Decision Making Across Health Care Providers, Patients,...

Decision Making Across Health Care Providers, Patients,...
There is a failure in using the research evidence to inform decision making across health care
providers, patients, managers, and policy makers. This knowledge to action gap needs behaviour
change, practice or policy change [94]. Behaviour change is a complex process, it needs an
assessment of the health care system to identify the adaptability and feasibility of change, and
facilitators and barriers to change [95]. Therefore, this gap has to be addressed using effective
knowledge translation interventions, which may result in improve health outcomes among patients
[94]. Knowledge Translation (KT) is defined as "a dynamic process that includes exchange,
synthesis, and application of knowledge to improve patient outcomes, provide more effective
services and products and strengthen the healthcare system" [96]. "This process takes place within a
complex system of interactions between researchers and knowledge users" [97]. The aim of The KT
interventions implementation is to facilitate using the evidence–based practices within the
healthcare system [94]. Implementing KT interventions need "unique skills including an
understanding of the health care context and how to effect change in addition to the ability to
develop relationships with relevant stakeholders in the implementation process" [94]. Implementing
KT research needs a framework to be used as a guideline. There are many models and frameworks
to guide KT research projects, this may cause confusion [98–101]. However,
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The IPIP-NEO Test
Personality #3
What the IPIP– NEO test was trying to measure, was comparing my results to other males less than
21 years of age in the United States. The test helps estimate the levels of how well you relate to the
five factors of personality. The test breaks down the five factor model by showing six subdomains in
each category of the five factor personality model to help get a more clear, and better understanding
of the score i relate to. How the test measures your score is if you score a fifty on a section for
example your levels will be estimated to be higher than 50 percent.
My test scores for extraversion is average, meaning i enjoy time with others, but also time alone,
which I believe is a true statement about my personality. The highest subdomain I scored on the
extraversion test was the activity level, I live a very busy life being a full time student and also
maintaining a job is very fast paced. My ... Show more content on Helpwriting.net ...
The highest subdomain in the category is trust, it assumes that people are fair and honest, I always
believe when i meet people to not judge a book by its cover and think that person is trustworthy
until proven against so. My scores for conscientiousness were high, which means i set clear goals
and pursue them with determination, for example i'm very determined to finish college, and that's on
my mind constantly is to finish it out. The highest subdomain i scored on the conscientiousness
section is self discipline, an example is I hardly get upset if i can't do something right i realized that
practice takes time. My score on the neuroticism test was average, meaning that stressful and
frustrating situations are upsetting to me which is typical among the general population, but
according to the subdomain will soon get over the situation and cope with these situations. The
highest score I got on the

The World Health Organization Quality Of Life Essay
WHOQOL–SRPB
The World Health Organization Quality of Life, (WHOQOL) assessment instrument is a 100
question Likert scale, which assesses an individual 's quality of life in seven domains. These seven
domains and 24 subdomains ask quality of life questions in the following subject matter: physical,
psychological, level of independence, social relationships, environmental, spiritual beliefs, and
overall health (2016). These questions respond to the definition of Quality of Life as an individual 's
' perception of satisfaction with their life as it pertains to culture, goals, and expectations in
American society (See Appendix A).
Reliability
The WHOQOL–SRPB instrument was a convenience sample of 404 patients and workers of a
university hospital between 2006 and 2009. The sample was stratified by sex, age, health status and
religion/belief. The retest of the two first instruments was conducted with 54 participants (Pavia,
2015). The WHOQOL has been retested for reliability in 23 countries including United
States(Skevington, 2004).
Validity
The General SRPB–Domain showed construct validity, with a discriminatory validity between
spiritual beliefs, and concurrent criterion validity between individuals who display characteristics of
depression (Pavia, 2015). The convergent validity of WHOQOL–SRPB was 0.73. A high value of
Cronbach's alpha 0.94; (95% CI 0.91–0.96)
WHOQOL–BREF
The WHOQOL–BREF assessment instrument is a 26 question Likert scale, instrument which
measures the

American History Website Evaluation Essay
The American Revolution Website Evaluation
The United States revolution is one of the most iconic events in not just American, but world
history. So when performing research on a platform as vast as the internet, proper precautions must
be taken. A well designed and thorough web evaluation should be done to ensure the credibility and
integrity of the website's content. Certain Criteria involve who authored the website, when the
website was created, when it was last updated, who the website was intended for, what types of
resources the website offers, and the sites overall value to the reader.
The website www.ushistory.org is a very informative website that tells about the people and events
of the American Revolution. The website ... Show more content on Helpwriting.net ...
Another informative and authoritative website about the American Revolution is
www.theamericanrevolution.org. The website is authored and updated by Joseph Logan, who is a
self–proclaimed historian and revolutionary enthusiast. He frequently works with schools and
universities to inform and educated students on the revolutionary period. The site was originally just
a way for Logan to document and share his readings about the revolutionary leader John Adams.
However, after only one year, the site started to explode exponentially. Logan read over 200 books
about the revolution and documented everything he could from revolutionary leaders to iconic
events. This extensive research is reflected in the wide amount and detailed writings about the
revolution. The last update took place in February of 2010 however since this type of website is very
static in nature, that update was a fairly recent one. Originally created for middle and high school
students, this website now informs readers of all ages and education levels. The resources and
content that this website offers is beyond valuable. Every single revolutionary leader from Adams to
Wilson has a biography and picture associated with them. The site also has summaries and related
documents to all of the major battles in the war. Including how

Exploratory Summary
Patients and Methods This study was a part of an exploratory analysis of a sample of COPD patients
evaluating the relationship between fatigue and serum biomarkers of autoimmunity. Initially we
demonstrated that in patients with COPD the presence of fatigue is associated with worse health
status, lung function and exercise capacity.The protocol of this clinical study was approved by the
Ethics Committee of the University of Medicine and Pharmacy `Gr. T. Popa` Iași, România.
Participants who were willing to participate based on signed informed consent were subsequently
enrolled. Inclusion criteria for COPD patients consisted of: COPD diagnosis known for at least one
year, absence of systemic corticosteroids in the therapeutic regimen during the ... Show more
content on Helpwriting.net ...
This questionnaire has several subdomain scores including Vitality, Physical Functioning or
Emotional Role Functioning and two component scores Physical (SF–PCS) respectively Mental
(SF–MCS), the scores ranging from 0 (worst possible) to 100 (best possible) [10]. In this study, SF–
36 was used to compare HRQoL in both populations and in particular, to detect the presence of the
clinically significant fatigue: this is defined with scores for Vitality subdomain of 50 or less. This
cut–off being validated in other autoimmune debilitating diseases such as multiple sclerosis or
rheumatoid arthritis [11–13]. Health status (HS) was evaluated only in COPD patients with the
disease–specific Clinical COPD Questionnaire (CCQ). This has a 10 items and three domain scores
for symptoms (CCQ–S), mental status (CCQ–M)and functional status (CCQ–F), and it also has a
total score (CCQ–T) [14]. Higher scores are associated with worse health

