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Global Healthcare Cold Chain Logistics Market Report & Forecast (2011-2016)
Report Description & Highlights
Driven by a strong growth in the sales of temperature sensitive healthcare products, the
demand for cold chain logistic services is currently experiencing explosive growth. IMARC
Group, one of the world’s leading research and advisory firms, finds that the total size of the
healthcare cold chain logistic services market is expected to expand from its current figures
of US$ 6.1 billion to nearly US$ 9.5 billion by 2016.


IMARC’s new report entitled “Global Healthcare Cold Chain Logistics Market Report &
Forecast (2011-2016)” provides an analytical and statistical insight into the logistic
opportunities in the global healthcare market. The study that has been undertaken using both
desk based as well as qualitative primary market research has analyzed three aspects of the
global healthcare cold chain logistics market.


The first aspect involves the quantification of the global market for temperature sensitive
healthcare products into three major classes and evaluation of the current and future
opportunities in each of these classes. The second aspect involves an in-depth understanding
on the global healthcare cold chain distribution process and logistic requirements for various
temperature sensitive healthcare products. The third aspect involves the quantification of the
global healthcare cold chain logistic services market and a comprehensive evaluation of its
various segments.


What we have achieved in this report:

Comprehensive Market Analysis of Temperature Sensitive Healthcare Products:
Classes Covered: Biopharmaceuticals, Vaccines & Clinical Trial Materials
Focus of the Analysis in Each Class:
         Drivers and challenges
         Historical sales trends
         Logistic requirements
         Impact of temperature excursions
         Opportunities in cold chain services
         Market outlook (2011-2016)




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Understanding the Operations of a Healthcare Cold Chain Distribution Process
Focus of the Analysis:
         Understanding    the   various    methods   of   cold   chain   distribution   and   their
         advantages/disadvantages
         Understanding the cold chain requirements for various temperature sensitive
         healthcare products and the impact of temperature excursions
         Understanding the various costs involved in cold chain transportation and comparing it
         with non-cold chain transportation
         Understanding the key steps required in the setting and organization of an efficient
         cold chain distribution process


Comprehensive Market Analysis of the Healthcare Cold Chain Logistic Services Market
Focus of the analysis:
         Quantifying the global healthcare cold chain logistic services market
         Quantifying the market size by product
         Quantifying the market size by service
         Quantifying the market size by region


Information Sources:
Information has been sourced from both primary and secondary sources:
         Primary sources include industry surveys and face to face/telephone interviews with
         industry experts.
         Secondary sources include proprietary databases and search engines. These sources
         include company websites and reports, books, trade journals, magazines, white
         papers, industry portals, government sources and access to more than 4000 paid
         databases.




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Table of Contents


1     Research Methodology & Market Definitions ................................................................................................. 10

2     Executive Summary .......................................................................................................................................... 12

3     The Global Healthcare Cold Chain Logistics Market ..................................................................................... 14

    3.1       Current Trends .......................................................................................................................................... 14
      3.1.1           Healthcare Cold Chain Products are Exhibiting Exponential Growth ................................................. 14
      3.1.2           Temperature Sensitive Healthcare Products Have Well Defined Logistic Needs............................... 15
      3.1.3           Outsourcing Trends in Research & Manufacturing Have Increased Logistic Demands ..................... 17
      3.1.4           Increasing Regulatory Focus on the Integrity of Transported Healthcare Products ........................... 19
      3.1.5           Cost is Not Always the Most Important Driver in Supplier Decisions ................................................. 21

4     The Global Healthcare Cold Chain Products Market ..................................................................................... 22

    4.1       Current Market Trends & Forecast .......................................................................................................... 22
    4.2       Market Segments ...................................................................................................................................... 25
      4.2.1           Biopharmaceuticals............................................................................................................................ 25
          4.2.1.1         Current Market Trends & Forecast ................................................................................................ 25
          4.2.1.2         Cold Chain Requirements for Biopharmaceuticals ........................................................................ 28
          4.2.1.3         Cold Chain Opportunities for Biopharmaceuticals ......................................................................... 30
      4.2.2           Vaccines ............................................................................................................................................ 36
          4.2.2.1         Current Market Trends & Forecast ................................................................................................ 36
          4.2.2.2         Cold Chain Requirements for Vaccines ......................................................................................... 38
          4.2.2.3         Cold Chain Opportunities for Vaccines .......................................................................................... 40
      4.2.3           Clinical Trial Materials ........................................................................................................................ 43
          4.2.3.1         Current Market Trends & Forecast ................................................................................................ 43
          4.2.3.2         Cold Chain Requirements for Clinical Trial Materials .................................................................... 46
          4.2.3.3         Cold Chain Opportunities for Clinical Trial Materials ..................................................................... 47

