Bill Faloon presented at RAADfest 2023. Topics he emphasized included the delay in translating research findings into routine medical practice, delays and restrictions by the FDA, and advancements in age-reversal since RAADfest 2022.

1. RAADfest 2023
Anaheim, California
William Faloon
September7th,2023
What’s Delaying
Regenerative Medicine?

2. April 5th, 2023
“only about 1 in 5 interventions end up in routine clinical practice”
https://jamanetwork.com/journals/jama/fullarticle/2803716
“It Takes an Average of 17 Years for Evidence to Change Practice—the
Burgeoning Field of Implementation Science Seeks to Speed Things Up”
“Why aren’t clinicians in the community
using evidence-based practices?”
17 Year Wait For Better Treatments!
“Eventhen…
New term:
“Implementation
Science”

3. January 6, 2023
“The reversal of aging could hinge on one huge decision.”
“If the FDA classifies aging as a disease,
drug companies can take a new
approach to curing death.”
https://www.popularmechanics.com/science/health/a42419017/anti-aging-drugs-fda-approval/
“Humans Can Start Living Longer
—Once the FDA Does This”
“Scientists are already targeting proteins
in cells to keep them from degenerating.”
“TheWHOsupportsthegrowingtrendofcallingagingadisease.”

4. “How To Demand A Medical Breakthrough:
Lessons From The AIDS Fight”
npr.org/sections/health-shots/2019/02/09/689924838/how-to-demand-a-medical-breakthrough-lessons-from-the-aids-fight
“AIDS activist group
ACT UP organized
numerous protests
on Wall Street in the
1980s. The group's
tactics helped speed
the process offinding
an effective
treatment
for AIDS.”
February 9th, 2019

5. October 11th, 1988

6. While also Slowing Aging NOW?
Age Reversal Needed Today!
How to Rapidly
Assess Efficacy

7. A SOLUTION:
The Perpetual Project
to Remain Healthy &
Utilize Scientific Advances
& Measure the Results
…in

8. Decades
Track Record Available at: https://www.lifeextension.com/about/life-extension-story/history
1981
1985
1986
1992
1983

9. Shelves Today Packed with Melatonin, DHEA, CoQ10, et al

11. Our Less Controversial Contention
It may be possible…
www.age-reversal.net

12. Media Highlights Since Last Year’s
RAADfest-October,2022

13. CaliforniaInstituteofRegenerativeMedicine
awarded Alpha $8 million in additional
fundingtoconducthumanstemcellresearch.
health.ucsd.edu/news/releases/Pages/2022-11-21-uc-san-diego-awarded-8m-to-expand-stem-cell-therapy-clinical-trials.aspx
November 21, 2022
UC San Diego Awarded $8 million
To Expand Stem Cell Human Trials
Alpha Stem Cell Clinic at UC San Diego is
a network of stem cell clinics in California.
This comes to $72 million in
recent funding from the California
Institute of Regenerative Medicine.

14.  The field of geroscience aims to find ways to delay onset of age-related diseases.
 Geroscience experts met virtually at a symposium of the New York Academy of Sciences.
 Advances made in understanding the mechanisms underlying biological aging.
“The presentations focused on identifying biomarkers
of aging and the search for interventions to prevent and
treat age-related diseases.”
https://www.medscape.com/viewarticle/985809
“FDA does not recognize aging as an indication for drug approval…”
December19th,2022

15. https://www.nationalgeographic.com/magazine/article/aging-cure-longevity-science-technology-feature/
Dec. 28, 2022

16. “A Drug to Treat Aging May Not Be a Pipe Dream”
“By the end of 2023, it’s likely that one of these
ideas will be shown to work in humans.” www.wired.com/story/drugs-aging-medicine-biotech/
►“In 2023, early success of these treatments
could kickstart the greatest revolution in
medicine since the discovery of antibiotics.”
►“Senolytics aren’t the only contenders…but
the success of a drug targeting an aspect of
aging in clinical trials will allow us to consider
this loftier goal in the not-too-distant future.”
Jan. 1st, 2023
New approaches to the biology of senescence can make lives longer and healthier.

17. The start-ups seeking a cure for old age
 Eric Verdin, chief executive of the Buck Institute, “scientists
have completely changed how they think about ageing”
“Tech billionaires are funding research
to help us live longer and healthier lives”
“Thestart-ups seeking acureforoldage”
January 2, 2023 https://www.ft.com/content/649b0446-698c-4363-82ad-0be5b5faa68f
 Nir Barzilai, Institute for Aging Research at Albert Einstein College of Medicine “the world is
on the cusp…of finding transformational drugs that prevent the effects of ageing…”
 Mehmood Khan, chief executive of Hevolution Foundation (Saudi Arabia),
“its vision is to “extend healthy lifespan for the benefit of all humanity”

18. Female rat ‘Sima’ (pictured right) is the last
surviving rat in a group given young plasma
transfusions at the University of Maryland.
February 8th, 2023 theguardian.com/science/2023/feb/08/anti-ageing-scientists-extend-lifespan-of-oldest-living-lab-rat
“Anti-agingScientistsExtendLifespanOfOldestLivingLabRat”
Researchteaseshopesthat‘rejuvenationofthebodymaybecomecommonplacewithinourlifetimes’
Treated rats also had improved grip strength
Sima is 47 months old, older than
the oldest known rat of 45.5 months.
This was a small study of only 8 rats, but suggests a
significant effect of the young plasma treatment

19. - March 8th, 2023
technologyreview.com/2023/01/09/1066488/biotech-says-mice-live-longer-after-genetic-reprogramming/
Sam Altman invested $180 million
into a company trying to delay death
“Can anti-aging breakthroughs add 10 healthy years to the
human life span? The CEO of OpenAI is paying to find out.”
The $180 million went to start Retro Biosciences which said
that it would “prize speed” and “tighten feedback loops” as
partofan“aggressive mission”tostall aging, or evenreverse it.

