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Process Intensification
Contract R&D at TNO




 TNO | Knowledge for Business




Martijn de Graaff - Business Development Manager
Current forces in the process industry


                    Competitive forces (€)
                        • More cost-efficient processing
                             - raw materials
                             - energy consumption
                             - waste treatment
                        • More consistent quality
                        • Shorter time-to-market



                    Regulatory forces
                        • Environmental
                        • Safety
                        • Quality control


2   Process Intensification at TNO
                                                           European Roadmap for Process Intensification
Process Intensification at TNO
    Continuous process technology that replaces batch technology for
     economical and ecological efficiency.
      Mainly in specialties, fine chemicals & pharmaceuticals.




    Technical hurdles
       • Downstream processing and integrated process control
       • Multi-phase / multi-purpose processes
       • Cost-effective Scale up
3   Process Intensification at TNO
TNO Process Intensification Strategy

    1.    Invest & cooperate in integration of technologies.
    2.    Invest & cooperate in piloting & demonstration.
    3.    Exploit individual TNO technologies
    4.    Involve all stakeholders from the PI ecosystem.




4   Process Intensification at TNO
TNO Project approach

    We work with customers and partners in the following way:

          • Contract R&D

          • Consultancy

          • Process evaluation

          • Feasibility studies

          • Scale-up conceptual engineering

          • Demonstration & pilot plant testing

          • Licensing

5   Process Intensification at TNO
Technologies      TNO Technology portfolio




                  Continuous reactors              Separation technology    Process Analysis & Control
    Competences




                               Integration of operations            Piloting & Scale-up
6                 Process Intensification at TNO
TNO technology portfolio - Details
    Separation technologies           Reactor technologies         Analytical technologies

       Crystallization based                                         Sensor technologies



                                          TNO Helix® reactor                Flowmeters
        TNO    HWC®    purification


                                                                          Particle monitors


      TNO HWC® solvent switch
                                        Microreactor technology            FBG sensors

          Membrane based                                           Interpret, model & control




      Pertraction                       Membrane slurry reactor   Chemometrics & data processing
                                MGA




               Pervaporation                                           Model predictive control

7   Process Intensification at TNO
Track record industrial pilots & demonstrations




8   Process Intensification at TNO
For more information please contact:

                                     Dr. Jean-Marie Bassett
                                     Business Development Manager
                                     Chemicals & Separation Technology
                                     jean-marie.bassett@tno.nl
                                     +31 (0)15 269 2833
                                     +31 (0)6 104 804 73



                                     Ir. Martijn P. de Graaff
                                     Business Development Manager
                                     Chemical & Life Science Equipment
                                     martijn.degraaff@tno.nl
                                     +31 (0)15 269 2243
                                     +31 (0)6 222 608 71


9   Process Intensification at TNO

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Process Intensification at TNO

  • 1. Process Intensification Contract R&D at TNO TNO | Knowledge for Business Martijn de Graaff - Business Development Manager
  • 2. Current forces in the process industry Competitive forces (€) • More cost-efficient processing - raw materials - energy consumption - waste treatment • More consistent quality • Shorter time-to-market Regulatory forces • Environmental • Safety • Quality control 2 Process Intensification at TNO European Roadmap for Process Intensification
  • 3. Process Intensification at TNO Continuous process technology that replaces batch technology for economical and ecological efficiency. Mainly in specialties, fine chemicals & pharmaceuticals. Technical hurdles • Downstream processing and integrated process control • Multi-phase / multi-purpose processes • Cost-effective Scale up 3 Process Intensification at TNO
  • 4. TNO Process Intensification Strategy 1. Invest & cooperate in integration of technologies. 2. Invest & cooperate in piloting & demonstration. 3. Exploit individual TNO technologies 4. Involve all stakeholders from the PI ecosystem. 4 Process Intensification at TNO
  • 5. TNO Project approach We work with customers and partners in the following way: • Contract R&D • Consultancy • Process evaluation • Feasibility studies • Scale-up conceptual engineering • Demonstration & pilot plant testing • Licensing 5 Process Intensification at TNO
  • 6. Technologies TNO Technology portfolio Continuous reactors Separation technology Process Analysis & Control Competences Integration of operations Piloting & Scale-up 6 Process Intensification at TNO
  • 7. TNO technology portfolio - Details Separation technologies Reactor technologies Analytical technologies Crystallization based Sensor technologies TNO Helix® reactor Flowmeters TNO HWC® purification Particle monitors TNO HWC® solvent switch Microreactor technology FBG sensors Membrane based Interpret, model & control Pertraction Membrane slurry reactor Chemometrics & data processing MGA Pervaporation Model predictive control 7 Process Intensification at TNO
  • 8. Track record industrial pilots & demonstrations 8 Process Intensification at TNO
  • 9. For more information please contact: Dr. Jean-Marie Bassett Business Development Manager Chemicals & Separation Technology jean-marie.bassett@tno.nl +31 (0)15 269 2833 +31 (0)6 104 804 73 Ir. Martijn P. de Graaff Business Development Manager Chemical & Life Science Equipment martijn.degraaff@tno.nl +31 (0)15 269 2243 +31 (0)6 222 608 71 9 Process Intensification at TNO