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histamina derivada del aminoácido esencial histidina por descarboxilación
- 1. Neurotransmisor HISTAMINA Maryliz Martinez Ramón Universidad Juárez Autonóma de Tabasco División Académica de Ciencias de la Salud Maestría en Ciencias Biómedicas Docente: Dra. Isela Esther Juárez Rojop
- 2. Our Projects • La histamina, derivada del aminoácido esencial histidina por descarboxilación, contiene un anillo característico de cinco miembros con dos átomos de nitrógeno. • Autacoide, activo cuando se libera de los mastocitos en la reacción inflamatoria y en el control de la vasculatura, el músculo liso y las glándulas exocrinas (p. ej., secreción de jugo gástrico altamente ácido). La histamina es un transmisor tanto en invertebrados como en vertebrados. Se concentra en el hipotálamo, uno de los centros cerebrales encargados de regular la secreción de hormonas. La descarboxilasa que cataliza su síntesis (paso 1 a continuación), aunque no se analiza exhaustivamente, parece ser característica de las neuronas histaminérgicas. Las aminas biogénicas se cargan en vesículas sinápticas y secretoras mediante dos transportadores, VMAT1, principalmente en células periféricas, y VMAT2, principalmente en el sistema nervioso central. Como los transportadores no son selectivos para una amina biogénica determinada, puede estar presente una mezcla de transmisores. HISTAMINA
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