Difference between prognostic, diagnostic and predictive molecular biomarkers

1. Saeed Bashir 2017-Ag-9340 (HORT)
Waseem Sajjad 2018-Ag-6452 (FT)
Adeel Asim Hashmi 2018-Ag-6662 (FT)

2. WHAT ARE
MOLECULAR BIOMARKE

3. DNA
RNA
TISSUES
URINE
Molecules or set of
molecules that can
help for diagnosis or
prognosis of diseases
or disorders.
Used to provide more
detailed information
about cellular
processes and genetic
variations.

4. PREDICTIVE
MOLECULAR
MARKERS
PROGNOSTIC
MOLECULAR
MARKERS

5. Diagnostic
Molecular
Biomarkers
Specific molecules
in bodily fluids or
tissues that are
used to detect the
presence of a
disease or
condition.
Circulating Tumor DNA (ct DNA)
Prostate-Specific Antigen (PSA)
Human Epidermal Growth Factor Receptor 2
Hemoglobin A1c (HbA1c)

6. Prognostic
Molecular
Biomarkers
Specific molecular
markers that provide
information about the
likely outcome or
progression of a
disease once it's
already diagnosed. Oncotype DX Test (Gene Expression)
Gleason Score (Grading System)
Epidermal growth factor receptor (EGFR)
Mutation

7. Predictive
Molecular
Biomarkers
Markers that
provide
information about
how a patient is
likely to respond
to a
Epidermal growth factor receptor (EGFR) Mutation
Anaplastic lymphoma kinase (ALK) rearrangements
ALK inhibitors
(ceritinib, alectinib)
Tyrosine kinase
inhibitors
(Imatinib, erlotinib)
Estrogen receptor (ER) and Progesterone receptor
(PR) Positive status
HER2 (Human Epidermal Growth Factor Receptor 2)
Hormone
Therapy
Targeted Therapies
(Trastuzumab)

8. Specific /Personalized Treatment

9. Improved Early Detection
More Accurate Diagnosis
Personalized Treatment
Improved Monitoring

10. Specificity
Technical
Challenges
Ethical & Privacy Concerns
Cost