University Of Toronto Essay Medical School

University Of Toronto Essay
Medical School
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University Of Toronto Essay Medical SchoolUniversity Of Toronto Essay Medical School

Immigrants And Citizenship
The citizenship and immigration Minister of Canada Chris Alexander touted the success of start up
visa program. The start up program will help entrepreneurs create economic growth in the country
and in a variety of industries. Those who are successful applicants and their companies are based in
Toronto, Halifax, Thunder Bay, Victoria and Vancouver can apply for this visa. Entrepreneurs
would be granted permanent citizenship if their ventures are commercially successful. Prospective
applications would require bringing financial backing for their idea. Qualification process Before
you apply, you will be required to secure a commitment from a designated Canadian angel investor
group or venture capital fund. The citizenship and immigration
... Get more on HelpWriting.net ...

Mih Case Study
MIH Treatment Treatment approaches The available treatment modalities for MIH is extensive
but the decision on which treatment should be used is complex and multi factorial. Factors may
include: condition severity, the patient s dental age, the child/parent s social background and
expectations. [1] Prevention Prevention is of prior importance at an early developmental age as
the defective tooth is more likely to have caries and post eruptive breakdown due to its increased
porosity. [1] Appropriate dietary advice and toothpaste with a fluoride level of at least 1,000 ppm F
should be recommended. [2] For treating spontaneous hypersensitivity, professional applications of
fluoride varnish (e.g. Duraphat 22,600ppm F) or 0.4% stannous... Show more content on
Helpwriting.net ...
[8] Creamy yellow or whitish creamy defects are less porous and variable in depth [6], and may
respond to microabrasion with 18% hydrochloric acid or 37.5% phosphoric acid and abrasive
paste. [9] [10] Again, this should be undertaken cautiously as microabrasion may result in loss of
enamel. [11] Cavity Design There is still much debate of whether margin extension should
include removal of all defective enamel or only the porous enamel. The former provides sound
enamel for bonding but leads to excessive tooth tissue loss, the latter is less invasive, but the
margins may have a high risk of breakdown due to defective bonding. [1] Yet, it is agreed that
adhesive restorations should be used as opposed to those reliant upon mechanical retention
(such as amalgam). [12] Glass ionomer cement (GIC) restorations. GIC materials have adhesive
capabilities with both enamel and dentine, long term fluoride release and hydrophilicity when
there is inadequate moisture control intra orally, during early post eruptive stages. However
GIC s poorer mechanical properties suggest avoidance in stress bearing areas. In later post
eruptive stages GIC may be valuable as sub layer beneath composite restorations. [1] Composite
resin restorations Composite resin material has been shown to have longer term stability in MIH
teeth, with a median survival rate of 5.2 years [13] and a success rate of 74% 100% [14] [12]
during a 4 year follow up period. Self etching adhesive was found to have

Why Parents Should Adopt Children Of Different Origins Are...
1.Those who want to adopt children of different origins are more open minded and in a sense
already have an idea of how they will raise their child. My perspective on the subject is that not
all parents really know what parenting will be like at first, or, if they adopt a child after having
a biological child then they need to be open to how to raise different ethnicities of them.
Considering the shocking amount of children that haven t been adopted in the world, it is quite
depressing that they don t have a home. In the future these transracial adoptions will enable
people to have children to care for, but the issues are laid out. For example, if a white parent
adopts a black child, there will be questions among those who are not very aware of transracial
children. In the future though, it will become more common.So many people have made
changes in America that most people look for the soul of the person. The physical
characteristics don t always matter. However, those who want to sustain each race are more
concerned that they will ruin the uniqueness of the world. In marriages this can be an issue, but
should it really be a concern? Honestly, I don t know what the Lord wants in the world, but he
most indeed gave different characteristics to create diversity. Some people don t like diversity.
But it was made for a reason and no one can tell a person who they should and shouldn t marry or
in a child s case, adopt. I think that the demographics of people in

The, The Gender Knot, By Allan G. Johnson
The biological sex of a person, in most cases, today can still be considered one of the main
identifying characteristics of an individual. In the past the sex of a person was more than an
identifying characteristic, it was who they were. They were either men or women, there was no in
between or changing it. Society today has come a long way in terms of genderidentity and gender
roles, but the concept of patriarchy still has the upper hand when it all boils down. Allan G.
Johnson s, The Gender Knot, provides for a more diverse outlook on the women s expected
roles in life, how they are expected to handle difficult situations in marriage, and how they
demonstrate courage, in Mona Lisa Smile. For years the expected roles of women have been
confined to such things as, housekeeping, cooking, and child care, in the majority of the cultures
around the world. The expected roles of the women in, Mona Lisa Smile, are also confined to
limits such as those. In this movie the women are expected to attend college and make excellent
grades, all while trying to find a husband. They are to graduate from Wellesley College, but going
on to further attend a graduate school is unthinkable. These women all possess the same goal,
which is, to get married and then they think no further than having children. They are expected to
stay at home and take care of the house and the children, while their husband is out working to
provide for the family. They are above all else supposed to respect their

Sexual Selection
The impact of Sexual Selection in the Asian Population There are many reasons as to why couples
as in the Asian continent decide to take part in the decision making process of sexual selection.
These arguments fluctuate depending on the region where the family is located. In China couples
often resort to ultrasounds to reveal the fetus gendersince in this country is preferable having a son
over a daughter in order to prolong the family line and at the same time undergo China s strict one
child policy. Whereas, in India women are often obligated by their husbands and/or their conjugal
families to go under an ultrasound in order to acknowledge the fetus gender, especially in rural
areas where the masculine gender is favored over the feminine... Show more content on
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This causes a possible scarcity of partners for the generations to come, especially in India and
China. Prohibition on more than one child per family in China has drastically increased female
abortions and infanticides to secure male offspring, while in India the expensive dowries have led
to the mass appeal of ultrasound test followed by abortions of female fetuses.
Feminist groups see the high female mortality rate and the men excess as a possibility for a status
increase for women at least in some aspects since men need women to created more men. So the
first feminine response against sexual selection is that the decrease in the number of women might
lead exactly to the increase in their social status .
In conclusion sex selection and gender preference is the manifestation of an anti women bias, and
they are also indicative of a prejudicial and discriminatory attitude towards women. The only
possible solution for this issue is to fight against the social structures that disguise the birth of
girls a social and economic burden, by doing this not only the social and general aspect towards
women will change but also a demographic and gender balance will be achieved in both of these

Wrestling Is An Ancient Sport
Wrestling is an ancient sport and has lots of history. Wrestling was originally from the Greeks.
Wrestling in Greece was a big sport; it was the biggest event in the Olympic Games. Wrestling
also was blessed by Greek mythology. The God Zeus wrestled the God Cronus for the possession
of the universe, and to celebrate the win by Zeus, they made wrestlingthe decisive final event in the
pentathlon.
There 3 styles of wrestling and all are similar but have different qualities. The first style is Greco
Roman. This style is very aggressive, all styles of wrestling are. This was the first of all the
styles, and back then they used to wrestle to the death. An ancient wrestling coach would say to
his team don t stop till he s dead , and that s would his students would follow. In the matches they
would slam with no regards if their opponent was hurt, unconscious or dead. Now the Greek
wrestling has much more rules, fellow a point system, can only use upper body, and is a lot safer
than what it was.
The other style is free style. This style is very similar to Greco. It has the same type of
aggression as Greco, but you can use your upper body as well as your lower body. Domenici s
Theotocopoulos Roman hand to hand struggle and freestyle wrestling both involve grappling with a
resist, but the two sports have their differences. Although it has an ancient sounding name, Greco
Roman wrestling originated in France in the 1900 s; the name comes from a desire to include
ancient values.

Compromise Of 1850 Dbq
The Compromise of 1850 was constructed by Henry Clay in desire to keep the nation from a
Civil War. These documents failed and slowly began to divide the nation into two sections,
proslavery and antislavery states. The reason this document was produced was because of the
ongoing conflicts over slavery. This is a significant part in history because this compromise moved
the country towards the Civil War. It had brought conflict because it seemingly caused more riots
throughout the nation. However, it also had created compromise because their initial plan was to
balance the amount of free states and slave states and it had taken away the Civil War from
happening for ten years.
Many people were affected in the production of the Compromise of ... Show more content on
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The five bills constructed by Henry Clay and passed by the United States Congress were created in
attempt to solve the crisis between the Northern and Southern states. Bringing these bills into the
situation had kept more of a balance between these two sections than in the past. This document
brought the United States into smaller tensions and resolved many issues due to the difference of
viewpoints in slavery distributed along the United States. This compromise had fundamental
significance on individuals, communities, nations, and the world. The amount of trouble between
both areas of the United States started to lessen when the compromise was created and brought
more balance into the community. The immediate impact of the compromise less conflicts
between the Northern and Southern states, but it had also caused more tension at the same time.
To every compromise, there are always positives and negatives sides to it. A positive impact for
the South would be the reinforcement of the fugitive slave act. Another advantage they had
would be Texas being given ten million dollars to pay for their debt towards Mexico. Positive for
the North would be having California admitted as a free state. An additional advantage would be
slave trade being prohibited in Washington D.C., the nation s capital. Although a bill can be
positive for one side, it would be negative for the opposing side

