-
lli·n~, rl,enJ-htin, tt.~el1-mJ'"ap~~n {l "1kti:, 11ie~ 1-d ~ d;~C'.'f re~Jton,lJ'r heliJ~f'n
·lhe r1._( ~f- dr'1 rnefJ,,,f;5M and I~ €li'mh1~~1"ori ·},"ff- life -{;>ri_ 1~ dn.V .
Md.
Imran
Nur
Manik

I
1
for e~mr~I .1~~er~l"V~j c,, riilro~ycertp t~dulJ h11v~ ~n F
w...,. 1.50 ~h·n 1 kc..uge .r1ie4,e dp~§ v"~tf $,il,,;A;.,.nt .r,,'6/ r~ eff'"~ .
11""', ~~-- ~~ ol f musH<{T~fhAn fl~ J~~d utiJertrmo ·
frrel r~ :effe(!t . ' . ,,.,
""""·- -, - .
-· -. oC
[tlu~J0 ~vdo~~ o,.,J
, ["Ur]: l..v/d~e tv
-1
IiI
I
fir6/ ·-w~ eff..,/ tntl/ !,.. ~U!>f"~/ecl 1.:ihen. U•<I"'- is ®"'f
t~'r.tl~ tr ;h~<!t) d~~t jn ~h~ r6f'-tn;'l! !!jpcul~li'-'11 ~·~~ O,,e:f l.'c/mi'l1l,~1t'&'.~rl'rl.
j;, ~1J('."l1 a ca~. ~Jh~ ~.fz,r ~ drufl iliven oh~ljt jr; }:55 ·/J,an /he Aue f,-, 1he.
~~i·ne clor.e. of drXJ tfien inJr~venl!'osJ'. 7het>~{or4!, itie_(;;b;;]r_,fe ~totvtU/P-b;l;l(J([)_
mi 1><v.J .. ~Tdm<'<? i{ dr>"f) b"1J l'emovec/ h;' lh~oe ./a fir~~ f"t/.. ef{~'"1
.a~ folf~'6,' .
. ')
J/F~
:, ·v..-:.(rn~ .frr~f· ct4'.> ~rrqcr wilh j/; evf.ki~e.
A. Mr.tn( d"'"35 (eB 1~opro1~wnol. mo,.eh~) tt il_e@.t.1d~ml~/ro.·/lm? ar" ah1or&.J
'jn}~d from ih~ ~t"rl~ll tn~~Jtne ar.cli Jr,HJ6f..Ot>~ f;r5/ Vt(;l 1~ (ft~I ,,~~!'0Jfo
. (J,(2 l~er, '"'1"1"¬ ·lh7 unckrao ~-x·kn~ive. tn~f,..b~/jGtn . ·11rd Y'""? ha~ kf'n c.·eiJ~c/
-Orr~I p:tt6 effe~~ eir pti''2o/!Jitm1~ .. metbo~m or r"'ep/€t11Tc. e[1;11r71~1t~ .
..,

· ;;n. hl'lf"rte.nf· 1?0(€ ;in_drva "C!~t111.
)
'.
Md.
Imran
Nur
Manik

-in cl~-
, Tmpor ~n~~:
, J< liv~r .c11C-JrtJ1.<!.fren. ,,,~~e rroyf~t, tA.~u•tl~ in{ormiAkm
l•~"~"'6 Jh~~-J~ 4 ~·. ~- wh~n 1h@ i~ ~n'"'1l.
. . ...A. 1~ rv~ i11~•rm.../1M ,.b.uf l~e ~LJoW--_,___;.._.--'-'
~l~ ..f do /"o me~n h ·~:;-;:,:~/r:n ~i-:10 'rtsmf, J•"W
;/li . '!Ii~ 1""1' ~"'".,,.,,<!'./tell r...Jro M pvovTcltS <( dired "'"""VI"' me nt •r J~
!~r""' l~. l!Wr a.{l~,..,;..,,r,./,..Jrdl of«. dru3.
tr?· -= l'j( - ev
, _c,
bJJ,~r~, C~}5 ~he J.,.u.~ CDn~.nl~4ran . in 1he hlo.Dd ~nlet-ti~ 1~~ liver ~nol
(v i6·.1~e dr~ conc~nl~c?.Jr'dn '~~ ~~e. bve; ' cu~ l.J5vt-t}7 oretil(li /l1e-tn ~'
Ep. fo ui; u"l7 1~•4 f~An 1 . ror """'"'"'·· (..,. 'f!T"""/o/, f~r (E) I~ about
o·1, j..... ..1o.0@ ·u~~ ""'us .r. <te(w.~ ~ '1 ~"" /;~ be{~ it
ls' tt.~i/~bl~ .fer 3e~ Jrs/ri;bv~·l3rl jn1h~ ~l· &>,~ if 1~E' dr11g is~.
i~-~~iwe>J~· , mo5l- ~ 1~e Jr'Q. ':~.w/J t~ Jrs/ri'1u#J ~fot~ ~~(!J,_;'1 I~~ livero
!i- r~~ of lhe.: dT'~ t.tJbold L~ m~P,tab·aecl.
F~(!·hn·r. o.lf~c~1n~ E~ ~ve :
l .
~ %~@of ·/J,e J,~.
Ji!! ?k-~ •f dru3 · ..
Jfi ru;~ @..Pi;/.,8~i/§) o(IJ,,.. "1Jer1/ "'3- L/MJ<! //•'" ./o
Md.
Imran
Nur
Manik