20. April 8th, 2023
“First anti-aging pills to hit shelves in 2028, expert
predicts – as Silicon Valley races to conquer death”
ChatGPT boss Sam Altman has invested
$180 million in anti-aging biotech firm.
Long line of Silicon Valley billionaires throw
considerable wealth behind the science.
Jeff Bezos put $3 billion into anti-aging startup.
Pills to help people reverse the effects of aging
“could be on the market in the next 5 years”
https://www.dailymail.co.uk/sciencetech/article-11844303
SamAltman

21. | March 12th, 2023
Report on the Science of Aging
The WSJ cited several studies associating
telomerelengthwithhealthoutcomesinolderpeople.
“Smoking,excessivedrinking,pollution,stress,socialisolation
andeatingprocessedfoods…causestelomerestoshortenfaster.”
Shorter telomeres were associated with depression
and cognitive problems in people aged 60-79.
Peopleover60withshortertelomereswere3xmorelikelyto
diefromheartdiseaseand8xmorelikelytodiefrominfections.

22. https://www.lifeextension.com/magazine/2009/3
MarkHyman,M.D.
on cover of March
2009 issue of Life
Extension Magazine
LE Features Dr. Mark Hyman

23. www.nytimes.com/books/best-sellers/2023/03/12/
Explosion of Interest in Anti-aging
Science today sees aging as a
treatabledisease.Byaddressingits
rootcauseswecanlivelongerand
prevent/reversemaladiesofaging.
March 12th, 2023

24. The Pro-longevity view of why healthcare delivery
in the U.S. “routinely fails to treat or cure many long-
term conditions” and how “Modern doctors are trained
to solve ‘the problems of an earlier era’—that is, acute
illnesses and injuries with fairly short event horizons.”
www.wsj.com/articles/outlive-review-heaven-can-wait-6a50eb2 www.nytimes.com/books/best-sellers/2023/04/16/
“Medicine3.0,’thenexterainmedicineifDr.Attiahashis
way, will be ‘proactive’ and focus on prevention.
It will also avoid one-size-fits-all treatment
protocols of the sort that are common today.”
WSJ Review of Outlive:
March 29th, 2023

25. https://scitechdaily.com/turning-back-the-clock-genetic-engineers-rewire-cells-for-an-82-increase-in-lifespan
“Lifespan Extension Record Set In Yeast
Cells Using Synthetic Gene Oscillator”
“Turning Back the Clock: Genetic Engineers
Rewire Cells for an 82% Increase in Lifespan”
“Engineering longevity---design of a synthetic
gene oscillator to slow cellular aging”
“Researchers make breakthrough in quest for longer life”
Major Life Span Increase - April 27th, 2023
https://www.science.org/doi/10.1126/science.add7631
https://nypost.com/2023/04/28/life-expectancy-could-grow-80-with-anti-aging-breakthrough/
https://www.genengnews.com/news/lifespan-extension-record-set-in-yeast-cells-using-synthetic-gene-oscillator/

26. 105%LifespanExtensioninYeastUsingGeneticOscillation
Study finds yeast cell aging and death
affectedbya circuitoftwo criticalpathways.
https://www.science.org/doi/10.1126/science.add7631
Yeast were engineered to overexpress two
genes (Sir2 & HAP4) in such a way that yeast
flipped between functioning pathways.
April 27th, 2023
This genetic oscillation extended
life 105% more than normal yeast.

27. Genetic Engineering - 2023
To control aging the team manipulated the
expressionof 2 conservedtranscriptionalregulators:
2) HAP4: Promotes mitochondrial biogenesis
1) SIR2: Regulates nucleolar functions/DNA repair
https://www.genengnews.com/news/lifespan-extension-record-set-in-yeast-cells-using-synthetic-gene-oscillator/

28. https://www.science.org/doi/10.1126/science.add7631
105%Lifespan ExtensionUsingGeneticOscillation
April 27th, 2023
Yeast cells engineered to overexpress two genes (Sir2 & HAP) in
a way that they consistently flip between functioning pathways.

29. Substantial Lifespan Increase with Modest
Gene Expression Alterations in Yeast Cells
Stem cell exhaustion is a core aspect
of the aging process. Yeast are often
used as a model of human stem cells.
https://www.science.org/doi/10.1126/science.add7631
LifespanChangeinYeast
If these results translate comparably
to humans, the average lifespan of
human stem cells could increase
105% with maximum lifespans also
increasing substantially.
This would go far in solving one of the
major documented aspects of aging.
-

30. https://www.science.org/doi/10.1126/science.add7631
105%LifespanExtensioninYeastUsingGeneticOscillation
April 27th, 2023
This yeast model “has
proven to be a genetically
tractable model for the
aging of mitotic cell types
such as stem cells and has
led to the identification of
well-conserved genetic
factors that influence
longevity in eukaryotes.”
GoldilocksZone
Side-effects
Certain Decline
Modest effects
or

31. “Scientists safely and
effectively reverse the
aging process in
middle-aged and
elderly mice by partially
resetting their cells to
more youthful states.”
https://www.salk.edu/news-release/cellular-rejuvenation-therapy-safely-reverses-signs-of-aging-in-mice
March 7,2022
Salk Scientists Reverse Aging in Mice

32. March 9, 2022
“Newresearchbythe
SalkInstitutehasshown
cellularrejuvenation
therapysafelyreverses
signsofaginginmice.”
https://www.drugtargetreview.com/news/101826/scientists-have-shown-ageing-process-can-be-safely-and-effectively-reversed-in-mice/
“Scientists have shown aging process can
be safely and effectively reversed in mice”