Alicia Moore (Pink) Essays
Alicia Moore (Pink)
Alicia Moore, or Pink as she is better known, has become a music sensation around the United
States. My reason for choosing her as a topic is the fact that she was born and raised in
Doylestown, Pennsylvania my hometown. Doylestown is about an hour northeast of
Philadelphia, and it s easy to take note of anyone famous who comes out of D Town, as it is
called, because it is not the largest of areas. Pink went to the rival high school of mine, Central
Bucks High School West, and I actually know a few people who knew her as AliciaMoore through
various activities.
Pink had a very rough childhood. She wanted to leave her house and envisioned a better life for
herself when she was growing up. I was screwed up, lost ... Show more content on Helpwriting.net
...
She also began to spend a lot of time in the city of Philadelphia at different dance clubs.
Her frequent visiting of the clubbing scene was actually how she got noticed. She landed a
Friday night singing spot at Club Fever. A talent scout spotted her there one night and signed
her up for an R B group. The R B group quickly fell apart, but Pink was determined, and was able to
find another group to join. That second group was picked up by LaFace Records, and eventually
the label signed Pink as a solo artist and her first album Can t Take Me Home was produced.
Two million albums and three top 40 singles later, Pink was asked to do the remake of LaBelle s
1975 #1 hit, Lady Marmalade, for the Moulin Rouge soundtrack, along with well known artists
Christina Aguilera, Lil Kim and Mya. Their compilation song shot to the top of the charts, and,
with an award winning, truly cabaret type, video to match, sent Pink and her powerful soprano to a
world stage.
Pink has recently released a second album Missundaztood, which has already reach number eight
on the Top 200 album charts. There is even a new single, Get The Party Started which has hit
number four on the Top 100 Singles.
With Pink now dominating the airwaves she finds herself dogged by questions about certain other
big name musical talents. She addresses this issue directly on the very rock sounding new cut Don t

My Aspiration At Work Worth Doing
My aspiration in life is to earn an honest living by providing health care to those in need of such
attention. With this career path, I believe that I will have both an exciting and rewarding
occupation. Helping those in need by promoting health and preventing disease I something that I
found interesting ever since I was little. For when I was younger, I was in the hospital quite
often for countless reasons, and knowing that I was going to be perfectly okay lead my
impressionable self to gaining the utmost respect for those in the health care business and
eventually leading me to pursue a career in the field. Ultimately, I feel that the profession will
allow for me to contribute to society and in doing so I remain confident that I will learn a great
deal from such as occupation as one in health care. For Theodore Roosevelt once said, Far and
away the best prize that life has to offer is the chance to work hard at work worth doing . With
this quote in mind, health care appeals to me and appears to be the true career field for me and is
my calling.
At the beginning of the semester, it was revealed to the Hicks Honors students our Strong Interest
Inventory and Myers Briggs Interpretative Report. From my Strong Interest Inventory, I learned that
my interests attribute to my occupation being in either health care services or medical science.
Additionally, under my Top Ten Strong Occupations, several professions in the health care were
listed, such as a registered nurse or a

Plan D Affaire Auberge
PLAN D AFFAIRES Auberge LA SOUCHE Nom des promoteurs : * FrГ©dГ©ric Laplante *
Simon Raby * Marius Plourde * Mathieu Boulianne Tremblay Adresse complГЁte : * 26 rue des
merles, Blainville, J7C 3P2 * 867 MontГ©e du Gore, St Sixte, J0X 3B0 * 14380 des bouleaux,
Mirabel, J7N 2L1 * 961 St Luc, Mascouche, J7K 2Z9 TГ©lГ©phone : * 911 Courriel : *
fredericlaplante@hotmail.com * Simonraby7@hotmail.com * mariusplourde@hotmail.com *
Bouli_show_222@hotmail.com DerniГЁre mise Г jour : * 13 avril 2010 * TABLE DES
MATIГ€RES TABLE DES MATIГ€RES1 1.PROJET4 1.1.SOMMAIRE EXГ‰CUTIF4
1.2.MOTIVATION5 1.3.MISSION DE L ENTREPRISE5 1.4.OBJECTIFS DE L ENTREPRISE5
1.5.... Show more content on Helpwriting.net ...
MISSION DE L ENTREPRISE L auberge La Souche s engage Г offrir un service hors pair Г ses
clients de l accueil Г son dГ©part. Le client reprГ©sente le centre de nos prГ©occupations, c est
pourquoi nous nous efforГ§ons Г lui offrir une expГ©rience unique Г notre Auberge. La
satisfaction de nos clients est notre meilleure publicitГ©. OBJECTIFS DE L ENTREPRISE *
Obtenir un taux d occupation de 19 % aprГЁs 3 mois. * Augmenter l achalandage de 20% pour
le restaurant public d ici 2 ans * Augmenter la superficie du terrain de 30 000 pieds carrГ©s
CALENDRIER DE RГ‰ALISATION Г‰TAPES| DATE DE RГ‰ALISATION| RГ©daction
du plan d affaire| 1er mai 2010| DГ©claration d immatriculation au registre de l entreprise| 1er
mai 2011| Permis d affichage le long des routes| 1er mai 2011| Permis d alcool| 1er mai 2011|
Autorisation pour le systГЁme de traitement des eaux usГ©es d origine domestique| 1er mai
2011| Autorisation pour des projets en milieux aquatique humique et riverain| 1er mai 2011|
Autorisation pour le captage des eaux souterraine| 1er mai 2011| Inscription au fichier de revenu
QuГ©bec| 1er mai 2011| Obtention du permis requis pour la prГ©paration et le vente d aliment|
1er mai 2011| Inscription au registre des lobbyistes| 1er mai 2011| Demande de prestation

Impact Of Sigmund Freud And The Pull Of Imperialism
Between the time WWI and WWII broke out the world was in flux changing rapidly and
civilization all over the world was changing with it. There is many reasons for the change like the
push of imperialism or the enlightenment era. During this time Sigmund Freud, an austrian
psychiatrist and world renowned scholar, wrote a piece called Civilizationand its Discontents where
he talked about civilization, his theory of instincts, and the individual psyche. Freud claimed that
civilization had many problems because mankind would instinctively look after themselves and that
lead to how a personwould think and act. Freud argued that man would instinctively want to survive
and find their own happiness. Freud saw civilization as something that went completely against a
person s instincts as civilization forced people to follow rules that would limit them or at times
interfere with their happiness. Man having those instincts would lead them to fight with each other
in wars and have rebellions against those who tried to control their lives. He also theorized that
man had a mental psyche that was developed from instincts and civilization. Freud uses reasoning
and historical evidence like war, religion, and examples of people in civilization to back his
claims. Freud states that mankind s main goal in life is to find happiness and reasoning for that
statement can be found through religion. People have adopted religions to give more meaning in
their life and a belief that they are a

Character Aspects Of Physical Appearance
Character Over Physical Appearance. One time, there was a 26 years old women who had just
finished her bachelor s degree. She is five feet six inches tall, and when she graduated, she
weighed about 145 pounds. She has an athletic build, which is great, healthy weight at which she
was pleased. She was so glad of herself and enthusiastic about starting her very first career. Her
first appointment was at a small employment agency. After done filling out the paperwork, she
was interviewed by a woman who had to leave the interview room briefly. Of course, she, then,
lean over to see what the women had written in large letters at the top of her application form.
Surprisingly, there was her first impression: BIG GIRL. At that time, she was shocked. She
learned that her physical appearance would be a thing that prospective employers would need to
know. It was kind of harsh is not it? People judges the book by its cover, while the truth is people
come in all sizes and everyone should and deserves to be judged based on their character, not by
physical appearance. In Jennifer A. Coleman s Discrimination at Large, Coleman displays
perseverance and the ability to overcome obstacles presented to her being overweight. Coleman
starts by explains that she understands that people with fat appearance is unexamined bigotry
(176). She wanted to have a good body shape like most people does. Therefore, she is proving that
she is able to become fit by swimming, cycling, jogging, and ate low

Western Vs Alternative Medicine For Western Medicine
Rakalah R. Ravariere
Scotland Harris
English I
Imagine this, you ve just had another visit to your Doctor and been told yet again that your
condition hasn t improved and may even be getting worse. There is nothing they can recommend
for you. You ve had all the tests, they ve diagnosed your condition, but the only thing they can
offer you is a drug that may help relieve your symptoms. And possibly only for the short term at
that. Having family in Dominica I always hear how I should drink different varieties of bush tea in
order to cure sicknesses. Majority of the islands and other countries use traditional Chinese
medicines in order to cure sicknesses like the common cold the flu and other things. And I they
need a major ... Show more content on Helpwriting.net ...
Western Medicine focuses on dealing with the symptoms of the disease in many cases and
treatment suppresses these, rather than curing the problem. This can lead to a lifetime need for
drug therapy.
A one size fits all approach if you are diagnosed with a particular condition you will be prescribed
a particular type of Drug e.g. if you have raised cholesterol you will probably be given a stronger.
Dosing and regimen is standardized this is ok for the majority of patients. But you may fall outside
the norm and therefore the treatment doesn t work as well for you or you have tolerability problems.
Treatment with conventional medicine in many countries is very expensive and without access to
health insurance can be out of the reach of many. Even in countries where there is free access to
health care, certain Drugs or treatments may not be available, due to the local health care services
being unable to pay for them.
The modern focus on disease and the time and other pressures many physicians are under means
that sometimes the patient can feel like they are on a treatment treadmill and not being listened to.
Alternative Medicine The Pros
Most alternative medicine practices work to restore balance to the body. This allows the body to
heal itself. This holistic approach can often impact positively on other aspects of the patient s life.
Alternative Medicine and Alternative

