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Presentación de las Startups
     Modera: Paris de l’Etraz
Spain Startup Pitches 3
Javier Campos
David Canós
NOTIKUMI
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Xavier Carrillo
DIGITAL LEGENDS
Company Overview
Spain Startup & Investor Summit
          Madrid, 2012
DLE trusted by industry leaders




 “What they have been able to accomplish in 2 weeks makes you forget that you are
 watching it on a mobile device and think you are watching it on a game console”
 Scott Forstall, SVP iOS iPhone, Apple Keynote

 “Digital Legends was able to push the limits in the development of Icebreaker ”
 Torsten Reil, CEO, Natural Motion on Icebreaker

                                        21
Karisma: The most-advanced 3D game development
 environment for multi-platform mobile devices

 Comprehensive development environment including
  libraries, tools, game engine and diagnostics

 Completely OS and device agnostic: Supporting all
  relevant mobile platforms, connected TVs as well as
  Flash11 and browser (Chrome)

 Native performance for all popular mobile/portable
  platforms
  (iPhone/iPad, Android, Symbian, WinMo, Linux, Meego, B
  ADA and PSP)

 Most agile in industry in supporting new devices and
  graphics technology (e.g. OpenGL 2.0)

 Young code base (4 years) with zero legacy unlike
  competitors: 100% optimized for mobile


Systematically 18 months ahead of closest competitors, very few competitors worldwide with access to similar high-
                         performance technology required to deliver high-end 3D games

                                                         22
Strong underlying KPIs confirm DLE’s ability to create successful
         games

                                   Battlefield Bad Company 2 (2010)                                                         Icebreaker (2011)

                      Total downloads since launch       Nearly 2 Million downloads in 7            Total downloads since launch     Over       200,000       paid
                               (in Million)               months                                              (in Million)             downloads in under a month
                                                         Consistently in top 10 adventure                                             since launch
                                                          games, #1 globally for all apps in                                          Ranked 8 in USA, top 10 in 14
                                                          Christmas 2010                                                               countries
                                                         To be pushed by key US carriers                                             #2 for sports games on
                                                          (Xperia PLAY) in 2011                                                        AppStore in June 2011
                                                         iPad version (launched June 2011)                                           Rated 4+ of 5 on iTunes
                                                          already #1 in most key markets                                              Featured App (chosen by
                                                          (UK, Germany)                                                                Apple) in over 60 countries
                                                         Featured App (chosen by Apple) in
                                                          over 60 countries                               Weeks since launch




                            Bruce Lee Dragon Warrior (2010)                                           Kroll (2008)
                                                                                                                                                Key figures (DLE)
                   Total installs since launch    Game played by close to 2,5                  Close to 850,000 players
                           (in Million)                                                         #1 in Japanese AppStore top 5
                                                   Million gamers                                                                          Nearly 10 Million players
                                                  #1 in Japan and UK, #2 in                     in most European countries
                                                   USA, top 10 in major                         Featured App (chosen by                   One #1 game world wide
                                                   European countries, #1 in                     Apple) in over 60 countries               Three #1 games in Japan
                                                   Samsung Bada store                           First OpenGLES 2.0 title                  Five top 25 games in USA
                                                  Multi-platform success story:                Samsung Bada #1 free
                                                   Across all platforms incl.                    downloads                                 15 awards and nominations
                                                   iPhone, iPad, Bada, Android                  PocketGamer Silver, IMGA
                                                   and Xperia PLAY                               People’s Choice Awards
                                                  iPad App of the week in June
                                                   2011




                                                                                               23
es based on publically available sources. All data per H1 2011
Explosive recent top line growth confirms major market
traction – growth to accelerate going forward



       Revenue and EBITDA 2009-2014F (in € Million)                Achievements

            Revenues
            EBITDA                                             10 Million players
                                                                Very high revenue growth
                                                            
                                                                Endorsed and trusted
                                                               by industry leaders

                                                                Best-in-class multi-platform
                                                               technology platform

                                                                Top ranked in various
                                                               App Stores
     2009   2010     2011   2012F   2013F   2014F   2015F




                                              24
Key value considerations



 Part of a $11 billion mobile gaming market opportunity

   Proprietary state-of-the-art technology

   Riding on top of key trends: mobile, 3D, multiplayer, multi-platform, multi-
    screen, virtual goods, gamification

   Competitive advantage in addressing all platforms with the best 3D performance

   High-end games validated by customers, hardware vendors such as Apple, AMD and
    Intel. as well as publishers such as EA, Disney and Natural Motion

   Highly skilled management with experienced R&D team

   Unique expertise and know-how to pioneer the development of games for new
    generation devices like tablets, gaming handhelds and TV Set-top Boxes

                                              25
THANK YOU!

  Xavier Carrillo-Costa
          CEO

xcc@digital-legends.com



             26
Spain Startup Pitches 3
Julio Castro
PALO BIOFARMA
New medicines based on the
   Coffee Pharmacology




 Company Presentation
 Spain Startup & Investor Summit - Madrid
               6-8 June 2012
Adenosine Receptors: The Basis of the
                      Caffeine Pharmacology




