Angina pectoris is chest pain due to myocardial ischemia caused by an imbalance between myocardial oxygen supply and demand. There are four main types of angina which differ based on precipitating factors and symptoms. Treatment aims to relieve symptoms, slow disease progression, and reduce future cardiac events. Primary treatment includes nitrates, beta blockers, calcium channel blockers, and other medications to reduce oxygen demand and increase supply.
This document discusses angina pectoris, or chest pain due to ischemia of the heart muscles. It describes the four main types of angina - stable, unstable, microvascular, and Prinzmetal's. It then provides details on the causes, symptoms, and treatments for each type. The treatments discussed include drugs like nitrates, beta blockers, calcium channel blockers, ranolazine, and nicorandil. It explains the mechanisms of action and effects of these drugs in reducing oxygen demand and increasing oxygen supply to relieve angina symptoms and slow disease progression.
Stable angina occurs when myocardial ischemia is caused by fixed atherosclerotic narrowing of one or more coronary arteries. Vasospastic angina occurs when ischemia is caused by coronary artery spasm, with or without endothelial dysfunction. Microvascular angina refers to ischemia without an obstructed epicardial artery, potentially caused by microvascular or endothelial dysfunction. The main classes of antianginal drugs are organic nitrates, calcium channel blockers, and beta blockers. They work by decreasing myocardial oxygen demand, increasing supply, and inhibiting platelet aggregation. Organic nitrates like nitroglycerin are enzymatically converted to nitric oxide, causing smooth muscle relaxation and vasodilation to treat all types of angina.
This document summarizes different types of antianginal drugs. It discusses the pathophysiology of angina pectoris and different causes of chest pain. It then describes various classes of antianginal drugs including nitrates, beta blockers, calcium channel blockers, potassium channel openers, and other drugs. For each class, it discusses mechanisms of action, pharmacokinetics, uses, and adverse effects. The document provides an overview of treatment approaches for angina pectoris and ischemic heart disease.
This document discusses drugs used to treat angina pectoris. It describes three types of angina - atherosclerotic, vasospastic, and unstable - and their causes. The main therapeutic strategies for angina are increasing oxygen delivery, reducing oxygen demand, and improving oxygen efficiency. Nitrates like nitroglycerin are described as relieving angina through venodilation and arterial dilation. Calcium channel blockers and beta blockers are also discussed as treatments that reduce myocardial work and oxygen demand. Side effects and mechanisms of these drug classes are summarized.
Antianginal Drugs Pharmacology 5th sem B.Pharm.pptxMrSALAJKHARE
This document provides information on angina pectoris and antianginal drugs. It defines angina pectoris as recurring chest pain due to decreased blood supply to the heart muscle. It describes the three main types of angina and the mechanisms of classical and variant angina. It then discusses several classes of antianginal drugs in detail, including their mechanisms of action, effects, uses, and adverse effects. The major drug classes covered are nitrates, calcium channel blockers, beta blockers, and potassium channel openers.
Acute Coronary Syndrome (ACS) refers to conditions caused by reduced blood flow to the heart and includes unstable angina, non-ST elevation MI, and ST elevation MI. It develops due to an imbalance between the heart's oxygen supply and demand, usually due to atherosclerotic plaque rupture in the coronary arteries. Major risk factors include hypertension, high cholesterol, smoking, diabetes, and these are all modifiable. Nitroglycerin is commonly used to treat ACS as it causes dilation of blood vessels to increase blood flow and decrease oxygen demand on the heart.
This document discusses angina pectoris, or chest pain due to ischemia of the heart muscles. It describes the four main types of angina - stable, unstable, microvascular, and Prinzmetal's. It then provides details on the causes, symptoms, and treatments for each type. The treatments discussed include drugs like nitrates, beta blockers, calcium channel blockers, ranolazine, and nicorandil. It explains the mechanisms of action and effects of these drugs in reducing oxygen demand and increasing oxygen supply to relieve angina symptoms and slow disease progression.