Epidemiological Studies On Erds
Epidemiological data
The annual incidence of ARDS is 13 23 people per 100,000 in the general population and it is
higher in the mechanically ventilated population in intensive care units which represents 16.1%
percent in ventilated. Pneumonia and sepsis are considered as leading trigger of ARDS as
pneumonia represent in up to 60% of patients and may be either causes or complications of ARDS
and according to literature approximately 30% of patients with severe sepsis may develop ARDS or
ALI. Other triggers include aspiration, circulatory shock, mechanical ventilation, smoke inhalation,
trauma especially pulmonary contusion major surgery, massive blood transfusions, drug reaction
or overdose, fat emboli and reperfusion pulmonary edema after lung transplantation or pulmonary
embolectomy. Alcohol excess appears to increase the risk of ARDS. Until the 1990s, majority of
studies reported a 40 70% mortality rate for ARDS. However, 2 reports in the 1990s, one from a
large county hospital in Seattle and one from the United Kingdom, suggested much lower mortality
rates, in the range of 30 40%. Possible explanations for the improved survival rates may be better
understanding and treatment of sepsis, recent changes in the mechanical ventilation, and better
overall supportive care of critically ill patients. (Koh et al, 2012)
We noticed that most deaths in ARDS are related to sepsis or multiorgan failure rather than to a
primary pulmonary cause, although the recent success of mechanical

Black Tailed Prairie Dogs
This profile is on the black tailed prairie dog. It will be introducing their background, life cycle,
structure and function, evolution and an additional interest. It will also be going over their unique
social structure and the way they form communities called prairie towns, which are a large system
of burrows. The importance of burrows, in particular, to the black tailed prairie dogcannot be
overstated.
Black Tailed Prairie Dogs
The black tailed prairie dog s scientific name is Cynomys ludovicianus that, colorfully, means dog
mouse of Louisiana. It lives in North America in the Great Plains region of the United States. Its
territory stretches all the way to the borders of Canada and Mexico, but not to the coasts. The
black tailed prairie dog is the most common and prolific of all prairie dogs, and has the largest
territory. Prairie dog towns, a system of burrows that are close together and can span miles, are
subdivided into wards, coteries, and individuals on a downward sliding scale depending on
population size.
Life Cycle
Mating
The breeding season of black tailed prairie dogs varies depending on the temperature of their
locale. In warmer climates, breeding season may begin in what is still technically the winter. In
colder climates, the breeding season may not come until March. The breeding season is a once a
year event that starts when the lengthening hours of daylight after the winter solstice trigger onset
of estrus (Graves, 2001). Males of the

The Long Way Home Analysis
The Long Way home was written by David Laskin, a passionate reader who graduated from
Harvard College in 1975 with a degree in literature and history. Laskin in recent years has been
writing about non fiction events in which people are thrown into situations they cannot control,
such as war, horrific weather, and genocide. In The Long Way Home, Laskin did not hold back
details from the reader. His focus on the details are what made the monograph so impactful, and
with that, they give the reader a very good sense of what these individuals in past time hardships
had to deal with. The horrors of the immigration boats, coming to an America that was nothing like
they were told it was, and the unimaginable mental destruction of war; All of these... Show more
content on Helpwriting.net ...
The same year Meyer had also been enlisted just only five years after coming to America. Meyer
s experience on the front lines began when he was called in as a replacement for a man who bled
too much to keep fighting. He was now part of America s big offensive. His first night of active
combat consisted of old trenches and bomb shell torn land. There was little German resistance...
There was no other sign of life (pg. 250). That night there was harsh rains and no fires could be
built. He spent the night cold and wet, but he was alive. Epifanio s army life came differently in
a sense. His division early on in the summer had joined with British Forces. His fellow comrades
kept talking about how the front lines weren t so bad unless you were at Ypres. Turns out that s
exactly where they ended up. Laskin quotes a soldier I can t describe the awfulness of war ... As
most men say, it is not war, it is slaughter. Don t go near Ypres (pg. 230). Epifanio had it rough; He
was amongst the toughest lines of battle known amongst men at the time, and every combat soldier
that thought they wouldn t see action, did not get off easily in the autumn of 1918. Both men
experienced hell, and while they were on different fronts, they both shared a life known as a soldier
s

Bajaj vs Lml
BAJAJ VS LML
A Comparative Analysis
In today s world the two wheeler segment is a very competitive industry and there is a very stiff
competition among the various companies. There have been many two wheeler companies in
India present in the market since a long time, some have been able to transform itself and cope
with the modern market and some have faded away into the past. Companies like Hero Honda,
Bajaj and TVS have transformed themselves into major giants, while companies like LML and
Rajdoot have failed miserably and collapsed and had to shutdown. So in our case study we are
taking into consideration two such companies like Bajaj and LML which have been there from the
very beginning and trying to analyse why Bajaj was a huge ... Show more content on
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With a larger selection of two wheelers on the Indian market, consumers started to gain influence
over the products they bought and raised higher customer expectations. The industry produced more
models, styling options, prices, and different fuel efficiencies. The foreign companies new
technologies helped make the products more reliable and with better quality. Indian companies had
to change to keep up with their global counterparts.
Motorbikes are a major segment of Indian two wheeler industry, the other two being scooters and
mopeds. Indian companies are among the largest two wheeler manufacturers in the world.
In the initial stages, the scooter segment was dominated by API; it was later overtaken by Bajaj Auto
and LML. Although various government and private enterprises entered the fray for scooters, the
only new player that has lasted till today is Bajaj.
The motorcycle segment was initially dominated by Enfield 350cc bikes and Escorts 175cc bike.
The two wheeler market was opened to foreign competition in the mid 80s. And the then market
leaders Escorts and Enfield were caught unaware by the onslaught of the 100cc bikes of the four
Indo Japanese joint ventures, namely; Hero Honda, TVS Suzuki, Bajaj Kawasaki and Kinetic
Motor Company (Kinetic Honda). With the availability of fuel efficient low power bikes, demand
swelled, resulting in Hero Honda then the only producer of four stroke bikes (100cc category),
gaining a

Comparing Death Of A Salesman And American Beauty
By examining the connections between works composed in different time periods, responders may
elevate their understanding of how context influences composers. Arthur Miller s 1949 play Death
of a Salesman subverts the materialistic values promoted by the American Dream, whilst Sam
Mendes film 1999 film American Beauty challenges the expansion of consumerist culture in the late
20th century. Miller s play and Mendes film further challenge their respective societies focus on
outward displays of personal wealth and perfection, respectively. Both Miller and Mendes critique
the materialistic nature of American society by exploring how a preoccupation with material goods
causes individual emotional stress and discontent within a family. Miller s... Show more content on
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This context is reflected in Willy s projection of his materialistic desires upon Biff: I ll get him a
job selling , the stage directions with pity and resolve highlighting Willy s determination to help
his son get big , or become wealthy. However, Willy finds himself unable to leave a financial
legacy for his family, embodied in the metaphorical seeds , which he has failed to plant . Willy s
subsequent emotional turmoil is palpable in the desperate tone of his lament: Ben, nothing s
working out. I don t know what to do . In his final moments, the pursuit of money remains as Willy
s primary motivation, underscored by the irony of his description of a life insurance payout as
magnificent , emphasising that he values an insurance pay out more than his own life. Therefore,
Miller critiques the materialistic nature of post war American society by demonstrating how Willy s
relentless pursuit of wealth causes his inner emotional conflict and suicide. Similarly, Mendes
examines how Caroline Burnham s obsession with material goods prevents her family from
attaining emotional fulfilment. In the 90s context of

Clown Sighting Research Paper
In light of clown sightings across the nation, Slate.com addressed the concern in an article, Police
Can t Find Evidence of Clown Luring Tales, Arrest Man for Making up Sighting. The article
mentions that creepy clown sightings have been reported since August in South Carolina and
have spread to North Carolina. However, there has been no evidence in these cases. This issue has
not been taken lightly with Winston Salem Police of North Carolina where David Armstrong, 24,
has been arrested with fabricating a story. The sightings are classified but a Greenville policeman
quotes, We re still investigating to see what the actual purpose is, whether it s for ill intent or if it s
a prank. An unknown psychologyprofessor told the New York Times that

Discuss Augustine s Questions On The Problem Of Evil
Freedom and Evil
This paper I m going to discuss Augustine s answers to the problem of evil. Why didn t God only
create free beings who use their freedom for good? What is the source of the free movement of
will? Lastly why do some free begins sin and others do well if they are in the situation?
First question I will talk about is why didn t God only create free beings who use their freedom for
good? We all see good and evilaround us every day. The sources of good and evil are independent
and eternal. God made everyone good, but it s the induvial choice to do good or bad. God is
fair, but sometimes life isn t and that s what makes it hard to understand. God is good but people
do bad things and that s what makes them bad. It s up to us day to day to the right things, god
gave us all the tools to do good and bad but it s the induvial choice on whether they will or not. We
make mistakes and that can cost dearly.
As long as people do bad things someone will pay the price. For example if you killed someone
that person s family will have to suffer. As long as people make mistakes there will be suffering.
Evil actions are not our responsibility but the product of what s playing out within us. If you
really think about it evil isn t something, but the lack of something. There s a reason why the
person is mad there s a reason for everything that happens. For instance why people get sick is
because of lack of health, why are people poor, lack of wealth. As we talked about in class

Eminent Domain Case Study
In the eminent domain hypothetical, my town has been outsourcing most of the manufacturing to
cheaper overseas labor markets in China and India. There has been an increased demand for
revenue for police, fire, schools, and other essential infrastructure. Because of the high
unemployment rate in the town, young people are not returning after finishing college. This had
led to a downward economical spiral. There is a small Indian reservation on the outside of town.
The state laws now permit full Las Vegas style gambling but only on Indian reservations. The town
council requests my position that would take a large amount of private land owned by local
farmers and give it to the tribe. As required by the Constitution, the farmers would be compensated
... Show more content on Helpwriting.net ...
158). By applying this theory to the hypothetical, it is an ethical decision to seize the property from
the farmers. The decision to take the land from the farmers and give to the local Indian tribe for
gambling will result in decreased unemployment rates and increased revenue. While the farmers
may suffer with a sentimental loss of their families land, they will be compensated for the cost.
With weighing the costs to the farmers against the benefits to the town and community as a whole,
it is in the best interest to exercise eminent domain. Society will benefit from the increased revenue
and decreased unemployment rates. As the unemployment rate decreases, the amount of
unemployment pay decreases. New opportunities will entice the younger generation to finish
college and return home to pursue their careers. The schools receiving more funding and revenue
will continue to operate and be able to provide strong curriculum and extracurricular activities. This
will certainly benefit the children in the

