Content and Visual Design by Tiffany Simms Cambridge Healthtech Institute's 23rd International Molecular-Med Tri-Con presents a short course on the Microbiome. DrBonnie360 brings together two rising stars of the Sonnenburg Lab and the Knight Lab, and four microbiome companies, Second Genome, Osel Inc, AOBiome, and WholeBiome, to discuss the importance of the microbiome and how we can harness its power. The course took place Sunday, March 6, 2016 in San Francisco.

1. The Microbiome Lifeline
Bonnie Feldman, DDS, MBA – Your Autoimmunity Connection
www.drbonnie360.com | @DrBonnie360

2. 100+ 16% 10
diseases US population Top leading
cause of death
in women
less than 64 yrs
An Invisible Epidemic

3. The Gut
is Where
It’s At
Organ of Immunity

4. The Gut
is Where
It’s At
Brain-Gut Axis

5. Different Microbiome Views: 2 Scientists & 4 Companies
•Andrew Hryckowian PhD – The Sonnenburg Lab
•Embriette Hyde PhD - The Knight Lab
•Peter DiLaura – CEO of Second Genome
•Peter Lee MD – Co-Founder Osel Inc.
•Larry Weiss MD – Chief Medical Officer of AOBiome
•Colleen Cutcliffe PhD – CEO of Whole Biome

6. Company Indication What How
Second Genome Therapeutic - Oral
Crohn’s Disease
Microbiome Modulating
Discovery Platform (MMDP)
ID key microbial community
members/activities/metabolites
& assay for modulatory
potential against host targets
-Measure & ID changes in the microbial
community composition/function/signaling
in health or diseased states w/ MMDP
-Generation & evaluation of small
molecules/peptide biologic/bacterial strains
that modulate microbe-microbe & microbe-
human interactions
Osel Therapeutic - Topical
Women’s Health
“Live Biotherapeutic Products”
(LBP) focusing on women’s
health (GU & GI)
-Library of proprietary human bacterial
strains
-Screening methods to ID strains w/ unique
protective properties
-Produce stable high quality LBP from
selected strains
AOBiome Therapeutic - Topical
Skin
Advance the science of
Ammonia Oxidizing Bacteria
(AOB) to restore the skin’s
microbiome
-Topical therapeutic & consumer product of
AOB to reintroduce Nitrosomonas to skin’s
bacterial flora & restore Nitric Oxide balance
Whole Biome Diagnostics &
Therapeutic
Metabolic Syndrome
Proprietary discovery platform
for targeted equilibration of the
microbiome. Focus on metabolic
syndrome
-Target novel symbiotic functionality
inherent in the human-microbial interface
with a microbiome diagnostic discovery
platform

7. • Autoimmune Disease: An Invisible Epidemic
http://bit.ly/1m0ttsl
• The Serious Health Concern All 20-somethings
Should Know About
http://bit.ly/R9cEgp
• Decoding Autoimmunity – a Summary of the State
of the Art
http://bit.ly/1knzaAQ
• The Lonely Voices of Autoimmune Disease via
Youtube
http://bit.ly/X41mMv
• Believe It or Not – The Real Voices of
Autoimmunity
http://bit.ly/20xRCXO
Your Autoimmunity Exploration

8. Exploring The Microbiome Lifeline
• Fasano, Alessio. “Leaky Gut and Autoimmune Diseases.” Clinical Reviews in Allergy & Immunology 42.1 (2012) :
71–8. <http://www.ncbi.nlm.nih.gov/pubmed/22109896>.
• Gomez, Andres, David Luckey, and Veena Taneja. “The Gut Microbiome in Autoimmunity: Sex Matters.”Clinical
Immunology 159.2 (2015) : 154–162. <http://www.sciencedirect.com/science/article/pii/S1521661615001576>.
• Kamdar, K et al. “Genetic and Metabolic Signals during Acute Enteric Bacterial Infection Alter the Microbiota and
Drive Progression to Chronic Inflammatory Disease.” Cell Host & Microbe 19.1 (2016) : 21-31.
<http://www.cell.com/cell-host-microbe/pdfExtended/S1931-3128(15)00498-9>.
• McLean, Mairi et al. “Does the Microbiota Play a Role in the Pathogenesis of Autoimmune Diseases?” Gut 64.2
(2014) : gutjnl–2014–308514. <http://gut.bmj.com/content/early/2014/11/28/gutjnl-2014-308514>.
• Waldor, Matthew et al. “Where next for Microbiome Research?” PLoS Biology 13.1 (2015) : e1002050.
<http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1002050>.
• Wu, Hao, Valentina Tremaroli, and Fredrik Bäckhed. “Linking Microbiota to Human Diseases: A Systems Biology
Perspective.” Trends in Endocrinology & Metabolism 26.12 (2015) : 758-770.
<http://www.cell.com/trends/endocrinology-metabolism/abstract/S1043-2760(15)00194-0>.
Autoimmunity and the Microbiome

