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BONE TUMORS PPT malignant and benign for study
- 1. Histopathology of Chronic osteomyelitis, Fibrosarcoma, osteosarcoma, osteoclastoma, ameloblastoma DR. NEHA BANSERIA
- 3. •Chronic osteomyelitis is infection in a bone •Infections can reach bone by travelling through the blood stream or spreading from nearby tissue.
- 4. Gross • Sequestrum is dead bone with irregular edges • A shell of new bone called involucrum may cover the sequestrum. • The involucrum is smooth and ivory white colour
- 5. Microscopic (histologic) description • Necrotic bone • Inflammatory infiltrate rich in plasma cells • Fibrosis, variable • Granulomas, in cases of tuberculosis or fungal infection
- 10. OSTEOSARCOMA • It is the most common primary bone tumour. • Mostly seen in <20 years of age • MEN >>WOMEN • Most commonly involves metaphyseal region of long bones of extremities.
- 12. Gross Appearance • The tumour appears large, bulky, grey-white, gritty mass with areas of haemorrhage and cystic degeneration. • The tumour frequently invades cortex and lifts the periosteum resulting in reactive periosteal bone formation • Radiologically the triangular shadow between cortex and raised ends of periosteum is called CODMAN’S TRAINGLE often characteristic of this tumour.
- 15. MICROSCOPY
- 17. OSTEOSARCOMA
- 19. osteosarcoma
- 20. FIBROSARCOMA • Common age group is 20-50 years. • Males>>females • 80-90% occurs in soft tissues • Metastasis is uncommon • It is radioresistant
- 21. GROSS EXAMINATION • Fibrosarcoma may be well circumscribed , bulky, poorly defined masses. • Cut section reveals soft, pearly greyish white tissue masses resembling raw flesh . • Areas of haemorrhage and necrosis may also be seen
- 22. • May appear well circumscribed but nonencapsulated • Fleshy, hemorrhagic, necrotic, white-tan
- 23. FIBROSARCOMA
- 24. Fibrosarcoma • Microscopic (histologic) description • Highly cellular fibroblastic proliferation in herringbone pattern (cells in columns of short parallel lines with all the lines in one column sloping one way and lines in adjacent columns sloping the other way) • Cells have scant cytoplasm, tapering elongated dark nuclei with increased granular chromatin, variable nucleoli • Mitotic activity present, often with abnormal forms • Variable collagen • Usually no giant cells • No pleomorphism (or call pleomorphic MFH), no other distinct cell type
- 28. OSTEOCLASTOMA
- 34. • Most common sites are mandible and maxilla • Seen in 4th and 5th decade of life • Arise from the epithelial lining of dentigerous cyst, remnants of dental lamina, enamel.
- 35. GROSS APPEARANCE •The tumour is grey white mass , usually solid, sometimes cystic and replaces the affected bone.
- 36. Microscopy • There may be several histological patterns. • Follicular pattern is the most common pattern. • Follicular pattern is characterized by follicles of varying size and shapes which are separated bt fibrous tissue • The follicles are lined by cuboidal or columnar cells and show central area of stellate cells.