Sevoflurane is a fast-acting volatile anesthetic agent that provides hemodynamic stability, rapid recovery, and airway tolerability. It is well-suited for all types of surgical procedures, including cardiovascular, neurological, ambulatory, and those involving obese patients. Sevoflurane has advantages over desflurane, isoflurane, and nitrous oxide in terms of hemodynamic stability, lack of airway irritation, rapid induction and emergence from anesthesia, and lack of genotoxic effects. Abbott's Quik-Fil delivery system for sevoflurane is designed for ease of use and minimal waste.

1. Features
Reasons to Believe
Brand Positioning
Hemodynamic Stability RapidRecovery
AirwayTolerability
Procedures
DES+ve
SEVO +ve
ISO +ve
SEVOrane® Message Map
Titratability

2. SEVOrane is the original fast acting, cost-effective
anesthetic agent offering the clinical versatility and
predictability needed through speed, control and cardio-
protective effects ideally suited for all general
anesthetic procedures.
®
Brand Positioning
Back

3. “Sevoflurane: The best volatile anesthetic ever developed” Dr.LarsonUCLA /Stanford
University LINK83
A passion for anesthesia and a
commitment to excellence leading to 18
years of trust between Abbott and the
worldwide anesthesia community
The #1 worldwide inhalational anesthetic,
the gold standard for all procedure types
SEVOrane represents the
cornerstone of today’s anesthesia
around the world
(Continued)
Reasons toBelieve

4. Reasons toBelieve
Abbott SEVOranehas been commercialized in over 85 countries around the world
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5. HemodynamicStability
 SEVOrane offers ideal cardiovascular stability and has demonstrated
exemplary cardio protective effects LINK 1
SEVOrane had a stable cardiovascular profile, particularly in aged
patients LINK 4
 When managing elderly patients, SEVOrane provided a more stable
cardiovascular homeostasis compared to isoflurane LINK 4
 Hypotension was observed in 16 patients receiving isoflurane and in 5
patients receiving SEVOrane (p<0.02) LINK 4
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6. Airway Tolerability
 SEVOrane has a pleasant, non-irritating aroma, which allows for
inhalational induction in adults and children with minimum
excitement or signs of upper respiratory irritation LINK 1
 SEVOrane is fast acting non irritating agent, and is associated with
a smooth, rapid loss of consciousness during inhalational
induction LINK 1
 SEVOrane is an excellent option for use in patients breathing
through an LMA LINK 1
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7. Airway Tolerability
 SEVOrane was associated with a lower incidence of coughing and
signs of airway irritation than isoflurane and desflurane. LINK 2
 At 2 MAC concentration, SEVOrane is significantly less irritating
on the airways than isoflurane and desflurane. LINK 2
 Smokers inhaling isoflurane had a 45% incidence of adverse
airway events compared to 10% in those inhaling SEVOrane.
LINK 3
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8. Rapid Recovery
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 SEVOrane facilitates fast track eligibility LINK 104
 SEVOrane allowed for a significantly faster emergence from anaesthesia
than isoflurane LINK 4

9. Titratability to Response
 Blood:Gas: Determines the speed at which an agent will saturate the blood stream. The lower the number, the
faster the agent will be washed-in and eliminated.
Brain:Blood: Determines the speed at which the agent will enter and leave the cerebral tissues, important
for neuro-anesthesia post surgical assessment. The lower the number the faster the agent. Compare
with Isoflurane and Desflurane. SEVOrane is closest to N20
Agent
Blood:Gas Partition
Coefficient
Brain:Blood
Partition
Coefficient
Halothane 2.4 2.9
Enflurane 1.9 1.4
Isoflurane 1.42 2.6
Desflurane 0.42 1.3
Nitrous Oxide 0.47 1.1
SEVOrane 0.63 - 0.69 1.15
Key Coefficients of Volatile Agents *
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10. Versatility & Predictability
The features of SEVOrane:
Hemodynamic stability
Airway tolerability
Rapid recovery
Titratability
All translate into the ideal inhalational anesthetic for all
procedures and patient types: pediatrics, adults and
elderly
That’s the SEVOrane Versatility and
Predictability !
Back

11. DES +ve
CardiacProcedure
Ambulatory Procedures Obese ProceduresNeurological procedures
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Toxicity COMPA Pollution

