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Sharing and Open Knowledge and the Future of Scientific Research Hiroaki Kitano The Systems Biology Institute Sony Computer Science Laboratories, Inc.
 
EGF Receptor Cascade Oda, et al. Molecular Systems Biology, 2005
Architectural Feature Kitano, Nature Reviews Genetics, Nov. 2004
Copyright ©2007 by the National Academy of Sciences Kim, Pan-Jun et al. (2007) Proc. Natl. Acad. Sci. USA 104, 13638-13642 Fig. 1. Characteristics of essential and nonessential metabolites in E. coli metabolism
Ma et al, Molecular Systems Biology, Sept 2007
Bow-Tie Architecture of Wikipedia links Capocci, et al., Phys Rev. E 74, 036116, 2006
EGF Receptor Cascade Oda, et al. Molecular Systems Biology, 2005
Oda, et al. Molecular Systems Biology, 2005
 
TLR Bow-Tie Structure Oda and Kitano, Molecular Systems Biology, April 2006
低下する製薬産業の生産性
Copyright ©2003 by the National Academy of Sciences Borisy, Alexis A. et al. (2003) Proc. Natl. Acad. Sci. USA 100,  7977-7982 Multicomponent therapeutics that prevent proliferation of fluconazole-resistant C. albicans CombinatoRX (CRXX: NASDAQ) cHTS
Copyright ©2003 by the National Academy of Sciences Borisy, Alexis A. et al. (2003) Proc. Natl. Acad. Sci. USA 100,  7977-7982 Chlorpromazine , an antipsychotic agent, and  pentamidine , an antiprotozoal agent, together selectively prevent tumor cell growth in vitro and in vivo Phase 1/2A Stage
Copyright ©2003 by the National Academy of Sciences Borisy, Alexis A. et al. (2003) Proc. Natl. Acad. Sci. USA 100,  7977-7982 Chlorpromazine , an antipsychotic agent, and  pentamidine , an antiprotozoal agent, together selectively prevent tumor cell growth in vitro and in vivo Phase 1/2A Stage Efficacy
 
朝鮮人参の成分分析 Wang, M. et al., Phytother Res. 2005 Mar;19(3):173-82
Open Pharma ,[object Object],[object Object],[object Object],[object Object],The Rule of the Game Will Change
“ PAYAO” Web 2.0 Community Tagging System to SBML models Okinawa Institute of Science and Technology The Systems Biology Institute
“PAYAO” ,[object Object]
Payao: Web2.0 Community-Based Biological Knowledge Accumulation System
SBML Models Tagging System Manage  Models,  Users, Groups Register a model Store  models,  Tags,  Comments Login Users Visitors Model Owner Add Comments  Add/Edit Tags  to the model View Models with CellDesigner notation Group A Group B *CellDesigner files PAYAO SBML Models Tagging System SBML files
Model View
Model View with Tag Marks
Tag
View a Tag
Add Comments to a Tag
View Comments to a Tag
PubMed ID Link
Healthcare & Wellness Concierge Genome Diagnosis (23 and me) Wellness (India, etc) Personalized & Preventive medicine How to integrate medicine and wellness? Herbal medicine, meditation, etc. Novel Drug Design and Integrated Healthcare Support
Summary ,[object Object],[object Object],[object Object],[object Object]

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Sharing and Open Knowledge and the Future of Scientific Research by Hiroaki Kitano

  • 1. Sharing and Open Knowledge and the Future of Scientific Research Hiroaki Kitano The Systems Biology Institute Sony Computer Science Laboratories, Inc.
  • 2.  
  • 3. EGF Receptor Cascade Oda, et al. Molecular Systems Biology, 2005
  • 4. Architectural Feature Kitano, Nature Reviews Genetics, Nov. 2004
  • 5. Copyright ©2007 by the National Academy of Sciences Kim, Pan-Jun et al. (2007) Proc. Natl. Acad. Sci. USA 104, 13638-13642 Fig. 1. Characteristics of essential and nonessential metabolites in E. coli metabolism
  • 6. Ma et al, Molecular Systems Biology, Sept 2007
  • 7. Bow-Tie Architecture of Wikipedia links Capocci, et al., Phys Rev. E 74, 036116, 2006
  • 8. EGF Receptor Cascade Oda, et al. Molecular Systems Biology, 2005
  • 9. Oda, et al. Molecular Systems Biology, 2005
  • 10.  
  • 11. TLR Bow-Tie Structure Oda and Kitano, Molecular Systems Biology, April 2006
  • 13. Copyright ©2003 by the National Academy of Sciences Borisy, Alexis A. et al. (2003) Proc. Natl. Acad. Sci. USA 100, 7977-7982 Multicomponent therapeutics that prevent proliferation of fluconazole-resistant C. albicans CombinatoRX (CRXX: NASDAQ) cHTS
  • 14. Copyright ©2003 by the National Academy of Sciences Borisy, Alexis A. et al. (2003) Proc. Natl. Acad. Sci. USA 100, 7977-7982 Chlorpromazine , an antipsychotic agent, and pentamidine , an antiprotozoal agent, together selectively prevent tumor cell growth in vitro and in vivo Phase 1/2A Stage
  • 15. Copyright ©2003 by the National Academy of Sciences Borisy, Alexis A. et al. (2003) Proc. Natl. Acad. Sci. USA 100, 7977-7982 Chlorpromazine , an antipsychotic agent, and pentamidine , an antiprotozoal agent, together selectively prevent tumor cell growth in vitro and in vivo Phase 1/2A Stage Efficacy
  • 16.  
  • 17. 朝鮮人参の成分分析 Wang, M. et al., Phytother Res. 2005 Mar;19(3):173-82
  • 18.
  • 19. “ PAYAO” Web 2.0 Community Tagging System to SBML models Okinawa Institute of Science and Technology The Systems Biology Institute
  • 20.
  • 21. Payao: Web2.0 Community-Based Biological Knowledge Accumulation System
  • 22. SBML Models Tagging System Manage Models, Users, Groups Register a model Store models, Tags, Comments Login Users Visitors Model Owner Add Comments Add/Edit Tags to the model View Models with CellDesigner notation Group A Group B *CellDesigner files PAYAO SBML Models Tagging System SBML files
  • 24. Model View with Tag Marks
  • 25. Tag
  • 30. Healthcare & Wellness Concierge Genome Diagnosis (23 and me) Wellness (India, etc) Personalized & Preventive medicine How to integrate medicine and wellness? Herbal medicine, meditation, etc. Novel Drug Design and Integrated Healthcare Support
  • 31.