Stable angina occurs when myocardial ischemia is caused by fixed atherosclerotic narrowing of one or more coronary arteries. Vasospastic angina occurs when ischemia is caused by coronary artery spasm, with or without endothelial dysfunction. Microvascular angina refers to ischemia without an obstructed epicardial artery, potentially caused by microvascular or endothelial dysfunction. The main classes of antianginal drugs are organic nitrates, calcium channel blockers, and beta blockers. They work by decreasing myocardial oxygen demand, increasing supply, and inhibiting platelet aggregation. Organic nitrates like nitroglycerin are enzymatically converted to nitric oxide, causing smooth muscle relaxation and vasodilation to treat all types of angina.
This document summarizes different types of antianginal drugs. It discusses the pathophysiology of angina pectoris and different causes of chest pain. It then describes various classes of antianginal drugs including nitrates, beta blockers, calcium channel blockers, potassium channel openers, and other drugs. For each class, it discusses mechanisms of action, pharmacokinetics, uses, and adverse effects. The document provides an overview of treatment approaches for angina pectoris and ischemic heart disease.
This document discusses drugs used to treat angina pectoris. It describes three types of angina - atherosclerotic, vasospastic, and unstable - and their causes. The main therapeutic strategies for angina are increasing oxygen delivery, reducing oxygen demand, and improving oxygen efficiency. Nitrates like nitroglycerin are described as relieving angina through venodilation and arterial dilation. Calcium channel blockers and beta blockers are also discussed as treatments that reduce myocardial work and oxygen demand. Side effects and mechanisms of these drug classes are summarized.
Antianginal Drugs Pharmacology 5th sem B.Pharm.pptxMrSALAJKHARE
This document provides information on angina pectoris and antianginal drugs. It defines angina pectoris as recurring chest pain due to decreased blood supply to the heart muscle. It describes the three main types of angina and the mechanisms of classical and variant angina. It then discusses several classes of antianginal drugs in detail, including their mechanisms of action, effects, uses, and adverse effects. The major drug classes covered are nitrates, calcium channel blockers, beta blockers, and potassium channel openers.
Acute Coronary Syndrome (ACS) refers to conditions caused by reduced blood flow to the heart and includes unstable angina, non-ST elevation MI, and ST elevation MI. It develops due to an imbalance between the heart's oxygen supply and demand, usually due to atherosclerotic plaque rupture in the coronary arteries. Major risk factors include hypertension, high cholesterol, smoking, diabetes, and these are all modifiable. Nitroglycerin is commonly used to treat ACS as it causes dilation of blood vessels to increase blood flow and decrease oxygen demand on the heart.
This document discusses different types of angina and drugs used to treat them. It defines angina as chest pain caused by inadequate blood flow to the heart. The main types of angina discussed are stable angina, unstable angina, and Prinzmetal's variant angina. The document outlines several classes of drugs used to treat angina, including nitrates, beta-blockers, calcium channel blockers, and some newer drugs. It provides details on the mechanisms and effects of these drug classes and recommendations for treating different angina types.
Ischemic heart disease occurs when coronary arteries become narrowed by atherosclerosis, reducing blood flow to the heart muscle. Angina, myocardial ischemia, and myocardial infarction can result. Myocardial infarction is caused by sudden blockage of a coronary artery and leads to cell death in the affected region. Treatment focuses on pain relief, oxygenation, volume maintenance, acidosis correction, and preventing/treating arrhythmias. Drugs like nitrates, beta blockers, and calcium channel blockers aim to reduce oxygen demand and increase supply.
This document provides learning objectives and content on the management of ischemic heart disease. It defines stable and unstable angina, describing their underlying pathologies. It classifies drugs used to treat angina, describing the mechanisms of action, uses, and side effects of nitrates, calcium channel blockers, beta blockers, nicorandil, and ivabradine. The management of myocardial infarction is also covered, outlining treatment strategies for pain, oxygenation, hemodynamics, arrhythmias, and use of antiplatelet/anticoagulant drugs and thrombolysis.
This document discusses angina pectoris, its types and treatment. It defines angina as chest pain due to insufficient blood supply to the heart. There are three main types - stable angina, unstable angina and vasospastic angina. Treatment focuses on reducing oxygen demand on the heart and increasing oxygen supply. The main drug classes used are organic nitrates, beta blockers, and calcium channel blockers. Nitrates provide quick relief of chest pain while beta blockers and calcium channel blockers are used long-term to prevent angina episodes.