The Effect Of Human Activity On The Abundance Of...
The Effect of Human Activity on the Abundance of Freshwater Microorganisms
Fatima Cubillas Flores
Biology Honors Period 5
Dr. Frank
21 November 2016
It is an undoubted fact that humans can impact the quality of water, and there has also been an
immense increase in the need for water for survival in today s society. Water is used for many
purposes such as in manufactured goods, for the growth of food, for mere drinking, and for the
production and use of energy (Gleick). The National Research Council of the National Academy
of Sciences in the U.S.A. suggests that humans get an average of one and a half milliliters of
water per calorie of food.. Bathing is suggested to need an average of 70 litres of water for every
human being a day. 11.5 liters of water is on average used for food preparation a day; from this it
becomes clear that freshwater sources are very important to the survival of the human race (Gleick).
Water is so important to the survival of all organisms that as human activity increases in sources of
freshwater, it calls to attention: How does human activity affect the abundance of microorganisms
and water quality of the water?
The presence and variety of microorganisms in water accounts for most of the indicators of water
quality. The presence of Coliform is a big indicator of fecal contamination in freshwater sources.
Coliform bacteria is an organism that is naturally present in the human digestive tract; these tend to
be rare and

The Ebola virus (EBOV) Essay
1.Introduction
The Ebola virus (EBOV) is a dangerous virus which has a chance of mortality when infected up
to 90%. This makes it one of the most deadly viruses for humans in the world. 1, 2 It does not stop
there. Various EBOV outbreaks have fatally infected tens of thousands of chimpan zees, duikers
and gorillas. It those areas it is a great threat to the wildlife.3
EBOV belongs to the order of the nonsegmented negative sense (NNS)RNA type viruses, the
Mononegavirales and it is part of the family Filoviridae. EBOV is a member of the genus
Ebolavirus. This genus has five distinct species: Bundibugyo ebolavirus, Zaire ebolavirus, Su dam
ebolavirus, TaГЇ Forest ebola virus and Reston ebolavirus.4 The Ebola virus should not be confused
... Show more content on Helpwriting.net ...
Interferon signaling is the release of proteins by the host cell to communicate to the immune
system that there are pathogens present in the host cell. Second in combination with NP and VP35
it takes part of the formation of the nu cleocapsid and third, it is shown that without VP24 there is
far les VP30 in virus like particles. The last shows VP24 is nessecary for a fully functional
nucleocapsid.13
The polymerase cofactor VP35 is a protein in the nucleocapsid that just as VP24, possesses the
ability to inhibit interferon signaling.14 Also it probably regulates the transcription and
replication.15
VP30 is also in the nucleocapsid and possible has a direct interaction in the transcription of EBOV
RNA. Also it probably regulates replication. 15
The RNA Polymerase L protein is a part of the replication and transcription cycle. It is also believed
that it regulates the enzymatic activities for replication and transcription
The NP plays an central role in virus replication. Also it is necessary, together with VP24 and
VP35, to build nucleocapsid like structures.6 Although NP is so important for the virus, its exact
role is still unknown.
Figure 1:6 A. This is a schematic diagram of EBOV genome The proteins depicted are the three
prime untranslated region (UTR), nucleoprotein (NP), the viral proteins (VP) 35 and 40, the
glycoprotein (GP), VP30, VP 24, the RNA dependent RNA polymerase (L) and the five prime
untranslated region.7, 16 The transcription starts at the

London 1908, Machinery Hall Essay
missing image
London 1908, Machinery Hall
This image represents the entrance to Machinery Hall of the 1908 Franco British Exhibition in
London. The original is one in a series of 3.5 x 5.5 inch postcards, printed by Valentine Sons Ltd.
The Machinery Hall covered 125,000 square yards. In this image it looks very elaborate, garish,
and reminiscent of Gothic architecture. The flags seen on the top of the building are French and
British. There are decorations looking like lanterns around the perimeter of the building. Within the
context of the fair, the pavilion was vast yet not imposing.
The London 1908 Exposition was located on an area of agricultural land in Shepherd s Bush, West
London, which provided 140 acres of land, close to ... Show more content on Helpwriting.net ...
In the Machinery Halls, heavy industry was represented by displays on mining, iron and steelwork,
armaments manufacture, shipbuilding, pumping and motive power machinery, electricity
generation, as well as textile and printing machinery. Many displayed objects were instruments of
war such as a gun carried on the backs of three dummy men. Warship firms displayed models of
their scouts, destroyers, armed cruisers and torpedo boats. War relics included an astrolabe of 1578,
the barge of the great Napoleon, the flat bottomed boats which the French used when they captured
Algiers, and some of the small cannons used on the gunwales of eighteenth century warships.
Numerous modern inventions were also featured. The steel and iron industry displayed flywheels,
and suction producers, while railway companies made a model of a Scenic Railway outside. The
place of honor in the French hall was taken by the great Pont Г Mousson blast furnace. The
London Electricity Companies demonstrated modern cooking with electric range and kettles, and
showed sewing machines.
One of the great luxuries in the building was a free rest room, in the middle of which was a
pleasant fountain. The Franco British Exhibition: illustrated review commented on this idea:
Remembering the general comfortless ness of the grounds, it was a stroke of real genius to put that
oasis of rest in the centre of the grim and dour Machinery Halls.
The exhibition lasted from May 14 to October 31, 1908. The

Rhetorical Analysis Of President Trump s Inauguration Speech
The presidential inauguration speech started off with the new president swearing in, and taking
his oath, then he made his way to the podium where he began his inauguration speech as the 45th
president of the United States of America. In his speech, he went over his plans and goals for his
future term: through him people will regain their political power. He uses pathos, ethos, and logos
to persuade his audience of this. President Trump started off with presenting his views and
aspirations for the country. As he had been saying all throughout his campaign, about rebuilding the
Americans a super power and making it great again. He reaffirmed those ideas for the citizens that
he will do as he promised even though it would be hard. He highlighted... Show more content on
Helpwriting.net ...
Trump has also pledged to suspend America s intake of Syrian refugees. The topic of health and
addictions was also briefly touched upon saying The crime and gangs and drugs that have stolen
too many lives and robbed our country of so much unrealized potential, said Trump. This
American carnage stops right here and stops right now. This statement shows ethos for the
people who might be victims of such crimes in the country. Trump then reassures the people that
they are protected and secure by saying We assembled here today are issuing a new decree to be
heard in every city, in every foreign capital and in every hall of power. From this day forward, a
new vision will govern our land. From this day forward, it s going to be only America first
America first. Once again this ethos and he gives emotion feel that they are going to be protected
again. He also referred to the Bible to emphasize how much potential America has to once again
be great as he said The Bible tells us how good and pleasant it is when God s people live together
in unity. We must speak our minds openly, debate our disagreements honestly but always pursue
solidarity. When America is united, America is totally unstoppable. This aspect of unity that he
explains about in the Bible is correct but, not to

The Aftermath And Acts That Followed The Boston Tea Party
The Aftermath and Acts That Followed the Boston Tea Party
Karla Valeria Gonzalez
Formatted Rough Draft
Mr. Isaac G. Pietrzak
U.S. History 1301
November 4, 2016
On the Thursday of December 16th of the year 1773, several men began to dump what is now
worth over a million dollars of British tea into the Boston Harbor. This later became known as the
famous Boston Tea Party. The Boston Tea Party was the initial cause of the American Revolution
and the freedom America has gained. The Boston Tea Party was also the beginning of all of the
aftermath that followed it. The Intolerable Acts, the Continental Congresses, and battles following
the Boston Tea Party were the beginning to America s freedom.
To start off, the Intolerable Acts were a part of the effects of the Boston Tea Party. They were
basically a punishment from Britain to the colonists of Boston, Massachusetts for dumping their tea
into the harbor. Some of the most known Intolerable Acts are the Boston Port Act, Quartering Act,
Massachusetts Government Act, and the Administration Justice Act. Not only were the Intolerable
Acts put into place after the colonists dumped tea into the harbor, but there were some agreements
that the colonists made with Britain. For instance one of the many agreements made together was
the, Boston Non Importation Agreement. It was made in August 1, 1768. This agreement was from
the colonists to Britain, although most of the Intolerable Acts actually derived from

My Welding Career
Welding has been one of my passions throughout my years as a highschooler, and this position
gives me a great opportunity to expand on my welding career and to follow my dream of welding
for work. Some of the ways that show I am good for this position are that I m a dedicated worker, I
m passionate about weldingand that I am a good responsible worker. The reason I am a good
applicant for this position is because I am an extremely skilled welder. I am skilled in the field of
mig welding, arc weldingand pulse tig welding. A past experience that shows I am skilled was
when there was a time that I went to a job shadow for welding and I welded for the guy I was
shadowing and he said You d make a hell of a tig welder. I also am better than some