33. https://www.dailymail.co.uk/sciencetech/article-10589031/Scientists-REVERSE-ageing-mice-using-cellular-rejuvenation-technique.html
• Experts injected mice with molecules called the Yamanaka transcription factors
• Treatment period of seven to 10 months was effective for restoring youthfulness
• The 'safe' treatment could one day help humans wind back their biological clock

34. • Long-termcell reprogrammingresults in “younger”skin age.
• Skin cells divide more rapidly.
• Lower inflammation and reduced senescent-associated
secretory phenotypes in treated animals.
• No data collected on lifespan.
Cell Rejuvenation in Live Mice
https://www.nature.com/articles/s43587-022-00183-2
https://www.salk.edu/news-release/cellular-rejuvenation-therapy-safely-reverses-signs-of-aging-in-mice/

35. https://hms.harvard.edu/news/loss-epigenetic-information-can-drive-aging-restoration-can-reverse
“Study in mice implicates changes to
way DNA is organized, regulated rather
than changes to genetic code itself”
“Loss of Epigenetic Information Can
Drive Aging, Restoration Can Reverse it”
Jan.12th,2023
1
“the extensive experiments led the team to conclude that “by manipulating
the epigenome, aging can be driven forwards and backwards”

36. Jan 12, 2023
https://www.cnn.com/2023/01/12/health/reversing-aging-scn-wellness/index.html
“Old Mice Grow Young Again…
Can People Do The Same?”
 Harvard researchers show
aging may be caused by
changes in epigenetic markers.
 No data on lifespan that we know of.
 Age reversed at will using
Yamanaka factors in live mice.
 No data on lifespan that we know of.

37. - January 9th, 2023
technologyreview.com/2023/01/09/1066488/biotech-says-mice-live-longer-after-genetic-reprogramming/
This Biotech Startup Says Mice Live
Longer After Genetic Reprogramming
“A small biotech company claims it has used a
technology called reprogramming to rejuvenate old
mice and extend their lives, a result suggesting that
one day older people could have their biological clocks
turned backwithaninjection—literally becomingyounger.”

38. Scientists at Rejuvenate Bio recently tested
epigenetic reprogramming in elderly mice
Jan. 5th, 2023
They gave 124-week-old mice gene
therapy with three Yamanaka factors: OSK
They reported that remaining lifespan
was more than doubled with treatment
Reference: https://www.biorxiv.org/content/10.1101/2023.01.04.522507v1 *Study has not yet been peer reviewed as of 1/24/2023.
Frailty was also reduced in treated mice

39. Jan.5th,2023
Old mice injected with the Yamanaka factor-encoded virus.
Adeno-associated virus encoded with three Yamanaka factors (OSK)
(Doxycycline used as Yamanaka factor promoter.)
Doxycycline in drinking water (one week on and one
week off) controllably promotes Yamanaka factors.
The start-ups seeking a cure for old age
RESULTS
► Reversal of epigenetic aging markers
► Restored youthful functions
► Extension of remaining lifespan by 109%
Reference: https://www.biorxiv.org/content/10.1101/2023.01.04.522507v1 *Study has not yet been peer reviewed as of 1/24/2023.

40. Typical 77-year-old American expected to live to age 87
If extend remaining lifespan as reported:
98
MissedTimeforAgeReversalTechnologies
87
Averageremaininghumanlifespansgo from 87to98years.

41. April 9th, 2022
https://www.cnbc.com/2022/04/08/elon-musk-humans-could-eventually-download-their-brains-into-robots.html
“ElonMusksays a lot of seeminglyfantastical
things.Forexample: The billionaireTesla and
SpaceX CEO seemsto believethathumanswill
eventually be able to
by downloading their brains into robots”
LIVE FOREVER,

42. https://www.bloomberg.com/news/articles/2022-12-01/musk-s-neuralink-hopes-for-human-trials-approval-within-six-months
►Elon Musk’s company Neuralink
is testing computer-brain implants
for human enhancement.
►A recent article reports Neuralink
expects to test brain implant in
humans within the next 6 months.
►One Neuralink project focuses on
curing paralysis.

43. March 7, 2022
reuters.com/science/elon-musks-neuralink-gets-us-fda-approval-human-clinical-study-brain-implants-2023-05-25
May 25, 2023
“Elon Musk's Neuralink says ithas FDAapproval
for Study of Brain Implants in Humans”
“The FDA acknowledged in a statement that the
agency cleared Neuralink to use its brain
implant and surgical robot for trials on patients”
“Musk envisions brain implants could cure a
range of conditions including obesity,
autism, depression and schizophrenia as well
as enabling web browsing and telepathy.”
The company had applied for FDAapproval
on “at least four occasions” since 2019.

45. www.dailymail.co.uk/sciencetech/article-11911975/Humans-achieve-immortality-eight-YEARS-says-former-Google-engineer
March 29,2023
“Humans will achieve immortality in EIGHT YEARS, says former
Google engineer who has predicted the future with 86% accuracy”
“Ray Kurzweil predicts nanobots will
help achieve human immortality.”
“These tiny robots will repair damaged
cells and tissues that deteriorate as
the body ages and make us immune
to diseases like cancer.”

