STEMI Mimic WHAT IS IT AND HOW TO IDENTIFY IT ?

1. STEMI MIMICS
Dr. HAITHAM S HABTAR
SBEM, PGY-4

2. WHY IS THIS IMPORTEANT ?
Chest pain is a common cause of ED visits.
In patients with ECG findings consistent with a STEMI, the primary goal is t
o salvage myocardium through rapid reperfusion.
However, before activating the cardiac catheterization lab for ECG changes
,
it is important to consider non-ischemic causes of ST-segment elevation

5. Early repolarization was initially associated with young healthy athletes,
but increasingly is found in a wider variety of individuals.
The dramatic appearance of ST segment in multiple contiguous leads results in early repolarization being cited as the most
common cause of false-positive catheterization laboratory activations in patients without elevated cardiac biomarkers.
Over the years, different authors have used different criteria for the diagnosis of early repolarization. To provide consistency, in
2015, Hancock et al proposed three criteria that are required for the diagnosis of benign early repolarization:
• The QRS slur or notch (termed a J wave) must be on the downslope of the R wave and be above the isoelectric
line.
• The peak of the J point must be elevated ≥ 0.1 mV in two or more contiguous leads, except V1-V3.
• The QRS duration must be < 120 ms.
Early Repolarization

6. ST segment / T wave morphology
The ST segment-T wave complex in ER has a characteristic appearance:
• There is elevation of the J point
• The T wave is peaked and slightly asymmetrical
• The ST segment and the ascending limb of the T wave form an upward concavity (smiley
-shaped )
• The descending limb of the T wave is straighter and slightly steeper than the ascending li
mb

7. J-point morphology
One characteristic feature of ER is the presence of a notched or irregular J-point so-called
“fish hook” pattern.
This is often best seen in lead V4.

8. a healthy 17-year old female who was admitted to hospital following a benz
odiazepine overdose.
She had no chest pain, and cardiac biomarkers were normal.

9. heart rate = 76 bpm

10. heart rate = 54 bpm

12. Left Bundle Branch Block
ECG Diagnostic criteria of LBBB:
• QRS duration ≥ 120ms
• Dominant S wave in V1
• Broad monophasic R wave in lateral leads (I, aVL, V5-6)
• Absence of Q waves in lateral leads
• Prolonged R wave peak time > 60ms in leads V5-6
In hemodynamically stable patients with a presumed new LBBB, evaluation of their sympt
oms requires both measurement of cardiac biomarkers and observation.
In patients with hemodynamic compromise (including acute heart failure), revascularizatio
n should be emergently considered.

14. Sgarbossa criteria for LBBB
The Sgarbossa criteria can help guide the decision for emergent catheterization and coronary intervention in the
presence of both new and old LBBBs.
• Concordant ST elevation > 1mm in leads
with a positive QRS complex (score 5)
• Concordant ST depression > 1 mm in V1-V3 (score 3)
• Excessively discordant ST elevation > 5 mm in leads
with a -ve QRS complex (score 2)
These criteria are specific, but not sensitive (36%)
for myocardial infarction
. A total score of ≥ 3 is reported to have a specificity of 90%
for diagnosing myocardial infarction.

15. Smith-Modified Sgarbossa Criteria

18. Electrolyte derangements of potassium, calcium, magnesium, and sodium alter the cardiac action po
tential,
resulting in ECG changes.
Hyper K
Hyperkalemia frequently can cause ST elevation, most commonly in leads V1 and V2 and s
hould be suspected when there is any QRS widening, especially when associated w
ith some symmetric
peaking of the T waves
(“T waves that will poke you if you touch them”)
Short QT, PR
Flat P wave
Loss of SA conduction <<< wide QRS <<< V Fib and asystole
Electrolyte

20. Hypercalcemia
Characteristic ECG changes include shortening of the QT interva
l.
This shortening of the QT interval is what may mimic ST elevatio
n.
Electrolyte

22. Sodium channel blocker (SCB) toxicity
Sodium channel blocker (SCB) toxicity may manifest as ST elevation,
particularly in lead aVR.
SCB TOXICITY Like ??
Electrolyte