The Life and Times of the Wicked Witch of the West
Imagine a child that was born with a bright green tint to their skin and had razor sharp teeth. This
happened to Melena Thropp in the book The Life and Times of the Wicked Witch of the West,
written by Gregory McGuire. The Broadway musical Wicked, by Winnie Holzman, was based on
this novel. When it made its debut it astounded the world as it won many awards. Wickeddraws in
many people because they can relate to the feeling of being ostracized the way Elphabawas. In the
21st century, musicals have progressed along with technology due to the use of new special
effects in musicals today. The New Millennium marks the beginning of the 21st century. On
September 9th 2001 one of the most horrific events had occurred (History.com Staff). Al Qaeda
terrorists had taken over four planes. The terrorists had purposely crashed two of the planes into
the Twin Towers. A third plane had then been crashed into the Pentagon. The first plane had
crashed at 8:46 in the morning. The plane had crashed between the 80th and 110th floor. 18
minutes after the first crash another plane had crashed into the south tower near the 60th floor.
Fifteen minutes later the south tower collapsed causing a huge cloud of dust to arrive. At 10:30
a.m. the second tower collapsed. 3000 people were killed in this disaster (History.com Staff). It is a
day America will never forget. One thing that has really progressed in the 21st century is the
technology. In 2005 YouTube was launched (FutureTimeline.net). It

King Nebuchadnezzar
Nebuchadnezzar isn t only famous from being known from what he achieved, but he was also
known from the bible. His attack on Judah was documented in the bible specifically at Jeremiah
25:9. In the bible, Nebuchadnezzar is portrayed as a violent, greedy ruler who only wanted to
improve his life, but this is false. He was very violent and aggressive, but he wanted the best for
his city and empire.(Jeremiah 25.9) Nebuchadnezzar would also dream about godspeaking to him.
He dreamt an image of a sculpture of himself. He would have a head of gold representing the
strongest civilizations at the time which was arguably the one he and his father built. Next on the
sculpture was silver representing the strong cities he beat. Then bronze for the next... Show more
Daniel then stepped up to make an attempt at the interpritation. He successfully interprited it
which then had Nebuchadnezzar promote him to a main advisor. (Daniel 2:47) Later,
Nebuchadnezzar created a gold statue of himself. People of the empire were ordered to bow
down to this statue when the music played. People who failed to complete this task were killed
by Nebuchadnezzar. The most known case of this was of Daniel s friends Shadrach, Meschach,
and Abednego. They were thrown into a boiling furnace when they decided against bowing
down. Surprisingly, these three men came back out alive. Nebuchadnezzar is quoted for saying
this quote in the bible, Blessed be the God of Shadrach, Meshach, and Abednego, who has sent
his angel and delivered his servants, who trusted in him, and set aside the king s command, and
yielded up their bodies rather than serve and worship any god except their own God. Therefore I
make a decree: Any people, nation, or language that speaks anything against the God of Shadrach,
Meshach, and Abednego shall be torn limb from limb, and their houses laid in ruins, for there is
no other god who is able to rescue in this way (Daniel 3:28 29).241In Daniel Chapter Four,
Nebuchadnezzar was supposdly given another

Health Insurance Law Essay
Massachusetts Health Insurance Law Around the month of June the year 2006, a survey that was
carried out revealed that there were close to 375,000 residents of Massachusetts who were
uninsured which sum to about 6% of the total population of the state (Raymond, 2007). Health care
is one of the key needs that any person is required to have. Since it comes at a cost, health insurance
is always a platform to ease the hustle here and there. The health insurance law, chapter 58, was
enacted with the main aim of reducing the percentage of the residents living without health
insurance in Massachusetts (Polestar Communications Strategic Analysis, Associated Industries of
Massachusetts Foundation, 2006). The law was introduced to make sure that both... Show more
This move that was taken by the Massachusetts state has lots of advantages as far as the healthy
well being of the residents is taken into considerations. Some of the top advantages include:
1.Improved Health care
A state that comes up with legislations that are to ensure that all its residents have access to
health care insurance is a state that has health as pillar at its heart. The approach is one of the
effective ones in ensuring that all the residents have access to proper and affordable healthcare
services. When the health care is made accessible to everyone, the entire state of healthcare will
be greatly improved. Having improved healthcare is always a priority and a desire to very many
not only states but even countries across the globe.
2.Control Over Health Services
The state through its laws that were implement safeguards the residents from exploitation by
people who have the aim of making more money from the gap that did exist. The law stipulates the
premium rates through a board which is renewed on an annual basis. This also helps in bringing
order in all matters to do with health care insurance.
3.Reduced ethnic disparities in

Medical Billing Research Paper
Medical coders, are always working side by side with medical billers and although many people
confuse these professions as the same thing, medical coders and billers have different
responsibilities individually. It s a good idea to get your medical coding certification not only
because most jobs now a days require some type of schooling, but its also a good idea because it
shows the company that you are someone that could fit in just fine. Certifications also shows that
you are proficient in your area and are committed to quality healthcare by disseminating quality
information, it s one of the first qualifications that employers look for when they review you as a
potential candidate, and it s an asset when you re negotiating a salary. In addition, the majority of
billing companies have contracts with their clients that obligate... Show more content on
Helpwriting.net ...
Yes you will use your CPT, ICD 9 CM and HCPCS manuals for the current year or the year you
applied for. You are not allowed to use a medical dictionary. You can use any version of ICD 9
CM or HCPCS but you can t use the expert version of CPT. Review application instructions
carefully. At least eight weeks prior to your desired exam date mail in your completed exam
application form, letters of reference (not needed if applying for apprentice designation) and
exam application fee ($285). You should also be a member of the AAPC and it is a good idea to
apply for membership before applying for the exam so you are established in their system. No,
the AAPC does not require that you take a course in order to sit for the exam. However if your
experience is limited to only one or two specialties it is recommend you take a course or at the
very least attend a review class. The AAPC has several educational products to help your prepare.
They have an independent study program (ISP), the Professional Medical Coding Curriculum
(PMCC) which is a classroom course offered by approved curriculum sites, and a study

Shakespeare Essay example
Shakespeare
Who was Shakespeare? Was he a man from Stratford Upon Avon who started with little and
became the greatest English author to ever live; or was he a privileged Earl who was a favorite at
Queen Elizabeth s court? That is the great mystery. This particular mystery is difficult to solve
because of the lack of documentary evidence. The Elizabethans did not believe in getting
everything in writing as people do today. Therefore, the truth may never be known with certainty.
However, evidence does exist to support at least two theories about the Shakespearean authorship:
one that the man from Stratford wrote the works, the other that Edward de Vere the Earlof Oxford
was the author. The question then becomes, which ... Show more content on Helpwriting.net ...
He then searched for a man of the same time period who met these criteria (Ogburn). The
characteristics that come up again and again in the debates include: the author s education and
knowledge of the Classics, law, and Italy; and the documents and poems of the time that have
survived.
The most controversial and subjective argument stems from the apparent wealth of knowledge
possessed by the Shakespearean author. Throughout the plays and sonnets, he makes numerous
classical allusions. Oxfordians claim that the Shakespeare from Stratford (usually referred to as
Shakspere in the debates) could not have possessed the necessary knowledge to draw upon these
sources. Tom Bethell, another noted Oxfordian, writes that Shakspere is not known to have
attended Stratford grammar school ... [and] if he was a pupil, he probably was not one for long
(Bethell). However, respected Stratfordian Irvin Matus argues that no records of anyone attending
the school exist before the 1800 s (Matus). He also notes that Ben Jonson, a contemporary of
Shakespeare s and a revered playwright, did not have much more than a few years of rudimentary
schooling and that there are no attendance records for Jonson s school before 1715 (Matus). On his
comprehensive Stratfordian website, David Kathman asserts that Shakespeare s classical
knowledge, while impressive by our standards, was

The Challenges Of Poverty In Education
Poverty is an increasing problem in the world that greatly impacts our most vulnerable population.
Children who are born into poverty are automatically placed at a disadvantage going into school.
Before they are even in the school system they are achieving less than their richer counterparts
(Morrissey, Hutchison, Winsler, 2014). The academic achievement gap between students of low
income and higher income is staggering, by implementing solutions that address the needs of
transportation and meals as well as offering therapy programs and investing time into building
strong relationships with students, educators can attempt to bridge the gap. Children coming from
low income families are greatly affected by the financial strain within their household. Their
parents are often working odd hours, shift work and or multiple jobs leaving these children to take
care of themselves. This not only affects the cognitive development, but also may cause tardiness
and absences if the children are responsible to get themselves ready and to school. Parents may also
find it difficult to manage the pick up and drop off times in combination of their work schedules.
When students do not attend school or arrive late they miss out on crucial instructional time from
their teachers, as well as social interactions with peers (Morrissey, Hutchison, Winsler, 2014). In
order to minimize tardiness and absences, and their effects, there a few things administrators and
teachers can implement into

Determinism Vs Compatibilism
Freewill has been thoroughly discussed by ancient philosophers and modern scientist alike yet no
conclusion has ever been reached. With the issue that whether freewill is consistent or inconsistent
with the idea that everything happens out of mechanistically that is deemed appropriate by the
universe. There are three common camps of thoughts on the matter of free will. Determinismand
Libertarianismand Compatibilism. This essay argues the fact that freewill is indeed not an illusion
and attempts to redress the balance between these camps of thoughts by offering an overview of
strategy via that of a compatabilism point of view.
Humans are a determined and free agents that has the ability to critique and modify their
behaviours. The term ... Show more content on Helpwriting.net ...
The argument is based on a crucial differences between the past and the future. Simply put, the
future is a open for things to happen without our prior knowledge of what is to come. It is
possible to look back at the past and reflect on what has happened but the same cannot be said for
the future. We are able to influence what the past became but we cannot literally change the past
even if we admit the possibility of time travel. The asymmetry between past and future is
illustrated by the fact that we do not deliberate about what has happened but we do so about
what is to come. One can certainly question about whether the past action that we have chosen is
the best, but one can also both question what future acts would be best as well as which future
action should be performed, making the future open in a way the past is not. When an individual
is using free will, what is happening is that the person is given a range of different opinion and
selecting the best course of action, each option is possible given the past and the laws of nature.
This view of free will is often called the Garden of Forking Paths