46. www.dailymail.co.uk/sciencetech/article-11911975/Humans-achieve-immortality-eight-YEARS-says-former-Google-engineer
March 29,2023
“Humans will achieve immortality in EIGHT YEARS, says former
Google engineer who has predicted the future with 86% accuracy”
“We’d like to advance human life
expectancy – my life expectancy,
by more than a year every
year, and I think we can get
there by the end of this decade.”
- Ray Kurzweil, Lex Fridman Podcast #321

47. “Mr. Kurzweil believes we may achieve immortality
as soon as 2030, thanks to the development of
‘nanobots,’ tiny robots that will constantly repair
our bodies at the cellular level. He predicts people
will soon be able to eat whatever they want and
stay trim while nanobots in their bodies cure
diseases, create immunities and heal injuries.”
| May 2nd, 2023
www.wsj.com/articles/immortality-isnt-all-its-cracked-up-to-be-nanobots-science-health-death-penalty-healthcare-33ae5abf
“Even if this fantastical breakthrough becomes
reality, is human immortality a good thing?”
“ ”
“ ”

48. - May 19th, 2023
technologyreview.com/2023/05/19/1073374/i-just-met-the-founders-of-a-would-be-longevity-state/
“I just met the founders of a would-be longevity state”
“What if I told you there’s a group of people who think death
is morally bad…Who seek to create a new state with its own
laws that expedite the development of longevity drugs, partly
by encouraging biohacking and self-experimentation?”
“A community of such individuals have been living together in
a resort in Montenegro for the past 7 weeks. They’ve been
sharing ideas, collaborating on projects, running hackathons,
and having plenty of parties. They call their gathering Zuzalu.”

49. | July 10th, 2023
https://www.wsj.com/articles/longevity-clinics-aging-living-longer-2b98e773
“The Longevity Clinic Will See You Now…”
“The clinics cater to a growing number of people obsessed with fighting aging”
“ThecenterscapitalizeonAmericans’ obsessionwith
livinglongeranddesireforpersonalizedmedicalcare.”
“They are often wealthy people in their
40s to 60s who are seeing signs of aging.”
“Venture-capital investment in longevity clinics
more than doubled between 2021 and 2022,
from $27 million to $57 million globally.”

50. August 2nd, 2023
“There's one major key to unlocking extreme longevity.”
“If humans living for 1,000 years seems like
a complete stretch, aging expert João Pedro
de Magalhães will do you one better: how
about humans living for 20,000 years?”
https://www.popularmechanics.com/science/health/a44713943/humans-can-live-20000-years-aging-expert/
“An Aging Expert Thinks Humans Can
Live for 20,000 Years. He's Not Crazy.”
“All it takes, he believes, is new technology—
yet to be created—that can eliminate aging at
the cellular level, repair DNA, and reprogram
cells for a drastically different aging process.”

51. | August 26th, 2023
“Insights into the underlying
mechanismsofagingarerevolutionizing
the hunt for longevity treatments”
“HowWeAge—andHowScientists
AreWorkingtoTurnBacktheClock”

52. Singapore Opens World’s First Healthy
Longevity Clinic in a Hospital
August 31, 2023
https://www.lifespan.io/news/singapore-opens-worlds-first-healthy-longevity-clinic/?utm_source=rss&utm_medium=rss&utm_campaign=singapore-opens-
worlds-first-healthy-longevity-clinic&mc_cid=fc12615531&mc_eid=8205f6945d
The Healthy Longevity Clinic at Alexandra Hospital is
partnering with National University of Singapore to:
 Test evidence-based treatments including repurposed drugs
 Conduct clinical research on new longevity technologies
 Make effective therapies widely available at a public hospital.
 Optimize health and reduce burden of age-related disease

53. “Saudi Arabia Is Dangling Billions for Research on Aging.”
“Scientists Are Lining Up to Take It.”
Sept 1, 2023
Wall Street Journal
 Saudi government allocated more than a billion dollars a year to develop
new treatments for aging.
 American Federation for Aging Research received $7.76 million grant.
 Univ of Pittsburgh received $375,000 to study how nanoparticles could help
detect cell senescence. Norn Group, U.S. nonprofit received $7 million.
Since starting in July 2022, the Saudi foundation has dispersed less than $20
million. They expect to ramp up towards $1 billion as geroscience research
projects are identified.
https://www.wsj.com/science/biology/saudi-arabia-is-dangling-billions-for-research-on-aging-scientists-are-lining-up-to-take-it-7f459eff?mod=Searchresults_pos1&page=1

54. Age Reversal Research Facility-2022
Betterhumans.org
new facility will be a
28,000 square foot
Age Reversal Vivarium
and Diagnostic Lab.
Pictured is the construction
of four of the six planned
20’ by 40’ lab rooms.

55. Betterhumans.org
Outside of 2 Story 15,000 sq. ft Cleanroom Building

56. Common Area, Kitchen, and Wet-lab
Rooms in Analytical Laboratory Building

57. Air-gapped cleanrooms within outer cleanroom for incubating,
processing,performingqualityanalysisandpackagingofbiologicals
(iPSs, stem cells, exosomes, mitochondria etc.).

58. Air Shower:
for Use Before
Entering Each
of the Inner
Cleanrooms

59. “Air shower” for bringing large equipment
into the HEPA-filtered air of the cleanrooms.

60. Outer Cleanroom with 2 of 4 Inner Cleanrooms visible.
Stairs go up to 2nd floor (expansion of labs and cleanrooms)

61. Betterhumans.org
Outside of 2 Story 11,000 sq. ft Laboratory Building

63. RAADfest 2023
Anaheim, California
William Faloon
September7th,2023
Healthy Longevity
Advance 2023
-

64. The Age Delay Advance of 2023
 Affordability (not cost prohibitive)
 Practicality (easy to take)
 Availability (broad consumer access)
 Historic evidence of efficacy
 New data of increased healthy longevity

65. https://www.science.org/doi/10.1126/science.abn9257
Major study published in
journal Science describes
taurine use an “anti-aging
intervention”
“Taurine Deficiency
As A Driver Of Aging”
-June 8th, 2023

66. “Can Taurine SlowAging? Here’s
What the Latest Science Says”
“Higher taurine levels help slow aging
in animals, new research shows”
https://time.com/6285686/taurine-anti-aging-supplement-science/
JUNE 8th, 2023
JUNE 8th, 2023
nbcnews.com/health/aging/taurine-aging-energy-drinks-protein-food-study-rcna88259

