Recommended
More Related Content
Similar to jakstat signaling pathway (Cellular and Molecular Pharmacology)
Similar to jakstat signaling pathway (Cellular and Molecular Pharmacology) (20)
Recently uploaded
Recently uploaded (20)
jakstat signaling pathway (Cellular and Molecular Pharmacology)
- 1. JAK-STAT SIGNALLING PATHWAY Prepared by: Purva Vighneshwar Vernekar
- 2. Cell signalling • Intercellular and Intracellular signalling pathways • Five parameters: a. Signalling molecule b. Receptor c. Cellular activators d. Transcription factors e. Cellular effects
- 3. Cytokines • Cytokines is derived from the words: cyto(cell) and kinos (movement). • Low glycoprotein • Cell to cell communication • Trigger the signal transduction pathway
- 4. Introduction • Janus kinase (JAK)- Signal transducer and activator of transcription (STAT) signalling pathaway. • Intracellular signalling pathway. • This pathway communicates signal from
- 5. • JAK‘s ranges from 120-140 kDa in size. • JH (1-7) • Janus kinase have four families which are as follows: 1. JAK 1 2. JAK 2 3. JAK 3 4. TYk2
- 6. Structure
- 7. Clinical significance • Formation of WBC • Activation of lymphocytes • Cell division • Activation of T-cell
- 8. • There are seven STAT proteins 1. STAT 1 2. STAT 2 3. STAT 3 4. STAT 4 5. STAT 5A 6. STAT 5B 7. STAT 6
- 9. Mechanism: JAK-STAT signalling is composed of components such as receptor, Janus kinase, Signal transducer and activator of transcription.
- 10. STAT dimer binds to RNA and activate gene transcription STAT dimer travels to the nucleus Dimer using SH2 domains JAK KINASES phosphorylates STATS This phosphorylation attracts inactive stats Dimerization activates JAK proteins associated with the receptors and come closer Cytokines bind to their receptor
- 11. Negative feedback or regulation of JAK-STAT signalling pathway • Alteration in JAK-STAT signalling pathway can lead to cancer and several diseases and disorders. • High amount of STAT3 and STAT5 activation leads to tumor growth. • STAT4 mutation is associated with rheumatoid arthritis. • JAK 2 mutation is associated with leukaemia.
- 12. Jak inhibitors • Type of immune-modulating medication. • Pharmacological inhibition of this signal transduction pathway occurs through JAKi. • Short half life. • Inhibit the JAK enzymes.
- 13. THERAPY • JAK inhibitor and STAT inhibitor are proposed as a drugs for therapy. • Tofactinib has been used for psoriasis, ulcerative colitis and rheumatoid arthritis treatment. • Ruxoltinib has been used for lymphoma. • Ritlectinib inhibits the tyrosine kinase and Janus kinase for the treatment of alopecia.
- 15. THANK YOU