Anti Anginal Drugs and its side affect and useswajidullah9551
This document discusses anti-anginal drugs used to treat angina pectoris. There are three main classes of drugs: nitrates, beta blockers, and calcium channel blockers. Nitrates work by reducing preload and afterload, increasing coronary blood flow and oxygen supply. Beta blockers decrease oxygen demand by lowering heart rate and contractility. Calcium channel blockers increase oxygen supply by dilating coronary arteries and reduce afterload by decreasing peripheral resistance. The document provides details on the mechanisms, effects, and examples of drugs in each class.
This document summarizes different types of angina pectoris and treatments for it. It describes:
- The main causes of angina pectoris including atherosclerosis and coronary vasospasm.
- Classes of drugs used to treat angina including nitrates, beta blockers, calcium channel blockers, and others.
- The mechanisms of these drugs in reducing oxygen demand on the heart and increasing oxygen supply such as dilating blood vessels and reducing heart rate/contractility.
- Guidelines for use of different drug classes for stable angina, unstable angina, and variant angina. Potential side effects and cautions for combinations are also outlined.
This document discusses various drugs used to treat angina pectoris. It begins by defining angina and describing its causes as inadequate blood flow through the coronary arteries. It then discusses the different types of angina - stable, unstable, and Prinzmetal's variant angina. The main drugs used to treat angina are described - nitrates, beta-blockers, calcium channel blockers, and newer drugs like ranolazine. Nitrates work by dilating blood vessels to reduce preload and afterload. Beta-blockers reduce heart rate and contractility. Calcium channel blockers inhibit calcium entry to arteries and heart muscle. Ranolazine inhibits sodium channels to reduce oxygen demand. Combinations of these drugs
Angina pectoris is chest pain due to ischemia of the heart muscle. It is usually felt as a tightness or pressure in the middle of the chest that may spread to the neck, jaw, or arm. There are three main types - stable angina brought on by exertion, unstable angina that occurs at rest, and Prinzmetal or variant angina caused by coronary artery spasm. Treatment involves medications to relieve symptoms like nitrates, beta blockers, calcium channel blockers, and newer drugs that open potassium channels or have a cytoprotective effect. Combination therapy with two or more classes is often used for better management of angina.
Angina and myocardial infarction are caused by reduced oxygen supply to heart muscles due to coronary artery spasm or obstruction. Angina presents as chest pain and comes in different types based on triggers and severity. It is treated with nitrates, beta blockers, calcium channel blockers, and ranolazine to prevent symptoms and disease progression. Myocardial infarction, also called a heart attack, occurs when blood flow decreases or stops to the heart, damaging the heart muscle. It is diagnosed through cardiac biomarkers and ECG and managed initially with analgesics, anticoagulants, and antiplatelet drugs, followed by lifestyle modifications and secondary prevention medications long-term.
This presentation discusses angina pectoris and its treatment. It is caused by an imbalance between myocardial oxygen supply and demand. There are three main types of angina - stable, variant, and unstable - depending on the triggers and severity. The main classes of drugs used to treat angina are organic nitrates, beta-blockers, and calcium channel blockers. Nitrates work by dilating blood vessels to reduce preload and afterload. Beta-blockers decrease heart rate and contractility to lower oxygen demand. Calcium channel blockers dilate coronary arteries and reduce afterload. The presentation discusses the mechanisms and effects of representative drugs from each class.
1. Ischaemic heart disease is caused by an imbalance between myocardial oxygen supply and demand, usually due to atherosclerosis limiting blood flow in the coronary arteries.
2. The main types of ischaemic heart disease are stable angina, unstable angina, myocardial infarction (STEMI and NSTEMI), and sudden cardiac death. Clinical presentation and ECG/biomarker findings are used to distinguish these conditions.
3. Treatment involves lifestyle modifications and medications like nitrates, beta-blockers, and calcium channel blockers to reduce oxygen demand and increase supply. Revascularization procedures like PCI or CABG may also be used in certain patients.
1. Ischemic heart disease results from an imbalance between myocardial oxygen supply and demand, usually due to atherosclerotic plaques narrowing coronary arteries.