Fundamentals Of Ssl Certificates And Certificate...
The Fundamentals of SSL Certificates and Certificate Authorities (CA) By adding an SSL
certificate, Experts Exchange members not only protect their business but also increase customer
confidence by safely encrypting their customers' most sensitive data. For online transactions, an SSL
certificate turns sensitive data into encrypted secure code. The web browser then checks the SSL
certificate to make sure that the website is legitimate. Once verified, the web browser and server
processes the encoded information. This helps to ensure that the sensitive data delivered between the
web browser and server is handled safely, securely, and that the website is PCI (Payment Card
Industry) compliant. Certificate Authorities (CA) play an integral role in the entire SSL process
because they're the ones issuing these digital certificates. In essence, digital certificates, such as an
SSL, are small verifiable data files containing identity credentials that help authenticate the online
identity of people, websites, and devices. Each digital certificate includes valuable information like
the expiration date of the certificate, the owner's name and other important information, along with a
public key – a value provided by some designated authority as an encryption key. As a trusted entity
issuing these digital certificates, the CA must meet strict and detailed criteria before being accepted
as a member. Once accepted, the CA is authorized to distribute SSL certificates. The longer the

Cerebral Palsy Research Paper
Cerebral Palsy has become increasingly prevalent in our communities and it is important to
understand what cerebral palsy is and how it affects language acquisition for those reasons. There
are many linguistic subsets of language that are affected by cerebral palsy and this essay goes into
depth the details concerning those aspects influenced. Cerebral Palsy is classified as a physical
health disorder that affects the acquisition of language in the domains of receptive and expressive
language by delaying the onset of phonology, semantics, syntax, and vocabulary development.
Overall, there is a lot to learn about cerebral palsy and the influence it has on language and ways
that these delays can be improved or managed.
Cerebral palsy is classified ... Show more content on Helpwriting.net ...
Communication difficulties associated with cerebral palsy can be multifactorial, arising from motor,
intellectual and sensory impairments. Children with this diagnosis can and often do have mild to
severe difficulties in expressing themselves. This can include production of speech, language or
even gestures due to their poor muscle control, which all influence communication. The process of
speech therapy first starts off with a referral and its goal it to maximise their ability communication
as best they can and to help them be as independent as possible during social interactions or
activities. To improve on both of these there are a few ways to go about it. A speech therapist can
choose to introduce an augmentative and alternative communication (AAC) system. An AAC, is a
communication method used to supplement or replace speech or writing for people with
impairments in the production or comprehension of spoken or written language. There are things
such as symbol charts and communication aids with synthetic speech. However, a speech therapist
can also choose to just treat the children's natural forms of communication, without a supplement.
Many types of remedies are available to people with cerebral palsy, but sadly there is not a lot of
evidence on their ability to improve symptoms

Explain The Two-Step Aminoacylation Reaction Between Aars...
The two–step aminoacylation reaction that is required to attach an amino acid to the tRNA is
displayed in Figure 6.
Figure 6: Word equation for the 2–step aminoacylation reaction within aaRS's. Please note that aa
(amino acid), aaRS (aminoacyl tRNA synthetase), and aaRS.aa–AMP (amino acyl adenalate) are the
abbreviations within the word equation. Adapted from Ibba, M 2000:
Within the first step of the reaction, the binding of the ATP to the enzyme induces a conformational
change, allowing the specific amino acid to bind to the aaRS, thus forming the active amino acid
AMP complex (aaRS.aa–AMP). The amino acid binds to the aaRS such that the carboxy terminus of
the amino acid is bound to the tRNA in step 2, and a O=C–O bond is formed between the OH group
of the 3' end of the tRNA and the amino acid. The DHU loop and the anticodon nucleotides are
important structural features that determine the specificity between the amino acid and tRNA. A
covalent bond is formed ... Show more content on Helpwriting.net ...
To prevent incorrect amino acid joining to a tRNA, an editing domain is required. The 3.90.740.10
(connecting–peptide domain) is a post–transfer editing and proofreading domain, which hydrolyses
the misacylated tRNA, and is found in ValRS, IleRS and LeuRS. For example, isoleucine is larger
than valine by just one methyl group, therefore these aaRS's need to distinguish between the smaller
amino acids to ensure the correct amino acid is transferred to the tRNA. The 3.90.740.10 domain is
inserted into the catalytic core and if valine enters the editing domain, it will be hydrolysed and
broken down, as is too small to accommodate the binding of isoleucine (Arnez. J, 2009).
1.10.730.10 (Orthogonal bundle) is another example of an editing domain, and helps with the
binding of the correct bases to the anticodon (Sugiura et al.

The Importance Of Sports
Sport is an activity involving physical effort and skills there are governed by a set of rules and often
undertaken competitively. Therefore, sport is a type of physical activity. In order to have a better
health, there are couple factors we should consider, not only we should have balanced, healthy, and
nutritional meals, but also exercise and other physical activities played an important role in a healthy
lifestyle. The paper will explain how culture and other factors such as educational difference and
social status affect our abilities to maintain a better health or a healthy lifestyle. In big events that
have participants with different ethnicities from different countries competing together, such as the
Olympic Games, different marathons, and the Ironman Triathlon. Especially in certain events in the
Olympic Games, for example, China has been the most successful nation in table tennis, winning a
total of 53 medals (28 gold, 17 silver, and 8 bronze). Since 1992, Chinese players have won at least
one medal in every event. Does genetic played an important role in terms winning or hard work
beats talent? Through different studies from different articles. In the first article "Cultures and Sports
Preference" by Kasem Nakornkhet, sports and recreational activities are part of a culture. Since
games and sports in certain societies help provide social interaction and when an individual won
certain events it help gain influence and honor. In the investigation, researchers

Mathematics : Computational Mesh And Grid
LITERATURE REVIEW:
COMPUTATIONAL MESH AND GRID
DEPENDANCY
(Technical Report by Vignesh)
ABSTRACT
The purpose of this paper is to explain the generation of computational meshes for complex
problems having intricate shapes and to study the grid dependency for obtaining accuracy in those
problems. In finite element method of numerical computation it is important to divide the domain
into a number of simple elements.
Some portion of domain may require still smaller elements so that the computation is more accurate
there. A large number of algorithms have been proposed to automate the process of mesh generation
but they do not guarantee about the quality of results produced. Some methods which eliminate the
problem of intersection in elements are discussed.
INTRODUCTION
Mesh generation has received immense attention from assorted scieŶtific aŶd engineering branches
since the emergence of numerical methods for partial differential equations. During the past few
decades, many sequential methods have been proposed, some of which are now very popular and
commercially available[1].
Several algorithms are being proposed to automate this process of grid generation.
Some of them are Sweepline algorithm,
Ruppert's algorithŵ, BidivisioŶ procedure,
Parallel mesh generation etc.
CLASSIFICATION OF MESH
Structured Mesh:
Structured meshes are those in which the topology of elements is regular. They are generally easy to
compute but may require more number

Adaptive Behavior Analysis
The Vineland Adaptive Behavior Scales, Second Edition, Teacher Rating Form (Vineland–II TRF)
provides acomprehensive assessment of personal and social sufficiency for students aged 3 through
21 years in a school, preschool, or structured day care setting. Adaptive behavior refers to an
individual's typical performance of the day–to–day activities required for personal and social
sufficiency. The Vineland–II TRF Adaptive Behavior Composite standard score summarizes a
student's performance across all adaptive behavior domains. Elliot has an Adaptive Behavior
Composite standard score of 50, which is Low when compared to other students his age in the TRF
norm group. Different areas of adaptive functioning are assessed by the Communication, Daily

