The medicinal properties of mushrooms had been recognized more than 5,000 years ago. Modern science has discovered that these medicinal properties are associated with beta-glucans which are complex forms of sugars. China and Japan had approved Maitake, turkey tail, and shiitake mushrooms as drugs.

1. IMMUNO-MODULATORY
BETA-GLUCANS
IN
MEDICINAL MUSHROOMS
By
Kevin KF Ng, MD, PhD.
Former Associate Professor of Medicine
Division of Clinical Pharmacology
University of Miami, Miami, FL., USA
Email; kevinng68@gmail.com
A slide Presentation for Healthcare Providers Dec. 2023

2. BETA-GLUCANS AS IMMUNO-MODULATORY AGENTS
IN
MEDICINAL MUSHROOMS
▪ Medicinal mushrooms have been used in China and Japan for
thousands of years. Their medicinal properties are now known to
be associated with beta-glucans.
▪ Beta-glucans are part of a group of biologically active natural
molecules that are steadily gaining strong attention not only as an
important food supplement but also as an immunostimulant and
potential drug.
▪ With more than 80 clinical trials evaluating their biological effects,
the question is when will beta-glucans move from food
supplements to immuno-modulatory and anticancer agents.
▪ Maitake, turkey tail, and shiitake mushrooms have already been
approved as drugs in China and Japan.
https://www.mdpi.com/1420-3049/24/7/1251/htm
God of Longevity

3. Mushrooms with immunomodulating properties

4. Beta-glucan Concentration in Different Mushrooms
https://bard.google.com/chat/f4f296573ebd75d0

5. Changes in salivary immunoglobulins after 30-day glucan
supplementation in children with respiratory problems (2019)
https://www.mdpi.com/1420-3049/24/7/1251/htm#

6. Total numbers of NK cells in peripheral blood of
cancer patients before and after 60-day glucan supplementation (2019)
G—glucan group
C—placebo group.
https://www.mdpi.com/1420-3049/24/7/1251/htm#

7. Timeline of studies on the biological effects of Maitake:
Grifola frondosa polysaccharide (GFP) 2018
http://www.discoverymedicine.com/Yanli-He/2018/04/grifola-frondosa-polysaccharide-antitumor-and-other-biological-activity-studies-in-china/
SFDA=State FDA of China