Differences Between Arab Immigrants And White Race
Arab immigrants living in the Western society often compare their identity to the White race. The
two main factors that differentiate the Arab immigrants and the Western White race are the two
factors of gender and religion. Gender relations is often associated with Arabs creating their
identity compared to the whites, this is because gender is associated with gender roles and the
hierarchy of power (Ajrouch, 2004, p. 372). Another type of comparison is the factor of religion;
White Christians often follow the Bible, which talk about the ideal breadwinner man and caretaker
women. But, studies have shown that between Christians and White women both were affected by
religiosity and ethnicity that relate to traditional gender roles (Ajrouch, 2004, p. 374) In the western
society, Arab women can choose to accept or... Show more content on Helpwriting.net ...
This word is often associated with recent Arab immigrants who have not fully adopted the
mainstream culture (Ajrouch, 2004, p. 379). Moreover, the boater identity was seen as
undesirable label, therefore, more immigrants worked hard to get rid of this label over time to
be considered Arab American (Ajrouch, 2004, p. 380). Conflicts also arise between girls who
wear hijabs and those who choose not too; girls who wear hijabs are seen as morally superior
which symbolizes the pinnacle of respect and distances themselves from the idea of freedom
(Ajrouch, 2004, p. 383). Another aspect compares the relation between Arab men and women;
women are expected to adhere to the religious restrictions as it enhances their worth. An example of
this would be Arab girls not getting into relationship or doing anything sexually with a guy; this is
a double standard that the men do not have to follow through with and only perpetuates the idea of
the social hierarchy with men on

The Advantages Of Vernacular Architecture
Architecture is inhabited sculpture to serving human needs, apparently forgotten in modern age
architecture. However,there has been a dependence and increase on energy expending such as
cooling, heating, ventilation and lighting frameworks to accomplish human solace in structures. the
pattern has sensibly swung the other way. designers are grasping regionalism and cultural building
tradition, given that these structures have turned out to be vitality productive and sustainable. In
this season of urbanization and rapid technological advancement, there is still much to be gained
from the customary information of vernacular architecturein order to achieve sustainable.
Vernacular building design started when humanity was compelled to make utilization of the natural
resources from the region, and give them self house and solace which is receptive to the
atmosphere. It is an immaculate response to a distinctive individual s or society s building needs,
even before the architect, to built house as per their situation. The humanistic longing to be socially
associated with ones surroundings is reflected in a symphonic architecture, a typology which ...
Show more content on Helpwriting.net ...
Indeed, even during a time where materials are accessible well past our district, it is important to
consider the exemplified energy lost in the transportation of the materials to the development site.
The advantages of vernacular building design have been acknowledged all through the vast piece of
history, and are currently making an arrival among green structural engineering and draftsmen. So
as to advance later on of structural planning and manageable building, we should first pick up
learning not as an investigation of past tradition, but rather as a commitment to new techniques,
arrangements and accomplishments for the future built environment.(Sarah

Background Of Intelligence Testing During Wwi
Individuals can vary in multiple ways in regards to their personalities, mental abilities,
emotional reactions, skill sets, etc. (Bauer Erdogan, 2012). These differences in people are
referred to as individual differences (IDs) and have been a significant area of study in Industrial
/Organizational (IO) psychological research due to their presumed effect on work related
outcomes (Bauer Erdogan, 2012). However, focus on IDs greatly declined due to the lack of
research supporting the predictive power of IDs in regards to work related variables, such as job
performance, as well as, adverse impact caused by the inappropriate use of ability testing (Daus,
2016; Bauer Erdogan, 2012). Despite these reasons for the decline in studying IDs, many arguments
exist to support the importance and practicality of once again studying IDs. Rationales for studying
IDs are discussed.
Interest in the study of IDs rose partly due to the introduction of intelligence testing during WWI
(Daus, 2016) and the development of the Big Five model of personality (Barrick, Mount, Strauss,
1993). When Robert Yerkes introduced intelligence testing into the selection procedures used by the
military, it allowed the military to efficiently and accurately place recruits into the appropriate
positions based on their cognitive ability scores (Kevles, 1968). After the war ended, intelligence
testing became much more commonplace in public areas outside of the military, such as schools,
immigration offices, and

Sexism In King Lear
Emotions: The Real Villain There is a misconception that those who show their emotions are
weaker than those who hide them. Women are thought to be fragile due to this fallacy, which is
revealed through the play, King Lear. William Shakespeare s King Lear is about a king who is
stripped of his power by two of his daughters, Goneril and Regan, that deceive him by professing
their love for him. King Leareventually realizes his mistake of banishing his other daughter,
Cordelia, who does not vocalize her love for him. Soon after, he becomes insane from the shock
of the betrayal he faces. Shakespeare presents ideas of internalized sexism and exploitation in
this play, to show the tendency towards misogyny. He uses the motifs of body and animals to
illustrate that women are portrayed as lesser than men because of the stigma of their emotional
vulnerability. Internalized sexism reveals how Goneril uses masculine characteristics to hide
her sensitivity, attempting to reach for power. Goneril expresses fake love to King Lear to obtain
land and plans to eliminate Lear, so she can have more power. After Goneril forces Lear to leave
her castle, unless he reduces the number of his knights, the Fool states that the hedge sparrow fed
the cuckoo [for] so long / [t]hat it had [its] head bit off by it[s] young (1.4.212 213). The Fool
refers to Lear as a hedge sparrow and Goneril as a cuckoo to exemplify one of the first acts of
betrayal that Lear faces. A cuckoo generally lays its

Analysis Of The Movie Brent Staples
Don t judge Others
It has been said, Judging a person does not define who they are...but defines who you are. Being
judged is discrimination toward a person s character. Discrimination is a practice to judge others
based on their person beliefs. There are many areas in which people are judge others such as
appearance, beliefs, race and religion. People discriminate against others because they base their
judgment off appearance. We all are human and we all should be treated equal. In this case, Brent
Staples, Susan Boyle, Travon Martin and myself are people who know what it means to be judge
base on their appearance. You can t judge people based on their appearance.
First, Brent Staples is a black man who is judged based on physical appearance by the public.
Brent Staple address his experiences of being discriminated by the public and mistakenly
accused of being a burglar at his job. Brent Staples first victim was a white woman that was in
her late twenties (520). As a graduate student, Staples took a late night walk on the avenue. Brent
was walking behind a woman, but notice there seem to be a discreet of inflammatory distance
between them (520). Suddenly the woman casted back with a fearful glance at Brent. When
woman the observe Brent Staples appearance for being a black man a broad six feet two inches
with a beard and billow hair, both hands shoved into the pockets of a bulky military jacket (520).
The woman judged based on his physical features that Brent was harmful

The Epic Of Gilgamesh And The Iliad
The Epic of Gilgamesh and the Iliad are two extremely different stories, The Iliad being a tale of
war (specifically the Trojan War) while the Epic of Gilgamesh is a true Epic in the sense that it is
a journey, all about the development of the characters. While there are many different themes
throughout both books, one of the most important themes is the way that friendship develops both
of the people involved and the way that it ties into the story overall. In the Epic of Gilgamesh,
Enkidu and Gilgamesh start off as polar opposites while in the Iliad, Achillesand Patroclus are great
friends from the very beginning. In each of the stories, one of the friends dies and it leaves a
permanent mark on the other that changes his behavior in a way that sets the stage for the rest of
the story. However, I think that the greater change of the two happens in Achilles since the death
of his friend leads him to completely change character, from the man who allows his friend to take
his place while he cowers in fear to the man who leads the charge that wins the war. Gilgamesh on
the other hand, continues the journey that he and Enkidu started but even until the end he struggles
with his selfish nature. Prior to Enkidu and Patroclus their deaths, the friendships in each of the
stories already have a profound effect on Gilgamesh and Achilles. At the beginning of the Epic of
Gilgamesh, Gilgamesh is a tyrannical ruler in the land of Uruk. At the beginning of the story, we
learn that he two

Research Paper On The Great Bear
The Bear: the Hunted Protector Ask any child about constellations and they will know about the
star formation known as The Big Dipper . The stars that form this asterism (Dubhe, Merak,
Phecda, Megrez, Alioth, Mizar, and Alkaid) are the brightest part of the constellation they make
whole, Ursa Major: The Great Bear. Although the constellation is certainly common enough to
recognize, I hold a more personal attachment to it. I grew up nearby a convent which owned a
crest marked with Ursa Major. The convent was a central root of the area, so the people often
had the crest and familiar Ursa Major constellation everywhere. When I look into the night sky
and see these familiar stars, they remind me of the people in the area who became close family
and friends. Like the bear it symbolized, this constellation will always be like a mother bear
protecting my sweet memories as if they were cubs.... Show more content on Helpwriting.net ...
In the tale, the bear is part of a great celestial hunt. According to the Micmac, the bear s positions
through the year are because the bear is running and fighting off the hunters that follow it. During
most of the months, the bear runs on four feet. Then, in autumn when the stars are in different
positions, the bear rears on two legs and a hunter attacks it spraying the bear s blood on the trees.
This is why the leaves change colors in the fall. The hunters kill and eat the bear, but the skeleton
still remains on its back during the winter. Then, during the spring, a new bear comes out of its den
and, the hunt begins