2. Stable angina is chronic, exertion-induced chest pain relieved by rest, while unstable angina involves more frequent or severe chest pain at lower exertion levels or at rest.
3. Diagnostic tests include electrocardiograms, which may show transient ST segment changes during chest pain, and stress tests, which can provoke chest pain and ECG changes. Coronary angiography can identify blockages.
This document discusses anti-ischemic drugs used to treat angina. It defines ischemia as insufficient blood supply and oxygen delivery to tissues. The main causes of ischemia are discussed as atherosclerosis and blood clots blocking arteries. Different types of angina - stable, unstable, and variant - are also defined. The document then summarizes the mechanisms and uses of several classes of anti-ischemic drugs - nitrates, beta-blockers, calcium channel blockers, and antiplatelet drugs. Specific drugs within each class are mentioned along with their mechanisms of action, indications, contraindications and importance in treating different forms of angina and acute coronary syndromes.
This document discusses drugs used to treat angina pectoris, or chest pain due to reduced blood flow to the heart. It defines angina pectoris and describes the types as stable, unstable, or Prinzmetal's variant angina. The mechanisms and uses of various drug classes are outlined, including nitrates, beta blockers, calcium channel blockers, and potassium channel openers. Nitrates are discussed in depth regarding their mechanisms to reduce preload and afterload, relieving coronary spasm and redistributing blood flow. Combination drug therapies are also mentioned.
PH1.28 Describe the mechanisms of action, types, doses, side effects, indicat...Dr Pankaj Kumar Gupta
PH1.28 Describe the mechanisms of action, types, doses, side effects, indications and contraindications of the drugs used in ischemic heart disease (stable, unstable angina and myocardial infarction), peripheral vascular disease
Anti-Angina & Anti arryhthias Drugs .pptssuser504dda
This document discusses drugs used to manage angina and arrhythmias, and current guidelines for managing acute coronary syndrome (ACS). It describes the classification and pathophysiology of angina, then focuses on pharmacological management including nitrates like nitroglycerin, calcium channel blockers like nifedipine, beta blockers like atenolol, and alpha/beta blockers like carvedilol. It provides details on their mechanisms of action, indications, interactions, and side effects in treating conditions like angina, heart failure and ACS.
Angina pectoris is a medical terms to referring to the chest pain or discomfort by reduced blood flow to the heart muscle .
it is usually a symptoms of coronary artery disease often triggered by physical or emotional stress.
the treatment of angina pectoris
by medication ,changes life style proper exercise.
This document provides information on myocardial infarction (MI), also known as a heart attack. It defines MI as necrosis of heart muscle tissue due to reduced blood flow and oxygen supply. Causes include atherosclerosis, blood clots, or spasms blocking coronary arteries. Risk factors include age, smoking, hypertension, high cholesterol, diabetes, obesity, physical inactivity, and stress. Symptoms include chest pain and shortness of breath. Diagnosis involves ECGs, blood tests of cardiac markers, and imaging tests. Treatment focuses on restoring blood flow, reducing pain and complications, and lifestyle changes to prevent future MIs.
This document provides information on myocardial infarction (MI), also known as a heart attack. It defines MI as necrosis of heart muscle tissue due to reduced blood flow and oxygen supply. Causes include atherosclerosis, blood clots, or spasms blocking coronary arteries. Risk factors include age, smoking, hypertension, high cholesterol, diabetes, obesity, physical inactivity, and stress. Symptoms include chest pain and shortness of breath. Diagnosis involves ECGs, blood tests of cardiac markers, and cardiac imaging. Treatment focuses on restoring blood flow, reducing pain and complications, and lifestyle changes to prevent future MIs.
This document discusses different types of angina and drugs used to treat them. It defines angina as chest pain caused by inadequate blood flow to the heart. The main types of angina discussed are stable angina, unstable angina, and Prinzmetal's variant angina. The document outlines several classes of drugs used to treat angina, including nitrates, beta-blockers, calcium channel blockers, and some newer drugs. It provides details on the mechanisms and effects of these drug classes and recommendations for treating different angina types.
