Systemic Inflammatory Response Syndrome (SIRS) is an inflammatory state affecting the whole body, frequently in response to infection.

1. Systemic Inflammatory Response Syndrome (SIRS) Prognosis www.ipgdx.com

2. Systemic Inflammatory Response Syndrome (SIRS) is an inflammatory state affecting the whole body, frequently in response to infection. www.ipgdx.com Phase Angle a Prognostic Factor for Survival in SIRS

3. SIRS is nonspecific and not always related to infection. It is related to Sepsis ,a condition in which individuals both meet criteria for SIRS and have a known or highly suspected infection. www.ipgdx.com INFECTION SIRS SEPSIS Phase Angle a Prognostic Factor for Survival in SIRS

4. SIRS is defined as 2 or more of the following variables: Fever of more than 38°C or less than 36°C Heart rate of more than 90 beats per minute Respiratory rate of more than 20 breaths per minute or a PaCO2 level of less than 32 mm Hg Abnormal white blood cell count (>12,000/µL or <4,000/µL or >10% bands) www.ipgdx.com Phase Angle a Prognostic Factor for Survival in SIRS

5. SIRS is one of several conditions related to systemic inflammation, organ dysfunction, and organ failure. www.ipgdx.com SIRS Pancreatitis Trauma Burns Bacteraemia Irradiation ?? Infection Phase Angle a Prognostic Factor for Survival in SIRS

6. Leucocytes Endothelial cells Complement Plasmatic hemocoagulation system Platelets www.ipgdx.com Phase Angle a Prognostic Factor for Survival in SIRS

7. The causes of SIRS are broadly classified as infectious or noninfectious. www.ipgdx.com Causes: When SIRS is due to an infection, it is considered sepsis. Noninfectious causes of SIRS include trauma, burns, pancreatitis, ischemia and haemorrhage. Phase Angle a Prognostic Factor for Survival in SIRS

8. Septic shock is severe sepsis with hypo tension (systolic BP < 90mmHg) despite adequate fluid resuscitation or the requirement for vasopressors/inotropes to maintain blood pressure. www.ipgdx.com Phase Angle a Prognostic Factor for Survival in SIRS

9. Here is an excerpt of the clinical observation study from 23rd International Symposium on Intensive Care and Emergency Medicine. www.ipgdx.com It was concluded from the study that phase Angle acts as a predictor for survival in patients with SIRS . Phase Angle a Prognostic Factor for Survival in SIRS

10. PrognostiCheck ® for prognosis based upon a noninvasive diagnostic test measures the resistance,reactance and phase angle (in degrees).A low phase angle has been associated with an altered cellular membrane function. www.ipgdx.com Phase Angle a Prognostic Factor for Survival in SIRS

11. www.ipgdx.com Phase Angle a Prognostic Factor for Survival in SIRS Tests were conducted on 30 consecutive patients( 11 female, 19 male ,median age of 67 [ 16.5 ] years ) after admitting them to the intensive care unit ,all of whom met 2 or more SIRS Criteria.

12. In Septic shock patients,a phase angle of less than 4 degree has been reported to be associated with increases mortality. www.ipgdx.com Severity of the illness was characterized according to APACHE II(Acute Physiology and Chronis Health Evaluation) Phase Angle a Prognostic Factor for Survival in SIRS

13. Non-invasive impedance analysis was performed using a tetra-polar hand-to-foot measuring device and derived phase angle was calculated as arc tan (reactance/resistance). www.ipgdx.com increasing Reactance ( )‏ Phase Angle a Prognostic Factor for Survival in SIRS

14. All measurements were performed in the supine position of the patient with special care. www.ipgdx.com After 28 days, out of the 30 patients investigated, 10 had died and 20 survived. In seven out of 20 survivors,a phase angle of more than 4 degree was measured on the first day study,whereas in all patients who died,the phase angle was less than 4 degree (P=0.038) Phase Angle a Prognostic Factor for Survival in SIRS

15. The conclusion was that an initial phase angle of more than 4 degree may be correlated with survival,in patients suffering with SIRS. www.ipgdx.com Phase Angle a Prognostic Factor for Survival in SIRS

16. www.ipgdx.com [email_address] By IPGDx, LLC [email_address] For more information or inquiries regarding direct investments, collaborative product development and partnerships please contact below. PrognostiCheck R