This is a Mettler-Toledo Webinar scheduled for September 23, 2008.

1. Optimization of the Ugi reaction using parallel synthesis and automated liquid handling Jean-Claude Bradley Sept 23, 2008 Mettler-Toledo Webinar E-Learning Coordinator College of Arts and Sciences Associate Professor of Chemistry Drexel University

2. Open and Closed Science Traditional Lab Notebook (unpublished) Traditional Journal Article Open Access Journal Article Open Notebook Science (full transparency) CLOSED OPEN Traditional Paper Textbook F2F lectures Lectures Notes public Assigned problems public Archived Lectures Public and free online textbooks RESEARCH TEACHING

4. UsefulChem Project: Open Primary Research in Drug Design using Web2.0 tools Docking Synthesis Testing Rajarshi Guha Indiana U JC Bradley Drexel U Phil Rosenthal UCSF (malaria) Dan Zaharevitz NCI (tumors) Tsu-Soo Tan Nanyang Inst.

5. BLOG WIKI Mailing List GoogleDocs Architecture: Distributed, Interlinked and Redundant ChemSpider CDD FriendFeed Nature Precedings JoVE

6. Where’s the Beef?

7. Link to Lab Notebook Page in Wiki

8. Link to Molecules

9. Link to Docking Procedure (Rajarshi Guha)

10. Link to Docking Results: Lists of SMILES in GoogleDocs (Rajarshi Guha)

11. Link to Raw Data with JSpecView (data in JCAMP-DX format) (by Robert Lancashire)

12. Conclusion is Fully Supported

13. Comparing Experiments Ugi Master Table

15. Mettler-Toledo MiniBlock System

16. Mettler-Toledo MiniMapper

17. XML reports from MiniMapper robot

18. GoogleDoc to program and report

19. Paper written on Wiki

20. References to papers, blog posts, lab notebook pages, raw data

21. Paper on Journal of Visualized Experiments (JoVE)

22. Pre-print on Nature Precedings

23. Best Yield: 66% 0.4 M methanol 1.2 eq imine But… what are the trends?

24. At 0.2 Molar

25. At 0.2 Molar – complex solvent and reagent excess effects

26. Methanol 0.4M xs of imine best