Ischemic heart disease occurs when coronary arteries become narrowed by atherosclerosis, reducing blood flow to the heart muscle. Angina, myocardial ischemia, and myocardial infarction can result. Myocardial infarction is caused by sudden blockage of a coronary artery and leads to cell death in the affected region. Treatment focuses on pain relief, oxygenation, volume maintenance, acidosis correction, and preventing/treating arrhythmias. Drugs like nitrates, beta blockers, and calcium channel blockers aim to reduce oxygen demand and increase supply.
This document provides learning objectives and content on the management of ischemic heart disease. It defines stable and unstable angina, describing their underlying pathologies. It classifies drugs used to treat angina, describing the mechanisms of action, uses, and side effects of nitrates, calcium channel blockers, beta blockers, nicorandil, and ivabradine. The management of myocardial infarction is also covered, outlining treatment strategies for pain, oxygenation, hemodynamics, arrhythmias, and use of antiplatelet/anticoagulant drugs and thrombolysis.
This document discusses angina pectoris, its types and treatment. It defines angina as chest pain due to insufficient blood supply to the heart. There are three main types - stable angina, unstable angina and vasospastic angina. Treatment focuses on reducing oxygen demand on the heart and increasing oxygen supply. The main drug classes used are organic nitrates, beta blockers, and calcium channel blockers. Nitrates provide quick relief of chest pain while beta blockers and calcium channel blockers are used long-term to prevent angina episodes.
Anti Anginal Drugs and its side affect and useswajidullah9551
This document discusses anti-anginal drugs used to treat angina pectoris. There are three main classes of drugs: nitrates, beta blockers, and calcium channel blockers. Nitrates work by reducing preload and afterload, increasing coronary blood flow and oxygen supply. Beta blockers decrease oxygen demand by lowering heart rate and contractility. Calcium channel blockers increase oxygen supply by dilating coronary arteries and reduce afterload by decreasing peripheral resistance. The document provides details on the mechanisms, effects, and examples of drugs in each class.
This document summarizes different types of angina pectoris and treatments for it. It describes:
- The main causes of angina pectoris including atherosclerosis and coronary vasospasm.
- Classes of drugs used to treat angina including nitrates, beta blockers, calcium channel blockers, and others.
- The mechanisms of these drugs in reducing oxygen demand on the heart and increasing oxygen supply such as dilating blood vessels and reducing heart rate/contractility.
- Guidelines for use of different drug classes for stable angina, unstable angina, and variant angina. Potential side effects and cautions for combinations are also outlined.
This document discusses various drugs used to treat angina pectoris. It begins by defining angina and describing its causes as inadequate blood flow through the coronary arteries. It then discusses the different types of angina - stable, unstable, and Prinzmetal's variant angina. The main drugs used to treat angina are described - nitrates, beta-blockers, calcium channel blockers, and newer drugs like ranolazine. Nitrates work by dilating blood vessels to reduce preload and afterload. Beta-blockers reduce heart rate and contractility. Calcium channel blockers inhibit calcium entry to arteries and heart muscle. Ranolazine inhibits sodium channels to reduce oxygen demand. Combinations of these drugs
Angina pectoris is chest pain due to ischemia of the heart muscle. It is usually felt as a tightness or pressure in the middle of the chest that may spread to the neck, jaw, or arm. There are three main types - stable angina brought on by exertion, unstable angina that occurs at rest, and Prinzmetal or variant angina caused by coronary artery spasm. Treatment involves medications to relieve symptoms like nitrates, beta blockers, calcium channel blockers, and newer drugs that open potassium channels or have a cytoprotective effect. Combination therapy with two or more classes is often used for better management of angina.
Angina and myocardial infarction are caused by reduced oxygen supply to heart muscles due to coronary artery spasm or obstruction. Angina presents as chest pain and comes in different types based on triggers and severity. It is treated with nitrates, beta blockers, calcium channel blockers, and ranolazine to prevent symptoms and disease progression. Myocardial infarction, also called a heart attack, occurs when blood flow decreases or stops to the heart, damaging the heart muscle. It is diagnosed through cardiac biomarkers and ECG and managed initially with analgesics, anticoagulants, and antiplatelet drugs, followed by lifestyle modifications and secondary prevention medications long-term.