12. Cardiovascular Procedures v Desflurane
Anesthesiologist’s Goal: Stability & Speed
Hemodynamic Stability
• Sevoflurane maintains mean arterial pressure better than desflurane. LINK 98
• Sevoflurane shows a lower incidence of postoperative atrial fibrillation than propofol,
desflurane and midazolam. LINK 13
• Desflurane appears to cause a greater systemic and intrapulmonary pro-inflammatory
response than sevoflurane. LINK 60
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13. Neurologic Procedures vDesflurane
Anesthesiologist’s Goal: Speed & Stability
Stability
• Patients receiving desflurane demonstrated greater cerebral artery blood flow velocities,
heart rates and blood pressures than those receiving sevoflurane. LINK 74
• Desflurane causes more cerebral vasodilatation at hypocapnia therefore less suitable
for neuro Anesthesia (study done with Pigs) LINK 109
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14. Ambulatory Procedures v Desflurane
Anesthesiologist’s Goal: Rapid Recovery & Airway Tolerability
Rapid Recovery & Smooth Emergence
• Wake up times were faster with Desflurane but the hospital discharge times were faster with
sevoflurane. LINK 108
Airway Tolerability
• Desflurane enhances reactivity during the use of the LMA. LINK 22
• Sevoflurane is a better bronchodilator than desflurane. LINK 23
• Sevoflurane is non-pungent and produces minimal airway irritations. LINK 27
• Initiation of desflurane anesthesia resulted in significant changes which resulted in
hypertension, tachycardia, facial flushing, tearing and moderate upper airway obstruction.
This study observes response to desflurane, it uses no sevoflurane. LINK 110
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15. 15
Obesity Articles
Vs. Desflurane
• No clinically relevant difference was found in recovery in the PACU between
morbidly obese patients anesthetized with desflurane or sevoflurane. LINK 35
• No difference in emergence and recovery profile in morbidly obese patients
receiving desflurane or sevoflurane. LINK 36
• Commentary: Obesity, Surgery, and Inhalational Anesthetics: Is there a Drug
of Choice? LINK 81
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16. Toxicity
Vs. Desflurane
• Desflurane produces a systemic and local oxidative stress. LINK 59
• Desflurane may be capable of producing genetic damage. LINK 56
Sevoflurane
• Short- term administration of sevoflurane did not induce sister
Chromatic exchanges. No indication for a possible genotoxic effect
has been observed. LINK 61
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17. Compound A Clinical Studies
Low flow Sevoflurane/Low flow Isoflurane:
• No statistically significant differences in measured parameters of renal
function after low flow sevoflurane anesthesia compared with
isoflurane. LINK 105
Low flow Sevoflurane:
• No evidence for nefrotoxicity was observed with sevoflurane. LINK 106
Low flow Sevoflurane:
• Prolonged low flow sevoflurane anesthesia had the same effect as high
flow sevoflurane and low flow isoflurane anesthesia. LINK 107 Back

18. ORPollution - Articles
Desflurane:
• Even if the trace concentrations of anesthetic agents were low in the
present investigation the NIOSH limit for desflurane could not be
ensured. LINK 68
Desflurane & Isoflurane:
• Routine use of scavenging devices during cardiopulmonary bypass is
recommended. LINK 69
Swedish OR Pollution guidelines:
• The guidelines are for your information. LINK 111 Back

19. Sevoflurane vs.Desflurane
Back
• Has a pleasant odour that does not irritate the airways
• SEVOrane does not increase heart rate at < 2MAC
• SEVOrane causes less air way irritability
• SEVOrane is indicated for mask induction
• SEVOrane is linked to a low incidence of PONV
• SEVOrane is an ideal bronchodilator
• Can be safely used in neurosurgery and coronary artery surgery
• Can be safely used in patients at risk for myocardial ischemia
• Can be used with standard vaporizer technology, desflurane requires and
expensive heated vaporizer

20. ISO +ve
CardiacProcedure Ambulatory ProceduresNeurological procedures
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Pollution