5     Healthcare Cold Chain Logistics: How Does It Operate? .............................................................................. 51

    5.1       Cold Chain Packaging & Transportation Methods ................................................................................ 51
      5.1.1           Dry Ice ............................................................................................................................................... 52
      5.1.2           Liquid Nitrogen ................................................................................................................................... 53
      5.1.3           Gel Packs .......................................................................................................................................... 54
    5.2       Modeling the Cost of Cold Chain Packaging & Transportation ............................................................ 56
    5.3       Setting Up a Cold Chain ........................................................................................................................... 57
      5.3.1           Initial Considerations .......................................................................................................................... 57
      5.3.2           Choosing the Correct Model .............................................................................................................. 58
      5.3.3           Regulatory/Custom Clearance ........................................................................................................... 59
      5.3.4           Final Stages ....................................................................................................................................... 59
      5.3.5           Quality Assurance .............................................................................................................................. 60

6     The Healthcare Cold Chain Logistic Services Market .................................................................................... 61

    6.1       Current Trends & Forecast ...................................................................................................................... 61


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6.2       Market Segmentation ............................................................................................................................... 63
      6.2.1           Market by Product .............................................................................................................................. 63
           6.2.1.1        Biopharmaceuticals & Vaccines .................................................................................................... 63
           6.2.1.2        Clinical Trial Materials ................................................................................................................... 64
      6.2.2           Market by Segment ............................................................................................................................ 66
           6.2.2.1        Packaging & Instrumentation ......................................................................................................... 66
           6.2.2.2        Transportation ............................................................................................................................... 68
      6.2.3           Market by Region ............................................................................................................................... 71
           6.2.3.1        North America................................................................................................................................ 71
           6.2.3.2        Europe ........................................................................................................................................... 72
           6.2.3.3        Asia Pacific .................................................................................................................................... 73
           6.2.3.4        Rest of the World ........................................................................................................................... 75

7     Challenges in the Healthcare Cold Chain Logistics Market .......................................................................... 77

    7.1       Cold Chain Infrastructure Remains Underdeveloped in Many Regions .............................................. 77
    7.2       Lack of Funding to Implement an Efficient Cold Chain Infrastructure ................................................ 77
    7.3       New Technologies Nullifying the Need of Cold Chains......................................................................... 78

8     Key Company Profiles ...................................................................................................................................... 80

    8.1       World Courier............................................................................................................................................ 80
    8.2       DHL ............................................................................................................................................................ 80
    8.3       Fedex ......................................................................................................................................................... 81
    8.4       United Parcel Service ............................................................................................................................... 82
    8.5       Kuehne and Nagel .................................................................................................................................... 82
    8.6       Cavalier Logistics ..................................................................................................................................... 83
    8.7       DB Schenker ............................................................................................................................................. 84
    8.8       Life ConEx ................................................................................................................................................. 84
    8.9       American Airlines Cargo .......................................................................................................................... 85
    8.10      Continental Air Cargo............................................................................................................................... 86
    8.11      Marken ....................................................................................................................................................... 86




