Soft tissue lesions can present in various forms and require careful examination and description. Skin cancer is the most common cancer type, with over 1 million cases diagnosed yearly in the US. The two main types are melanoma, which causes most skin cancer deaths, and nonmelanoma skin cancers like basal cell and squamous cell carcinoma. Oral and pharyngeal cancers also present risks, with over 30,000 cases yearly and 25% of oral cancer patients dying from the disease. Soft tissue lesions should be carefully examined and described based on location, border, color, configuration and other traits to aid in diagnosis and treatment.