NurseReview.Org Pharmacology Bullet Review

Slide 1: Pharmacology Bullet Review Nursing Board Examination Review

Slide 2: Drug classification Pharmacodynamic s Nursing process Pharmacokinetics applied to pharmacology

Slide 4: Diuretics Comparison Diuretic class Major site of action Special Side effect (s) 1. Carbonic Proximal tubule Acidosis anhydrase inhibitor 2. Thiazide and Proximal tubule Hyperuricemia thiazide like Hypokalemia 3. Loop diuretics Loop of Henle Hypokalemia Ototoxicity 4. Potassium Distal tubule Hyperkalemia sparing 5. Osmotic Glomerulus Hypovolemia & diuretic hypotension

Slide 5: Diuretics Comparison Diuretic class Special Uses 1. Carbonic Mountain sickness anhydrase inhibitor Meniere’s disease Nephrolithiasis due to calcium stones 2. Thiazide and thiazide like Hypocalcemia Hypercalcemia 3. Loop diuretics 4. Potassium CHF taking digoxin sparing 5. Osmotic diuretic Increased ICP LITHIUM TOXICITY

Slide 6: Thiazides Prototype: Hydrochlorothiazide 1. Bendroflumethiazide  2. Benthiazide  3. Chlorothiazide (Diuril)  4. Hydroflumethiazide  5. Methylclothiazide  6. Trichlormethiazide 

Slide 7: Thiazide-like 1. Indapamide  2. Quinethazone  3. Metolazone  4. Chlorthalidone 

Slide 8: Thiazides Pharmacodynamics  These drugs BLOCK the chloride pump  This will keep the Chloride and Sodium in the distal tubule to be excreted into the urine  Potassium is also flushed out!!

Slide 9: Thiazide Special Pharmacodynamics: Side effects  Hypokalemia   DECREASED calcium excretion hypercalcemia  DECREASED uric acid secretion hyperuricemia  Hyperglycemia

Slide 10: Loop Diuretics Prototype: Furosemide 1. Bumetanide  2. Ethacrynic acid