--=-----
[Au(]: o:_&"clo~6to~:h::
~t- ~ . .
[_Aue] o l}!j doseJV
-,JJ~ j~, ~"~ t~t:l"'~rcn~hlr beJween hioavttiltill.liy and ltv€t''
e:1<-lr~~lion t-c~jra .
F==- 1-E~ -F'' ==P Et'<-~ 1-F -p I/
~ tft.ifl-l+- ~-'! "-}
~'~~·/ r ~ r-rd~Jrm ft{__~;-~~~'"' hk drua I
E~ e, Vriu~ frM·/1-lrtl ~erekc' r ~~·<~et'.
Ff "' fh<~on •f J~"t} t-ein• ved Y<~ 7'":.e;~ .
tf- y'' ~1 a$~om~d I-ob~ h~[j!!~Jhl~,11""J rs,'jilfl'~ i.1 ~Jog~ tt{
cl,..ull Jue Iv e/..,m1""' ~Pd.cl,,./i'6Y1, ~i_me1ilhol&m a.J Inwme'e~• ,.l,M~r.Jrm,
·l)~n .'
l>-'iJh ihe ~r"tJ . prof"r1J1/ • IJ. +('J, h~J,..,cp;J;ci..s_.• i1 tiee<~
lo p·odl>'• 50{~·.,;enf ~~:""P"u./.'t. b/b•clJeve/~ ~e<"a11fe <>{ c/r~~J!f!p I,/. . ""'·
H,~ liyQ~. - ..,!
/-:-:- . I
:{~J;.,,, J~e · rel1-lionsJ,;1, b.l,,,w1 ..bs•lof• 6~/,.b;/;/ ard {rvei• <?"'-1,,,.e/ii>n ,,,.to.
~ !Jwr e,,.J,.,«l1•h ,,,,..J;o FovtJ~ .. dir.e..£/ met.15ut>emenl of d~"(J ~
~...... "'" llv"" "{l••· "''tl.L ,,.cl,,.;.,,;~I"'Ir"' o 1 dr"3 . ·
-./E~::. Ca-l'v (p_ = D•~t(J ·~one:". In b/a,d ~~/e,.,·,.V
Ca · ·/h.e. l,.w,,..
ev !::: Dri(J .<!()fie'. /E'e..vm3 }ht:! b~ver
' i~e. Minon.a J;'/..~on 6IJ'I' be""""" I;o"w,j/~£;~~ 1.1 nd Iiver e.></r~,/~<'Yl
1::rt~ hf".~· (!.._ roi'.---~~fE~4ft of ihe · erx.f~nt_o_lli"ver €'X-.fr~c/Tm.
r ;; _·;~,-.,.,,.~~J~
Md.
Imran
Nur
Manik

I
~
-~---...·~· -~-····-----·--...--;-------·~·_,,_.-·--~·-·:.... ~'--· ~: •.~·....:.;.;._. -~· .o,..• .....
ll.J, ;nd;<!,h~s tW e}J of /J,-e. dr>ug r~ ;76/emi~lfl ~b~t'bed ·
(A_.r~~l' b"v~t- ~x~~c·l1a.ri,. et/~li~n@ i~ used .i-o e9/i"rno..~ejh~ "'rr~~t of liv~ bll't1cl
. . """'""' - . .
rlow ot; bi°"vo~~l,;/17 . .A ~~" ltw1• {i;/ood - f/Dtv/ 1.r17 e-tlf:2· J,...,XA:/iC'." c/{·a1.,m~
?rid j .. A(f19 /olo•dJ'J6'<> 7 del{vep enot:f J,,"O ~o I/,.,, t,·wr 4• ..//.,.., //1('
·~eJ ..t.li111ri. 'l'n corrlra.sf, e hlood flow' t'>/ ~o~ lire
t±!•y of J,·tia. ·I" 111~ . l;vE?p.
tv~.~, crh_ ;~ i"" kr~ic .clear-ttn<:>e of 4h~ dr·u.tr _ ~ncl ,a...i6 111~ eff~cHw.
. t· -
l1<'(:Jr<° Unod (low,~ jG ~J,~ .fr,,,cdran of dt>u0 1hAI· l'tJi'1~0 . brolt•an~(or tn~tlffl •
lh~"'- u~w~f ~{fec:dl~ ~era~1,c b/ot)d_{[o,v )5@L'i,tnk1, bul jf ni7 v~7
ft·m(Jl~]L/>TVn d~rnJr.o on d~i .f..~/ ..k~.P,,r~~~d;v;~ o~ cl~
):,~~k~. Ecvu.~~ion·(D i} tY.3ecl ~t> ~wJ,,_·k-nn ~1'1~ E_u~;J ·~,ro~wuf~hif;!l du€ io .firt61-
:rc~~ t•;I~ -11.e d~"fl ~~ 5?~c~/oriJj'[ htM l,,..n eab/..1~
~,0tn. hefJk _ el~~r:tlnC.-~ (990 rrVjm;n) and ~n o.1some.cl /Jv€~ h[,,.,,d /[t,eu of
~rnin ..
F':: 1- Clh
·. 'p
•, . '/o( -- .~rri"'/ uu £6 rm_~(> tte~O-<!~J]to_~y,Jr~~~lt:'-'®-e}~r~Jrd·~n5(ortrr"-~otJ~?
:·j. P,/,,,,J (ltJw .f-o l~<J§rl7~ rM1 imF~f~nl ·:.r,," .1.n JJ,~EE!)~f-c:lt'~-2"-~/~kli!-~n-i-
1 t'fln· or~f "'drrJnit?fr~k"n. e in b/~l f/"'4> to ft,~ m 7 ~~'16~nlr'illl1-- ~H"t>
. -~~ f"(!~~t ef dr«Q. ~~t-.'1oL§ec1 ~,J -lhe~~r~ ~ll~~ 1h't' F"~~nLof J,r~:~I~ tJJ~
/~~"Yl. Th~ r~l"'·lbn~tirp be/wi'en hto~ flit(.), i,~p"lic- (!1('~~·n~ c1ncl ret?~nl of J,'UtJ
Md.
Imran
Nur
Manik