Gross Motor Domain Case Study
Out of the five domains that were assessed in the BDI–2 assessment, the area where Aidan
performed the highest and received the highest score was in the Motor domain, where he scored a
104, which falls into the average range. The motor domain then includes three subdomains– gross
motor, fine motor, and perceptual motor. The gross motor domain assesses the child's development
of their large muscles that they use to walk, run, throw, and catch, among other movements and
activities. Within the gross motor domain, Aidan received a subdomain standard score of eleven,
which falls in the average range. This puts his developmental age at three–years and four months.
Aidan's strengths in this area are that he is able to use both of his legs to kick ... Show more content
on Helpwriting.net ...
Aidan received a standard score of 71, which falls into the mild developmental delay range. This
domain is then grouped into three subdomains; attention and memory, reasoning and academic
skills, and perception and concepts. In the attention and memory subdomain, the child is assessed in
their ability to recognize and attend to various situations around them, and their ability to remember
certain information. In this domain, Aidan received a standard score of 3, which falls into the
delayed range, and is consistent to the developmental age of a one–year, nine–month child. One of
Aidan's strengths in this area was that he is showed his ability to pay attention during a certain
activity for up to three minutes. He was also able to find an object that was under one of of the two
cups being used. One thing Aidan is still working on is reciting words from a movie or from a book
when asked. One other activity that Aidan did not yet master was pointing to the one hand that had a
toy in it. In the second subdomain, reasoning and academic skills, Aidan received a score of 8,
which is in the average range. This is consistent to the developmental age of 2 years and 6 months.
One of Aidan's strengths in this area was his ability to match similar colors together. Another one of
his strengths was that he was able to stack nesting blocks on top of one another according to their
size. Two things Aidan is still working on is naming his colors and identifying and grouping
common objects. The third and last subdomain is perception and concepts. Aidan received a
standard score of 3 in this subdomain, which falls under the delayed range. This also states that his
developmental age is at 2 years and 2 months. Aidan showed his strengths of matching the same
shapes together, building puzzles, and identifying objects that were familiar to him.

The Need For Multi Store For B2b Solutions
The Need for Multi–store for B2B Solutions The Need for Multistore for B2B Solutions Multistores
grow increasingly popular on world–class B2B eCommerce platforms for many reasons, but the
primary factor that fuels the trend is customer convenience. Unique branding options, popular store–
within–store applications, simplified ordering, easier–to–find product information, dedicated
manufacturer catalogs and creating regional stores are among the top benefits of creating multiple
stores in one B2B platform. The benefits of establishing multiple stores within an eCommerce
platform framework include: Creating niche shops that can provide greater focus and visibility on
key products and brands Enhancing the ability to close deals without ... Show more content on
Helpwriting.net ...
The trends of B2B eCommerce favor platforms where customers can find multiple products and
services from a range of manufacturers, product vendors and service providers. These B2B
marketplaces are gradually taking over the traditional, static website that offers only one supplier
even when the supplier markets a vast range of products and services.[1] Multistores make shopping
easier for buyers by categorizing products in greater detail. That makes it easier for advanced
structural engineers to find the construction products they need without having to wade through
pages designed for neighborhood handymen and plumbers. About 33 percent of procurement
specialists complain that their biggest ordering difficulty is finding product information because
many suppliers carry too many products and ordering options for simplified ordering.[2] An
astonishing 89 percent of survey respondents also expressed a desire for B2B ordering as simple and
compelling as consumer

The Proposed Framework, Information Security Human Factor...
The proposed framework, Information Security Human factor framework has two dimensions;
organization & employee dimensions. Each dimension has two domains, under the organization
dimension there is environment and management domains. Environment domain relates to cultural
and regulation issues while the management domain is concerned with mainly security policies and
practice of information security. The next dimension is the employee dimension. Preparedness and
responsibility domains are included in this dimension. Preparedness is concerned with security,
education, training and awareness while the responsibility domain is concerned with mainly
employee practice and performance. Figure 2
The proposed framework considers the SCT and previous other research of human factors in
information security. From the proposed Information Security human factor framework, domains of
the proposed framework relate to the SCT factors in a couple of ways. Firstly, the SCT
environmental factors relate to environment and management domains (Organization dimension) of
the proposed framework. Secondly, SCT's cognitive and behavioral factors are in relation with the
employee dimension of the proposed framework.
The proposed framework is further enhanced by mapping factors considered in previous studies thus
identifying subdomains of the four main domains (environment, responsibility, management,
preparedness). The below table lists the domain, human factors and previous studies that

Increase In Online Q & A Websites
In recent years, we observed increasing in online Q&A websites, such as Stack Exchange, Quora,
and Yahoo! Answer etc. These websites become a favourite destination for most of internet users,
because they are able to asking any question in any field, and share it with community, and then they
receive the answer from different sources. User's questions can be ranking using up or down voting;
also user's answers can be ranking using up or down voting and accepting as correctly or incorrectly
answer. Stack Exchange is a network of Q&A websites for different domains lunched in 2010; it is
consist of 133 Q&A websites and contains 3.7M questions asked and 17.9M comments according to
stack exchange statistics at 2015 [1]. In presence of ... Show more content on Helpwriting.net ...
The objective for these studies is to improve the performance of Q&A websites and to satisfy the
user's demands. Liu and Eugene [9] study the behaviour of expert answerers, they depend on the
topic of the question, and how the expert chose a question to answer on it. They used a Yahoo!
Answer n build their model. Qiongjie et.al [10] proposed a model to predict if the answer will be
selected as best answer or not, depending on Stack Overflow answers; they extracted features from
the answers textual content, and then apply random forest classifier. Liu, Duen–Ren, et al [12]
proposed a model to find a right expert user to answer a specific question depending on expert's
reputation; they tested their model on Yahoo! Answers website. 3. DATA COLLECTION AND
FILTRATION Stack Exchange website provides a dump data for all subdomains including in it,
throw archive website [2]. Each dump data represents a user–contributed content on specific stack
exchange community, and it contains 8 xml files representing information about: 3.1. Data Source
We downloaded the ProWebmaster dump data from archive website [2] in November 15, 2017 to
analyse and play with it, the size of zipped dump data was 57.4MB. 3.2. Data filtration After process
of downloading the ProWebmaste dump file, we use a SQL Server 2012 to Import these xml files
into SQL database and convert these

The Developmental Assessment Of Young Children Second...
The Developmental Assessment of Young Children–Second Edition (DAYC–2) is a test given to
children from birth through age 5 to measure if there are any delays in the early childhood
development through the five different domains: cognition, communication, social–emotional
development, physical development, and adaptive behavior. This test is individually administered
and is norm referenced measure of early childhood development. – The Cognitive Domain measures
the child ability to conceptual think, measure memory, and mental process. – Communication
Domain measures the ability to comprehend language and express his thoughts, which is divided
into two subdomains: Receptive Language and Expressive Language. – Social–Emotional Domain
measures social awareness, social relationships, and social competence. This will help the child
form meaning relationships with parents or caregivers in their environment. – Physical Development
Domain measures motor development, which is divided into two subdomains: Gross Motor and Fine
Motor. – Adaptive Behavior Domain measures the ability to achieve daily tasks. If the child scores
below average in one or more domains or 2 or more standard deviations below the mean they are
eligible for services. Procedure: Administration: In order to achieve accurate results, the examiner
must determine the correct age. This isn't just the child's chronological age, but the child's month
age as well. The child's age has to be written out in months