The Importance Of Heteronormativity In School Education
Introduction
Despite improvement in recent years, LGBT+ people still face systematic inequality in western
society. This results in discrimination and prejudice towards them, or a reluctance to talk about
LGBT+ issues. When it comes to education, the current situation in many western countries is that
there is little or no information available about LGBT+ topics for students, in part because of the
stigma that still surrounds LGBT+ identities. Indeed, up until 2003, it was illegal in the UK for
schools to promote the teaching [and the] acceptability of homosexuality (Legislation.gov.uk, 2017),
and LGBT+ education is still a controversial topic in many places today. For example, in New
York, a teacher was recently fired for teaching 11 to 16 year olds about LGBT+ terms, because
parents complained it was inappropriate for the children to learn about them (Toscano, 2017).
Thus, there is still a view that LGBT+ identities are inappropriate or even unsafe for children,
which partially explains this lack of information given to students at school. In the UK, a survey
published this year found that 40 per cent of LGBT pupils are never taught anything about LGBT
issues (Bradlow et al, 2017).
The prevalence of heteronormativity in school education paired with the lack of LGBT+
information is a serious problem, as it puts pressure on LGBT+ students to find information by
themselves and sets them apart from their peers. For instance, my personal experience growing up
in France was

Snowshoe Hare Research Paper
The snowshoe hare is an important consumer in the ANWR food chain. Without it, top predators
such as the brown bear would lack an important food source. The snowshoe hare is an herbivore.
Like all herbivores, it eats only plants. Some plants that the snowshoe hare eats are the reindeer
lichen, the arctic willow, and the arcticsedge. In the ANWR, it is important that the snowshoe hare
has useful adaptations since it lives in the tundra, one of the world s toughest biomes to survive in.
Its signature adaptation is its ability to change color. During the winter, its coat is white as snow,
which helps it blend in with its tundra habitat. During the spring and summer, its fur changes
reddish brown, which helps it blend with the dirt and mud that is common in the tundra during and
after the period... Show more content on Helpwriting.net ...
Toxic chemicals caused by pollution may harm or kill the snowshoe hare. The snowshoe hare
may develop chronic respiratory diseases or lung cancer. This is also a threat for the snowshoe
hare s predators as well since toxic chemicals built up in the snowshoe hare may render the
snowshoe hare unsafe to eat. Freshwater may also be poisoned by the toxins, which the
snowshoe hare needs. Regulations may or may not be established to protect the snowshoe hare if
oil drilling is established. The snowshoe hare will most certainly be protected if the oil drilling
plan is canceled. The snowshoe hare needs protection due to its sheer importance in the ecosystem
s food web. Humans, by oil drilling, will negatively impact not only the snowshoe hare, but one of
the world s greatest arctic wildlife reserves. Protecting the snowshoe hare will also increase
biodiversity in the ecosystem. Humanity should be careful about fossil fuel exploration and not
squander its precious wildlife refuges. By doing this, it can ensure that ANWR and its unique
snowshoe hare lives on for future

Ethical Effects Of Data Surveillance
Mehmet Utku ERAY 704
Ms. Rizvi
11G English
26 December 2014
Privacy Technology:
Unethical Effects of Data Surveillance Over Individuals and Groups
Data surveillance is a way for government and special agency to collect personal information from
different sources or monitoring people s daily life activities. Data surveillance is the far cheapest
and yet the easiest way to have control over people and its popularity increasis mildly in
different fields (Ethicapublishing 1). Data surveillance can be used to observe people s actions or
examine their situations. An article called Ethical Issues of Data Surveillance states that every
item we use or every action we do in our daily life is being tracked down by government since
1980s. In today s world government uses surveillance techniques to have control over their ... Show
more content on Helpwriting.net ...
Researches have shown that government does not use mass surveillance only for protection. The
document, written by Stony Brook University states that most countries collect data from direct
servers like Microsoft, Google, Apple and Yahoo which are the biggest sources for government
to be fed on (Antoninis). Today, the government collects information about individuals and
groups for unknown reasons. Does the usage of these information harms society? Usage of both
individual and mass surveillance is harmful since it attacks people s privacy without any
permission and is not regulated properly by government. There are different types of data
surveillance in today s world which are Personal Data Surveillance and Mass data surveillance,
government uses data surveillance against its actual purpose which poses ethical danger to society.
Mass data surveillance is actually a surveillance of groups of people while personal data
surveillance refers to surveillance in individuals (Ethicapublishing 1). In personal data surveillance,
profiling is the most used one

Paul Vidal De La Blanche
Agriculture and Regionalism Geographers frequently use environmental determinism, the belief
that environment directly affects human social growth, to help explain how, where, and why
human populations and cultures evolve; the idea is that our physical environment directly affects
the way our culture grows. Paul Vidal de la Blanche was one of the first modern geographers to
take interest in the different regions of his native country of France. He focused on how different
regions in France created different cultures based on food and climate. His work was important in
helping to shape how important climate is in the creation of regions. He discussed briefly how
environmental differences helped to shape agricultural practices from one region... Show more
On the East coast we see a prevalence of small farms producing huge varieties of produce, grains,
meats, etc. These regions are heavily populated with most of the food produced being sold
locally. In the Deep South, fruits and textiles, such as cotton, are grown. The Entire Mid west to
the west is full of gigantic factory farms that produce goods for the massive factory food systems
within the United States. What is so important about knowing the different regions in the US?
Knowing what is produced in these regions can help to point out how and why cultures in
certain regions develop. In Louisiana where rice is grown in flooded fields a culture of eating
Crawfish has sprung up. The rice patties created by Louisiana farmers make a great living space
for crawfish. The crawfish population explosion was caused by rice agriculture, and to combat the
problem a culinary culture of eating mud bugs

The Global Debate on Death Penalty
The death penalty is one of the most hotly debated legal issues in the democratic world today. This
is particularly the case in the United States, where some states have implemented capital
punishment as a response to major crimes and others have abolished the practice. Among
legislators, policy makers, and the general public, there appears no likelihood of resolving the
debate. The wide array of moral, religious, humanitarian, and criminological views simply appears
too divergent to ever meet. At the basis of the debate is the issue of whether capital punishmentis a
suitable response to severe criminal activity such as murder, or if there are better and more effective
ways to respond to these. While there are compelling arguments both in favor of and against
capital punishment, one may draw the conclusion that the death penalty serves little purpose
beyond revenge, which ultimately does little to compensate the affected parties. Generally, a
search for arguments relating to capital punishment tends to result in a majority of articles against
this type of response to crimes involving murder. Some writings in favor of this type of justice,
however, can be surprisingly compelling. One of these is the article by Jacoby (2003), where he
argues for the death penalty without overtly religious or emotional appeals to the reader. Jacoby
makes two main points in support of his view. First, the death penalty results in justice for the
victims. According to the author, murder is

Feudal And The Feudal System
The Middle Ages were a time full of war and poverty, and such they birthed the feudal system to
lessen the effects of both those societal ailments. There were both military and economic
structures that feudalism operated on. The manor supported those structures using the payments
and life of a peasant and by giving the income of a lord. The free peasant filled in the gap
between classes and was neither in nobility, or in servitude. The economic and military system
known as the feudal system relied on a combination of the workings of a manor as well as the role
of the freeman peasant.
The Middle Ages in Europe founded a economic and military system known as feudalism. This
system was based on a series of personal relationships and loyalty ... Show more content on
Helpwriting.net ...
Vassals owed service to the monarch and protection to their serfs. Vassals had to take an oath of
homage and fealty to the king, and this caused them to owe the king (Smith 4). There was a
large ceremony for the proceeding of the homage or fealty, and this was due to the fact that
written contracts were often rare since most were illiterate, and all that attended could testify
that the proceeding had taken place (Nardo 16 17). The services that were owed by a vassal
were mostly military service in field, as well as the recruitment of knights to also serve the
monarch (Smith 4). For example, vassals could be called to guard the monarch s castles (Smith
4).The requirement of knight recruitment was called servicium debitum, and there was no real
set way of completing it (Norman 113). Some vassals hired the knights, and other kept them
permanently in their service and household, with the prior becoming more and more popular
over time, converging with the giving of a small fief (Norman 113). There were non military
services vassals were obligated to do as well. Vassals often had to be present at royal courts for
the king, usually for other vassals (Smith 4). Vassals might even need to aid the monarch
financially, if ever called upon (Smith 4). During the early ages of feudalism, the monarch had
the power to randomly tax his vassals, but that transformed into three events that the vassal had
to pay tax for; the knighting of the monarch s eldest son, his eldest daughter s first marriage, and
his ransom if captured (Norman 104). A lord also had obligations to the peasants that worked
their land, for example, he was in control of the justice system and had to provide that service in
the courts (Norman 105). The lord was also impelled to protect the peasants from all threats,
human or otherwise (Norman 105). However, the process of becoming a vassal often

Essay On Mtr
One of the most challenging aspects of the job so far for me is how to stage changes without
breaking anything and how to always keep the service running without any downtime. When you
factor in the multiple microservices we have and the number of developers checking in at any
time plus the multiple client applications we have, then you can have a sense of the
combinatorial explosion of possibilities that are possible. The following are a couple of
techniques that I use I learnt most the hard way and so far they ve worked great for me and I
always use them when developing new features or potentially harmful features. 1. Live
configurations Most applications allow you to set configuration as part of code but distinct from it.
The... Show more content on Helpwriting.net ...
The major goal is that changes should be transparent to the users and things should not break. I
remember once trying to integrate a brand new v1 service into our offering. the challenge was
that the v1 service we were going to depend on was in flux and things were broken at times not
pointing fingers or blaming them but that is expected when you are building things from scratch
at the beginning. Consequently I had to mock the expected responses and thankfully the set of
possible responses then was quite small there were only two possible states since we were just
starting out. I hardcoded these responses into our configuration files, wrote the code in such a
way that it would read the configuration files and choose the expected response and return it. To
the end users, it didn t make a difference however the beauty of it was that it gave us a way to
slowly swithc to the service without any downtime. And when the v1 service did break, all we
had to do was flip the flag / feature switch and we would fall back to the configuration without
having to do a code deploy or spin up a live site incident. Eventually the service became mature
and stable and the hardcoded configuration fallback went away. 3. Opt ins for breaking changes
Breaking changes are inevitable the service has to grow and evolve and things have to change. In
fact, some underlying major piece of the software might get rewritten and we ll have to respond
(Yes, I am looking at you