This presentation discusses angina pectoris and its treatment. It is caused by an imbalance between myocardial oxygen supply and demand. There are three main types of angina - stable, variant, and unstable - depending on the triggers and severity. The main classes of drugs used to treat angina are organic nitrates, beta-blockers, and calcium channel blockers. Nitrates work by dilating blood vessels to reduce preload and afterload. Beta-blockers decrease heart rate and contractility to lower oxygen demand. Calcium channel blockers dilate coronary arteries and reduce afterload. The presentation discusses the mechanisms and effects of representative drugs from each class.
1. Ischaemic heart disease is caused by an imbalance between myocardial oxygen supply and demand, usually due to atherosclerosis limiting blood flow in the coronary arteries.
2. The main types of ischaemic heart disease are stable angina, unstable angina, myocardial infarction (STEMI and NSTEMI), and sudden cardiac death. Clinical presentation and ECG/biomarker findings are used to distinguish these conditions.
3. Treatment involves lifestyle modifications and medications like nitrates, beta-blockers, and calcium channel blockers to reduce oxygen demand and increase supply. Revascularization procedures like PCI or CABG may also be used in certain patients.
1. Ischemic heart disease results from an imbalance between myocardial oxygen supply and demand, usually due to atherosclerotic plaques narrowing coronary arteries.
2. Stable angina is chronic, exertion-induced chest pain relieved by rest, while unstable angina involves more frequent or severe chest pain at lower exertion levels or at rest.
3. Diagnostic tests include electrocardiograms, which may show transient ST segment changes during chest pain, and stress tests, which can provoke chest pain and ECG changes. Coronary angiography can identify blockages.
This document discusses anti-ischemic drugs used to treat angina. It defines ischemia as insufficient blood supply and oxygen delivery to tissues. The main causes of ischemia are discussed as atherosclerosis and blood clots blocking arteries. Different types of angina - stable, unstable, and variant - are also defined. The document then summarizes the mechanisms and uses of several classes of anti-ischemic drugs - nitrates, beta-blockers, calcium channel blockers, and antiplatelet drugs. Specific drugs within each class are mentioned along with their mechanisms of action, indications, contraindications and importance in treating different forms of angina and acute coronary syndromes.
This document discusses drugs used to treat angina pectoris, or chest pain due to reduced blood flow to the heart. It defines angina pectoris and describes the types as stable, unstable, or Prinzmetal's variant angina. The mechanisms and uses of various drug classes are outlined, including nitrates, beta blockers, calcium channel blockers, and potassium channel openers. Nitrates are discussed in depth regarding their mechanisms to reduce preload and afterload, relieving coronary spasm and redistributing blood flow. Combination drug therapies are also mentioned.
PH1.28 Describe the mechanisms of action, types, doses, side effects, indicat...Dr Pankaj Kumar Gupta
PH1.28 Describe the mechanisms of action, types, doses, side effects, indications and contraindications of the drugs used in ischemic heart disease (stable, unstable angina and myocardial infarction), peripheral vascular disease
Anti-Angina & Anti arryhthias Drugs .pptssuser504dda
This document discusses drugs used to manage angina and arrhythmias, and current guidelines for managing acute coronary syndrome (ACS). It describes the classification and pathophysiology of angina, then focuses on pharmacological management including nitrates like nitroglycerin, calcium channel blockers like nifedipine, beta blockers like atenolol, and alpha/beta blockers like carvedilol. It provides details on their mechanisms of action, indications, interactions, and side effects in treating conditions like angina, heart failure and ACS.
Angina pectoris is a medical terms to referring to the chest pain or discomfort by reduced blood flow to the heart muscle .
it is usually a symptoms of coronary artery disease often triggered by physical or emotional stress.
the treatment of angina pectoris
by medication ,changes life style proper exercise.
This document provides information on myocardial infarction (MI), also known as a heart attack. It defines MI as necrosis of heart muscle tissue due to reduced blood flow and oxygen supply. Causes include atherosclerosis, blood clots, or spasms blocking coronary arteries. Risk factors include age, smoking, hypertension, high cholesterol, diabetes, obesity, physical inactivity, and stress. Symptoms include chest pain and shortness of breath. Diagnosis involves ECGs, blood tests of cardiac markers, and imaging tests. Treatment focuses on restoring blood flow, reducing pain and complications, and lifestyle changes to prevent future MIs.