9. The Microbiome and Inflammatory Bowel Disease
• De Souza, Heitor, and Claudio Fiocchi. “Immunopathogenesis of IBD: Current State of the Art.” Nature Reviews
Gastroenterology & Hepatology (2015) : 13-27 <http://www.ncbi.nlm.nih.gov/pubmed/26627550>.
• Sartor, R. Balfour. “The Intestinal Microbiota in Inflammatory Bowel Disease.” Nestle Nutrition Institute
Workshop Series 79 (2014) : 29–39.<https://uncch.pure.elsevier.com/en/publications/the-intestinal-microbiota-
in-inflammatory-bowel-diseases>.
• Sartor, RB, and SK Mazmanian. “Intestinal Microbes in Inflammatory Bowel Diseases.” The American Journal of
Gastroenterology … (2012) : 15-21. <http://www.nature.com/ajgsup/journal/v1/n1/abs/ajgsup20124a.html>.
• Wlodarska, Marta, Aleksandar Kostic, and Ramnik Xavier. “An Integrative View of Microbiome-Host Interactions
in Inflammatory Bowel Diseases.” Cell Host & Microbe 17.5 (2015) : 577-591.
<http://www.cell.com/cell-host-microbe/abstract/S1931-3128(15)00166-3>.

10. • Costalonga, M, and MC Herzberg. “The Oral Microbiome and the Immunobiology of Periodontal Disease and
Caries.” Immunology Letters 162.2 (2014) : 22-38.
<http://www.sciencedirect.com/science/article/pii/S0165247814001874>.
The Microbiome and Periodontal Disease
Rheumatoid Arthritis
Systemic Lupus Erythematosus
• Scher, JU, and SB Abramson. “The Microbiome and Rheumatoid Arthritis.” Nature Reviews Rheumatology 7
(2011) : 569-578. <http://www.nature.com/nrrheum/journal/v7/n10/abs/nrrheum.2011.121.html>.
• Mu, Q, H Zhang, and XM Luo. “SLE: Another Autoimmune Disorder Influenced by Microbes and Diet?” Frontiers
in Immunology (2015) : n. pag. <http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4663251/>.

11. Prevention – Diet, Food, & Nutrition
• Tilg, H, and AR Moschen. “Food, Immunity, and the Microbiome.” Gastroenterology 148.6 (2015) : 1107-1119.
<http://www.sciencedirect.com/science/article/pii/S0016508515000128>.
• Zeevi et al. “Personalized Nutrition by Prediction of Glycemic Responses.” Cell. 163.5 (2015) : 1079-1094.
<http://www.cell.com/abstract/S0092-8674(15)01481-6>.
• Zmora, N et al. “Taking It Personally: Personalized Utilization of the Human Microbiome in Health and
Disease.” Cell Host & Microbe 19.1 (2016) : 12-20.
<http://www.cell.com/cell-host-microbe/pdf/S1931-3128(15)00508-9.pdf>.
Prevention – Prebiotics & Probiotics
• Hemarajata, P, and J Versalovic. “Effects of Probiotics on Gut Microbiota: Mechanisms of Intestinal
Immunomodulation and Neuromodulation.” Therapeutic Advances in Gastroenterology. (2012) : 39-51.
<http://tag.sagepub.com/content/early/2012/09/24/1756283X12459294.abstract>.
• Petschow, B et al. “Probiotics, Prebiotics, and the Host Microbiome: The Science of Translation.” Annals of the
New York Academy of Sciences (2013) : 1-17. <http://onlinelibrary.wiley.com/doi/10.1111/nyas.12303/full>.

12. The Microbiome Lifeline
+1.310.666.5312
drbonnie360@gmail.com
www.drbonnie360.com
@DrBonnie360
www.facebook.com/YourAutoimmunityConnection
Bonnie Feldman, DDS, MBA
DrBonnie360 is helping companies and
entrepreneurs counteract the autoimmune
epidemic.
Through consulting, market research, writing and
speaking, she works with teams using data and
digital tools to reshape research, diagnosis,
treatment and prevention of autoimmune disease.