Hyperactivity                              Diuretic




                        CAFFEINE




Antiarrythmic                           Bronchodilation
Adenosine Receptors: The Basis of the
                                      Caffeine Pharmacology

                                                       Caffeine exert a strong
                                                       bronch0dilatory effects in
                                                       humans: Potential new
                                                       therapies for asthma

Hyperactivity (A2a receptors)




People consuming high
Caffeine levels daily shows
less risk to develop
Neurodegenerative                     CAFFEINE
Diseases: Potential new
therapiest for Parkinson and
Alzheimer Diseases
                                                    Bronchodilation (A1 receptors)
Pipeline Status at the proposed
                               next financing round and Exit
                               2012                            2013            2014



                            Phase Ia                         Phase I        Phase IIa
                            completed                       completed       completed

PBF-509:
PD Treatment



                                                             Phase I        Phase IIa
                             IND Filed                       completed      completed


PBF-680:
Asthma Treatment

                   Financing Round of 5Mio € seeked in two tranches:       Company Exit
                   2,5 Mio. € 2013 to support Phase I clinical trials     Company Value:
                   2,5 Mio. € 2014 to support Phase IIa clinical trials
                                                                            150 Mio.€
Excellent Market Potential
                                RECENT DEALS

Projects involving adenosine receptors modulators originated over 50 deals and over $300
Billions investment from the Pharmaceutical companies in the last three years e.g:

- Vernalis/ Biogen deal on A2a antagonists for PD (15 Mio € upfront after Phase I)
- Synosia/Roche deal on A2a antagonists for PD (40 Mio € upfront after Phase IIa)
- Merck acquisition of Novacardia on A1 antagonist (350 Mio USD)


                         TARGET INDICATION MARKET


    The therapeutic indications targeted by our programs represent high unmet
    medical needs with an excellent market potential:
                                             Estimated Peak Sales (in Mio €)

    PBF-680 (Asthma):                       3000
    PBF-509 (Parkinson's Disease):                    600
The Team


Management

•   Julio Castro, PhD (CEO):
      – PhD in Chemistry at the University of Konstanz, Germany (1998)
      – > 10 years of pharmaceutical research experience (Bayer, Almirall and Oryzon Genomics)

•   Juan Camacho, PhD (CSO)
      – PhD in Chemistry at the University of Jena, Germany (1997)
      – > 10 years of pharmaceutical research experience (IBML, Jenapharm)

•   Nahomi Castro, PhD (Clinical Project Leader)
     – PhD in Biology at the University of Frankfurt, Germany (2000)
     – > 5 years of experience leading preclinical and clinical programs (Adavancell, Salutis)

•   Jose Maria Echarri: (Board Member/Interim CFO)
      – Graduated in economy and enterprise administration at the University of Barcelona
      – Former CFO of Oryzon Genomics
      – CEO of Inveready
All the elements of a successful Biotech

                         Specialized
                        Bio-investors

A well defined                           A well trained and
 exit strategy                           well advised team



                         PALOBIOFARMA



 Attractive Market                               A solid IP
     Potential


                         A diversified
                     promising Pipeline of
                     competitive products
Spain Startup Pitches 3
Pedro Álvarez
PANCRACIO
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Spain Startup Pitches 3

