The benefits of biologicals for food & health industries

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Partners with Nature
Peter Jens, Director Strategic Alliances / CEO AND Biopharma BV. Thanks Irene and Jan!

“Help ensure that every body can enjoy a long, productive and dignified life…
MY MISSION:

“Help ensure that every body can enjoy a long, productive and dignified life
….and dies healthily.”
MY MISSION:

“Help ensure that every body can enjoy a long, productive and dignified life
….and dies healthy.”
Director Strategic Alliances at Koppert Biological Systems
Chief Executive Officer at AND Biopharma BV
Responsible for Education and Innovation at Koppert Foundation
Food & Knowledge Business Platform, Ministry of Foreign Affairs; PuraNatura Foundation; Urban Farmers AG
MY MISSION:

Find out how the use of biologicals in the primary production will improve the
lives and health of consumers, other than “absence of bad stuff” and towards
“presence of good stuff”.
TODAY’S MISSION:

Martin Koppert, director Koppert Agri

Opening by EIT Health & EIT Food
14-06-2018
Menno Kok – 14 June 2018

Food for Health: Objectives
• Develop a joint strategy and build a shared portfolio
to better exploit the opportunities offered by the
overarching area of food for health
• Joining forces in Campus and Business Creation,
especially in activities of a generic nature
• Team up in development of sustainability plans

Opportunity:
cross-KIC engaging EIT Health and EIT Food
Campus: Citizen oriented activities
Entrepreneurship education
(Generic) Innovation training
New teaching methods….
Accelerator: All activities: share succesful approaches*
Create communicating vessels…
Innovation: Exploit strength of both networks
Use 2019 to establish common grounds and
initiate shared innovation activities….
Leuven, September 26: Investor forum

Connecting high potential areas with an integrated
innovation processes
Challenge 1
Promote
Healthy Living
Challenge 2
Support
Active Ageing
Removing
Barriers to
Innovation
Leveraging
Talents &
Education
Leveraging
Enabling
Technologies
and Exploiting
Big Data
Successful start-ups
Economics growth
Fast market access and
diffusion of innovative
products and services
Globally competitive
European industry
Better quality of life
Citizens enabled to take
ownership of their
health
Empowered citizens to
take choices for longer
active and social life
Improved patient
pathways, cost-
effectiveness,
sustainability and quality
of healthcare
Stronger innovation eco-
systems at CLCs and the
EIT Health InnoStars
A
B
C
Challenge 3
Improve
HealthCare
Better trained personnel
and new jobs

Start from innovation areas of common interest:
Imaging technology
Care pathways
Reimbusement
Food processing
Crop yields
Logistics
Such as:
Consumer behavior and a healthy diet
Obesitas: Prevention strategies
Role of food intake in clinically relevant situations
Human health and the microbiome
Biomarkers of a healthy GI tract
Food composition: eliminating sugar, salt and saturation
Allergy and hypersensitivity to food components
Dietary consequences of ageing
Food and wellbeing
Food as a source of endocrine disrupters…..
Cross-over technologies: (e.g. imaging and food quality)

Set-up a platform for common activities
Make choice for “starter” based on:
- Relevance to both KICs and KIC to KIC complementarity
- Preferably a short cycle time
- Evident business opportunities and partner(s) to exploit these
- High impact and “starter nature” of 2019 activities
1. Consumer behavior and a healthy diet
2. Obesitas: prevention strategies
3. Role of food intake in clinically relevant situations
4. Human health and the microbiome
5. Biomarkers of a healthy GI tract
6. Food composition: eliminating sugar, salt and saturation
7. Allergy and hypersensitivity to food components
8. Dietary consequences of ageing
9. Food and wellbeing
10.Food as a source of endocrine disrupters…..

Foundation
2020
2019
2018
Build the foundation of a joint innovation strategy
H F
Select partners to project lines
and develop these
Operational fit
Selected partners prepare
the foundation
Mechanism to build shared innovation portfolio

In 2018:
• Prepare cross KIC project
• Start building foundation for joint Innovation activities
In 2019:
• Call for partners to Innovation projects
• Operational fit
• Joint Campus and Accelerator activities
• Integrate Food for Health into both business cycles

A KIC must be borne from a strong desire to do things
differently, (..) experiment at the boundaries of innovation!
www.eithealth.eu
menno.kok@eithealth.eu

HOW TO FEED AN ASTRONAUT
ANGELO VERMEULEN
Greenport Hub
TU Delft | IPStar | SEAD
Cross-KIC of EIT Food and EIT Health
Koppert Biological Systems, Berkel en Rodenrijs
14 June 2018

GREENPORT HUB
Leiden + Delft + Erasmus
Horticulture oriented
4 research tracks:
• Digital innovation
• Circular horticulture
• Health and well-being
• Internationalization

GREENPORT HUB
We seek collaboration:
• Strategic innovation program
• Direct R&D
• Research agenda

Space food, Project Mercury, NASA (1958-1963)

Space food, International Space Station

MENU FATIGUE
PRESERVATION
LIMITED SUPPLIES
HEALTH

HI-SEAS Mission I, Mauna Loa, Hawai'i, 2013

HI-SEAS Mission I, Mauna Loa, Hawai'i, 2013
Photos: Yajaira Sierra Sastre, Sian Proctor, Angelo