Security Flaws And Weaknesses And Vulnerabilities
The entire security testing process is performed so that security flaws and software vulnerabilities
can be reviled. There have been many system security breaches lately like Home Depot, Apple Pay
competitor Current C and Home Depot that has prompted companies to look more seriously at tools
and techniques that they can utilize to better identify and analyze potential threats and
vulnerabilities. The main objective of security testing is determining how vulnerable the systems are
and if the data and resources contained on those systems are protected against potential intruders.
The chart below outlines several common tools that can be used to identify and analyze potential
threats and vulnerabilities.
Tools Technique or way the tool ... Show more content on Helpwriting.net ...
Nessus This tool is an excellent vulnerability scanner which features asset profiling, high speed
discovery of sensitive data, configuration auditing, and vulnerability analysis. This tools scanners
can be spread throughout an entire enterprise, used inside DMZs, and also utilized across multiple
physically separate networks.
Nmap This tool is what's known as a Network Mapper. This tool is mainly used as a network
discovery scanner and as a security auditing tool. This tool can determine the availability of hosts on
a particular network through the use of raw IP packets. The tool can also determine what services (
including application name and version) the hosts is offering, as well as what OS and versions they
are running. This tool can also determine the type of firewalls and/or packet filters that are in use,
and other important characteristics of the network environment.
Zed Attack Proxy This tool is a very useful penetration testing tool that can be used to find
vulnerabilities in web applications. This tool is simple to use and almost anyone with or without
security experience can become functional testers even if they are new to penetration testing.
Paros This tool is a HTTP/HTTPS proxy that is Java based and it is mainly used for assessing the
vulnerability of web applications. This scanner is capable of intercepting all of the data in HTTP and

Security Policies And Control And Password Management...
Security policies are rules and guidelines formulated by an organization to manage access to
information systems and/or computer networks. Simply put, these policies exist to govern
employees, business partners, and third–party contractors with access to company assets.
Furthermore, some policies exist to comply with laws and regulatory requirements. These policies
are part of the company information security management system (ISMS), and are usually
administered to employees by Human Resources or distributed to business partners and contractors
via the Technology department. In sum, security policies protect assets from illegal or damaging
actions of individuals. Of course, many security policies exist, but this review will focus on the ...
Show more content on Helpwriting.net ...
These standards appear in the ISO/IEC 27000 series, the industry recognized best practices for
development and management of an ISMS (pg. 68 of CISSP). To clarify, ISO 27002 Information
Technology Security Techniques Code of Practice for Information Security Management module
falls within the ISO 27000 Framework. Ultimately, HHI's objective will be to comply with industry
standards and governmental regulations by designing sound security policies using ISO 27000
standards.
As has been mentioned in the previous section, the ISO/IEC developed the ISO 27000 framework,
which includes the ISO 27002 standards (page 37). Furthermore, the ISO 27002 standards contain
12 domains; nevertheless, this review will focus on the Access Control domain to rewrite the new
user and password requirement policies. Moreover, the Access Control domain has seven
subdomains:
Business Requirements for Access Control;
User Access Management;
User Responsibilities;
Network Access Control;
Operating System Access Control;
Application and Information Access Control;
Mobile Computing and Teleworking.
Specifically, the Network Access Control subdomain delves into user access management and user
responsibilities. In summary, the ISO 27002 standards encompasses 12 domains to "establish
guidelines and principles for initiating, implementing, maintaining, and improving information
security management within and organization

Tele 5330 : Data Networking
TELE 5330 – DATA NETWORKING ASSIGNMENT #3 Name: Prashanth Reddy Edunuri 1. I.
SComm is under LAN (Local Area Network) Sundar Communications (SComm) which resides in
Tewksbury, Massachusetts is a small company and within the same building. By definition,
connections must be high speed and comparatively low–priced. MNets is under LAN (Local Area
Network) Magesh Networks (MNets) which is based in Burlington, Massachusetts is a small
company and within the same building. By definition, connections must be high speed and
comparatively low–priced. SM Inc. is under WAN (Wide Area Network) SM Inc. is a new venture
formed by merging SComm and Mnets. Larger networks that are usually spanned in the different
city or town come under WAN (even different states, countries and continents). Tewksbury and
Burlington both are different towns in Massachusetts. II. They would approach Tier II ISP or Tier III
ISP to merge their networks. Tier II ISPs purchase their internet service from a tier I ISP and tends
to cover a specific region and take attention on business customers. Tier III ISPs also purchase their
internet service from a tier I ISP and tends to cover a specific region and focus on the retail market.
Buying hundreds of megabytes, more likely tier II will quote higher than tier I. We can use tier II or
tier III as they are small start–up companies planning to merge and form a new venture. We should
be aware of speed

Mercury Recover Essay
This review is of the case study conducted on the cleanup operations of the Mercury Recover
Facility located in Albany, New York. In 1956 the Mercury Refining Company (MERECO) began
accepting mercury–containing waste such as batteries, thermometers, and dental amalgams, and
refining it for sale (VanGuilder, 2012). MERECO also reclaimed silvers and other precious metals at
their facility. Because MERECO was receiving waste from off–site companies and storing them on–
site, they were deemed a commercial hazardous waste facility. From 1955 until 1980, MERECOs
contaminated waste was dumped over an embankment on their property into an unnamed tributary
that led to Patroon Creek ("Human Exposure," 2005). After a structural fire in 1981, water used ...
For subdomains I and II, no recommendations could be identified. The primary challenges in these
zones is the connection of achieving site wide remedial objectives, and decisions and actions.
Another recommendation is to invest in basic research for the possibility of decommissioning
buildings and to remediate soil, limiting the mercury in the food chain (Looney, 2008). The
workshop had greater success in subdomain III, identifying several recommendations. Because
mercury input in surface water happens in this subdomain, the workshop determined that stannous
chloride could be used to treat water in NS pipes, and sodium thiosulfate could be used as a
dechlorinating agent. With access to the water and the use of chemistry, alternative strategies of
reducing methylmercury in fish are available (Looney, 2008). Finally, the workshop had also
identified recommendations in subdomain IV. The workshop noted that the addition of trace Se
could be used to reduce methylation uptake while potentially maintaining low fish tissue levels. The
workshop also noted that through other technology, physical modifications such as bank
stabilization and channel relocation could be a possibility

