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typesofvaccines-180616064303.pdf
1. 1
Prepared by: Anish Dhakal (Aryan)
anishdhakal718@gmail.com
MBBS Student
Patan Academy of Health Sciences
2. OBJECTIVES
To define vaccine
To discuss the types of
vaccines
To discuss the Expanded
Program on Immunization
(EPI) schedule of Nepal
with OPV and IPV rationale
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3. WHAT IS VACCINE?
Vaccine is an immuno biological substance
designed to produce specific protection against
a give disease
Artificial Active Immunity
Triggers humoral and cell mediated immune
response or both mimicking the natural infection
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4. TYPES OF VACCINES
Live attenuated vaccines
Inactivated /Killed vaccines
Toxoid vaccines
Cellular fraction / sub unit
Conjugate vaccines
Acellular vaccines
DNA vaccines
Recombinant vaccines
Combination vaccines
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5. LIVE ATTENUATED VACCINE
Prepared from live (generally attenuated) organism
Organisms lost pathogenicity but retain immunogenicity
due to repeated culturing
More potent than other vaccines because:
Resultant antigenic dose is higher and sustained
Contain all major and minor antigenic components
Engage body tissues causing persistent immune response
Viral live vaccines are provoke excellent immune response
Immunization usually with a single dose
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6. LIVE ATTENUATED VACCINE
Example of live vaccines
include Measles, Mumps,
BCG, Influenza, Rubella and
oral polio vaccine
Contraindication
Immunocompromised state
(due to therapy or disease)
Pregnancy
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7. INACTIVATED OR KILLED VACCINE
Organism are killed by heat or
chemical and injected into body
Usually safe, requires adjuvants
and less efficacious than live
vaccine
Requires booster dose
Examples include J.E , Rabies,
Hepatitis B, IPV
Contraindication
Severe local or general reaction
in previous dose 7
8. TOXOID VACCINES
Toxins produce by organism
are detoxicated and used in
preparation of vaccine
Antibodies produced
neutralized the toxin rather
than act upon the organism
Toxicity is lost but antigenicity
is retained
Examples – Diphtheria and
Tetanus
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9. CELLULAR FRACTION / SUB UNIT
Conjugate vaccines
Pieces from coats of bacteria are
linked to carrier protein which cause
immune response
Example – Hib
Acellular vaccines
Vaccine that contain cellular material but
not complete cell
Only those antigen/epitopes that evoke
best immune response are selected
Example - Pertussis
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10. DNA VACCINES
Genes for microbe’s antigen are introduced into
body, some cells take up the DNA
Microbe’s DNA then instructs cell to synthesize
antigens
The person’s own body become vaccine making
factories creating antigens required to provoke
immune response
DNA vaccines being tested in humans include
those against the viruses that cause influenza and
herpes
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12. RECOMBINANT VECTOR VACCINES
Similar to DNA vaccines
except use of a vector
Use of attenuated and live
virus or bacterium to introduce
microbial DNA to the body
Example – Hep. B , Cholera
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13. COMBINATION VACCINES
More than one kind of
immunizing agent is
included in the vaccine
It simplifies
administration and
reduces cost
Example - DPT, DT,
MMR
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16. Routine immunization with OPV must cease after the
eradication of poliovirus because of the danger of
outbreaks of circulating vaccine-derived poliovirus and
the risk of VAPP (Vaccine Associated Paralytic
Poliomyelitis)
In the regions of the world in which wild-type poliovirus has
been eliminated, moving to an IPV or IPV/OPV sequential
schedule will reduce or eliminate the risk of VAPP and
outbreaks of circulating vaccine-derived poliovirus, as well as
increase the likelihood of countries agreeing to stop
administering OPV after eradication is achieved.
IPV could also be used with OPV in routine schedules to
increase immune responses and to decrease the circulation of
wild-type poliovirus in countries in which transmission has not
been stopped.
17. IPV – RATIONALE
Type 2 poliovirus mutates into virulent form
IPV contains killed virus, so IPV mitigates this risk
IPV in addition to OPV provides better immunity
All countries switched from tOPV to bOPV (minus type 2) 2016
Introduction of IPV before this ensure protection against type 2
Once virus circulation stopped everywhere, OPV withdrawn
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