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List of Figures

Figure 3-1: Global - Healthcare Cold & Non Cold Chain Products Markets (in Billion US$), 2009-2010...................... 14
Figure 3-2: Global - Healthcare Cold & Non Cold Chain Products Market Forecast (in Billion US$), 2011-2016 ........ 15
Figure 3-3: Global - Potency of the Tetanus Component of a DTP Vaccine Stored for 45 Days at Various
Temperatures ............................................................................................................................................................... 16
Figure 3-4: Global - Contract Research & Manufacturing Market (in Billion US$), 2007-2010 ..................................... 18
Figure 3-5: Global - Contract Research & Manufacturing Market Forecasts (in Billion US$), 2011-2016 .................... 18
Figure 3-6: Estimated Costs incurred in Various Pharmaceutical Operations .............................................................. 21
Figure 4-1: Global - Healthcare Cold Chain Products Market - Break up by Product (in %), 2009-2010 ..................... 24
Figure 4-2: Global - Healthcare Cold Chain Products Market Forecast - Break up by Product (in %), 2011-2016 ...... 24
Figure 4-3: Global - Biopharmaceutical Market (in Billion US$), 2008-2010 ................................................................ 26
Figure 4-4: Global - Biopharmaceutical Market Forecast (in Billion US$), 2011-2016 ................................................. 27
Figure 4-5: US & Europe - Biosimilar Sales & Forecast (in Million US$), 2007-2016 ................................................... 32
Figure 4-6: Global - Share of Biopharmaceutical Manufacturers Planning to Outsource Some Production to Contract
Manufacturers, (in %), 2006 & 2011............................................................................................................................. 33
Figure 4-7: Global - Biopharmaceutical Contract Manufacturing Market (in Billion US$), 2009-2010 .......................... 33
Figure 4-8: Global - Biopharmaceutical Contract Manufacturing Market Forecast (in Billion US$), 2011-2016 ........... 34
Figure 4-9: Global - Vaccine Market (in Billion US$), 2008-2010 ................................................................................. 37
Figure 4-10: Global - Vaccine Market Forecast (in Billion US$), 2011-2016 ................................................................ 37
Figure 4-11: Global - Vaccine Production Volume by Region (in %), 2008 .................................................................. 41
Figure 4-12: Europe - Vaccine Export Volume by Region (in %), 2008 ........................................................................ 42
Figure 4-13: Global - Clinical Trials Market (in Billion US$), 2009-2010 ...................................................................... 43
Figure 4-14: Time Taken for Biopharmaceuticals to Get Approved (in Months), 1982-2009........................................ 45
Figure 4-15: Global - Clinical Trials Market Forecast (in Billion US$), 2011-2016 ....................................................... 45
Figure 4-16: Number of Multinational Clinical Trials (Phase II and III) in Asian Countries by the Top Twenty Global
Pharmaceutical Companies* ........................................................................................................................................ 48
Figure 4-17: Global - Break up of Biopharmaceuticals & Small Molecule Drugs in Preclinical & Clinical trials, (in %),
2009 ............................................................................................................................................................................. 49
Figure 4-18: Top Reasons for Conducting Clinical Trials in Each Country (in %), 2009 .............................................. 50
Figure 5-1: A Typical Drug Supply Chain from the Manufacturer to the End User ....................................................... 51
Figure 6-1: Global - Healthcare Cold Chain Logistic Services Market (in Billion US$), 2008-2010 .............................. 61
Figure 6-2: Global - Healthcare Cold Chain Logistic Services Market Forecast (in Billion US$), 2011-2016 ............... 62
Figure 6-3: Global - Healthcare Logistic Services Market, Share of Cold-Chain & Non Cold-Chain Services, (in %),
2008 ............................................................................................................................................................................. 62
Figure 6-4: Global - Healthcare Cold Chain Logistic Services Market by Product (in %), 2010 & 2016 ....................... 63
Figure 6-5: Global - Biopharmaceuticals & Vaccines Cold Chain Logistic Services Market (in Billion US$), 2008-2010
..................................................................................................................................................................................... 64
Figure 6-6: Global - Biopharmaceuticals & Vaccines Cold Chain Logistic Services Market Forecast (in Billion US$),
2011-2016 .................................................................................................................................................................... 64
Figure 6-7: Global - Clinical Trial Materials Cold Chain Logistic Services Market (in Billion US$), 2008-2010 ............ 65
Figure 6-8: Global - Clinical Trial Materials Cold Chain Logistic Services Market Forecast (in Billion US$), 2011-2016
..................................................................................................................................................................................... 66



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Figure 6-9: Global - Healthcare Cold Chain Logistic Services Market by Segment (in %), 2010 & 2016 ..................... 66
Figure 6-10: Global - Healthcare Cold Chain Packaging & Instrumentation Services Market (in Billion US$), 2008-
2010 ............................................................................................................................................................................. 67
Figure 6-11: Global - Healthcare Cold Chain Packaging & Instrumentation Services Market Forecast (in Billion US$),
2011-2016 .................................................................................................................................................................... 68
Figure 6-12: Global - Healthcare Packaging & Instrumentation Services Market, Share of Cold-Chain & Non Cold-
Chain Services, (in %), 2008 ........................................................................................................................................ 68
Figure 6-13: Global - Healthcare Cold Chain Transportation Services Market (in Billion US$), 2008-2010 ................. 69
Figure 6-14: Global - Healthcare Cold Chain Transportation Services Market Forecast (in Billion US$), 2011-2016 .. 70
Figure 6-15: Global - Healthcare Transportation Services Market, Share of Cold-Chain & Non Cold-Chain Services,
(in %), 2008 .................................................................................................................................................................. 70
Figure 6-16: Global - Healthcare Cold Chain Logistic Services Market by Region (in %), 2010 & 2016 ...................... 71
Figure 6-17: North America - Healthcare Cold Chain Logistic Services Market - (in Billion US$), 2008-2010 ............. 72
Figure 6-18: North America - Healthcare Cold Chain Logistic Services Market Forecast - (in Billion US$), 2011-2016
..................................................................................................................................................................................... 72
Figure 6-19: Europe - Healthcare Cold Chain Logistic Services Market (in Billion US$), 2008-2010 ........................... 73
Figure 6-20: Europe - Healthcare Cold Chain Logistic Services Market Forecast (in Billion US$), 2011-2016 ............ 73
Figure 6-21: Asia Pacific - Healthcare Cold Chain Logistic Services Market (in Billion US$), 2008-2010 .................... 74
Figure 6-22: Asia Pacific - Healthcare Cold Chain Logistic Services Market Forecast (in Billion US$), 2011-2016 ..... 75
Figure 6-23: Rest of the World - Healthcare Cold Chain Logistic Services Market (in Billion US$), 2008 - 2010......... 75
Figure 6-24: Rest of the World - Healthcare Cold Chain Logistic Services Market Forecast (in Billion US$), 2011-2016
..................................................................................................................................................................................... 76
Figure 7-1: Financing Sources and Gaps (in %), 2008-2010 ....................................................................................... 78