67. JUNE 9th, 2023 https://www.cnn.com/2023/06/08/health/taurine-longevity-wellness
“Is taurine the ‘elixir of life’? Maybe,
if you’re a worm, mouse or monkey”
| June 9th, 2023
“IsTaurinetheKeytoLongerLife?ItMadeMonkeysHealthier”
https://www.wsj.com/articles/is-taurine-the-key-to-longer-life-it-made-monkeys-healthier-d26a4cb4
“Amino acid extended lives of mice and worms,
and researchers plan more tests in people”

68. Taurine levels in middle-aged monkeys
85% lower than younger monkeys.
“Taurine Supplementation Makes
Animals Healthier and Live Longer”
June 9th, 2023
https://www.science.org/doi/10.1126/science.abn9257
Blood taurine levels 80% lower in
elderly humans relative to youth.
Lower taurine concentrations
associated with age-related problems.
Taurine concentrations in mice,
monkeys & worms plummet with age.
Taurine and Aging

69. Taurine Increases Animal Lifespan
Middle-aged mice receiving taurine appeared
healthier, having less body fat / more bone mass.
The median life span of taurine-treated mice
was 10-12% longer than control and life
expectancy at 28 months increased by 18-25%.
Taurinefedmiceperformbetterinmusclestrength,
endurance, coordination, and insulin sensitivity.
Lifespans of middle-aged worms fed taurine
were lengthened 10%-23% compared to control.
Taurine and Aging
https://www.science.org/doi/10.1126/science.abn9257

70. Taurine supplemented Normal Aged Mice
18%-25%lifeexpectancyincrease
Lifeexpectancygoesfrom 79to85-88years*
If Taurine Works Similar in 43-Year-Old Humans
https://www.science.org/doi/10.1126/science.abn9257
What if Taurine has Same Effect on Humans as Mice?
*(about 6-9 potential added human years)

71. https://www.science.org/doi/10.1126/science.abn9257
Impact of Taurine in Humans
⬆ Abdominal obesity
⬆ Hypertension
⬆ Inflammation
⬆ Type 2 diabetes
Lower taurine levels in humans
were found to be associated
with age-related problems…
These Include:
Systemic Benefits of Taurine Levels
Abdominal obesity
Hypertension
Inflammation
Type 2 diabetes

72. Dietary Sources of Taurine
Animal proteins such as meat, seafood, eggs, dairy.
Typical American diet provides 100-180 mg
Strict vegetarian/vegan diets around 17 mg
https://www.healthline.com/nutrition/what-is-taurine
Blood taurine level 80% lower in elderly compared to younger humans.
Consider supplementing with 1000-3000 mg/day.
Presumed culprit: Reduced activity of cysteine sulfinate decarboxylase activity

73. Taurine aces award criteria: having consistent research,
being affordable, with new findings that top expectations.
1-3 grams per day is a good starting
dose, but people weighing over 165lbs
might need to work up to higher doses.
End-stage kidney failure should avoid high-dose taurine
because they may not clear it from blood. Vegans and
vegetarians should consider taurine supplements.

74. William Faloon
What’s Delaying Regenerative
Medicine Implementation?
September 7th, 2023
And how to overcome
the needless delays…

75. Bridging the Longevity Gap
Urgent Need to Reform Clinical Trial Regulations

76. April 5th, 2023
“only about 1 in 5 interventions end up in routine clinical practice”
https://jamanetwork.com/journals/jama/fullarticle/2803716
“It Takes an Average of 17 Years for Evidence to Change Practice—the
Burgeoning Field of Implementation Science Seeks to Speed Things Up”
“Why aren’t clinicians in the community
using evidence-based practices?”
17 Year Wait For Better Treatments!
“Eventhen…
New term:
“Implementation
Science”

77. Heart failure kills
https://www.cdc.gov/heartdisease/heart_failure.htm
Epidemic Killer: Heart Failure
About 6.2 million adults in the
United States have heart failure.
Heart failure cost the United
States $30 billion in 2012.
400,000 Americans every year.

78. “Stem cell therapy may reduce risk of heart attack &
stroke in certain heart failure patients, study shows”
Feb. 27, 2023
https://www.cnn.com/2023/02/27/health/cell-therapy-heart-failure-patients-study
One dose of adult stem cells reduced heart attack
& stroke risk by 58% in people with heart failure.
Riskreducedby75% inthosewithhighinflammation.
Largest study of its kind on 565 patients – treatment
began a mean of 7.5 years after heart failure diagnosis.
The effects lasted for the entire follow up period – 3 years.
But human data 10+ years ago suggested this effect… Dr. Emerson Perin holds up adult stem cells
- The Texas Heart Institute
58%
75%

79. Backin ,JohnsHopkinshadaverysimilarstudyresultin31peoplewithheartfailure.
hopkinsmedicine.org/news/media/releases/stem_cell_therapy_safely_repairs_damaged_heart_muscle_in_chronic_heart_failure_patients_study_shows
“Stem cell therapy safely repairs damaged
heart muscle in chronic heart failure patients”
November6th,2012
The2012studywasreportedintheJournalofAmericanMedicalAssociation(JAMA)
The study reported that the stem cell therapy “reduced heart muscle scar
tissue” and “enhanced heart pumping ability” for many study patients.
Why the Lethal Delay in Using Stem Cells in Clinical Practice

80. “FDA Warns Doctors: ‘Do Not Do It Again’"
Boy regained enough heart function to play basketball
and pretty much live a near-normal life for a teenager.
16-year-old boy underwent a stem cell
transplant to help regain lost heart tissue
after he was shot in the heart by a nail gun
Stem Cells Save Boy's Life
Stemcells harvestedfrom the boy's own blood infused
into damaged portion of his heart via a catheter.
Boy's ejection fraction down to 20%. After the stem
cell transplant, ejection fraction went up to 40%.
lifeextension.com/magazine/2003/10/awsi
October 2003|

