Medical cyber-physical systems, image processing, microscopy, security, biomedical imaging, multi-modal sensing, automation, robotics, network layers, software design, and biometrics for high computational load (CL) are shown. The book addresses the dimensionality problem caused by balancing data collection, image modalities, resolutions, representations, subspace decompositions, compressed sensing, and communications constraints. AI, i.e., metaheuristics and deep learning (DL), may boost innovative, super- and multi-resolution designs and spur research and applications in many domains from researchers, technology experts, academia, and students. AI and smart design can solve complicated health issues and aim at new studies, broadening healthcare systems’ applications with the additional help of nanotechnology.