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List of Tables



Table 3-1: Various Regulations on Healthcare Cold Chain Logistic Requirements ...................................................... 20
Table 4-1: Global - Healthcare Cold Chain Products Market - Break up by Product (in Billion US$), 2009-2010 ........ 23
Table 4-2: Global - Healthcare Cold Chain Products Market Forecast - Break up by Product (in Billion US$), 2011-
2016 ............................................................................................................................................................................. 24
Table 4-3: Global - Biopharmaceutical Market - Sales by Class (in Billion US$), 2008-2010....................................... 27
Table 4-4: Global - Biopharmaceutical Market Forecast - Sales by Class (in Billion US$), 2011-2016 ........................ 28
Table 4-5: Stability of Various Biopharmaceuticals at Room Temperature .................................................................. 30
Table 4-6: US & Europe - Launch Dates of Various Biosimilars................................................................................... 31
Table 4-7: US & Europe - Biosimilar Market Sales & Forecast (in Million US$), 2007-2016 ........................................ 32
Table 4-8: Complexity of the Manufacturing Process Involved with Biopharmaceuticals & Small Molecule Drugs ...... 35
Table 4-9: Temperature Stability of Commonly Used Vaccines ................................................................................... 39
Table 4-10: The Effect of Temperature Excursions on the Usability of Vaccines ......................................................... 40
Table 4-11: Global - Major Vaccine Production Sites (in Numbers), 2008 ................................................................... 41
Table 4-12: Global - Clinical Trials Market - Spending on Biopharmaceuticals & Small Molecule drugs (in Billion US$),
2009-2010 .................................................................................................................................................................... 43
Table 4-13: Global - Patent Expiry Risks of Big Pharmaceutical Companies, 2011-2013............................................ 44
Table 4-14: Global - Clinical Trials Market Forecast – Spending on Biopharmaceuticals & Small Molecule Drugs (in
Billion US$), 2011-2016 ............................................................................................................................................... 45
Table 4-15: Ideal Storage Temperatures for Clinical Trial Materials ............................................................................ 47
Table 5-1: Average Amount of Dry Ice for Packaging Frozen Goods in a Single Well Insulated Container ................. 52
Table 5-2: Dry Ice Containers ...................................................................................................................................... 53
Table 5-3: Refrigerated Shipping Containers with Gel Packs ...................................................................................... 56
Table 5-4 : Costs Associated With the Cold Chain Shipment of Healthcare Products, 2011* ...................................... 57
Table 5-5 : Costs Associated With the Non-Cold Chain Shipment of Healthcare Products, 2011* .............................. 57
Table 7-1: Cold Chain & Logistic Funding Gaps Per Infant (in US$), 2008-2010 ......................................................... 78




imarc©                                                                                                                                                                            9
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Global Healthcare Cold Chain Logistics Market Report & Forecast (2011-2016)