Domain Name System Or Dns Is A Mechanism For Resolving...
Domain Name System or DNS is a mechanism for resolving host names into Internet Protocol (IP)
addresses and IP addresses back into host names. This is important because personally I feel as
though it can be kind of challenging to remember IP addresses so like a phone book if you don't
know a person's number but you can remember their name it can make things a whole lot easier. So
basically DNS is essentially providing that same service to computers. Paul Mockapetris originally
designed DNS at the University of California, Irvine in 1983 but many others have helped in the
development of DNS to make it what it is today. Before that a protocol name Advanced Research
Projects Agency Network (ARPANET) was being used but a rapid growth of networks required a
new system for maintaining the host names and addresses. ARPNET was created by Dr. Jon Postel.
In 1984, a couple UC Berkeley students wrote the first Unix name server implementation. It was
called the Berkeley Internet Name Domain (BIND) Server. In 1985 it was revised and has since
been then it has been a widely distributed mostly on Unix systems, and which is still the most
widely used DNS software on the Internet. Before I go into more details about DNS, I will go
through a quick run through on how to install DNS. It is actually pretty simple to install/configure
DNS but you need to make sure you have the prerequisites installed before DNS can be setup.
Installing a DNS server involves adding the DNS server role to an

Investigating New Sampling Strategies At Domain Level For...
Investigating New Sampling Strategies At Domain Level for Reliability Assessment
ABSTRACT
The objective of software testing technique is to expose failures. Testers prioritize inputs based on
the acquired quality attribute, e.g., correctness, robustness, reliability, security. When high reliability
is to be achieved, tester wishes to sample those failure–causing inputs that have the largest impact
on failure probability. This is the procedure followed by techniques based on the expected
operational proﬁle to derive tests. Testing software pose many practical challenges for assessing or
improving reliability. General Operational testing is a fundamental strategy that simulates the real
usage of the system in order to expose failures with the highest occurrence probability. Testing
relied on operational proﬁle estimation, known as operational testing, is considered as the natural
approach to test software for reliability assessment or improvement.
The field of software testing that relates to testing a software 's ability to function, given
environmental conditions, for a particular amount of time is called SRT(Software reliability testing).
SRT discovers many problems in the design of software and functionality. The application of
computer software is in different fields, with software being an essential part of industrial,
commercial and military systems. Because of its many application,software reliability is now an
important research area. Although software

The Multidimensional Model Of Leadership
After undergoing a dramatic and angst–ridden season, the Victorian Korfball Senior Team is in need
of significant transformation if there is any hope of fostering a high performance culture in the new
season. Due to their history of conflict, the players in their present state lack any indications of
cohesion. Selecting the right athletes for the new team will play a significant role in the baseline
level of cohesion. Each of these areas can be addressed through a method of careful analysis via the
Multidimensional Model of Leadership (Chelladurai & Saleh 1978), implementation of an
appropriate intervention and the structuring of a consultative leadership environment.
The scenario at hand is riddled with emotions and is hence sensitive and complex. Having been
absent from the situation responsible for athlete conflict, walking into this coaching role without
consideration for ones' actions and the emotional reactions they would incite could potentially be
detrimental (eg: further conflict, damaged relationships). As such, this situation needs to be mapped
out and dissected for analysis. Application of the Multidimensional Model (Chelladurai & Saleh
1978) most appropriately addresses this, allowing complex situations to be broken down into three
domains: antecedents, coach behaviour, and the resulting consequences. Each of these are then
comprised of several subdomains; antecedents considers the characteristics of the coach, the players
and the situation presiding over them;

DNS Essay
The Domain Name System or DNS is an international address system developed to ensure that
every computer connected to the Internet has its own address. DNS assigns addresses to Internet
web servers [10]. However, in the DNS system, that address is actually a set of numbers like
173.194.39.78. This set of numbers is called the computer's Internet Protocol (IP) address.
The Domain Name System is most often described as the Internet's phone book or address book. All
of us Internet users use it on daily basis without even realizing it. Its basic task is to convert human–
readable website name like coursera.org into its computer–readable numerical IP address like
107.21.240.231.Since such strings of numbers are difficult for humans to memorize, DNS allows
you to assign a domain name, such as facebook.com to you IP address. So, the domain name is
simply an address on the Internet. It has to be unique just like physical address or phone number.
Computers (and other network devices like smartphones or tablets) use IP addresses to identify each
other on the network and route your request to the site you are trying to access. It is just like dialing
a phone number to reach the person you want to talk to, but thanks to DNS, you don't need to
maintain your own address book of IP addresses. You will simply connect via DNS server (also
called "domain name server" or just "name server"). Domain name system servers match domain
names like coursera.org to their associated IP addresses.

Identity Status And Well Being Among Emerging Adults...
Identity Status and Well–being among emerging adults studying Psychology at RMIT University
Courtney Andrews Royal Melbourne Institute of Technology University Abstract A study involving
232 young adults studying Developmental Psychology at RMIT was carried out in order to examine
the correlation between the four identity statuses, in both the domains of 'ideological', 'interpersonal'
and 'wellbeing' in 8 subdomains. Each participant completed a confidential, 78 item online survey.
The core results that respondents provided categorised majority of young people within the
ideological diffusion status, with the least number placed within interpersonal foreclosure.
Alongside this finding, wellbeing was positively correlated with identity achievement and
negatively correlated with Identity foreclosure, with no separation of ideological and interpersonal
domains. Interpersonal moratorium and diffusion were also both negatively correlated with most of
8 subdomains of wellbeing. This research needs to consider the samples gender inequality, using
only correlational data and whether using one–time data collection would impact the results. Identity
Status and Well–being among emerging young adults There is no doubt that there are many things
that can contribute to a young, emerging adult's wellbeing. The theory that prompted research on
young adults distinctive characteristics, in other words,