This document provides information on myocardial infarction (MI), also known as a heart attack. It defines MI as necrosis of heart muscle tissue due to reduced blood flow and oxygen supply. Causes include atherosclerosis, blood clots, or spasms blocking coronary arteries. Risk factors include age, smoking, hypertension, high cholesterol, diabetes, obesity, physical inactivity, and stress. Symptoms include chest pain and shortness of breath. Diagnosis involves ECGs, blood tests of cardiac markers, and cardiac imaging. Treatment focuses on restoring blood flow, reducing pain and complications, and lifestyle changes to prevent future MIs.
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Angina pectoris-2013.ppt
1. • Spasm/obstruction of coronary arteries
• Myocardial ischemia
• Reduced O2 supply to myocardium
• Chest pain---Angina pectoris
Angina pectoris
Chest pain due to ischemia of heart muscles
2. •Weak relationship between severity of pain and degree
of oxygen supply- there can be severe pain with minimal
disruption of oxygen supply or no pain in severe cases
•Four types:
Stable angina
Unstable angina
Microvascular angina
Prinzmetal’s angina
3. Stable angina:
•Also called “Effort Angina”
•Discomfort is precipitated by activity
•Minimal or no symptoms at rest
•Symptoms disappear after rest/cessation of activity
4. Unstable angina:
•Also called “Crescendo angina”
•Acute coronary syndrome in which angina worsens
•Occurs at rest
•Severe and of acute onset
•Crescendo pain- pain increases every time
5. Microvascular angina:
•Also called Syndrome X
•Cause unknown
•Probably due to poor functioning of the small blood
vessels of the heart, arms and legs
•No arterial blockage
•Difficult to diagnose because it does not have arterial
blockage
•Good prognosis
6. Prinzmetal’s angina
•Prinzmetal’s angina is a variant form of angina with
normal coronary vessels or minimal atherosclerosis
•It is probably caused by spasm of coronary artery
7. •Symptoms
•What is the cause of ischemia ?
either oxygen demand or oxygen supply
•Inadequate blood supply and decreased
oxygen supply are directly related to blockade
or narrowed vessels
9. Drugs:
1. For treatment of acute attacks:
Organic nitrates/nitrites
2. For prophylaxis:
Organic nitrates
Beta blockers
Calcium channel blockers
Ranolazine
K+ channel opener- Nicorandil
10. • Heart rate
• Contractility
• Preload
• Afterload
• Coronary flow
• Regional
myocardial blood
flow
O2
D
e
m
a
n
d
O2
S
u
p
p
l
y
-Blockers/Ca2+ channel
blockers
Nitrates/Ca2+ channel
blockers
Nitrates/Ca2+ channel
blockers/antithrombotics/
statins
HEART
11. Organic nitrates
Pro drugs release NO
Levels of intracellular cGMP
Dephosphorylation of mysosin light chain
Cytosolic calcium
Relaxation of smooth muscle
EDRF –endothelium derived relaxing factor is NO
12. •Relaxation of vascular smooth muscles-
vasodilatation
•NO-mediated guanylyl cyclase activation inhibits
platelet aggregation
•Relaxation of smooth muscles of bronchi and GIT
14. Three different forms of NO synthase are found in
humans:
1. Neuronal NOS (nNOS or NOS1)- found in
nervous tissue, skeletal muscle- involved in cell
communication
2. Inducible NOS (iNOS or NOS2) found in immune
system and cardiovascular system- involved in
immune defense against pathogens
3. Endothelial NOS (eNOS or NOS3 or cNOS)
found in endothelium- responsible for vasodilation
15. CVS Effects:
•Vasodilatation- low concentrations preferably dilate
veins
•Venodilatation decreases venous return to heart
•Decreased chamber size and end-diastolic pressure of
ventricles
•Systemic vascular resistance changes minimally
•Systemic BP may fall slightly
•Dilatation of meaningeal vessels can cause headache
16. •HR-unchanged or may increase slightly (reflex
tachycardia)
•Cardiac output slightly reduced
•Even low doses can cause dilatation of arterioles of
face and neck causing flushing
•Higher doses may cause fall in systemic BP due to
venous pooling and decreased arteriolar resistance
•Reflex tachycardia and peripheral arteriolar
constriction occur which tend to restore the systemic
BP
17. •Coronary blood flow may initially increase transiently
•Subsequently, due to decreased BP, may decrease
•Nitrates have dilating effect on large coronary vessels
•Increase collateral flow to ischemic areas
•Tend to normalize blood flow to subendocardial
regions of heart- redistribution of blood
•Dilate stenoses and reduce vascular resistance in
ischemic areas
18. •Reduction in myocardial O2 consumption is caused by:
