Bioprocessing and its significance

1. Bioprocessing and its
significance

2. Definition of Bioprocessing
A bioprocess can be explained as a particular process that utilises
complete living cells or some of their cellular components to get
wanted items.

3. Definition of Bioprocessing
The process is used in the creation of nourishments, pharmaceuticals,
flavours, energy and synthetic concoctions with the guide of a
biocatalyst. A catalyst in bioprocessing can be microorganisms, plants
or creature cells in a bioreactor.

4. Definition of Bioprocessing
Alongside, it includes hereditary designing for the control of animals,
plants and microorganisms. Downstream handling is required to expel
debasements, mass volume decrease and concurrent convergence of
the ideal item from the bioreactor.

5. Upstream and Downstream Process in
Bioprocess
Cell treatment bioprocessing is an order that combines the fields of cell
treatment and bioprocessing. Cell treatment bioprocessing aims to
build up reproducible and sturdy manufacturing procedures to produce
remedial cells.

6. Upstream and Downstream Process in
Bioprocess
Commercially significant bioprocesses can:
• Generate items to keep up the entirety of the quality gauges of
biopharmaceutical drugs
• It can also offer clinical and industrial measures of remedial cells all
through different phases of improvement.
• Control the expense of merchandise (CoGs) of the last medication
item.

7. Upstream Bioprocessing
Bioprocessing hardware incorporates a wide range of gear for explicit
capacities and applications. In extensive terms and as for a procedure
stream graph, the hardware can be categorised in three categories:
• Upstream
• Downstream
• Support
Upstream gear manages the development of a host life form to deliver
a product. The product may be simply the living beings, it might be held
inward to the creature, or it may be discharged into the development
medium.

8. Downstream Bioprocessing
Downstream bioprocessing explains the part from the upstream where
the cell mass is handled to meet virtue and quality prerequisites. It is
typically partitioned into three primary areas: cell interruption, a
decontamination segment and a cleaning segment.

9. Downstream Bioprocessing
The means of downstream preparing are:
1. Insolubles are Removed
• Centrifugation
• Filtration
• Sedimentation
• Precipitation
• Electro-precipitation
• Flocculation
• Gravity settling

10. Downstream Bioprocessing
The means of downstream preparing are:
2. Product Isolation
• Precipitation
• Adsorption
• Solvent extraction
• Ultrafiltration

11. Downstream Bioprocessing
The means of downstream preparing are:
3. Purification of Product
• size inclusion
• affinity
• ion-exchange chromatography
• reversed-phase chromatography
• crystallisation
Reversed-phase chromatography

12. Downstream Bioprocessing
The means of downstream preparing are:
4. Polishing of the Product
• crystallization
• lyophilisation
• desiccation

13. Significance of Bioprocessing
Bioprocess engineering is concerned with translating biological science
into biologically based manufacturing.

14. Significance of Bioprocessing
OPPORTUNITIES
• Biopharmaceuticals and Biopesticides from Insect Cell-Baculovirus
System
Baculovirus-Insect Expression
System for Vaccine Production

15. Significance of Bioprocessing
OPPORTUNITIES
• Gene-Based Pharmaceuticals and Gene Therapy

16. Significance of Bioprocessing
OPPORTUNITIES
• Cell-Transplantation Therapy

17. Significance of Bioprocessing
OPPORTUNITIES
• New Catalysts

18. Significance of Bioprocessing
OPPORTUNITIES
• Cells, Organs, and Biomaterials

19. Significance of Bioprocessing
OPPORTUNITIES
• Transgenic Animals

20. Significance of Bioprocessing
OPPORTUNITIES
• Transgenic Plants

21. Significance of Bioprocessing
OPPORTUNITIES
• Non-traditional Organisms Living at the Extremes: Extremophiles

22. Significance of Bioprocessing
OPPORTUNITIES
• Energy and Renewable Resources

23. Significance of Bioprocessing
OPPORTUNITIES
• Agricultural Chemicals and Food

24. Significance of Bioprocessing
OPPORTUNITIES
• Plant-Cell Culture

25. Significance of Bioprocessing
OPPORTUNITIES
• Plants and Seeds

26. Significance of Bioprocessing
OPPORTUNITIES
• The Environment
Many environmental problems will require bioprocess
engineering.
eg.- minimization of manufacturing waste, treatment of
municipal waste, environmentally friendly manufacturing

27. Significance of Bioprocessing
OPPORTUNITIES
• Space
The unique problems presented by the manned exploration and colonization of
space pose major and important challenges for bioprocess engineering.

28. Significance of Bioprocessing
DEFENSE AND NATIONAL SECURITY
• Cleanup
The Department of Defense (DOD) and Department of Energy face enormous
problems in cleanup of military bases as they are closed or moth-balled and in
cleanup of weapons laboratories. In the former, biological methods might play
an important part.

29. Significance of Bioprocessing
DEFENSE AND NATIONAL SECURITY
• Chemical and Biological Warfare
A continuing problem in DOD concerns chemical and biological warfare. The
stated U.S. position is to be prepared in a defensive mode, but not to be
involved in production of biological weapons. The importance of either
chemical or biological agents as practical weapons systems remains to be
established.

30. Reference Book
Chapter 6 The Future | Putting Biotechnology to Work: Bioprocess
Engineering | The National Academies Press
https://www.nap.edu/read/2052/chapter/8