2. THIS MONTH IN Radiology ■ ContinueD
Functional MR Demonstrates Early Transarterial Chemoembolization Response in
Hepatocellular Carcinoma
Functional MR imaging of hepatocellular carcinoma demonstrates vascular and cellu-
lar response to transarterial chemoembolization (TACE) well before changes in tumor
size occur. In 24 patients who underwent TACE, Kamel and colleagues found a signif-
icant persistent reduction in tumor enhancement within 24 hours after treatment, as
well as changes in apparent diffusion coefficient values during the following weeks. Tu-
mor size remained unchanged up to 4 weeks after therapy. The researchers conclud-
ed functional images depicting vascularization and cellularity may be an early indica-
tor of TACE response and should be incorporated into early assessment. ❚ Page 466
An editorial by Padhani accompanies this article (p 324).
Right Pulmonary Artery Distensibility Assists Pulmonary Hypertension Diagnosis
Measuring right pulmonary artery (RPA) distensibility on electrocardiographi-
cally gated multidetector CT can improve diagnosis of pulmonary hypertension. In
45 patients, Revel and colleagues evaluated RPA distensibility, as well as right ven-
tricular outflow tract myocardial thickness, diameter, and cross-sectional area, dur-
ing the systole and diastole. They found the largest area under the receiver oper-
ating characteristic curve for RPA distensibility, which also showed the closest corre-
lation with mean pulmonary arterial pressure. RPA distensibility could be useful for
pulmonary hypertension risk stratification, the researchers concluded. ❚ Page 558
Airflow Obstruction from Asthma Persists Despite Treatment, Disease Severity
MR imaging with hyperpolarized helium 3 (3He) reveals that focal airflow impediment
within the lungs of asthma patients can persist over time. de Lange and colleagues ob-
served in 26 patients imaged twice on the same day that 75% of focal airway narrow-
ing defects remained in the same location, with 71% remaining unchanged in size. The
researchers observed in another 17 patients imaged on multiple days that up to 67% of
defects persisted between the first and second examinations, with 46%–58% remaining
unchanged in size. More than a third of defects remained in the same location after ap-
proximately 3 months, the researchers noted, and more than 50% of those defects did not
change in size. The persistence of regional airflow impediment was independent of disease
severity or whether patients used asthma medications, the researchers found. They con-
cluded that 3He MR imaging improves understanding of the changes in regional airflow
obstruction occurring over time within the lungs of patients with asthma. ❚ Page 567
PET/CT Algorithm Refines Characterization of Adrenal Nodules in Lung Cancer
A proposed combined PET/CT algorithm for evaluating adrenal nodules provides more
definitive characterization in patients known to have or suspected of having lung can-
cer. In 147 patients with 187 adrenal nodules, Brady and colleagues found that com-
bined PET/CT criteria utilizing a standardized uptake value (SUV) of the most intense
pixel within the adrenal nodule (maximum SUV) of greater than 3.1 and hyperattenua-
tion (>10 HU) was highly sensitive for depicting metastatic nodules, and applying a fur-
ther cutoff—ratio of nodule maximum SUV to liver average SUV greater than 2.5—identi-
fied 22 of 37 metastatic lesions and excluded all fluorodeoxyglucose-avid benign nodules.
The proposed algorithm refines adrenal nodule characterization, the researchers con-
cluded, and can spare some patients from undergoing further interventions. ❚ Page 523
In Patients with Intermittent Claudication Supervised Exercise Offers Same Benefits as
Endovascular Revascularization
Patients with intermittent claudication who undergo a supervised exercise program may ex-
perience the same benefits within a year of intervention as those who undergo endovascular
revascularization. Spronk and colleagues observed 151 patients who either underwent en-
dovascular revascularization with an angioplasty-first approach or participated in hospital-
based supervised exercise. The researchers found that, while patients who underwent en-
dovascular revascularization saw more immediate improvement in functional capacity and
quality of life, there was no significant difference in these parameters between the two treat-
ment groups after 6 months and 12 months. The researchers noted that the findings may lead
to further investigation of supervised exercise in addition to revascularization. ❚ Page 586
4A Radiology: Volume 250: Number 2—February 2009
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