.~ -·. -. ...,,.: --··' ....__.·_ - --···~~-..:..-;..:_.:.
, l6~> ta.n you - oVer:'cor.fl(. e.lirni11~/r(!n ·_
'~. l~ o~oml ·ffr{)i f~4~ 4?r("<''~ ~ .,~ . oti/e _:r., dJ,-•. ;,,;fJ/,,t11.,~'1. t) r llt4' Jpttu~)17-Jo~
±•r>a-J. 'for' '"""'fk.():>~""")' b" ojyey1 ~'-'~!;_)<'Er· Or' ./"¢""-IJr. and
~;El?~ "'/ I,. ,?l"'n j"'ninJ.,,,.,17 ~o '-'wid fhe f;,!l/ 1:xi15~ffj,;, An•l~fl' t'-'j'
fo ov~t·mn~ .rn,!;f r(l~t', e{~<'fs j6 1o ei·IJ~~f_ih~Jo~oP~~~e,,'111-< . j
'~'if- •['rnJu,f 1o " '"~<:....CT~M.!±-hle _do.1jJ$· jn ei-/her c~1e;, )
,<!~~' I e,
/
A . Il-
7,,j,,,,;,
.,1;,.,,;n,,.J;;,,;_ o,., f.·,.,gI F~ ~ff,~J,,, ;~ o. w"! imrorl• nI con•i .,,.:i.n...
(rt• ,.J,.,,34 lho.l ~ov< o.~ e1·lrac-/ton ,.,,..j;~~L~il ,.,jil(B_ex·/""dim .,,.-/101, SL>:'.h'
..,,,lli~h/~. h.v. v.7([[@r5x.5f·~,:< ~/tmin1..k111; s~ wmrJ,1~ y~Je,.,,;,
°'~o~~,~Tm ~ffer or~~----~dn:1ini~~pi;11/t{J(1. Tn ~nlraef-. dril~f1 Aii lh w_pe~Jt'&1 ~ktr11
l'C~~';i /it1Ve r(lr bfo~V(;/'1J,;t7 ~kn r: 1°._P~lly
1
-,hepe{C'I'~, /lie__ ~rC1 dose muul
ke_~ lh~n /i1e lnl•·~venou~ Jo~~ /19 aJieve ihe~il1e'r~u/i'<! riesEf~c .
'Jn ~~'m" ~t'.1eg... ot'c~-L~~~~~/r~·lilm C!>f "-- dr>'1 A-1ifl, ,.. I, "G~ ~-/em.1c dimlno../i011...
-;,11,•!1 1M h;.J•.'UZ~'4,.in, '"/' l,,._jn'fr{).(_·~·e~I ./11r: ~/t, ve7''P"f,.. 0,,(l_/ hioavtu/.~Liky
~L -1},p:> ·U1+' ".>:'blf-,.,.,aUt11 ,~rt nocler mt>.I ()I, t1a-J"'1 t> ovle.') r-f cl.<'/ rni n~t:·/rl'Jl ''ltY
~,,.•j:..,f.,,.,,.,c1.~~t • ': P!Dt•• , ir <-1n ~f'"-1 clrva r·~u·~ J·M ~ O•t i<I< l' i'°1 J,~,•- ~
~0·11lir1 or C'ffJ"'les, ~h·'(§J •f- ihe J'"fl .,JI/ ht ~li~Je".1 /c 1rrf a<S • " D
r~mror<'d ~o ii1e. d~~e!j ~f druo 0;ven
in o mor:. bJ()ttVttil~,~Je _form ~U~h ~!1 ~o/u/1',m.
'1),,,,D' ~i IhCSE)1":_"2'.~':mic elimin<>li0r1 ~enc! ~e de~116 J~d· mor'• vri !'J«IiiIi!z:_
in dt·un~~loaw~bi~!J b-h•eeri J... wilhin jnJiv{clu~ls~Pn4'}7, Jh~~,,J
:/&~of f/1{ rnd"'bnl~~~ ··forn1ec-l ""'/ "~~~t't'<-/;,O ·lg::·[/,~_ '-~-;..<:.--_,__-ti
t)d..1M1.1f.> J~p..~fon ·
-f----~----
Md.
Imran
Nur
Manik

..·.:.;........,....- ,_....,,....-·-"'-'·-----=--·~·--•' -~------ ,._._ -----------~-----'--- ------·---· ---------:·:-- ---- .. ,,__-------- ·- .. ·-· - .... - ---
-:::::-----·
.~. ~. E l?r --:-@ f. fl?. " . Gtvl
w~,rl' 1~"' h~C'l<l_f{~t~ ·lo ·f~~ ·li~r _1!; 'lt~ ,;~ ; 11~~le '~k~r'10t'~ 11 e~~~'
lhe rroJud . o.f- blo-od'11~~-(£) ttnd· Ii.er~;~ e«-lr~~licn rc4ter (E~).' '.
-..
1 t·h~~_±~rt:'nc" ~n~ · h'-p~/tc 4/eer~n<•e.· · c61 - ~'b::--- • ,,..
.. He,f~~<'!'"r<'nc• "'i Ile Jef.n•J "5 ~@ ~( b~.d 1h•J f'':f•~" Jk
)~ J¬ r r~~ j~ dear-eel of drv.0 ~.,, unif "f lirm~. Her~;~ d4?t{~~n~ 1$ dll~o ~llAl
, Joto.I bet e/ettrttnoe 0tr) mi~uG ~enal <:!fetn,6'nl'~_ @I~) ~~ {oll~wt; ~
~__:· erT ~ e•;;J
~lh~ bftn!>J .ff~ {fl) 4o ~~e l..ver tn7 l,e_ tn~etGUti~d ~~ t.'-'elf d6 fl,~ ~~n,- ·
"(;,~ C'r drua .in 4J,( a~-~7 ~ ~rd flit con~~nl1·~J14n: of df•IJ_a in tl1e. ~ein ~·
~ ih~-~~~,,nlrurJ~~ dr·uo ..rc•:(useB ·f~e kve1·, l'- ('('t>/N..!!_ Fp./i'n1 of
'"fi 1«~,.;;~3)~ /I,~ rn•~ boli~m and/oP bilia7 ei•P•J<-~ . 11..,..,foi:e. lh«
·~ -~•n,c•.r~r"-·11"'1 in fire ~~ l~ /~~ 11,,.n, I~ J.."O •&n«rtb·.../im in 1k ""k"L, .
, r J.,.r,,.·1~~.d''."'"no~ ""/' k c••.l,vl..4e.d ~ 1'1<. .folfo.ioinO 11"1'""~";"" :
- t;(cl).-Cv)
Cl" = Cei.
Md.
Imran
Nur
Manik

f,,c~ot'G 1ho..+ aff~c_at 1'1~ kr:)ic t!k~f'~n~-e cf ~ 4J"1"4f
o,.,, r<~~... ie9-flDl1u_ . u
J¥Bierod fl&OJ;~o -ib~ 1{'1¬ ~. ( !),)
Jil' Tnfrinfilc ...dM7 of lh~ rni-i_ {"!ft.,,, O?JJag.< _l.<1. ,
·i•,Jt·h11~ tle"re1t'1<.'e · (d h't) .
,Jr)<rhe .f~ of- J~~~r·trlf;".
JlooJeVer, !!'" li.ee~j"
0<',~MOl!I?
of "'- d1"'tJ js ~~- JI .J~o.-:
ttt"dh bl~"J {laiti a,J t~ 1n~rfn6ic c}~~ran~ of t:A. dr"ff, j~~- de5<!rihecl Jr" ~-y_uJrm
""-®· ro"' driuo l"":fkJ_~-~~lt'a<'Mm t7~ta -~(). 1~crJrymnv II-re 1,~r~J~, cle~n~
k. f~1~ ('•ffed..J_ 7 k·f"p.~Jie blrr~ flttiN. 1n!'>~~11~"~q ;./"'~ ~e~ tnPr(' ~f~c-µ
Ii/~; rirtsit adfvi7 rf fl,,. JYll'.,.ed-fun.fhn .,.Jdag-s, ·~
-@
[
Cf in! ·]·
fJ + ~,,,,
-
On 1k oi~ hancl. 1nlY.in5Te ~IE'a~rK'e (('~t-) j6 u~ed ·l('I J~~c-rib~
.lJ,~ ·lcJt19P{~ &f iht! liv~: ·le m:_/...bolw ~ Jr,,,V jn 1h~ ~~~en~~ tJf ff,,,0 lim'Jl!01
~, re{leeJto Jk 1hl><f"n~ adivili<!> <>f lk mio-.eJ-J..,e~iim o,,Jd,.~t: and .._(I
0 rJ,€Y' en~/'11<:1· Tdt·ln~i~,.·sL.~n(!€ 1~ ~ J;~Jtr-lcf ekt'a~/-eri~lr<-9$ ()f &I rPJt~J"r__ ·.
J~ ,;nJii ref/,.,~ 1h~l;J;ereJ abiuy, .ef 11.~ ~>.Jo rn~1~t.li.9"-. ~ dru.U.
11 '"i i.,' !>l•••••ti ·lo k ~~o Jh, :,,.../io of V.,,,••/ K,.. .(o,. "' d,,u8 Jh,J
follof.l'~ Mtc~o.eli(,· - Mt!nle:n krneltc!6.
- Ji ~ tone"p/ fr>,., . .
II~±~", ,,f,.,,..<'f•riZd cli•u§ .~;.,,.;;,~/i•n j.,4 <>eel im@
Ll.!?.n<f_J_(pttJ ~t 1r.~ ·U1" ~rt,Jf_T·nt'>i t elet1rc1 nee ".f 'fl1f' (,"vf"I' ?i~ rl!1 ·J'r.ll"f.l'C.
:<;~f''·
Md.
Imran
Nur
Manik

