agomelatina.pptx

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Este documento describe un nuevo antidepresivo llamado agomelatina que actúa como agonista de los receptores MT1/MT2 y antagonista del receptor 5-HT2C, sin afinidad por otros receptores. Los estudios clínicos mostraron que agomelatina redujo la anhedonia y tuvo menos efectos adversos que el placebo, y estudios a más largo plazo encontraron que agomelatina redujo las tasas de recaída en comparación con el placebo.

Health & Medicine

• Es el primero de una nueva generación de
antidepresivos.
• Agonista MT1/MT2 y antagonista 5-HT2C
• No tiene afinidad por ningún otro tipo de
receptores.

Efectos adversos
Agomelatina 25-50 mg. (n=1120)

Efectos adversos sexuales
Agomelatina Agomelatina

Eficacia
Agomelatina
Agomelatina (n=165)
Placebo (n=174)
Recaídas totales
Agomelatina 21,7%
Placebo 46,6%
Recaídas totales
Agomelatina 23,9%
Placebo 49,9%

Estudios a largo plazo
Agomelatina 25-50 mg.

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agomelatina.pptx

2. • Es el primero de una nueva generación de antidepresivos. • Agonista MT1/MT2 y antagonista 5-HT2C • No tiene afinidad por ningún otro tipo de receptores.

5. Estudios clínicos

6. Anhedonia

7. Efectos adversos Agomelatina 25-50 mg. (n=1120)

8. Efectos adversos Agomelatina 25-50 mg. (n=1120)

9. Efectos adversos sexuales Agomelatina Agomelatina

10. Eficacia Agomelatina Agomelatina (n=165) Placebo (n=174) Recaídas totales Agomelatina 21,7% Placebo 46,6% Recaídas totales Agomelatina 23,9% Placebo 49,9%

11. Estudios a largo plazo Agomelatina 25-50 mg.

12. Muchas gracias.