24. Left ventricular hypertrophy (LVH)
Left ventricular hypertrophy (LVH) is known to cause many false-positive cardiac catheterization lab activation
s.
Voltage Criteria
Limb Leads
• R wave in lead I + S wave in lead III > 25 mm
• R wave in aVL > 11 mm
• R wave in aVF > 20 mm
• S wave in aVR > 14 mm
Precordial Leads
• R wave in V4, V5 or V6 > 26 mm
• R wave in V5 or V6 plus S wave in V1 > 35 mm The most specific and widely used criteria are the So
kolow-Lyon criteria, which confer a specificity of almost 100%
• Largest R wave plus largest S wave in precordial leads > 45 mm
Non Voltage Criteria
• Increased R wave peak time > 50 ms in leads V5 or V6
• ST segment depression and T wave inversion in the left-sided leads: AKA the left ventricular ‘str

28. Acute Pulmonary Embolism
ECG findings compared to Acute Coronary Syndrome
• ACS is rarely associated with tachycardia
• Rt Axis deviation rarely seen in STEMI
• Bedside echo may be useful in differentiating the two, demonstrating features of RV dilatation and
pulmonary
arterial hypertension
• Kosuge et al have shown that simultaneous inversion in III and V1 are diagnostically significant:
Negative T waves in leads III and V1 were observed in only 1% of patients with ACS compared with 88% of patient
s with Acute PE (p less than 0.001). The sensitivity, specificity, positive predictive value, and negative predictive
value of this finding for the diagnosis of PE were 88%, 99%, 97%, and 95%, respectively. In conclusion, the presen
ce of negative T waves in both leads III and V1 allows PE to be differentiated simply but accurately from ACS in p
atients with negative T waves in the
precordial leads.

29. Acute Pulmonary Embolism

31. When a transmural infarct is not aborted by therapeutic intervention and the AMI completes itself, the
myocardium is replaced by a thin, fibrous layer, which is called an LV aneurysm.
On the ECG, a left ventricular aneurysm may manifest as persistent ST elevation in the territory of a p
rior infarct,
commonly concomitant with Q waves.
The rule states that when the differential diagnosis is acute LAD occlusion vs. anterior LV aneurysm,
if any of
leads V1-V4 has a T wave amplitude to QRS amplitude ratio of > 0.36, then STEMI is likely.
In general, aneurysm is favored by prominent Q waves in leads V1-V4 with corresponding diminishe
d T wave
amplitudes.
• T-wave/QRS ratio < 0.36 in all precordial leads favours LV aneurysm
• T-wave/QRS ratio > 0.36 in any precordial lead favours anterior STEMI
Aneurysm

34. Brugada syndrome
Brugada Syndrome is an ECG abnormality with a high incidence of sudden death in patient
s with structurally normal hearts.
Brugada syndrome is due to a mutation in the cardiac sodium channel gene.
• Diagnosis depends on a characteristic ECG finding AND clinical criteria.
• Further risk stratification is controversial.
• Definitive treatment = ICD.
• Brugada sign in isolation is of questionable significance.

35. Diagnostic Criteria
This ECG abnormality must be associated with one of the following clinical criteria to make
the diagnosis:
• Documented ventricular fibrillation (VF) or polymorphic ventricular tachycardia (VT).
• Family history of sudden cardiac death at <45 years old .
• Coved-type ECGs in family members.
• Inducibility of VT with programmed electrical stimulation .
• Syncope.
• Nocturnal agonal respiration.

36. TYPES
Type 1
• Coved ST segment elevation >2mm in >1 of V1-V3 followed by a negative
T wave.
• This is the only ECG abnormality that is potentially diagnostic.
• It is often referred to as Brugada sign.

37. TYPES
Type 2
• Brugada Type 2 has >2mm of saddleback shaped ST elevation.
Type 3
• Brugada type 3: can be the morphology of either type 1 or type 2, but with
<2mm of ST segment elevation.

39. Look for features of STEMI first:
• Search for ST depression in leads other than aVR and V1
• Look for ST elevation in lead III > II
• Search for horizontal or convex upward ST elevation
• New Q wave
pericarditis

41. Temp: 32 c

42. Hypothermia
Hypothermia is defined as a core body temperature of < 35 °C
The Osborn wave (J wave) is a positive deflection
at the J point (negative in aVR and V1).
• It is usually most prominent in the precordial leads.
• The height of the Osborn wave is roughly proportional
to the degree of hypothermia

43. RESOURSE

44. THANK YOU