·• ·-:-
efh -= ~ . [ {Q. Cl inf .J-· · I} t -fu._. Clint .
~irw: JJ,., ,,, .,/ion,; • • n J,., /{, ,fe«Mn<'<, 1h/.·in•;~ 'd,..~a1Je< ,.rJ
¢!gn bin<linp > -Mood JI•"·- h
~. ~ d,,uas ~r'<~fa6ife_ Efel,.Lol{id) w/.Jle ~-a c_/t>~~ G?pe. ~J,fecf -16 rnefi.~
br{fotn • f~o4~ih bound dr~3~ /do ~ "[Jif(~l-n"aun~ c~ll ·mernbr«nes w/J/e f~~
clP'1~ ~"~' f1~~h /he s~ t>f 1k rru·~~J t'!n~ff"n D?J'JA9e enaJ!_-ne.s ett:.i7. 1~t?e- .
·for~ 1 an jh~-e )n 1~4! r~ J)'l11 CDnt"en~tf,llbn Jn lhf? hlcsocl ~ln m-.k~ rnOt'e Jruo
CA-w",f"'bl~ for J~,:~f;~ ~Jrt(<?.J1'Cn · 'fhel"L a~ i 41.A'o 4 "' ef~~c~n_c-e {o.-. ft-~
~~ dr~ -De.1-lridrv' clear..ree • , on- J'¬ GMeA~ c/....r«n<"L
I
Mo~~ are re.iJr;~. 'J , </Jli3+m. tl{"'y.~,,
t.J('.fft11r}n . l~e ·clf?'m·~nc·e o-f t~~ee ~rt'u~ tG <g_•,ort~1~ f.t }he /r.ac-ftMl cf ~(Jn.~ '
~T?1"~~1d_±1). (ru) . llcu0e"~t-, ~D~ dr1ta~ ~re no., ~i:,ll'f±er €x.lr~<!1ed '1 lk {/wr
'''"aerdf~6~ ot_~ll~;_J) ~e pro*in ordBJ et) pr'?.Fd!(no/oL ~07hl'ne efa. 11 ~rl1"c
e~f,~·fr~n t'.J~ro ~) i~ 8rt2~1er .·/ht»n i~e ~~ dr~ fr,~c·g~M {fu),1kn tA. rlru8
i~ t10lll"'S/rklrve~ d~_4PeJ &- ih"- t>~ •f cir~ c/<ah>'¥'• is~ wfu'Yl
·II" clr11~ J~ dl.:.ria'"'-d {rum btnd"'O · lhe@mi.!'.:/,;,, ,~of "' ~
tr1~hvt!l eleAt-ed drUU is . ~ ~·~n.tf,·e1nl}y a.f_te<!lcJ · ·y. tt (.~"(]~ in IJK' Jt}re-e_
cj~o/•i~J · · <)!{'~ e.~/ _f...1 '14 ~ J ~ ~
l'i.~ o. cl1·1 AJ[lh <@f~e de,.1..liBJ r Iii~ , 1,.-l,.,Jl1,n,Jip o.f blood
flo&J, jnlrinni~ det:o•anLV and o. pro~'1m binJ.a fo ~ll ·~fle;.._,G !
·'
Md.
Imran
Nur
Manik

€th.· ~R
·1~u1 . .fr.,, " .,,~ bidh ~ ver'/ hft Cl,;,1 , e/h_j,-, ¥_!n1 on lie .;
r~lie. t.ib~d fl..;) ar.J ·irJ~t 41rd.in [j;,,J;~ .
~ 1--~/~ ~ is Ir••"nI b non t><'6l,.f<fr.,,, Pn d • lri" fiv-· e, "ranee -[:.om h;,,Ji11 7
y JlorJ. resJri~·I•'~ 4 -<~r,.n<'-1! ~ -V .
, ·g;e, ~~ ~u,1, <Ir~ 7·/h@, U.e. F""'.!.!'.uf r1M!"•
j'l'D~~J_indin~ dr<'!l~ ~J3~~(<>n~7 lilfet> jh<' I?<:'~ 1me/~ l,.}i<}m,
~.c~cu!Ge. -jJ,,<> ,j,.ion is ,~mov.,J f~•tn /lie · r1Mw IJ;,,J;. .. _..fr/eG Jo1•Ttll/ e/r .:_
· J · ..l,ou.n · } dn.~) -(I
cu~~rn /~11'ot1 ~ -fI,., Iher_ Ma7 of ·ft,,.., d,,i~~ <Wt l'e~rr<>d ·lo a» .!'D 1)-
t--1k~ ', ~ ;;; · 1h"" ~r,,,~cli~.- f)~ dro9 ~- .111 f/,e
~I'" :trrlrrn!tC" d~~(<JJ~'l vf-E· Jr1~·
~ ft.om etyuo~b, d). ,,ikn e.liid ;, ~ ,;rJ "'''"!"'";~,, ·lo /..-r··f,~
blood fl•"' 0>Cl;,~) ,1kn .-'VvJl,m {f) i~ (fwn ty-
c.l :: p. .fu. C.linl
i~ A
..• ('Jh = {u .·ct 1tJ -- ®
~o, "' cl~e..·Jn ~o@ iriU t'<l~ (!!~ cha__rl(J"- 1ri
~.·I~•· J,,".{J~ .,1th f"0~1n h~ ,
YL "J., n~ (!tt~e /.ih~re (1. l. (' t? ;'JI ·J ,t!f ~L! ~r-r--·~ e r I
"ff J • . ·:; • --=-~· "' ·, u /;J ~ ~t>fe-' }n =rr: ·10
fll't.> G_J.itii>> Q , ·1/1Hl th~ (!!vttJLi(Ml . .- • .,..
LI~ - fJ. Cl;.,1 Cf•"' <;'!:.CUJA: cJ -inf
Md.
Imran
Nur
Manik