What Is The Effects On The Fluid Dynamics Of The Addition...
Direct numerical simulations of FENE–P fluid have been used to analyze a time–dependent drag
reducing flow between parallel plates for turbulent regimes at (–– removed HTML ––) Re (––
removed HTML ––) (–– removed HTML ––) (–– removed HTML ––) h (–– removed HTML ––)
(–– removed HTML ––) = 1500 and (–– removed HTML ––) Re (–– removed HTML ––) (––
removed HTML ––) (–– removed HTML ––) h (–– removed HTML ––) (–– removed HTML ––) =
4000. In order to investigate the effects on the fluid dynamics of the addition of a polymer, these
viscoelastic flows were compared to two Newtonian cases at the same Reynolds numbers. We
simulated our viscoelastic cases fixing (–– removed HTML ––) Wi (–– removed HTML ––) (––
removed HTML ––) (–– ... Show more content on Helpwriting.net ...
The polymer–turbulence exchanges of energy were then investigated for each one of these
subdomains. (–– removed HTML ––) (–– removed HTML ––) Figure (–– removed HTML ––) 14
(–– removed HTML ––) summarizes the principal four stages related to the DR mechanism at the
beginning of the phenomenon. The open symbols denote the mean streamwise velocity profiles,
while the rotating lined arrows represent vortical (or elliptical, E) parts, the straight lined arrows
represent the extensional (or hyperbolic, H) parts, and the purple line illustrates the polymers. The
exchanges of energy between these four entities at each stage are represented by the dashed arrows.
First, at stage 1 [Fig. (–– removed HTML ––) 14(a) (–– removed HTML ––) ], the flow is primarily
laminar and, consequently, the wall shear stress is equal to the laminar one ( (–– removed HTML
––) τ (–– removed HTML ––) (–– removed HTML ––) (–– removed HTML ––) (–– removed HTML
––) (–– removed HTML ––) (–– removed HTML ––) w (–– removed HTML ––) (–– removed
HTML ––) (–– removed HTML ––) (–– removed HTML ––) (–– removed HTML ––) = (––
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Proposed Network Solution for Worldwide Advertising, Inc....
At the core of any successful business is a functioning, well–organized network. The design of that
network can be a daunting task for even the most skilled of Information Technology and Networking
Professionals. To make that task more manageable it's easier to divide it up into the key components
needed to implement a successful network design. In this proposal we will go through those key
areas and understand the needs of Worldwide Advertising Inc. and some of the suggested solutions
specific to the organization. Deployment and Server Editions Server Editions WAI is a relatively
small sized company in regards to IT needs and specifically when it comes to determining the
Windows Server 2012 edition that is appropriate. ... Show more content on Helpwriting.net ...
Beyond that server roles include things like managing the company email and website, print
services, backups and Active Directory. Each of our locations will have a physical presence so
determining the best roles to deploy at each location will take some careful consideration. Server
roles are the things a particular server does like Files Services, Email Services, or Active Directory.
Most of the critical roles will need to be installed on the equipment at the main office in Los Angeles
but since we have a functioning office in New York some server roles might need to be replicated at
that location to provide functionality for the network. Server Locations Although the company could
operate normally with all of the physical server equipment being located in one of the two locations
based on the budget we would recommend having some equipment at both locations. The Los
Angeles is clearly the primary location as most of the staff including IT will be located there but by
having some redundancy at the New York location we could provide a much higher level of
availability. This means that an outage or breach of security at the Los Angeles location could be
minimized since we could transition to the New York equipment as the primary. These redundancies
are extremely critical in our line of work. We can't afford to lose creative data that could take weeks

Essay On Epidermal Keratinization
The highly regulated process of epidermal keratinization is the result of differential expression of
within the epidermis. Basal keratinocytes express intermediate filament keratins 5 and 14.
Suprabasal keratinocytes express keratins 1 and 10, which comprises approximately 85% of total
proteins found in fully differentiated keratinocytes. Types I & II intermediate filaments (keratins)
(Figure 3) are composed of three domains: (1) a central alpha–helical rod domain, (2) an amino–
terminal head, and (3) a carboxyl–terminal tail domain both the head and tail globular domains
contain end, variable, and homologous subdomains. The central α–helical domain is approximately
330 amino acids long and is divided into four subdomains (1A, 1B, 2A, and ... Show more content
on Helpwriting.net ...
Sometimes, an electron dense thin line can be seen underneath hemidesmosomes, outside the cell
and adjacent to the plasma membrane. This structure is referred to as the sub–basal dense plate. The
hemidesmosome is composed of at least 5 distinict molecules: (1) bullous pemphigoid antigen 1
(BPAG1), (2) plectin, (3) integrins, (4) collagen XVII (BPAG2) (5) CD151. The first two molecules,
BPAG1 and plectin, are found within the basal keratinocyte, and have been localized to the inner
plaque of the hemidesmosome.[13]
The next two molecules, α6β4 integrin, and collagen XVII extend beyond the basal keratinocyte
membrane and into the lamina lucida layer of the basement membrane zone and hence they are
known as transmembrane molecules. These latter two molecules can be found within the outer
plaque of the hemidesmosome. The last molecule, CD151, the most recently discovered molecule, is
closely associated with α6β4 Integrin, and resides at or near the surface of the basal cell plasma
membrane. The intermediate filaments attach to BPAG1 and plectin, which compose the
hemidesmosome inner plaque. Both plectin and BPAG1 belong to the plakin family of proteins, and
share significant sequence homology.[14]
BPAG1 was one of the first hemidesmosomal components identified and has been associated with
bullous pemphigoid since the late 1990's. BPAG1 exists in several different isoforms, but it is the
230 kDa

Subdomain 724.7
SUBDOMAIN 724.7 – PROFESSIONAL ROLES & VALUES 1 SUBDOMAIN 724.7 –
PROFESSIONAL ROLES & VALUES Delegation Orchid Quiton Chefalo Western Governors
University Nursing Program 11/11/2011 Revised 11/30/2011 12/10/2011 SUBDOMAIN 724.7 –
PROFESSIONAL ROLES & VALUES 2 Delegation It takes a team approach to manage patient–
care. As a FNP, and a provider for this patient, she could collaborate with other experts and delegate
care of the patient. The nursing supervisor for the clinic can aid the FNP to identify her role in the
best utilization of the ... Show more content on Helpwriting.net ...
The goals of appropriate delegation are "All decisions related to delegation and assignment are
based on the fundamental principles of protection of the health, safety, and welfare of the public"
(ANA, NCSBN). If the FNP, in her nursing judgment, feels the care of the patient is better served at
another facility that can provide certain services that her clinic cannot provide, and then it is
appropriate and lawful to transfer care. The role of the nursing supervisor is to make sure the
appropriate steps of the delegation process is within the practice guidelines; The "Five Rights of
Delegation" (NCSNB, 1995). They are "right task, right circumstances, right person, right direction
and communication, and right supervision and evaluation" (NCSBN, 1995). Therefore, nursing
supervisor is still accountable for the delegation process even when the nurse may not have control
of delegation: "The RN may delegate components of care but does not delegate the nursing process
itself. The practice pervasive functions of assessment, planning, evaluation and nursing judgment
cannot be

Coma Membrane: Lipid Rafts
Lipid rafts are defined as the subdomains of the plasma membrane that exist as distinct liquid–
ordered regions of the membrane [1]. These membrane domains preferentially arise due to the
interaction of specific lipids. They are mobile, dynamic and insoluble in non–ionic detergents such
as Triton X–100 [2]. Lipid rafts are enriched in cholesterol, sphingolipids and phospholipids within
cell membranes (Figure 1).
Figure 1. Organization of lipid rafts (Note the higher concentration of cholesterol and sphingolipids)
within the raft region. (Image: WikiBooks Structural Biochemistry/Lipids/Lipid Rafts).
Sphingomyelin (SM) (also called ceramide phosphocholine), a type of sphingolipid, is a ubiquitous
component of the animal membrane [3].The major sources of sphingomyelin are the bovine brain,
egg yolk and milk [4]. It is, being analogous of phosphatidylcholine, typically consists of a ceramide
unit with a phosphocholine moiety attached to position 1. A typical example of sphingomyelin is a
d18:1/16:0 molecular species: ... Show more content on Helpwriting.net ...
These lipid rafts have been proposed to serve many functions in cell signalling, membrane
trafficking and signal transduction [7]. There are some special types of proteins (e.g.,
transmembrane proteins and GPI–anchored proteins) that can anchor on the nanodomains to play an
important role in transporting chemicals through the membrane [8]. Sphingomyelin rich rafts act as
hotspots or platforms to enable transmembrane proteins to aggregate so that they can promote cell
signalling events