21. Cardiovascular Procedures v.Isoflurane
Anesthesiologist’s Goal: Stability & Speed
Hemodynamic Stability
• Sudden increases in Isoflurane concentrations led to larger hemodynamic changes
and sympathetic nerve activity than with sevoflurane. LINK 15
• Sevoflurane bolus is more effective during maintenance than remifentanil bolus for
control of hemodynamic responses. LINK 17
• Preconditioning with sevoflurane decreases PECAM-1 expression and improves 1 year
cardiovascular outcome in CABG surgery. LINK 19
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22. Neurologic Procedures vIsoflurane
Anesthesiologist’s Goal: Stability & Speed
Stability
• Autoregulation is better preserved with sevoflurane compared to isoflurane. LINK 78
• Autoregulation was better preserved during sevoflurane than isoflurane anesthesia at 1.5 MAC
concentration. LINK 79
• Sevoflurane has less intrinsic dose-dependent cerebral vasodilatory effect than isoflurane.
LINK 49
• Sevoflurane demonstrates less total cerebral vasodilatory effects than isoflurane at the same
depth of anesthesia. LINK 53
• Sevo shows sustained inhibition of neuronal damage. LINK 66
• Sevoflurane decreased middle cerebral artery flow velocity. LINK 73
• Editorial warning of the potential limitations of isoflurane neuroprotection. LINK 80
Rapid Recovery
• Sevoflurane provides faster recovery and postoperative Neurologic assessment than
Isoflurane. LINK 48
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23. Ambulatory Procedures v Isoflurane
Anesthesiologist’s Goal: Rapid Recovery & Airway Tolerability
Rapid Recovery & Smooth Emergence
• Sevoflurane anesthesia recovery time is faster. LINK 39
• Sevoflurane allows for faster discharge than Isoflurane. LINK 21
• Sevoflurane allows for smoother clinical course with more rapid recovery. LINK 42
• Sevoflurane provides significantly faster emergence than Isoflurane. LINK 85
• Significantly faster emergence, orientation, response to commands compared with Isoflurane.
LINK 85
Airway Tolerability
• Smokers inhaling isoflurane had a 45% incidence of adverse airway event vs. 10% in the
sevoflurane group. LINK 21
Back

24. ORPollution - Articles
Desflurane & Isoflurane:
• Routine use of scavenging devices during cardiopulmonary bypass is
recommended. LINK 69
Swedish OR Pollution guidelines:
• The guidelines are for your information. LINK 111
- Please consult your local regulatory department before using these clinical reprints -
Continue

25. Sevoflurane vs.Isoflurane
Back
• Has a pleasant odour that does not irritate the airways
• Is effective for induction, without the need for intravenous induction agents
• Produces a rapid and smooth loss of consciousness
• Maintains heart rate more effectively with less tachycardia
• Appears to have less of a depressant effect on blood pressure
• Provides shorter times to emergence, command response, and orientation
• Two times less soluble
• Rapid induction, emergence and recovery
• Rapid adjustment of anesthetic depth

26. SEVO+ve
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ETC1.5% SEVO Bolus

27. • Spinal cord governs movement in response to painful stimulus under general
anesthesia. LINK 111
• The reduction in MACawake by nitrous oxide is non linear and smaller than would
be expected. LINK 112
• With end-tidal sevoflurane concentration increasing from 0.2% to 1.4%, BIS values
decreased almost linearly from 95.3 (median) to 45.5 LINK 113
• The most frequent cause of awareness is selection of an inadequate dose of
anaesthetic agent. Assurance of >0.8 MAC end-tidal makes awareness unlikely.
LINK 114
• TCI devices for remifentanil and propofol result in large variation in measured
serum concentrations. LINK 47
SEVOrane® Message Map 27Company Confidential
© 2007 Abbott
ETC 1.5%
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28. • An inhalation bolus of sevoflurane seems to be more effective than an IV
remifentanil bolus during maintenance, with more effective control of
hemodynamic responses to surgical stress. LINK 115
SEVOrane® Message Map 28Company Confidential
© 2007 Abbott
SEVOrane Bolus
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29. ABBOTT SEVOrane
Back
Quik Fil System
Ready-to-use delivery
system that does not
require the mounting of a
separate adaptor by OR
staff. Designed to
minimize the release of
anesthetic into the room
air and the risk of leakage
and spillage
Water content > 300ppm
Protects against Lewis acid
degradation and provides a
stable formulation
Polyethylene Naphthalate
(PEN) bottle
Shatter resistant, lightweight,
transparent, easily recyclable,
cost effective disposal, no
risk of Lewis Acid formation
from the bottle
New Tamper Evident Shrink
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