- -·--~·--- ----------. - - ~-~-------"'- --· ., ·----
~e~·lt>id1'v~ d~~r~riC1i ~ fC,, ii~ ~.,u3s. c~~:;r~ .1;@Tij>(]erit:>r,,.f?' '-"J/eP~
,1,.,11- ,,.i..._,.~'"""" , .(<,,. " J,.'() ,,;,jh~her•/'' ""'lr~"i:m t~i e ""'d@r Ia,m"'
lti~Ylfl' elet-tran('e tA-l/l jnc.9t~a6~ .. !?ut n£t/ 6i3n1.f(·ttnlfr tt'l,en lh~ dt·llg. }.)' JI.~ -
r.'"~.J -f.·orn b;nd,;(J. far "' c/'11I '·Wt.&,,,,n~ -/o '!faro. ~'f;,;nr, (11101•e_ H1an ~
" ~~ .f•m 1~ btrdiqj 9}.,5 ,.,jJI 6lffni'f,-~nlt. inci,..,.,ge ·kC8_
Ccm<'.'e·~J~.~icm· t>f -i,~ dr>l'G and l'Jettp~nc~ t~i/J in_~f'!as.e . ,
/~. [;JhtJ· i~ /he eff·uf· of t7okin brndin. on'~J,e '"'/1<:. c}c,w·(n1ee 7 --i »>:
e-: ~· y
~. -n~ effee1 · of rrol.,;w. binclrn3 on herlrc t:!/ea1·'1f1(''2. i~ e>/'l"n d.;fPcu-/l -~o
cf<~~ b~<"t:tlJAf' :{I ,;o µd_ ~fw7±_.fnt11vn W~,1/~1· ·/1-,.·<i~ js ..,~/rt(-.
~l~ -or non r:'<'5lrid~e) <!/...~. !Or e!Xll<mf)._ "nimJ f~oe /.,~/5 ..f i~-
pr~~h,e,, a ~r·eg·lrr<:Jty;jr cl~~ olrr.~ tttl1 ~J11,n3J *3 /he J<?0r:e of ria~m~
r)10 ':~- ~rndrn~ ~''"'1Jes~ 'br~v ft'01eJ"-n hfndmo is~ ·" ·~c!16r' Jn hef"'-li':-
d~t11ra~('Q. t>r ~9 /AAi hav<!'tj!!) 0:/N1<'/idr·; t0a.il'"', l/l,ae +r """ t•tmsi -
J",.,,l iv. lie./f[.w ~,,,,;J~J. Tn <!m/rn9/, +r 1kl hAv(fj.&}!11e·/1.,, ,.,./r~s
ri:7· i,. ,..lfeek.J_ r r'°~" roJ,,;,, b;,,J;'(J deF""'"n .,., -/h.. f,..."/t'm •f dr"tJ
,9.fi>r "'- dr1.1.3 iM J.,..i o!3e"'-~rae.lim ,.,._.Jr. s. k~ f/.u.n 7-s-- aor,
~;.} .@·.e4,e-a 'in pt·~1ein hind;,# wD~/c/ 1!$) ·1)1·odv..., ~!J'';f;e,,~J-
1,,,Ves in 1,.,rJ•'c__':_(.."'"'"n<'" . 'lh·~ Jr·u66 w,, ,.,,,~}.,,,,I [-~4'";::fli0l··.t
~hJr~ fu1enf>ilfve cJ.,~~·
./::~~,r~·l1'v± (! lf'ai·ed ~.r>(1S. Cfr9r~~nolf)b j6 an e'Xfl-tnff~ . A 6in1i/"~- 5-i{uo.,l,:..m
/~wr5 10Hh 1he ~~=-~e/i9f som« '}"'olein l_:.o~'?}- ~~tin5 e:
' P'vtl~ilftn.s ,.,i,,·,,I, ore '""-~'j ~~refed i11 fl-K renc{_/;j_v/es JnfJffe •f
r'~~ttl" r!:_tJ~'-~-~it]1cl;rl(} .
..
Md.
Imran
Nur
Manik