  • 1. Presentación de las Startups Modera: Paris de l’Etraz
  • 20. Company Overview Spain Startup & Investor Summit Madrid, 2012
  • 21. DLE trusted by industry leaders “What they have been able to accomplish in 2 weeks makes you forget that you are watching it on a mobile device and think you are watching it on a game console” Scott Forstall, SVP iOS iPhone, Apple Keynote “Digital Legends was able to push the limits in the development of Icebreaker ” Torsten Reil, CEO, Natural Motion on Icebreaker 21
  • 22. Karisma: The most-advanced 3D game development environment for multi-platform mobile devices  Comprehensive development environment including libraries, tools, game engine and diagnostics  Completely OS and device agnostic: Supporting all relevant mobile platforms, connected TVs as well as Flash11 and browser (Chrome)  Native performance for all popular mobile/portable platforms (iPhone/iPad, Android, Symbian, WinMo, Linux, Meego, B ADA and PSP)  Most agile in industry in supporting new devices and graphics technology (e.g. OpenGL 2.0)  Young code base (4 years) with zero legacy unlike competitors: 100% optimized for mobile Systematically 18 months ahead of closest competitors, very few competitors worldwide with access to similar high- performance technology required to deliver high-end 3D games 22
  • 23. Strong underlying KPIs confirm DLE’s ability to create successful games Battlefield Bad Company 2 (2010) Icebreaker (2011) Total downloads since launch  Nearly 2 Million downloads in 7 Total downloads since launch  Over 200,000 paid (in Million) months (in Million) downloads in under a month  Consistently in top 10 adventure since launch games, #1 globally for all apps in  Ranked 8 in USA, top 10 in 14 Christmas 2010 countries  To be pushed by key US carriers  #2 for sports games on (Xperia PLAY) in 2011 AppStore in June 2011  iPad version (launched June 2011)  Rated 4+ of 5 on iTunes already #1 in most key markets  Featured App (chosen by (UK, Germany) Apple) in over 60 countries  Featured App (chosen by Apple) in over 60 countries Weeks since launch Bruce Lee Dragon Warrior (2010) Kroll (2008) Key figures (DLE) Total installs since launch  Game played by close to 2,5  Close to 850,000 players (in Million)  #1 in Japanese AppStore top 5 Million gamers  Nearly 10 Million players  #1 in Japan and UK, #2 in in most European countries USA, top 10 in major  Featured App (chosen by  One #1 game world wide European countries, #1 in Apple) in over 60 countries  Three #1 games in Japan Samsung Bada store  First OpenGLES 2.0 title  Five top 25 games in USA  Multi-platform success story:  Samsung Bada #1 free Across all platforms incl. downloads  15 awards and nominations iPhone, iPad, Bada, Android  PocketGamer Silver, IMGA and Xperia PLAY People’s Choice Awards  iPad App of the week in June 2011 23 es based on publically available sources. All data per H1 2011
  • 24. Explosive recent top line growth confirms major market traction – growth to accelerate going forward Revenue and EBITDA 2009-2014F (in € Million) Achievements Revenues EBITDA  10 Million players Very high revenue growth  Endorsed and trusted  by industry leaders Best-in-class multi-platform  technology platform Top ranked in various  App Stores 2009 2010 2011 2012F 2013F 2014F 2015F 24
  • 25. Key value considerations  Part of a $11 billion mobile gaming market opportunity  Proprietary state-of-the-art technology  Riding on top of key trends: mobile, 3D, multiplayer, multi-platform, multi- screen, virtual goods, gamification  Competitive advantage in addressing all platforms with the best 3D performance  High-end games validated by customers, hardware vendors such as Apple, AMD and Intel. as well as publishers such as EA, Disney and Natural Motion  Highly skilled management with experienced R&D team  Unique expertise and know-how to pioneer the development of games for new generation devices like tablets, gaming handhelds and TV Set-top Boxes 25
  • 26. THANK YOU! Xavier Carrillo-Costa CEO xcc@digital-legends.com 26
  • 29. New medicines based on the Coffee Pharmacology Company Presentation Spain Startup & Investor Summit - Madrid 6-8 June 2012
  • 30. Adenosine Receptors: The Basis of the Caffeine Pharmacology Hyperactivity Diuretic CAFFEINE Antiarrythmic Bronchodilation
  • 31. Adenosine Receptors: The Basis of the Caffeine Pharmacology Caffeine exert a strong bronch0dilatory effects in humans: Potential new therapies for asthma Hyperactivity (A2a receptors) People consuming high Caffeine levels daily shows less risk to develop Neurodegenerative CAFFEINE Diseases: Potential new therapiest for Parkinson and Alzheimer Diseases Bronchodilation (A1 receptors)
  • 32. Pipeline Status at the proposed next financing round and Exit 2012 2013 2014 Phase Ia Phase I Phase IIa completed completed completed PBF-509: PD Treatment Phase I Phase IIa IND Filed completed completed PBF-680: Asthma Treatment Financing Round of 5Mio € seeked in two tranches: Company Exit 2,5 Mio. € 2013 to support Phase I clinical trials Company Value: 2,5 Mio. € 2014 to support Phase IIa clinical trials 150 Mio.€
  • 33. Excellent Market Potential RECENT DEALS Projects involving adenosine receptors modulators originated over 50 deals and over $300 Billions investment from the Pharmaceutical companies in the last three years e.g: - Vernalis/ Biogen deal on A2a antagonists for PD (15 Mio € upfront after Phase I) - Synosia/Roche deal on A2a antagonists for PD (40 Mio € upfront after Phase IIa) - Merck acquisition of Novacardia on A1 antagonist (350 Mio USD) TARGET INDICATION MARKET The therapeutic indications targeted by our programs represent high unmet medical needs with an excellent market potential: Estimated Peak Sales (in Mio €) PBF-680 (Asthma): 3000 PBF-509 (Parkinson's Disease): 600
  • 34. The Team Management • Julio Castro, PhD (CEO): – PhD in Chemistry at the University of Konstanz, Germany (1998) – > 10 years of pharmaceutical research experience (Bayer, Almirall and Oryzon Genomics) • Juan Camacho, PhD (CSO) – PhD in Chemistry at the University of Jena, Germany (1997) – > 10 years of pharmaceutical research experience (IBML, Jenapharm) • Nahomi Castro, PhD (Clinical Project Leader) – PhD in Biology at the University of Frankfurt, Germany (2000) – > 5 years of experience leading preclinical and clinical programs (Adavancell, Salutis) • Jose Maria Echarri: (Board Member/Interim CFO) – Graduated in economy and enterprise administration at the University of Barcelona – Former CFO of Oryzon Genomics – CEO of Inveready
  • 35. All the elements of a successful Biotech Specialized Bio-investors A well defined A well trained and exit strategy well advised team PALOBIOFARMA Attractive Market A solid IP Potential A diversified promising Pipeline of competitive products