The diacylglycerol (DAG) mediated regulation of protein...
The diacylglycerol (DAG) mediated regulation of protein kinase C (PKC) family of serine/threonine
kinases plays a critical role in several intracellular signaling pathways and the pathology of several
diseases including cancer, neurological, cardiovascular, and others. In consequence, PKC isozymes
are being actively pursued as the subject of intense research and drug development. Depending on
their enzymatic properties and activation mechanism, the mammalian PKC isoenzymes have been
categorized into classical (calcium–, DAG–, and phospholipid–dependent), novel (calcium–
independent, but DAG– and phospholipid–dependent), and atypical (calcium– and DAG–
independent) subgroups. The DAGs selectively interact with the C1 domain of PKC isoenzymes. ...
Therefore, C1 domains have become an attractive objective in designing selective PKC ligands.
There are two functionally nonequivalent C1 domains (C1a and C1b) positioned in tandem within
the regulatory domain of classical and novel PKC isozymes. The PKCα–C1a and PKCθ–C1b
subdmains shows higher DAG binding affinity than the C1b and C1a subdomain respectively. For
PKCδ–C1b/a subdomains, conflicting results have been reported regarding their DAG binding
affinity. Accumulating evidences suggest that anionic phospholipids like PS, phosphatidic acid (PA)
and phosphatidylglycerol (PG) enhance the DAG dependent membrane binding affinity and PKC
activity; although the anionic phospholipid dependence varies considerably among the PKC
isozymes. Among the classical PKCs, PKCα and PKCβII prefer PS to PG, whereas PKCγ shows
comparable affinity for PS and PG. Among the novel PKCs, PKCδ and PKCθ show a certain degree
of PS selectivity, whereas PKCε shows preference for PA. In case of isolated C1b subdomains,
similar selectivities have been observed for PKCδ, PKCθ and PKCε. Whereas the PKCβII–C1b
subdomain shows little preference between PS and PG. However, the reported experimental
measurements used either only DAG or a combination of separate DAG and anionic lipid molecules
in solution or under liposomal environment to determine the DAG dependent membrane binding
capabilities of the

The On Infringement Of Trade Marks And Spencer Private...
The following are some of the responses from various aspects of the society, which lays down the
duties as well as the responsibilities for the whole society:
5.1 The Judicial Response
There have been numerous judgments in India on infringement of Trade Marks through Domain
Name registration in UK, Spain, Italy, France and others. Depending on the nature of the
infringement, these violations have been called, in the absence of any standard terminology, by
various names like Cyber–squatting, Passing–off, Name–grabbing etc. Nearer home in India, when a
Website called htpp:/marks and Spencer.co. UK came up, Marks and Spencer Private Company
Limited had to seek judicial remedy against the British Company named 'One in a Million' for a
restraint order.
It was held that the name Marks and Spencer could not have been chosen for any other reasons
except that it was associated with the well known retailing group . In another case, it was held that
the Internet domain names are of importance and can be valuable corporate assets and that a domain
name is more than an Internet address. A company carrying on business of communication and
providing services through the Internet, carried a domain name "REDIFF" which had been widely
published. The defendant company also started using the same domain name transcripting it as
"RADIFF". It was found that the only object in adopting this domain name was to trade upon the
reputation of the plaintiff's domain name. An injunction was ordered

ELL Summary And Analysis
ELL stands for English Language Learners and are often students from countries which do not speak
English that come to school to learn not only the regular content that a school teaches but also the
English language. One of the many issues teachers face in helping students learn the content in class
is the challenge of integrating the students' native language along with the content of the lesson.
Studies have shown that "3 years of exposure to English is not long enough for all individual ELLs
to catch up to their monolingual peers for all subdomains of language" (Paradis, 2016). To properly
teach ELL students both content for subjects as well as the English language teachers need to help
integrate English and the students' native language

Tele 5330 : Data Networking
TELE 5330 – DATA NETWORKING
ASSIGNMENT #3 Name: Prashanth Reddy Edunuri
1.
I. SComm is under LAN (Local Area Network)
Sundar Communications (SComm) which resides in Tewksbury, Massachusetts is a small company
and within same building. By definition, connections must be high speed and comparatively low–
priced.
MNets is under LAN (Local Area Network)
Magesh Networks (MNets) which is based in Burlington, Massachusetts is a small company and
within same building. By definition, connections must be high speed and comparatively low–priced.
SM Inc. is under WAN (Wide Area Network)
SM Inc. is a new venture formed by merging SComm and Mnets. Larger networks that are usually
spanned ... Show more content on Helpwriting.net ...
We should maintain high speed connectivity.
III. We will be using Classless IP addressing in the existing internal networks.
The classless IP addressing is commonly known as Classless Inter Domain Routing
(CIDR). This method is used for allocating IP addresses and routing Internet Protocol packets. CIDR
is introduced by IETF in1993 to substitute the prevailing hierarchical addressing in network.
We are using 192.168.53.53/24, which comes under CIDR. We will assign different IP address based
on our required. We are not confined to use only one class for whole network. We provide the
network with different subnet masks in the same network to enable efficient use of IP address.
IV. We will be using Classless IP addressing in the existing internal networks.
The classless IP addressing is commonly known as Classless Inter Domain Routing
(CIDR). This method is used for allocating IP addresses and routing Internet Protocol packets. CIDR
is introduced by IETF in1993 to substitute the prevailing hierarchical addressing in network.
We are using 10.10.10.1/30, which comes under CIDR. We will assign different IP address based on
our required. We are not confined to use only one class for whole network. We provide the network
with different subnet masks in the same network to enable efficient use of IP address.
2.

NAME TTL TYPE DATA/VALUE test.com 1800 Type NS dns1.test.com dns1.test.com 1800 Type
A 192.168.1.1 test.com 1800 Type CNAME a.test.com

Standardized Measurement Analysis
No more long standardized academic test for public school students! Students and parents protest
near public schools all over the country along with lawmakers. One parent stated "my children are
not learning what they are supposed to learn school, they are only learning how to pass the test". A
unanimous student stated "I want to focus more on my curriculum at school, but like many other
students I get anxious about scoring high on these tests so I only focus on the tests". An angry
teacher with 16 years of experience wants to be able to have more time to teach her students all the
subjects so they can be prepared for college. She stated "I don't like where the public school system
is going, it seems that our organization pressure us for ... Show more content on Helpwriting.net ...
Again, long standardized tests have been designed so that each item contributes to the reliability of
the score. By reducing items from the test, it will lower the test reliability. Item selection is one of
the sources of measurement error. Having low items in a test will show low measurement precision.
For example the state of Illinois uses the National Assessment of Educational Progress (NAEP), it is
the only national assessment of what America's students know and can do in various subject areas
according to the Illinois State Board of Education. If we would to shorten this test by reducing the
items, then we would have difficulty validating the scores. Why? Because the tests also required to
report the subdomain scores. If we would to reduce the items per subdomain then it would further
reduce the value of domain scores (Kruyen et al., 2013). Further reducing items in the tests means
that each item is valued stronger, for example let's compare a 50 and a 26 item test. In order to score
50% in a 50 item test you would have to get 25, whereas in a 26 item test you would have to get 13.
Shortening the tests might decrease administration time in taking the test but it does not decrease
test anxiety for the students. Knowing that each item is valued stronger could potentially increase
their test anxiety