I
.,
·1_~·t1[f~~-r~ f.~l~_Jzoun( ·lo rJ~~"' pt·ol~~n bvl- t'-'Hf~,,et./T~t~
Jrc1._.,J ~~ily - /;1~ 6.. b;i;c/"'D !Jen9l/Tv~ j.,...,.,,U!lr " ""'"II di'T/aMT><'f1t
.i11 ~J'"' 7'':"/.,;,, hi,.Jtna of IJ.,,'1<' cl,,'13 wi6 e"tJG" o. Ve.Jr /,.'IJ" jnere «ee in lh~
~,~ cfpu - . c:!l'.'nce~Jrt1·lrcm. 1he~e dr'"-d~ ttri~ pee,/,,;~/;r;Jz__c/ea,.,eJ dri0s . A /~r>8<
JQ<!.~M Jn JI,., <ElJrun t!~rJ,...~fon wih <'"uses ""'~ i11 /k ~
of Jr1 ~' t••§_O/l~.)ll "-'1 "".,,...._II :ih<!t'e.,,'1-e in €-J•'c c/ea,.,.,_i!j) ·
/~ i w...;~ do-w11 iJ,e ~~ ,.; t'<!ctrt(Yl () me t:1.boli6m .
/ /~ · 'Dr()~ .i~ °"_.. IJ~~~ ~e /o.holiz;ed. &3. phew/oir_1. /l,~o~/rllinj 4,,.,0~ .. /es
I~~~-- Y'"'t''~·lron~ l~~n"Jrotl Mlf - l1~ in i1vt~~-~_t1s. Up}i& r~n~J dt·rt~-
~~~·~~~«"l', i.01'.i'ch 16 ~!>' -dert)denf Mt iJ~~e,·u/."1ry;Jl,."..J;l111 t'~, J,.u8.
tfig__} iJ0~'9 ,., j!J J~,,.~nclt?.1~J- ar1 -Jl-iecE1!iiii~ie ac/;vTJp<"1i"it1R L>t<'l ]r(!1r. /hrm"' ·/;"'01
· <'~n~f., "'k;,.h tn•y i,,_ a.lJ..,.,J ~ B- ~n1Jm $t,,
ii ir. ~...,l"',.J;.~t 1<> =qsl<le:~t0J.,J-cfuJ!~ of Jh-e dt>utJ 15(dinv';,;EJ f7
~~j"boltt3m ~nJ wJv,.l(f_~ 1s - e1~trJ71alecl lyQ~:~!~b ·
Md.
Imran
Nur
Manik

- ····--------·-·- - -------~-- -·' - --···~·------·-.~---'~ ~ -~- -- -,-..~···--· -··-···· ..-·-·~- ----· ---·· ·--~-·----------· ---- ~-·····
.. -
Cfu ::- C.IT - CIR r JJO "'j 1O
z: ?o mVh1· Ans.
C.
-,·-~"'-.;'
flere,
To/-A1 h~7 cleara•1c"'- .
11~ re.nJ c/~r~nce. .
li c non r<..,,./ cI"".~""'- "'r11,e, j,,_~ .
~a.
/
C ~.
c .
. .
/J . t;(l10-lcn :.-- !:------
' / "= • " - :'i;::.-,,,...- - ~ - _., ~-~ .- _, -- ,......,_ "-<-:~-_:-:-,;:,_";"""~ - ~~~~-~,;;.~,,_:..-:-_~·'=-: .4_ ~.... . ~!"
····~A ~;"Of" J.,,, 01>_'!)_m_g) o~ A Jrug ;.,,; /Jfv~n "'"''J'·JJ;, """9 ;,, ~kml-
. (~&__""'P-lJ~ble. 1~ J-oJrl "'mtrvnf of- @icl,anj<.d J,.,_,:prfco~r~J j,., lhe. ur•;ne.
I ------~-
;~ ,;.~ _~nd H,e JohJ amo-1.)nf of ~"!f~-~~!~ r'e:C()Vet•e:J .in flu vt•fr1<- 'is ~()tr].
11~" _ elitnmetP"n 1-v~IF [;k_ --~r JIJ9 drva ~ ~E '1r c.. ·,f? ~n~ren~ velutn~ of dJs}-1·ihv-
-llo11 is 1000 ml . 0-nd -
:1-h, tlrnt1vn.J- of uncl~~~-'fr::-/ JriW :ln tJf11.1e, D~ z: co ~n0
lf.(' ~p1~1,nf ,,f t>1el11b('li~e in Vdtw. M~ = 30 na
~-'l.i. == 5·:? ~· V0 =Jb-o-l!J rn/, C/-1:? CIR==?
Md.
Imran
Nur
Manik

.,
·- - .
. _·· ,: ., - --~,.-- -::- - - . -
·• -".::. .. ... .
_ ~ • cs~S :x c;soo ()
-
6·,~;3 1 I Ao::o;i~- :::" '6 • ' ',, /}11 ~ •
~·
---.·-··-
::: t'G" X S&t'"O ::: j.<o rnf1 ·,~
j~O ij. '
E'·~~~;····~-~~·~··I·~~; ~.••7
t • '"'.) f21' l:: -- .-----:..- + /oqi :2U>( ' ~.31),3 u
'. ' J
or.. Jz.. 7 O·O«S- hr- ..:_ j •• ;
~. 'ft"'lu~~J ~
. llen" 1 ~!' = 2..(5? rnu
Vt> = ~Ill'> "' ~@~ ll M~ ml
~~'· ~;r(5 ~i.i·0.9
Md.
Imran
Nur
Manik

..J
~1· d. Tubvl~r ..,,,,lq,.,..~1ki .
.r , fjlo.-n~rudlr fiJ_ 1r-i~J1m : 6lfomet>ult1r .fifl~·lltn i6 c-t @~~ppo('~ -/'1"J _...,_-
rr<'l'I'~, ·f~·t· ~tn"" m~1~('l~re{-) {_Mwl'°"?LJnclucl1ra Vtr:lr~o ('r(l1ed &n_!:~~geJ) 6:_
<~i~t:~~re'i~J (im~3€~). 1(~ t~Ot' drrvrno .for:~ {ot• o'f>rl_Jef?;,,((t, [if/r~ltm r~ 1/-i.e
(? T
t' ~«c: y.
~~ik ~he. t1nr"'~ ~ t<' IJ~lt ~ dr> l<idwy~ - ' ~
_ !1. ·· Ren,,J ·d~tt,,,an("<!' jr; ~ tmft!lr~ of elrmintAken {c:-r rntlf dr>uo~· t)r0,s.i!-t..._i
<1re(i)1~- -_ Vt>f~Jif~/UV'-'A~~ ~~!uhl~ , "'""ve· fofc-tu mo/E'l9ttfe-,r ~t'f{J/"'f, or c-it•e~/:«-1/y _ hio-
, 'I
~~~&noll~ 17 1h"(!3 t~ll l,e elr'rnhu1.t~ · 7 1->ent1 t~?(.("''e~~m1. 71;~
1">i•oc~".;
Ly i.._,/,i<"h
" JruJ i< · ,,...,.,td Vi<' 11.e~ ""'/ ind.J• "'J c.,.,bina/T,., ,,f {/.,_ {o//.,,>'n~ :
v{. 6'1lom~o l"t' .(;f.lrtA~i<n'I ·
L ti"l·rn ~j,,,. l'ri[Jin~L_~mce,.,~t't:'t~TM de_~-~ ·/o (fl1~- f,"f(, H~ e'Yu~·~'Un he~~m"s -
I
K~= '..2·.3 [.,a Es: :::. '.Z·.;i lria.2 -·~~~
{Y2 u c?'2 {* u -..,~
li"f""t-e; c,, ffi 1hf'. !fni~i~r cmt"etl~rt?t/trn t-fnt:~ c .16 .Jh~ l'l'nc:"enln:~/1~ taJ ./~
- - -
ifi(' . e 'V""' °'Jrl1'11 ~r> .r;~+ .~t'der
v ~~ :: ~ ' ,,,~ ctJ
~- .u C
~-'·Derlv~- ~J,e et?y'lf.t1.JTon for czlimin"'/fon rdf~ ~m1~f~,,/- {'c,P -firs} order· l"'eac:h°;,n-
- )11 · £ lrmm&(~<m of ~ clrtJO ~~om lhe '1eiJ; )s u6u~!]r "- re15ufl l'f~ @?Ebo&E) p_
~~"'f-rOC'~· 11"-.e r"-t~ ~f dru3 ellmin~/fi1J1 ~·om h1f13+ dru96 ~6 ckt•ived r
- ,~ .(i,'Gl rt~~~oce ~ ~
Md.
Imran
Nur
Manik