The Nuremberg War Criminal Trials
The Nuremberg War Criminal Trials
In the 1940 s, World War Two was drawing to a close, and Nazi Germany, while fresh in the
memories of many, was falling apart and was losing influence. The problem was that many of the
Nazi leaders were still out there, including Hermann Goering, the man responsible for starting and
constructing the first of his many Concentration Camps. The case consisted of 13 separate trials
for 22 leaders for the Nazi party, and many of whom received the death penalty. The trials were a
symbolic representation of the death of Nazism, and the world uniting for a greater cause and for
justice.
The Nuremberg Trials all started when the Soviet Union, Great Britain, and the United States of
America issued a joint declaration ... Show more content on Helpwriting.net ...
All of which had a bone to pick with Nazi Germany (Fireside 17 19). In any sense, the trials
helped put to rest many of the suspicions of the people as everybody was given a full and fair
trial, and several of the men on trial only suffered minor prison sentences and a few were even
acquitted of the crimes they were accused of. So in conclusion, the 13 trials that would later be
infamously known as the Nuremberg War Crime Trials charged dozens of Nazi criminals with
deaths of innocent people, and saw to it that Justice would prevail. The trials, signaling the end of
the Nazi s genocidal reign, helped unite the world and gave closure to those who suffered under
Hitler s and Hermann s

James Dobbins
It is a known pillar of the political philosophy known as realism that might makes right , a tenet
that can be traced back to Thucydides retelling of the Peloponnesian War. At its core, the saying
conveys the notion that those with power can push their idea of right into fruition. However, as
our society begins and continues to hold those with power accountable for their actions, an
updated version of the maxim is required: might must do right. Those with power are compelled to
do right by the freshly discovered strength of the little guy , and consequences can include
international sanctions or even a loss of power, be it gradual or sudden. This ideological transition,
from irresponsible to accountable, is exemplified in the realm of... Show more content on
Helpwriting.net ...
Immediately, the commitment thesis is called into question with a drastic disparity between these
two success stories. Both Germany and Japan are modern day global superpowers, but if we are to
believe that successful nation building has common traits, the idea that the common trait is
commitment can be immediately discarded. Granted, the number of troops in Japan was still high
compared to the number in other countries, but those other countries tend to have a much smaller
population than Japan, lessening the need for a great number of troops. It would foolish to think
that sending the same number of troops for every occupation regardless of population is an
effective strategy, and that is why effort is measured in troops per thousand citizens, not total

Fascism And The Great Financial Depression
After World War One with the defeat of Germany, Austrian Hungarian Empire, Bulgaria and the
Ottoman Empire (Turkey) and the great financial depression which followed in its wake; the
political map of Europe changed drastically. Ideas sprung out of Europe and began to take its hold;
Communism, Socialism, Democracy and other political ideas changed the mostly former
Monarchist states, but one political idea would long lasting impact in Europe it was fascism.
Fascism rose out of the need to change, by the middle class and petty bourgeoisie, the democratic
system and the values of the Enlightenment, but also against modernity and put a strong totalitarian
state in the center of the nation. So, my essay will be divided in to four main... Show more content
on Helpwriting.net ...
It was here that the term fascism took its ideological term (Heywood 2012: 199). In 1922
Mussolini managed to assume the post of Prime Minister, mostly by a show of force by his
armed men the Black Shirts . The government in Italy was paralyzed and fear of a civil war by
the King Victor Emmanuel III opened to the door for Mussolini and his National Fascist Party to
assume complete control in Italy. He used his paramilitary soldiers to crush all opposition to his
authority, something all the rest of the fascist states in Europe would follow. Around the same
time another fascist movement began to emerge in Germany it was called The National Socialist
German Workers Party ; it was led by Adolf Hitler. Fascists in Germany followed the same
concepts as Italian ones. In less than 15 years he had become the supreme leader of Germany
creating a totalitarian state, to what we know today as Nazi Germany. Both of these fascist
movements had most of their support from the middle class, the industrialists and the respective
militaries. It was not until 1935 with the Italian invasion of Ethiopia, the Spanish fascists struggle
for power and Hitler s constant aggressions in Europe that we today inherit military aggression with
fascism. Nazi Germany and Italy would eventually lose

Dollar Declines In Spectacular Fashion
Changes in the economy are neither simple to understand nor entirely predictable. Virtually every
metric that is used to evaluate the economic health of a nation can be influenced by a variation in
another metric. For example, consider the price of gold. Typically, when the dollar shows a pattern
of a record setting decline, gold prices tend to soar.
Why Do Gold Prices Typically Soar When the Dollar Declines in Spectacular Fashion?
As Investopedia explains, the value of the dollar and the price of gold usually have an inverse
relationship. A weak dollar normally drives up the price of gold, but a strong dollar depresses gold
prices. The three primary reasons for this are:
1.A weak dollar is a sign of economic uncertainty, stimulating people... Show more content on
Helpwriting.net ...
Medical devices such as stents, precision electronics and jewelry production account for
approximately 66 percent of the global demand for gold. If demand for these items declines, the
price of gold could fall.
Production: The United States, China, Australia, Peru and South Africa are important gold mining
countries. The amount of gold produced by all countries contributes to the supply, and if demand
exceeds the supply, gold prices increase. However, in most countries, the easily accessible gold
has already been taken from the ground, requiring miners to dig deeper and face exposure to
additional hazards. The impact to the environment may be affected as well. This means that mining
gold costs more to obtain less, which increases the price of gold.
Investors Attitudes: Investors tend to turn to gold when there is economic uncertainty. Gold is
typically considered to be a safe haven and a hedge against inflation, currency devaluation, political
instability or deflation; most investors believe that gold will always have value, but other
investments may turn out to be worthless. When returns on investments such as real estate and
bonds fall, more people turn to investing in gold, increasing its

Descriptive Essay On A Trampoline
The Trampoline Have you ever noticed how some yards seem to reflect the personality of the
homeowners perfectly? The perfectionist s home seems to always be positioned in the middle of a
perfectly manicured lawn. The artist has treasures and flowers in abundance. The yard endlessly
littered with toys and bikes seems almost exclusively to belong to the parents of several youngkids.
Our house seems to be no exception. Though our yard is small and sparsely decorated, its lone
ornamentation a worn trampoline given to my siblings and me when we were still young
enough to enjoy it seems to speak volumes about my family and our day to day life. Our house
sits on the top of a hill, and the trampoline is positioned so that it seems poised to jump right to
the bottom of the incline. The net is worn and ripped in several places, hanging lower on the
poles with every passing storm. Where once the enclosure could be safely zipped is now just a
gaping hole, an old man s toothless mouth hung open in shock at his own ability to survive.
Several springs are missing and those that remain creak and groan with the slightest pressure. It s
legs have been broken through the years so that, looking at it now, one of the metal rod hover
slightly above the ground. Sitting on the front porch, staring over at the poor dilapidated toy, a
thought crosses my mind: if this trampoline were a horse, it would be shot. In the next moment, I
hear a familiar voice yelling my name in the mangled

Essay on Endothelium in Health and Disease
Investigation of the influence of the endothelium on the actions of acetylcholine and nitroprusside.
Results (a) Estimate the maximum responses (Emax) and EC50 values for phenylephrine with the
two types of arterial ring. Put this data in a single, self explanatory table.
Table1. Emax and EC50 values for phenylephrine. Phenylephrine| Emax in grams tension| EC50 in
nM| Endothelium intact| 2.2| 40| Endothelium denuded| 2.9| 10|
(c) Estimate the EC50 values for the effects of acetylcholine and nitroprusside in both types of
arterial ring, and present these in a table. Table 2. EC50 values for the effect of acetylcholine and
nitroprusside. EC50 in nM| ... Show more content on Helpwriting.net ...
Shearing forces acting on the vascular endothelium generated by blood flow causes a release of
calcium and subsequent cNOS (cyclic nitric oxide synthase) activation. Therefore, increases in
blood flow stimulate NO formation (flow dependent NO formation). Nitric oxide then causes
independent vasodilation by inhibiting vasoconstrictor influences of phenylephrine and alters its
potency and contractile effect. (Richard E. Klabunde. 2010) However, it has a short half life of
only a few seconds. In endothelial denuded preparations there was no production of nitric oxide and
subsequently no flow dependent vasodilation occurred. So, without endothelium a response of
phenylephrine is not inhibited and therefore it exhibits a higher potency(lower EC50) and efficacy.
f) Account for the response to acetylcholine in the two preparations. Which receptor(s) mediates the
effects of acetylcholine in the rings with and without endothelium? As shown in the table 2 the
EC50 values of acetylcholine, calculated from the dose response curve, significantly differ from
each other. In fact, in endothelium denuded rings acetylcholine caused no relaxation at all.
Moreover, the prolonged exposure to increasing concentrations had given some constriction. In
human and animals 5 sub types of muscarinic receptors (M1 M5) have been identified. In the
particular case of human blood vessels, the M3 subtype seems to be prevalent on endothelial cells as

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