  • 2. Report Description & Highlights Driven by a strong growth in the sales of temperature sensitive healthcare products, the demand for cold chain logistic services is currently experiencing explosive growth. IMARC Group, one of the world’s leading research and advisory firms, finds that the total size of the healthcare cold chain logistic services market is expected to expand from its current figures of US$ 6.1 billion to nearly US$ 9.5 billion by 2016. IMARC’s new report entitled “Global Healthcare Cold Chain Logistics Market Report & Forecast (2011-2016)” provides an analytical and statistical insight into the logistic opportunities in the global healthcare market. The study that has been undertaken using both desk based as well as qualitative primary market research has analyzed three aspects of the global healthcare cold chain logistics market. The first aspect involves the quantification of the global market for temperature sensitive healthcare products into three major classes and evaluation of the current and future opportunities in each of these classes. The second aspect involves an in-depth understanding on the global healthcare cold chain distribution process and logistic requirements for various temperature sensitive healthcare products. The third aspect involves the quantification of the global healthcare cold chain logistic services market and a comprehensive evaluation of its various segments. What we have achieved in this report: Comprehensive Market Analysis of Temperature Sensitive Healthcare Products: Classes Covered: Biopharmaceuticals, Vaccines & Clinical Trial Materials Focus of the Analysis in Each Class: Drivers and challenges Historical sales trends Logistic requirements Impact of temperature excursions Opportunities in cold chain services Market outlook (2011-2016) imarc© 3
  • 3. Understanding the Operations of a Healthcare Cold Chain Distribution Process Focus of the Analysis: Understanding the various methods of cold chain distribution and their advantages/disadvantages Understanding the cold chain requirements for various temperature sensitive healthcare products and the impact of temperature excursions Understanding the various costs involved in cold chain transportation and comparing it with non-cold chain transportation Understanding the key steps required in the setting and organization of an efficient cold chain distribution process Comprehensive Market Analysis of the Healthcare Cold Chain Logistic Services Market Focus of the analysis: Quantifying the global healthcare cold chain logistic services market Quantifying the market size by product Quantifying the market size by service Quantifying the market size by region Information Sources: Information has been sourced from both primary and secondary sources: Primary sources include industry surveys and face to face/telephone interviews with industry experts. Secondary sources include proprietary databases and search engines. These sources include company websites and reports, books, trade journals, magazines, white papers, industry portals, government sources and access to more than 4000 paid databases. imarc© 4
  • 4. Table of Contents 1 Research Methodology & Market Definitions ................................................................................................. 10 2 Executive Summary .......................................................................................................................................... 12 3 The Global Healthcare Cold Chain Logistics Market ..................................................................................... 14 3.1 Current Trends .......................................................................................................................................... 14 3.1.1 Healthcare Cold Chain Products are Exhibiting Exponential Growth ................................................. 14 3.1.2 Temperature Sensitive Healthcare Products Have Well Defined Logistic Needs............................... 15 3.1.3 Outsourcing Trends in Research & Manufacturing Have Increased Logistic Demands ..................... 17 3.1.4 Increasing Regulatory Focus on the Integrity of Transported Healthcare Products ........................... 19 3.1.5 Cost is Not Always the Most Important Driver in Supplier Decisions ................................................. 21 4 The Global Healthcare Cold Chain Products Market ..................................................................................... 22 4.1 Current Market Trends & Forecast .......................................................................................................... 22 4.2 Market Segments ...................................................................................................................................... 25 4.2.1 Biopharmaceuticals............................................................................................................................ 25 4.2.1.1 Current Market Trends & Forecast ................................................................................................ 25 4.2.1.2 Cold Chain Requirements for Biopharmaceuticals ........................................................................ 28 4.2.1.3 Cold Chain Opportunities for Biopharmaceuticals ......................................................................... 30 4.2.2 Vaccines ............................................................................................................................................ 36 4.2.2.1 Current Market Trends & Forecast ................................................................................................ 36 4.2.2.2 Cold Chain Requirements for Vaccines ......................................................................................... 38 4.2.2.3 Cold Chain Opportunities for Vaccines .......................................................................................... 40 4.2.3 Clinical Trial Materials ........................................................................................................................ 43 4.2.3.1 Current Market Trends & Forecast ................................................................................................ 43 4.2.3.2 Cold Chain Requirements for Clinical Trial Materials .................................................................... 46 4.2.3.3 Cold Chain Opportunities for Clinical Trial Materials ..................................................................... 47 5 Healthcare Cold Chain Logistics: How Does It Operate? .............................................................................. 