.,
... -.. . . '.,.' -
-----·-·-'-~----"·· ---<•---~----'---...--- ....------ ---~-~-------..·~"""--------. ,...._~-=e;.:....:__ ~:-::r;:::~-:;:-.:--:..:.:.:---·--.:,.-·,.-_ ..i:::::._..:...~-:~.~,,:..o:·.,.:- .._;-...__._:. ~':_;_~----:"~.
·• ..,..
·~ 2, /cl'."' ·lvb.A-ir !le<!,Jt..i !. JJ. j<1 "~@"!2·/r«~"r-~"'> T/ j? "n
ea!'.l'.'.''e':~~~J <p}m ./J.,...i """V..!1'<'6~ ihf't l,•c;w,<Se ~~ cfP!l(/ js ir•nsr.r-
~""l (.?_x~~I- ~ _dtme'<'t!'J~~:~' .1l- j~ ~n 1mrt?~ryt .Jri'1tl~rt7f- m~('~rti6tn
,k~'·~~-4:~ 1he F~ .tlJofq. fOr ih." ~"""~IJJ ~f WeA~ MtJ~J-,,;m/<
k>11~~- 7 f"etJ.?..~'" ~el'~:Jrltt·, J..,0 tnf>/~€6 J;{:f.,tJe. '7]tVr76f eon~~n./rtA~~rocGenf
:-~-eto~ ~i,t' h;~"r-~~~f't:tn~ ~ ~~(<?. 1l;e_ ~~r1t>t1 ~~!'> J~-~-t~t>
"'"I ""'/ b... Gg,~. Dr(Js with -$irrU.':" ;;}pudwe ;,,7 ·~.,'f':'/e s; 11...,
~mne l't>.Pt'ier:;&lem . for ~~mpf.t. icgr_~i-.1i/f e.~f-{'~ tfJHh -penf~iflrri for
-I~· ~~"""'"" ~Jerri. ~, ,.i,.,., ~,JJ 16 c~,,Jtnirue/p,.,J w.i./l,))en-§.
(JJrot~ne~rd <!o~l~·t~z~~'!v~ 11iE? ./ub~kr ~~re~(111 "f r:n~6j' P-. j/J!J ·rn~r:..~a~e _
iJ,~- cluti~Jrt••1 of "~~~~-i-~-C?=LJ!n ~ t<;.- -----· ·--- ----
1 ~";J,
, lz4~·or;:J..4lc rt'e~ ,,,;Jt.;,, 11u glom.,,,J"t' , .. fr II111>i..: • ; q'"""""'":r t//,,,.~~. · .
cl .J"'':J iG dr1'."c!Jy .rdA)~J ./o ·Jt,,<f9 ~ €n ft'fif~1n J,~v!;J)J,,110 ~,,.,,,/,.~/A..:,,,_ ~;~
11,,. r"'5""" A,; i~e ~ "'"UO Cdlc...,.Jr.../mi in 11... r»: inCT>!t:t,;e,s. 1h,,, vl•nie"'1J'_
frfln,.J;~, .fo,, ·fJ,e cl,..~Q tJr// jnePe~GeCJ!oP?.,~§if~, ·1f111~ fn~t'E:'c1.aJn3 -f/,e tYru,./ J,,uq . _
elt11l>tl'lr<' fr Born<'. cJ~!il~.@ j5 rne,.5...•i:ec/ .7 wrnu. ,f' j,,"t} fJ,,.f j,; .,/imtn"'i;J
7 ·f~"'litr11. crnp.e., ffie JriLlO· ;-~ nei1her ~or(_~~. fMmpfe~ {
5uel" ~'"6" "-1''<.:_~J:)~· "(). :11i~ c/e~nee of }htJ/m cm/I be +':
.f,,, 6jFR ·I~~;~ <:?'Yu_J fo 1~~-jao tr1/~[n·""' .
Md.
Imran
Nur
Manik

--·-·"'··----·-- ··- ·-·-··--·-
::~···.
. ...-.-..- .
........._.... _
..
« tj s. ~'1.·lar t•e..~r.n : Wb.·l"r re,J,6"1rr"', ~"'~ ,.(f.r U~ ~;.";---
J~ <11!~3)_.,r•l(Jh -11,. al•mErolU8 mJ ~"h "" <8.!S>~ ·11 "" J.,.._3 ;~
ur..d•ler toe••J,.,.,.J,,.J CtJk.~61 /lte." lh· •±"- ~r lh., ~e""""-e. •I -!he dN'3 is
i' rr1·o:i:...1.~. ·ft,~ tlvJ....I'<. 'l""Jf·'Jr ,..,...k.~,,h,", cleft....n<e _.,/,,, .,; "
i,~cflt2_il-i~n fhe 6irtz "F 1~5'-190 tnVtnin· .
2. o ~ fluid ir1. 1f,e ~,b,Jfvl,1.1/e.
)'<El·., ~"'' '~" ..b,;""r/rari ,,f ¢U, ..erd;, or b1t11i0 Jr_ . <
~- 1r... """r~pl~, 4' Jr..ir tl...l-"r• ,.JrJ• or t-!j· (M~kt .!<' ~nf~ Jr i~
"f° Hlf· f(r.,j1 ;n H~ l'elltt.' 1vtu/ot' ~-'°. VNht' r») B- 110 {)f.iihf' Jit~ . Becttt.fSe ,11~5('
Jr,10 :1;,,.Joi"!< '°'rl~ol 1he ~~ JI..~ of clr•tr~ Gi'""""} I~ vndis"p!,"
1J""1,;1 }6 rnore(fffil;~~ s. ha« i1"""J~r per~/,;/;t. ·1~. vnJi,.<o,ia1i,{1'~
·1· """7 l'<'..k....loeJ .i;..,,, {J,.,_ f'en../ /olivlt .Ln•k ihlo s, ~,,'m;. re- ·~dr~
· ihe U
'c'(' lJ~()rr~'~ CtlYl 5rrufr<-'ttn°!!Y .~uee A a~~~- ef rlt1(J .l.;~('·~f~ I deFrJ~ (1)1 1lu
J~',,_r..r_~1,~· vl'lnaz __fl"rd e. 11~ rk" o(1he : Jr!Jd.
r
I .. - .
· ~---af ih., dN'{J ~ c~t"~ :but no1•h1ti./ t.;r!haj' r!1 m7 V4Y1J ·frnr-i
1f>io. i·a. dernJ~ •n dre~. r1~p~ro~oul· i·B- .J"(1 inf,.~. v(jd~lol~ drE'/s. bre!h rn
~'~. l<li II ""~ult .iri ~ uHl'r>7 rH • '""'"" d.rds rieli ~.,;n
l'•~ull lnS 1J•ina7 L.n-uas <Jvd1 "" <1Sl!ot>hk ""ref' ~7 J,,,,..,(k -6,e uri~J'
')'ti' JJUI- itH~t·etl~E:'S t~i11t ~nfAcJcl~ Such eM ·~ HCeJ3 •
-
Md.
Imran
Nur
Manik

