MAW Thesis

The Effect of Material Organization on the Architectural Properties of Porous Architectures Matthew A. Wettergreen Committee: Michael A.K. Liebschner, Chair Antonios G. Mikos Mateo Pasquali Eser Yuksel

Overview ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Bone Anatomy / Physiology ,[object Object],[object Object]

Pauwel’s Hypothesis of Tissue Differentiation Bone Growth Theories Perren’s Interfragmentary Strain Theory

Typical Micro-Architecture of the Human Skeleton Vertebral Trabecular Bone Femoral Trabecular Bone

PPF PLGA PCL PGA Scaffolds Structure ≠ Bone Morphology Interconnectivity Anisotropy Density Density Permeability Porosity Porosity Trabecular Spacing Pore Size Trabecular Thickness Scaffold Properties Trab. Bone Properties

Material vs. Architectural Properties ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Motivation ,[object Object],[object Object],[object Object]

Specific Aims ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Specific Aim 1 ,[object Object],[object Object],[object Object]

Research Design ,[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],Architecture Selection

Generation of Polyhedra ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Results – Geometric Comparison

Results - FEA ,[object Object],[object Object],[object Object],[object Object],1 Gibson, L.J. and M.F. Ashby, Cellular Solids: Structure and Properties . 1999, New York: Pergamon Press. 357. 1

Stress Distribution ,[object Object],[object Object],[object Object],[object Object]

Verification of FEA ,[object Object],[object Object],[object Object],[object Object]

Energy Absorption Efficiency (EAE) ,[object Object],[object Object],[object Object],[object Object]

Geometric Modeling Scaled Modulus Best Model, r 2 = 0.8335 Stiffness Best Model, r 2 = 0.9625 Strength Best Model, r 2 = 0.9502 Strain at Fracture Best Model, r 2 = 0.8596 EAE Best Model, r 2 = 0.845

Conclusions Specific Aim 1 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Specific Aim 2 ,[object Object],[object Object]

RP Evaluation / Porogen Creation ,[object Object],[object Object],[object Object],[object Object],[object Object]

Soft Lithography * Poly(dimethylsiloxane) # Poly(propylene fumarate) di-ethyl fumarate Glass PDMS Mold PPF-DEF # Place in Vacuum Metal Clamp Remove PDMS Microparticles Microparticle Platform Degassed PDMS Microparticle Platform Let cure 24 Hours, peel away PDMS 2) Pour PDMS platform ,[object Object],Silicon Master Negative

Morphological Analysis ,[object Object],[object Object],[object Object],[object Object]

Porous Scaffold Evaluation ,[object Object],[object Object],[object Object],[object Object],Porogen Dimensions Measured from Imaging 0 200 400 600 800 1000 Arm Length Leg Width Leg Length Dimension (um) Designed SEM uCT

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Permeability Models

Permeability and Modeling ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Conclusions Specific Aim 2 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Specific Aim recap ,[object Object]

Design of Drug Release Vehicle - Methods ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Sustained Drug Release ,[object Object],[object Object],[object Object]

Surface Area Contribution to Release ,[object Object],[object Object],[object Object],[object Object]

Permeability ,[object Object],[object Object],[object Object]

Bioactivity ,[object Object],[object Object],[object Object],[object Object]

Results ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Computer Aided Tissue Engineering Wettergreen et al. ABME 2005 Investment Casting of mold with biomaterial

Computer Aided Tissue Engineering

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],CATE - Tissue Imaging

CATE - Tissue Modeling ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Biomimetic Design Theory

Unit Cube Library ,[object Object],[object Object],8

Library Characterization ,[object Object],[object Object],[object Object],C

Analysis of Stress Profiles ,[object Object],[object Object],[object Object],[object Object]

Implant Design and Manufacturing ,[object Object],[object Object],[object Object],[object Object],[object Object]

Implant Assembly ,[object Object],[object Object]

Results ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Creation of Interface Library ,[object Object],[object Object],[object Object],[object Object]

Scaffold Fabrication from Density Data ,[object Object],[object Object]

Conclusions Specific Aim 3 ,[object Object],[object Object],[object Object],[object Object],[object Object]

Summary ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Acknowledgements ,[object Object],[object Object],[object Object],[object Object]

MAW Thesis

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MAW Thesis