Peripheral pooling of blood- reduced preload
Arteriolar dilatation- reduced afterload
in end diastolic volume and LV filling pressure
•In platelets increases cGMP: inhibits aggregation
•Strongest factor for nitrate effect is peripheral pooling
Nitrates infused into coronary artery- no effect
Sublingual- produces effect
Venous phlebotomy mimics effect of nitrates
19. How myocardial O2 consumption can be determined?
Double product: HR systolic BP- approximate
measure of myocardial O2 consumption
Triple product: Aortic pressure HR Ejection time-
roughly proportional to myocardial O2 consumption
•Angina occurs at the same value of triple product
with or without nitrates, therefore;
•The beneficial effects of nitrates appear to be due to
decrease in oxygen consumption rather than increase
in oxygen supply
•Relax all smooth muscles-GIT, biliary, bronchial etc
20. Pharmacokinetics:
•Orally ineffective because of high first pass metabolism
•Administered sublingually to avoid first pass matabolism
Tolerance:
•Repeated doses lead to tolerance
•Dose spacing is necessary
•Reasons for tolerance:
Capacity of vascular smooth muscle to convert
nitrates to NO – called true vascular tolerance
Pseudotolerance- due to other reasons
21. ADRs:
•Headache- may be severe
May disappear after continued use or,
Decrease dose
•Transient episodes of dizziness, weakness, pallor etc-
symptoms of postural hypotension
•Rash
•PDE5 inhibitor (sildenafil) and nitrates given
simultaneously can produce severe hypotension
•Uses: Angina pectoris, CHF, MI
22. Administration of nitrates:
•Sublingual
•Oral: For prophylaxis, require high doses due to first
pass metabolism, isosorbide dinitrate (20 mg or more)
every 4 h or mononitrate (20 mg or more) OD or BD
•Cutaneous:
Ointment (2%) applied to 2.5-5 cm patch of skin
23. Transdermal nitrogycerine discs impregnated with
nitroglycerine polymer- gradual absorption and 24 h
plasma nitrate concentration
Onset is slow
Peak concentration in 1-2 h
Interrupt therapy for at least 8 h a day to prevent
tolerance
25. -Blockers:
•Effective in reducing severity and frequency of
exertional angina
•May worsen vasospastic angina- contraindicated
•Reduce myocardial O2 demand by reducing cardiac
work (-ve iono and chrono effects; decrease in BP
during rest and exercise)
•All -blockers are equally effective
26. Ranolazine:
• Reserve agent for treatment of chronic, resistant
angina
• Inhibits cardiac late Na+ current
• Effects the Na+ dependent Ca2+ channels and
prevents Ca2+ overload that causes cardiac
ischemia
• Decreases cardiac contractility
• No change in HR, BP
• Prolongs QT interval so it is contraindicated with
drugs that increase QT interval
27. Nicorandil
• Vasodilatory drug used to treat angina pectoris
• It has dual properties of a nitrate and ATP sensitive K+
channel opener
• Nitrate action dilates the large coronary arteries at low
plasma concentrations
• At high concentrations it reduces coronary artery resistance
which is associated with opening of ATP sensitive K+
channels
• Nicorandil has cardioprotective effect which appears to be
due to activation of ATP sensitive K+ channels
• ADRs: Flushing, palpitation, headache, mouth ulcers,
nausea and vomiting