81. 1906-2023 = 117 Years of Needless Delays

82. “FDA is responsible for advancing the public health by helping to speed
innovations that make medical products more effective, safer, and more
affordable…”1
1. https://www.fda.gov/about-fda/what-we-do
FDA Headquarters, Rockville, Maryland

83. What FDA says: What FDA does:
2. FDA Holocaust Museum- 1994-2022
“FDA is responsible for
advancing the public
health by helping to
speed innovations that
make medical products
more effective, safer, and
more affordable…”1
“FDA impairs the public
health by delaying
innovations that make
medical products less
effective, less safe, and
less affordable…”2
= Delayed Research

84. "We stand on the cusp of a revolution in
health care. Advances in molecular medicine
will allow us to develop powerful new
treatments that can cure or even prevent
diseases like Alzheimer's and cancer."1
"What's missing," according to Dr. von Eschenbach:
1.https://www.lifeextension.com/magazine/2012/12/former-fda-commissioner-admits-risk
Former FDA commissioner
Andrew von Eschenbach, M.D.:

85. FDA Commissioner Margaret
Hamburg’s sworn testimony:
1.https://www.lifeextension.com/magazine/2012/12/former-fda-commissioner-admits-risk
Margaret Hamburg M.D.

86. Biotechnology Innovation Organization conference-2023
Source: Wall Street Journal-June 12, 2023
Robert Califf, M.D.
FDA Commissioner
Today’s FDA Commissioner
of Prescription Drugs
“I think the prices
of drugs are too
high in the U.S.”

87. https://www.cato.org/commentary/rethinking-fda
“If the FDA delays a good drug, the cost is less obvious
because most of those affected are not aware their illness
could have been treated more effectively. A great deal
of evidence supports this perspective and estimates huge
life‐​saving benefits would be derived from greater speed.”
August 24th, 2022
“Scientists have shown aging process
can be safely and effectively
“Rethinking the FDA”

88. https://www.bmj.com/content/379/bmj.o2628
“The FDA is “endangering public health” by not being candid about
violations that are uncovered during clinical trial site inspections”
“The lack of full transparency and data sharing does not allow
physicians and other medical scientists to confirm the data
independently and make comprehensive risk-benefit assessments…”
“The FDA has a long history of failing adequately to oversee clinical trial sites.
A report in 2007 by the Department of Health and Human Services’ Office of
the Inspector General found the FDA audited less than 1% of the nation’s
clinical trial sites between 2000 and 2005 and was highly critical of the agency
because it did not have a database of operational clinical trial sites.”
BritishMedicalJournalcitesHistoricFDAFailures
November 16, 2022
BritishMedicalJournal

89. | Jan. 11, 2023
“FDA Increasingly Halting Human Trials…”
Clinical holds by FDA can stifle progress:
2017-2020: 557 clinical holds*
2002-2021: 664 clinical holds
2021-2022: 747 clinical holds
“FDA is also saying that's probably part of the reason it's having to
press pause on more trials because the technology is just so new.”
*average each year

90. Lethal Delays in Approving Ribavirin
1972 - Anti-viral effects of ribavirin discovered by ICN Pharma
1983 - LifeExtension® recommends ribavirin to its members
1991 - FDAbringscriminalchargesagainstLifeExtension®founders
1995 - FDA brings criminal charges against ICN Pharm founder
1998 - FDA approves ribavirin as lifesaving anti-viral therapy
Tragic Outcome:
https://www.lifeextension.com/magazine/1998/9/wws
60,000 hepatitis C victims die
waiting for ribavirin to be approved.

92. Stock Photo Reenactment of FDA Raid

93. FDA indicted me in November 1991
Sought prison term of >80 Years

95. FDA Advocates that HIV
Patients Use Dietary Supplements
“There is widespread agreement that nutrition
intervention should begin as soon as a diagnosis is
made. Once people realize they are HIV positive,
they should take steps to improve nutrition…
Healthful eating principles, including
importance of certain nutrients and use
of vitamin and mineral supplements.”

96. April 2015
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382132/
Meta-Analysis Shows Dietary Supplements Slow HIV Progression
“…micronutrient supplementation substantially and significantly reduces the
risk of HIV disease progression by 38% in adults not on anti-viral therapy.”
“adding the mineral selenium improved the outcome
significantly” (disease progression reduced by 64%).
“addition of zinc to a micronutrient supplement reduced mortality (by 71%)”
“The annual cost per patient of micronutrient supplement
reported ranged from about $12 to $40/year.”

97. Lots of Free Publicity Courtesy of FDA Trying to incarcerate Bill Faloon

98. February 4, 1995

99. FDA Surrenders in 1996
This was the first time the FDA has been
forced to give up on a criminal prosecution.
https://www.lifeextension.com/magazine/1996/9/freedom
By February 1996, Federal Judge Daniel
Hurley dismissed all 56 criminal charges
against Saul Kent and William Faloon.
This victory goes beyond winning in court.
The FDA's defeat is a victory for everyone
who cherishes freedom in healthcare.

100. FDA Delays Age-Reversal Clinical Trials

101. “How To Demand A Medical Breakthrough:
Lessons From The AIDS Fight”
npr.org/sections/health-shots/2019/02/09/689924838/how-to-demand-a-medical-breakthrough-lessons-from-the-aids-fight
“AIDS activist group
ACT UP organized
numerous protests
on Wall Street in the
1980s. The group's
tactics helped speed
the process offinding
an effective
treatment
for AIDS.”
February 9th, 2019

102. October 11th, 1988

103. High Impact Event, Oct. 1988

104. High Impact Event:

105. High Impact Event:

106. ACT-UP Protest at FDA

107. FDA Allowed HIV Patients Unlimited Access
Beyond formal acceleration of AIDS research, FDA compromised and
allowed AIDS victims to try any intervention that might be effective.
https://www.tampabay.com/archive/1992/10/15/the-fda-s-cruel-indifference/
AIDS Buyers Clubs were allowed to import
unapproveddrugstheybelievedmightbehelpful.
Historic Precedent - Oct. 1992:
The result was more rapid development of effective
therapies and speedy recognition of worthless ones.