51 5.1 Cold Chain Packaging & Transportation Methods ................................................................................ 51 5.1.1 Dry Ice ............................................................................................................................................... 52 5.1.2 Liquid Nitrogen ................................................................................................................................... 53 5.1.3 Gel Packs .......................................................................................................................................... 54 5.2 Modeling the Cost of Cold Chain Packaging & Transportation ............................................................ 56 5.3 Setting Up a Cold Chain ........................................................................................................................... 57 5.3.1 Initial Considerations .......................................................................................................................... 57 5.3.2 Choosing the Correct Model .............................................................................................................. 58 5.3.3 Regulatory/Custom Clearance ........................................................................................................... 59 5.3.4 Final Stages ....................................................................................................................................... 59 5.3.5 Quality Assurance .............................................................................................................................. 60 6 The Healthcare Cold Chain Logistic Services Market .................................................................................... 61 6.1 Current Trends & Forecast ...................................................................................................................... 61 imarc© 5
  • 5. 6.2 Market Segmentation ............................................................................................................................... 63 6.2.1 Market by Product .............................................................................................................................. 63 6.2.1.1 Biopharmaceuticals & Vaccines .................................................................................................... 63 6.2.1.2 Clinical Trial Materials ................................................................................................................... 64 6.2.2 Market by Segment ............................................................................................................................ 66 6.2.2.1 Packaging & Instrumentation ......................................................................................................... 66 6.2.2.2 Transportation ............................................................................................................................... 68 6.2.3 Market by Region ............................................................................................................................... 71 6.2.3.1 North America................................................................................................................................ 71 6.2.3.2 Europe ........................................................................................................................................... 72 6.2.3.3 Asia Pacific .................................................................................................................................... 73 6.2.3.4 Rest of the World ........................................................................................................................... 75 7 Challenges in the Healthcare Cold Chain Logistics Market .......................................................................... 77 7.1 Cold Chain Infrastructure Remains Underdeveloped in Many Regions .............................................. 77 7.2 Lack of Funding to Implement an Efficient Cold Chain Infrastructure ................................................ 77 7.3 New Technologies Nullifying the Need of Cold Chains......................................................................... 78 8 Key Company Profiles ...................................................................................................................................... 80 8.1 World Courier............................................................................................................................................ 80 8.2 DHL ............................................................................................................................................................ 80 8.3 Fedex ......................................................................................................................................................... 81 8.4 United Parcel Service ............................................................................................................................... 82 8.5 Kuehne and Nagel .................................................................................................................................... 82 8.6 Cavalier Logistics ..................................................................................................................................... 83 8.7 DB Schenker ............................................................................................................................................. 84 8.8 Life ConEx ................................................................................................................................................. 84 8.9 American Airlines Cargo .......................................................................................................................... 85 8.10 Continental Air Cargo............................................................................................................................... 86 8.11 Marken ....................................................................................................................................................... 86 imarc© 6