~ {r.i.,Jlir, _or ~nl. ~- ,Jea~ ~.rJ1c d1·1J» ~ i•1 '7LB-n1viror1-
m'/ he ctA.tt!uJ~le.J f,,om ecyr;..t>Jrcrn. ~,
'ol'<· Fw ~ea/<~ -!he H.,.,,/e~,,,,,; l/t19Je{l,..J,h e~lin 1o s= ..~-
II v ' 14-icm - JonireJ7
'P /,~pr-I). + }03 ~ c/ j
I
I .'
1 ·

~
---------···
~onT5ed] + E~nn-io~1J~IJ
flt.pl<a . . •
= Jo lfJan- 1dl1iaad]
10r"-rie~f~.ic'fltJi?J_J+lN1m.iffi5ecj
Io r"-p'"'"
---o...,...fl --f'-.-~- - @
1-1- frJ' .
'..
·• ~
'R('~ ~t'~ >1u{1me flt of- 1"'6 ~ir.Jtan )'felds .....
Qot'15e~J 'f'H-pk«
::- 1D
[_Nm~imJ,grl_]
Md.
Imran
Nur
Manik

_ &1J[AJ
M - [_HA]
Ci', -lea I<~ ~ -lva[Htj- 1.8~j + /83 {iiA]
--©..·, ~ = &Jherf,, ~ e, A~rJ JrM,at!r~d16.1
l"tfll.6~nf
[itt][A-].
[1-ViJ
'11-J e ~HltiAJ -®
I.! 1-1+]
c)
...
rol' ~'1rrrfe, rt~'14~tn;n'! '1 t(v~k l>a~, lr,,,, Jl. c§t;Jfi91r~111-<? m~fn~
J~~-- j.r, tnttJe c.i!_<"-lm€ P-. more ~f.ld !3i>loLI:: ~~~!_o~1f£J :(7~~ie~ t~ .fo,,m~d. 1'>1
<1"nf.•nrJ, ~~J_J;li~"·lr~ of i/u. LWine.. tJJh CetU.6€ 1fu.. an}J!_h,e./1:1tn}_n<:z. ~ b.e~~ h')iWe_
~. ·11~:~.(i__jf)fN:"' i!3 mare t~tR/'(' ~flk1bl~ »'-. l1-i1~< f;k;f 1n. be ~"'~t,~ltr'bJ ·( __
I111~, ~ Jenden7 .Jo be ~Ct'e'l;.J into ihe ~t'~~ tntr'<Z lf~kJY•/ 'IJlfl'
~ot.l fMI. {01· i.iee_k._,.~iJle Jr"O, ·· 'JOJ;I 5!JlvM'.f, Sr " "'0 ~ + 1/-': ,
~ . Le}- L'6 tch~d('P "' fiecie{;O"( fo)? @eAJ< -tl.~ra~----ant?D _=:":. ' . u-
·• -
Md.
Imran
Nur
Manik

•. ---· - -~-·· ---·-·· -- ~-- •--• -·--'-w•~---: ...:-:_,_,..;~..~_:__.-· __ :__ '_ ·•··---~-· -~--""• • •-.:_~__.i;.:-:-~--'-""-••"•":~=~<"·--,,••"•,,,..-"-7=-~",;-·.',"";.-;-.<"';C. •-:,·.-
·'
,
' .
.!;. ~AJ !5 :1/-e "1llohi~y of ~k a~lJlc drug .in ·i~f.<ii,n}rmisecl .(o,3, -ii
d
LI ~) . . .
t.an. ~J('.' ~n11Jm , '-~S,,' . . . . ·.·I
it. A3M-i, .f~mi e'Vll#-~..,., ,<1),
· fA-] = :" .~IA]
t ~~]
•. [A'J_ = Ka -®
" -U1AJ UJtj
·• !""!9'"
1~~ ·fo~AJ l!m~~" o~ d'!{/ ~ r~ ~h~ 'f ~11~ ti~ .fo,.,n 0~J
11nJ ·Jill .on~~J ioft~J1 [HA]. 'SoI 1~ ~o~l soltJbiV~y. .
. - I ,
~T~ ll!AJ+~-]
. (l ~ .fftAJ [A @~
= flA] + LHiJ '-1"""'- '_J .
. 5T =(HA]··· (_}+ &; ) ~8J
.·.<Br" sot_+~)-©
.I
I
I
I
o-, 'Pi:,. ~ r" + '"8 ~] ;
"''. rI(,,_ r" ~ '·o ~~ .
t>~, f~'-p><"t = Iog [11-J -
· U 7}1Aj
. [~j p»- p~1t '
- • - s: j() - @
frlA] .
...... ---=:=::
r
Md.
Imran
Nur
Manik

- . ·-·--
. ... -- ·---- --··---- -~.
~
. (
..I
••
[e'J ["1JKa ~ -"--.~-
. [BH+J
er: - l~ l<a t= -loa [if] - Iaa[Hot] + f(J {i3Hj
fr·e•ri , ~eytt~~,~, @~
. ( 'PH- ~A
. Sr = ~~ 1 + Jo )
. . ~ove~
4. G~~ 11.t.f , f.,,~R !>Isl~ J~. Tof,./ Goj.,J,j~~. ~· " 50( H JO~ -pH} .
A . Lel v5 °'ti6r~ ~ ...e~tr011 .r:,~ t.i'ettr btt~i~ J,,LW . ·
+ •• +
BH ~ B + 1-1
~ =(CJJ ~fJ QJ
{!3H+J
... ~H+] " [B°~H'] . ~
c~"'f"'ri(j 1/,<' -"'f!IJL"Ofl §)_ lt;JJJ2, Me l"An wrile -
~ p}l-pJ<A
Wi =- 11> •
... -:-
2J-21
Md.
Imran
Nur
Manik

.. ,
!
.. ". -·--- -· - . . . -· . .. .. . .. . - . - . . .. . . .
----- - -·- ;.,... -;;:-__ ---~~::.:..-..;...!.·--=--=~-~ -- -- ----- ~-"""---= ...--------------- -- -- --- - -
·..a, -
G·om @,
-=-=--------- ---
f;1inn. @ J.... @ , toe ~n wrif<, · ·
a1i_] p~ - pH .
-Jett : .10 • I .
frt'JJl. @ .
·1~re, io~l Gvlu'1;u7.
5r == w-~+1+[8'] ,
o- [BJ[H'l + [in rJ<,,,, ~
~~ ~
5T ,,[jjJ (J +~) - {i) ~
~b;b}'_ ~f weal' ba~it ~~r"O ~_:&~,,,, ~ denol.:/ 7@ _
Sn, ~o!i_~t>fvbi~}r.
$1 °' 50(1+ ~) -@
'-·
Md.
Imran
Nur
Manik

Drug Clearance MANIK

Recommended

Recommended

More Related Content

What's hot

What's hot (20)

More from Imran Nur Manik

More from Imran Nur Manik (20)

Drug Clearance MANIK