108. Petition FDA-Congress to
Amend Clinical Trial Constraints
age-reversal.net
Over 10,000 people were asked…only 314 signed!

109. Dr. Robert Hayling
Florida civil rights leader
 Jailed for 6 months for asking to be served at a Woolworth's lunch counter.
 Offered plea deals in exchange for promise of no future protests.
 Released after appeals by Martin Luther King, Jackie Robinson, others
http://bigstory.ap.org/article/caec64fd3f9e4731bb9c4bdd801c0879/dr-robert-hayling-florida-civil-rights-leader-dies-86
In 1964 Dr. Hayling imprisoned for defying authority:

110. Petition FDA-Congress to
Amend Clinical Trial Constraints
age-reversal.net
Over 10,000 people were asked…only 314 signed!

111. Age Reversal
Interventions
Autophagy Plasma exchange
Remove
senescent cells
Combat
Immune senescence
Lengthen
telomeres
AMPK/
mTOR
NAD+
Exosomes

112. PNAS October 15, 2019 116 (42) 20817-20819; first published September 30, 2019
https://doi.org/10.1073/pnas.1913212116
Rapamycin Lithium Trametinib
+ +
Fruit Fly Lifespan Extension by 48%
=
“…a combination of drugs already approved for
human use is a viable strategy to maximize animal
longevity…”
This study supports the stairstep approach advocated to enable us to live significantly longer
Oct 15. 2019

113. Fruit flies received drugs separately and/or in combination.
 Each drug individually extended lifespan by 11%
 Pairing two drugs extended lifespan roughly 30%
 Three drugs combined extended lifespan by 48%
Castillo-Quan, Jorge Iván, Luke S. Tain, Kerri J. Kinghorn, Li Li, Sebastian Grönke, Yvonne Hinze, T. Keith Blackwell, Ivana
Bjedov, and Linda Partridge. "A triple drug combination targeting components of the nutrient-sensing network
maximizes longevity." Proceedings of the National Academy of Sciences 116, no. 42 (2019): 20817-20819.
Combination Treatments Are Essential
Oct 15. 2019

114. Compound Combinations Targeting
Longevity: Challenges and Perspectives
“Anti-aging drug therapy is one of the most
promising strategies to combat aging.”
“Aging is currently at the top of the major global concerns,
urgently requiring effective, large-scale interventions to decrease
the number of late-life disorders and improve human healthspan.”
“There is a great rationale for use of
combinations of anti-aging interventions”
“Most geroprotective compounds affect
only a few biological targets”
https://pubmed.ncbi.nlm.nih.gov/36642188/
Jan. 13th, 2023

115. Nov 29, 2015

116. April 24, 2016

117. https://www.webmd.com/healthy-aging/story/is-there-a-cure-for-aging
“If the results are what
they think they will be, the
whole world could go on
metformin and extend life
for everybody.”
- Nir Barzilai, lead researcher on
“Targeting Aging with Metformin”
Clinical Trial
February 20th, 2021

118. MetforminClinicalTrialAnnouncedin2015
As of Sept. 1st 2023:
The study is not listed on ClinicalTrials.gov.
The Federal regulations demand that any FDA
study conducted within the U.S. must be registered
on Clinical Trials.gov prior to commencing.
No known recruiting
for metformin anti-
aging clinical trial.

119. A SOLUTION:
The Perpetual Project
to Remain Healthy &
Utilize Scientific Advances
& Measure the Results
…in

120. Your Data
(Diagnostic tests + Lifestyle +
Experimental Interventions)
Thousands of other’s data
(Diagnostic tests + Lifestyle +
Experimental Interventions)
Uploaded to analytics database
Measurable Trends to Effects
of Patient-Driven Regenerative
Pre-enroll at:

121. Open to Everyone…No Exclusion Criteria!
Group Effort to Defeat Biological Aging
The Perpetual Project
 Individualized
 Not a clinical study
 No termination date
Not a Clinical Trial
No Termination Date
Track Patient-Driven
Individual Treatments

122. Reasons for You to Participate:
Pre-EnrollinthePerpetualProjectforfreeat:age-reversal.net
Easy upload/download your medical records
Store/retrieve Blood Test results, other diagnostics
Comparenewresultstopriorreports(areyouimproving?)
Identify/Track favorable (unfavorable) trends over time
One location for easy reference + expeditious analyses
Provide your doctor with comprehensive data, charts

123. Join the Perpetual Project private
association and receive updates
about regenerative medicine initiatives
www.age-reversal.net
How to Pre-Register

124. Level 1 is essential to
progress to Level 2
Optimal Health
Level 2
Level 1
- Hormones - Renal function
- LDL/ApoB - Sleep quality
- Blood Pressure - Glucose
- C-reactive protein - Homocysteine
- Insulin - Coagulation
Underlying Risk Factors
Individualized Age
Reversal Interventions
House of
Optimal Health
Correct Your

125. House of
Optimal Health
- Hormones - Kidney function
- LDL/ApoB - Sleep quality
- Blood Pressure - Glucose
- C-reactive protein - Homocysteine
- Insulin - Coagulation
- Senolytics
- NAD+ Restoration
- mTOR-inhibition
- Exosomes
- Mesenchymal Stem Cells - Mitochondria Transfer
- Young Plasma/Blood filtering
Failure to optimize
Level 1, preclude
benefits of Level 2.
Optional Approaches
Healthy Aging
- Perinatal tissues
- Hyperbaric - Gene therapy
Level 2
Level 1