  • 6. List of Figures Figure 3-1: Global - Healthcare Cold & Non Cold Chain Products Markets (in Billion US$), 2009-2010...................... 14 Figure 3-2: Global - Healthcare Cold & Non Cold Chain Products Market Forecast (in Billion US$), 2011-2016 ........ 15 Figure 3-3: Global - Potency of the Tetanus Component of a DTP Vaccine Stored for 45 Days at Various Temperatures ............................................................................................................................................................... 16 Figure 3-4: Global - Contract Research & Manufacturing Market (in Billion US$), 2007-2010 ..................................... 18 Figure 3-5: Global - Contract Research & Manufacturing Market Forecasts (in Billion US$), 2011-2016 .................... 18 Figure 3-6: Estimated Costs incurred in Various Pharmaceutical Operations .............................................................. 21 Figure 4-1: Global - Healthcare Cold Chain Products Market - Break up by Product (in %), 2009-2010 ..................... 24 Figure 4-2: Global - Healthcare Cold Chain Products Market Forecast - Break up by Product (in %), 2011-2016 ...... 24 Figure 4-3: Global - Biopharmaceutical Market (in Billion US$), 2008-2010 ................................................................ 26 Figure 4-4: Global - Biopharmaceutical Market Forecast (in Billion US$), 2011-2016 ................................................. 27 Figure 4-5: US & Europe - Biosimilar Sales & Forecast (in Million US$), 2007-2016 ................................................... 32 Figure 4-6: Global - Share of Biopharmaceutical Manufacturers Planning to Outsource Some Production to Contract Manufacturers, (in %), 2006 & 2011............................................................................................................................. 33 Figure 4-7: Global - Biopharmaceutical Contract Manufacturing Market (in Billion US$), 2009-2010 .......................... 33 Figure 4-8: Global - Biopharmaceutical Contract Manufacturing Market Forecast (in Billion US$), 2011-2016 ........... 34 Figure 4-9: Global - Vaccine Market (in Billion US$), 2008-2010 ................................................................................. 37 Figure 4-10: Global - Vaccine Market Forecast (in Billion US$), 2011-2016 ................................................................ 37 Figure 4-11: Global - Vaccine Production Volume by Region (in %), 2008 .................................................................. 41 Figure 4-12: Europe - Vaccine Export Volume by Region (in %), 2008 ........................................................................ 42 Figure 4-13: Global - Clinical Trials Market (in Billion US$), 2009-2010 ...................................................................... 43 Figure 4-14: Time Taken for Biopharmaceuticals to Get Approved (in Months), 1982-2009........................................ 45 Figure 4-15: Global - Clinical Trials Market Forecast (in Billion US$), 2011-2016 ....................................................... 45 Figure 4-16: Number of Multinational Clinical Trials (Phase II and III) in Asian Countries by the Top Twenty Global Pharmaceutical Companies* ........................................................................................................................................ 48 Figure 4-17: Global - Break up of Biopharmaceuticals & Small Molecule Drugs in Preclinical & Clinical trials, (in %), 2009 ............................................................................................................................................................................. 49 Figure 4-18: Top Reasons for Conducting Clinical Trials in Each Country (in %), 2009 .............................................. 50 Figure 5-1: A Typical Drug Supply Chain from the Manufacturer to the End User ....................................................... 51 Figure 6-1: Global - Healthcare Cold Chain Logistic Services Market (in Billion US$), 2008-2010 .............................. 61 Figure 6-2: Global - Healthcare Cold Chain Logistic Services Market Forecast (in Billion US$), 2011-2016 ............... 62 Figure 6-3: Global - Healthcare Logistic Services Market, Share of Cold-Chain & Non Cold-Chain Services, (in %), 2008 ............................................................................................................................................................................. 62 Figure 6-4: Global - Healthcare Cold Chain Logistic Services Market by Product (in %), 2010 & 2016 ....................... 63 Figure 6-5: Global - Biopharmaceuticals & Vaccines Cold Chain Logistic Services Market (in Billion US$), 2008-2010 ..................................................................................................................................................................................... 64 Figure 6-6: Global - Biopharmaceuticals & Vaccines Cold Chain Logistic Services Market Forecast (in Billion US$), 2011-2016 .................................................................................................................................................................... 64 Figure 6-7: Global - Clinical Trial Materials Cold Chain Logistic Services Market (in Billion US$), 2008-2010 ............ 65 Figure 6-8: Global - Clinical Trial Materials Cold Chain Logistic Services Market Forecast (in Billion US$), 2011-2016 ..................................................................................................................................................................................... 66 imarc© 7
  • 7. Figure 6-9: Global - Healthcare Cold Chain Logistic Services Market by Segment (in %), 2010 & 2016 ..................... 66 Figure 6-10: Global - Healthcare Cold Chain Packaging & Instrumentation Services Market (in Billion US$), 2008- 2010 ............................................................................................................................................................................. 67 Figure 6-11: Global - Healthcare Cold Chain Packaging & Instrumentation Services Market Forecast (in Billion US$), 2011-2016 .................................................................................................................................................................... 68 Figure 6-12: Global - Healthcare Packaging & Instrumentation Services Market, Share of Cold-Chain & Non Cold- Chain Services, (in %), 2008 ........................................................................................................................................ 68 Figure 6-13: Global - Healthcare Cold Chain Transportation Services Market (in Billion US$), 2008-2010 ................. 69 Figure 6-14: Global - Healthcare Cold Chain Transportation Services Market Forecast (in Billion US$), 2011-2016 .. 70 Figure 6-15: Global - Healthcare Transportation Services Market, Share of Cold-Chain & Non Cold-Chain Services, (in %), 2008 .................................................................................................................................................................. 