Tissues Specific Roles For Two Grp170 Chaperones Loci
Tissues Specific Roles for Two GRP170 Chaperones Loci in Protein Folding in Caenorhabditis
Elegans
Mengxin Wang
OVERVIEW
The cellular functions of chaperones are vital to all living organisms from prokaryotes to man.
Molecular chaperones are stress proteins that are involved in inhibition of protein aggregation and
that participate in numerous normal cellular processes such as protein folding, assembly, and
transportation of secretory or transmembrane proteins. The largest chaperone is the glucose–
regulated protein 170 (Grp170). It it evolutionarily related to the hsp70 superfamily and resides in
the endoplasmic reticulum (ER). It is induced by stress conditions such as hypoxia, ischaemia,
glucose deprivation, reductive reagents, anoxia ... Show more content on Helpwriting.net ...
One limitation of the early work on UPR induction is that it analyzed who worm gene expression. It
did not look to see if the response was limited to particular tissues or if GRP170 is essential to
normal protein folding throughout the nematode. The goal of my research is to investigate the tissue
specificity of the role of GRP170a and GRP170b in protein folding. To study the cell specificity of
UPR, I will use a reporter transgene that expresses GFP in cells undergoing UPR. I will conduct
genetic crosses to introduce this transgene into a genetic background deficient for GRP170a or
GRP170b. I will use fluorescence microscopy to identify which cells in the GRP170 deficient
worms are undergoing UPR. That will indicate which cells GRP170's are essential for normal
protein folding. Learning which cells depend on GRP170 will provide insight into the role of
GRP170 of the multicellular animals.
INTRODUCTION
The cellular functions of chaperones are vital to all living organisms from prokaryotes to man.
Molecular chaperones are stress proteins that are involved in inhibition of protein aggregation and
that participate in numerous normal cellular processes such as protein folding, assembly, and
transportation of secretory or transmembrane proteins. A newly synthesized polypeptide chain must
fold to its energetically stable, native, tertiary or

The Catalytic Subunit: B-family of Replicative DNA...
The catalytic subunit–Polα
Polymerase α is the first mammalian polymerase detected. It is a member of the B–family of
replicative DNA polymerases. Its primary role is to further extend the RNA primer by addition of
deoxy–nucleotides (dNTPs) into a total of 20–25 nucleotides of RNA–DNA primer. Generally,
replicative DNA polymerases, polymerize dNTPs by catalyzing nucleophilic attack of the 3'–
hydroxyl group of the primer onto the α–phosphate of an incoming dNTP aligned to the template
strand. The accuracy of the polymerases is achieved by a confirmation of the correct base pairing of
the incoming dNTP and the template strand according to Watson–Crick base–pairing. The accuracy
of the primases is further enhanced (100 fold) by their exonuclease activity where in the event of a
mismatch the growing strand is pushed back to the exonuclease active and the mismatched
nucleotide is excised.
Most of our structural knowledge of the B–family of DNA polymerases came from the structure of
the prototypical family member, bacteriophage RB69 Pol (Wang et al., 1997 in elife). Followed that
the structure of the bacterial DNA Pol II (Wang and Yang, 2009 in elife) and then yeast Pol δ (Swan
et al., 2009). Only recently, the crystal structure of the catalytic domain of the yeast Pol α subunit,
Pol α 349–1258, has been solved (elife). The structure confirmed that Pol α shares a polymerase and
an exonuclease domains similar to RB69 Pol, bacterial DNA Pol II and yeast Pol δ. Unlike the other

The Innate Immune System
In the initial phase of an infection, the innate immune system generates a rapid inflammatory
response that blocks the growth and dissemination of the infectious agent. This response is followed,
in vertebrates, by the development of an acquired immune response in which highly specific B and
T cell receptors recognize the pathogen and induce responses that lead to its elimination (Janeway,
Jr. et al., 2002). The antigen receptors of the acquired immune system are well characterized. They
consist of many structurally similar molecules with different binding specificities created by somatic
rearrangements and mutations within the binding site regions of the B and T cell receptor variable
domains (Jung et al., 2004;Schatz et al., 2005). By contrast, the receptors of the innate immune ...
All ECDs assume the typical horseshoe–shape, but their structures cannot be superimposed because
of variations in curvature. In the known structures, the glycans are
Botos et al. Page 3
Structure. Author manuscript; available in PMC 2012 April 13.
NIH–PAAuthor Manuscript NIH–PAAuthor Manuscript NIH–PAAuthor Manuscript distributed
throughout the molecule, except for the lateral face formed by the ascending loops of the LRRs
(Figure 2). This glycan–free face is involved in dimerization upon ligand binding in the known
TLR/ligand structures (see below).
The TLR1/2/6/10 subfamily
TLR2 resides on the plasma membrane where it responds to lipid–containing PAMPs such as
lipoteichoic acid and di– and tri–acylated cysteine–containing lipopeptides (Takeda et al.,
2003). It does this by forming dimeric complexes with either TLR1 or TLR6 on the plasma
membrane. The structures of TLR2/TLR1 and TLR2/TLR6 with lipopeptide ligands have been
determined (Jin et al., 2007;Kang et al., 2009). To facilitate crystallization and structure
determination the LRR–CT and the last one or two LRRs of TLRs 1, 2, and 6

Wgu Mgm Task 1
Table of Contents Course Weekly Timeline 3 TASK 1 Requirements 4 TASK 1 Rubics 5 TASK 1:
A1. Leadership Style Evalulation 6 A2. Leadership Style Comparison 9 A3. Effective Leader 11 A4.
Pitfalls 12 A4a. Overcoming Pitfalls 12 A5. Potential Synergies 13 References: 14 Week | Weekly
Assignments | Date Due | One | 1. Complete the Teamwork section of the course of study. 2.
Schedule and conduct first team meeting (Note: Detailed instructions for scheduling the first team
meeting can be found in the course of study.) 3. Complete the Team Contract and have team leader
submit to ... Show more content on Helpwriting.net ...
325.1.4: Leadership Ethics – The graduate identifies influences on ethical leadership and analyzes
the construction of a code of ethics. 325.2.1: Team Development – The graduate selects the
appropriate type of team structure for a project and proposes strategies and structures to build team
cohesion and effectiveness. 325.2.2: Improving Team Performance – The graduate analyzes the
performance of a virtual team and proposes strategies to improve team effectiveness. 325.4.2: Team
Communication – The graduate demonstrates best practices to overcome biases that inhibit
organizations and teams from communicating effectively. Task 1 Rubic A1. Leadership Style
Evaluation Provide a logical evaluation of the strengths and weaknesses of the candidate's
leadership style. A2. Leadership Style Comparison Provide an appropriate comparison of the
candidate's leadership style to that of 2 team members. A2a. Leadership Styles Includes 2 leadership
styles in the comparison. A3. Effective Leader Provide a logical discussion of how understanding
the leadership styles of team members helps the candidate become a more effective leader. A4.
Pitfalls Provide a logical explanation of 3 ways to overcome the pitfalls. A5. Potential Synergies
Provide a logical discussion of the potential synergies that may exist between leadership styles and
how you can capitalize on them to increase productivity. A1. Leadership Style Evaluations

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