126. Blood Tests Available in Exhibition Hall
Level 1
Level 2
Level 2

127. We Don’t Have Time for
Delayed Age Reversal

128. ►John Shea was chairman and co-founder of the
reincorporated J.F. Shea Co., the largest
privately held homebuilding company in the US.
►Favored healthful meals, including carrot and
broccoli sandwiches on wheat bread.
►Got up at 4:45am to stretch/exercise/swim laps.
►Dead at age 96 due to complications from a fall.
Who missed the longevity boat?
John Shea 1926-2022
Expiration date: Aug. 14, 2022
Net Worth > $2.3 billion https://labusinessjournal.com/obituary/john-f-shea-dies-at-96/

129. Who Missed the Longevity Boat
Sir Evelyn De Rothschild earned his fortune through
the Rothschild family and in his career in
international finance. He had served as a financial
advisor for Queen Elizabeth II, he held many chair
positions in Rothschild organizations and formed his
own holding company E.L. Rothschild.
https://www.nytimes.com/2022/11/08/business/evelyn-de-rothschild-dead.htm
SirEvelynDeRothschild(1939-2022)
Net worth > $20 billion
Expiration date: Nov. 7, 2022 Dead at Age 91

130. Scott Minerd (1960-2022)
Expiration date: Dec. 21, 2022
Net worth ~ $325 million https://www.ft.com/content/040ce114-de6e-49f9-a415-9e1f44ad7487
Who missed the longevity boat?
►Scott Minerd was the Global CIO and
founding partner at Guggenhiem
investments. At one point Minerd was
dubbed the “King of Wall Street”
►At the time he died he was earning a
salary of $60 million per year.
►Dead at the age of 63.

131. Who Missed the Longevity Boat
Shoichiro Toyoda was the son of the founder of the
Toyota Motor Corporation and served as the chief of
the automotive giant, under his leadership the
company expanded production into North America in
the 1980s and helped transform it into a global brand.
https://www.nytimes.com/2023/02/16/business/shoichiro-toyoda-dead.html
ShoichiroToyoda(1925-2023)
Net worth ~ 800 million
Expiration date: Feb. 14, 2023 Dead at Age 97

132. Who Missed the Longevity Boat
https://www.nytimes.com/2023/02/13/sports/football/ted-lerner-dead.html
TedLerner(1925-2023)
Net worth > $6.6 billion
Expiration date: Feb. 12, 2023 Dead at Age 97.
►Ted Lerner was a self-made billionaire who
conjured up a real estate empire out of the
help of a $250 loan from his wife.
►He became one of the biggest real estate
developers in D.C. and owner of the
Washington Nationals.

133. Who Missed the Longevity Boat
Sim Wong Hoo was a Singaporean inventor & billionaire
entrepreneur known for founding Creative Technology, a
designer/manufacturer of computer products, most
famouslytheSoundBlasteraudiocards.
At age 45, he became the youngest billionaire in Singapore.
https://www.wsj.com/articles/sim-wong-hoo-creator-of-sound-blaster-inspired-asian-tech-innovators-11673622316
SimWongHoo(1955-2023)
Net worth > $1 billion
Expiration date: Jan. 4, 2023
Dead at Age 67. (Heart Disease?)

134. Who Missed the Longevity Boat
https://www.nytimes.com/2022/10/24/world/europe/dietrich-mateschitz-dead.html
DietrichMateschitz(1944-2022)
Net worth > $27.4 billion
Expiration date: Oct. 22, 2022 Dead at Age 78.
►Dietrich Mateeschitz was a billionaire
businessman best known as the co-founder
and 49% owner of Red Bull GmbH.
►Mateschitz personally donated 70 million
euros for a research center on spinal cord
injuries.

135. Peter Buck (1930-2021)
Expiration date: Nov. 18, 2021
Net worth ~ $1.7 billion https://www.forbes.com/profile/peter-buck/
Who missed the longevity boat?
►Nuclear physicist Peter Buck loaned Fred
DeLuca $1,000 in 1965 to start a shop that
became the franchise-only chain Subway,
having 40,000 locations, exceeding McDonalds.
►Buck donated more than $200 million to his
PCLB Foundation, which supports focuses on
family issues.
►Dead at the age of 90.

137. “Scientists are reverse-
engineering patients’ own
skin or blood cells to behave
similarly to embryonic cells
and using them in tests to
treat incurable diseases.”
| March 23rd, 2023
“The Personalized Stem Cells That Could
One Day Treat Parkinson’s and Heart Failure”
www.wsj.com/articles/stem-cells-parkinsons-disease-heart-failure-60e9e21f?

138. FDA Delays Age-Reversal Clinical Trials

139. Human Age Reversal Project
$1,120,000
Goal: Statistically Significant
Human Age Reversal
age-reversal.net/donate

140. Harsh Penalty for
Challenging
Government Authority

141. October 11th, 1988

142. Petition FDA-Congress to
Amend Clinical Trial Constraints
age-reversal.net
Over 10,000 people were asked…only 314 signed!

143. age-reversal.net
To view this presentation, sign Petition,
and pre-register for Perpetual Project:

144. April 5th, 2023
“only about 1 in 5 interventions end up in routine clinical practice”
https://jamanetwork.com/journals/jama/fullarticle/2803716
“It Takes an Average of 17 Years for Evidence to Change Practice—the
Burgeoning Field of Implementation Science Seeks to Speed Things Up”
“Why aren’t clinicians in the community
using evidence-based practices?”
17 Year Wait For Better Treatments!
“Eventhen…
New term:
“Implementation
Science”

146. RAADfest 2023
Anaheim, California
William Faloon
September7th,2023
What’s Delaying
Regenerative Medicine?