70 Figure 6-16: Global - Healthcare Cold Chain Logistic Services Market by Region (in %), 2010 & 2016 ...................... 71 Figure 6-17: North America - Healthcare Cold Chain Logistic Services Market - (in Billion US$), 2008-2010 ............. 72 Figure 6-18: North America - Healthcare Cold Chain Logistic Services Market Forecast - (in Billion US$), 2011-2016 ..................................................................................................................................................................................... 72 Figure 6-19: Europe - Healthcare Cold Chain Logistic Services Market (in Billion US$), 2008-2010 ........................... 73 Figure 6-20: Europe - Healthcare Cold Chain Logistic Services Market Forecast (in Billion US$), 2011-2016 ............ 73 Figure 6-21: Asia Pacific - Healthcare Cold Chain Logistic Services Market (in Billion US$), 2008-2010 .................... 74 Figure 6-22: Asia Pacific - Healthcare Cold Chain Logistic Services Market Forecast (in Billion US$), 2011-2016 ..... 75 Figure 6-23: Rest of the World - Healthcare Cold Chain Logistic Services Market (in Billion US$), 2008 - 2010......... 75 Figure 6-24: Rest of the World - Healthcare Cold Chain Logistic Services Market Forecast (in Billion US$), 2011-2016 ..................................................................................................................................................................................... 76 Figure 7-1: Financing Sources and Gaps (in %), 2008-2010 ....................................................................................... 78 imarc© 8
  • 8. List of Tables Table 3-1: Various Regulations on Healthcare Cold Chain Logistic Requirements ...................................................... 20 Table 4-1: Global - Healthcare Cold Chain Products Market - Break up by Product (in Billion US$), 2009-2010 ........ 23 Table 4-2: Global - Healthcare Cold Chain Products Market Forecast - Break up by Product (in Billion US$), 2011- 2016 ............................................................................................................................................................................. 24 Table 4-3: Global - Biopharmaceutical Market - Sales by Class (in Billion US$), 2008-2010....................................... 27 Table 4-4: Global - Biopharmaceutical Market Forecast - Sales by Class (in Billion US$), 2011-2016 ........................ 28 Table 4-5: Stability of Various Biopharmaceuticals at Room Temperature .................................................................. 30 Table 4-6: US & Europe - Launch Dates of Various Biosimilars................................................................................... 31 Table 4-7: US & Europe - Biosimilar Market Sales & Forecast (in Million US$), 2007-2016 ........................................ 32 Table 4-8: Complexity of the Manufacturing Process Involved with Biopharmaceuticals & Small Molecule Drugs ...... 35 Table 4-9: Temperature Stability of Commonly Used Vaccines ................................................................................... 39 Table 4-10: The Effect of Temperature Excursions on the Usability of Vaccines ......................................................... 40 Table 4-11: Global - Major Vaccine Production Sites (in Numbers), 2008 ................................................................... 41 Table 4-12: Global - Clinical Trials Market - Spending on Biopharmaceuticals & Small Molecule drugs (in Billion US$), 2009-2010 .................................................................................................................................................................... 43 Table 4-13: Global - Patent Expiry Risks of Big Pharmaceutical Companies, 2011-2013............................................ 44 Table 4-14: Global - Clinical Trials Market Forecast – Spending on Biopharmaceuticals & Small Molecule Drugs (in Billion US$), 2011-2016 ............................................................................................................................................... 45 Table 4-15: Ideal Storage Temperatures for Clinical Trial Materials ............................................................................ 47 Table 5-1: Average Amount of Dry Ice for Packaging Frozen Goods in a Single Well Insulated Container ................. 52 Table 5-2: Dry Ice Containers ...................................................................................................................................... 53 Table 5-3: Refrigerated Shipping Containers with Gel Packs ...................................................................................... 56 Table 5-4 : Costs Associated With the Cold Chain Shipment of Healthcare Products, 2011* ...................................... 57 Table 5-5 : Costs Associated With the Non-Cold Chain Shipment of Healthcare Products, 2011* .............................. 57 Table 7-1: Cold Chain & Logistic Funding Gaps Per Infant (in US$), 2008-2010 ......................................................... 78 imarc© 9
  • 9. Prices and Order Information Single user license Single user license Single user license Multiple user license PDF CD ROM Hard Copy All Formats US$ 1200 US$ 1400 US$ 1400 US$ 1900 I would like to order the market study “Global Healthcare Cold Chain Logistics Market Report & Forecast (2011-2016)”. Kindly Complete Your Details Your Name: Job Title: Company: Email Id: Telephone Number: Adress: Contact IMARC Group Krishna Sharma International Market Research Analysis and Consulting Group : +91-11-4256531 (Asia), +1-631-791-1145 (North America) : sales@imarcgroup.com
  • 10. About IMARC For more than 5 years, the International Market Analysis Research and Consulting Group has been a leading advisor on management strategy and market research worldwide. We partner with clients in all sectors and regions to identify their highest-value opportunities, address their most critical challenges, and transform their businesses. IMARC's information products include major market, scientific, economic and technological developments for business leaders in pharmaceutical, industrial, and high technology organizations. Market forecasts and industry analysis for biotechnology, advanced materials, pharmaceuticals, food and beverage, travel and tourism, nanotechnology and novel processing methods are at the top of the company's expertise. IMARC’s tailored approach combines unfathomable insight into the dynamics of companies and markets with close cooperation at all levels of the client organization. This ensures that our clients achieve unmatchable competitive advantage, build more proficient organizations, and secure lasting results. imarc©