The document discusses how modularity has allowed for increased evolvability in biological and technological systems by separating functions and allowing independent development of modules. It argues that a similar increase in modularity could benefit scientific communication by making more research processes and results transparent earlier through preprint servers, comments, and finer-grained publications. This would reduce wasted effort and increase opportunities for collaboration.

1. Modularity and evolvability Cells Language Software Scientific process Pedro Beltrao http://pbeltrao.blogspot.com Creative Commons Attribution-ShareAlike 2.5

2. Recognition of input and transformation into an output is achieved in the same place Very difficult to change the recognition without affecting the reaction (input to output function) Example: metabolic proteins Ancestral mode of recognition of input/substrate “Lock and key” model Roby P. Bhattacharyya et al (2006) Domains, motifs and scafdolds: The Role of Modular Interactions in the Evolution and Wiring of Cell Signaling Circuits. Annual Review of Biochemistry Input: recognition, active site Output

3. Separating recognition from the active site Big step in protein evolution Makes it easier to explore new binding partners without affecting the reaction of the active site Ex: docking motifs in protein kinases Roby P. Bhattacharyya et al (2006) Domains, motifs and scafdolds: The Role of Modular Interactions in the Evolution and Wiring of Cell Signaling Circuits. Annual Review of Biochemistry Recognition Active site

4. Modular protein domains Recognition and activity are separated into independent folding structures tied together. The independent domains can be more easily copied in the genome by recombination. Recognition domain ex: SH3, SH2 domains Roby P. Bhattacharyya et al (2006) Domains, motifs and scafdolds: The Role of Modular Interactions in the Evolution and Wiring of Cell Signaling Circuits. Annual Review of Biochemistry

5. Adaptor/scaffold proteins Recognition is achieved by a protein complex (getting several proteins together) The active unit is a complex instead of a single protein Ex: MAPK signaling Effectors Input Roby P. Bhattacharyya et al (2006) Domains, motifs and scafdolds: The Role of Modular Interactions in the Evolution and Wiring of Cell Signaling Circuits. Annual Review of Biochemistry Scaffold

6. Modularity and evolvability Roby P. Bhattacharyya et al (2006) Domains, motifs and scafdolds: The Role of Modular Interactions in the Evolution and Wiring of Cell Signaling Circuits. Annual Review of Biochemistry Catalytic and regulatory functions coincide Regulation is separated from catalytic functions using modular standardized parts Increased modularity and evolvability

7. Language evolution Russell D. Gray & Quentin D. Atkinson (2003) Language-tree divergence times support the Anatolian theory of Indo-European origin Nature Nov 27;426(6965):435-9. Portuguese ST Brazilian Spanish Catalan Branch lengths are not meaningful Yes, I am Portuguese :) Relationships extracted from: The capacity to convey information with the use of symbols has been evolving since it’s origin. Perhaps similar principles might apply to language evolution has to gene/protein evolution.

9. More and more symbols Values taken from: Hong-Yu Zhang, (2006) The evolution of genomes and language EMBO reports 7: 748-749 Tackling communication complexity by increasing the number of symbols is a limited strategy

10. Use of symbols in a non-situation-specific fashion Concatenation of symbols Use of symbol position to convey basic semantic relationships Maybe similar to the evolution of modular protein domains? ≈ Jackendoff R. (1999) Possible stages in the evolution of the language capacity. Trends Cogn Sci. Jul;3(7):272-279. Possible stages in the evolution of the language capacity

11. Symbols that modify symbols Some symbols are only used to change other symbols or to convey semantic relationship ≈ Adapter/scaffolds ? Hong-Yu Zhang, (2006) The evolution of genomes and language EMBO reports 7: 748-749 了 The Chinese symbol “le” conveys a form of past tense

12. My naïve view of Software production before the internet Internal production cycles Top Secret ! Top Secret ! Competition to build the best program meaning the best box. Re-inventing the wheel under the hood Modularity of the programs’ components are only important for the program itself

18. Raw data stream Raw data stream Raw data stream 1 Manuscript Deposited manuscript in a pre-print server Deposited manuscript in a pre-print server Manuscript drafts Raw data stream Raw data stream Comments Peer-review Comments Peer-review Manuscript accepted for publication Comments Peer-review Comments Peer-review Comments Peer-review Editorial decision 2 3 4 Competition Bits of information Relevant data to prove a point Increasing modularity in science