Food study, HI-SEAS Mission I, Mauna Loa, Hawai'i, 2013
Photos: Sian Proctor

Photos: Sian Proctor

APPRECIATION
COMMUNICATION
CREATIVITY
SHARING

“So far the three of us have had one meal per day together, and are
settling into a comfortable conversational mode, talking a little
about the day, joking about what we’re doing at the moment.”
― NASA astronaut diary
“The original Space Station took out the table because nothing stays
on it anyway. But at a certain point, the astronauts said, ‘Bring back
the table. Put some straps on it. We want to sit around a table at the
end of the day and eat like humans.’”
― Mary Roach, author of Packing for Mars

MEAL VARIETY
SHELF-STABLE INGREDIENTS
CUSTOMIZED CONTENT
TIME-EFFICIENT

PROCESSED INGREDIENTS
VITAMIN LOSS
LIMITED TEXTURES

Sprout research (with Simon Engler), HI-SEAS Mission I, Mauna Loa, Hawai’i, 2013

ANTIMICROBIAL
TEXTILE
CONTROL
Sprout research (with Yajaira Sierra Sastre), HI-SEAS Mission I, Mauna Loa, Hawai’i, 2013

Sprout research (with Yajaira Sierra Sastre), HI-SEAS Mission I, Mauna Loa, Hawai’i, 2013
ANTIMICROBIAL
TEXTILE
CONTROL

“High-phenolic antioxidant-containing sprouts with no microbial load
were developed by elicitation with low dose phenolic antimicrobials
and a two-step, short-pulse microwave-induced heating step.”
― Kalidas Shetty et al., SAE Technical Papers, July 2003

Closed loop ecosystem, Biosphere 2, Arizona, 1991-1994

CLOSING THE LOOP
MATHEMATICAL MODELING
IMPACT SPACE ENVIRONMENT
GENETIC DRIFT

FOOD CULTURE
SELF-RELIANCE
COMFORT FOODS
EVOLUTION

CONTACT
Angelo Vermeulen
A.C.J.Vermeulen@tudelft.nl
COLLABORATION WITH GREENPORT HUB
Liselotte de Vries
Liselotte.deVries@tudelft.nl

Peter Maes Director Corporate Marketing

INTRODUCTION
KOPPERT BIOLOGICAL
SYSTEMS
▪ Founded in 1967
▪ Market leader and the a truly
“global” and “pure” biocontrol
company (thought leader)
▪ 1500 employees worldwide
▪ Family company
Koppert started with a beneficial mite
to combat spider mite infestation.
Nowadays a more holistic biological
approach is used in both horticulture
and agriculture.

HISTORY
Back in 1967, Jan Koppert was a
dedicated cucumber grower.
Diseases and pests were
controlled with chemicals but the
efficacy of this method
decreased each year.
Jan Koppert became allergic and
ill as a result of these products.
He had to look for alternatives
and immersed himself in the
world of natural enemies.
He was the first to introduce a
natural enemy to combat spider
mite infestation.
The results and effects were so
positive that Jan Koppert decided
to produce this solution.
He had to face a
fundamental choice

MISSION STATEMENT (2014)
Koppert Biological Systems
contributes to the better health
of people and the planet.
In partnership with nature, we
make agriculture healthier, safer
and more productive.
We provide an integrated system
of specialist knowledge and
natural, safe solutions that
improves crop health,
resilience and production.
Koppert Biological Systems

TRENDS
THE WORLD IS CHANGING
▪ Preserving biodiversity
▪ Reducing CO²
▪ Soil depletion/ water quality
▪ Sustainable intensification
▪ Food safety/security
▪ 10 billion 2050/70% city (1111-
1333)
▪ Economics
▪ Social/Politics

TRENDS
▪ The Market (consumer)
demands residue-poor or even
residue-free products
▪ Retailers and supermarket
impose extra-legal
requirements on farmers
▪ More attention for work safety
▪ Society and Legislator want
less impact on the environment
and public health
▪ Sustainable production: more
production with less input and
less impact
▪ Certification and trust
▪ Circular economy

KEY DRIVERS
Key drivers for implementing
Biological solutions
▪ Pesticide resistance
▪ Residu management ( license
to supply) re-entry time
▪ Organic production
▪ Environment and health
▪ Productivity and Quality.
Influence of pesticides and fertilizers

MicrobialsPollination
WHAT DO WE DO? SUSTAINABILITY-FOOD-HEALTH
Macrobials

CORE DISCIPLINES
KOPPERT’S CORE
DISCIPLINES:
▪ Research and development
▪ Worldwide production and
distribution of solutions
– Resilient Growth with NatuGro
– Biological Pest Control
– Natural Pollination
– Application techniques
& monitoring
– Seed treatment
– Livestock (BSF)
▪ Know-how and knowledge
sharing

PEST AND DISEASE CONTROL
KOPPERT’S PEST
MANAGEMENT SOLUTIONS
▪ Widely used throughout the
horticultural industry, and
starting in agricultural industry
▪ Dramatically reducing the use
of agro-chemicals over the
years
▪ The greatest impact has been
in tomato cultivation
▪ The use of crop protection
chemicals has been decreased
upto 95%
▪ (beneficials and biopesticides)

NATURAL POLLINATION 1/2
WHY POLLINATION BY NATUPOL?
▪ Pollination results in considerably higher
yield through better fruit setting
▪ Under many conditions bumblebees are
more effective pollinators than honeybees
▪ Improves the quality and shelf life of both
seeds and fruit
▪ Reduced labour costs for the grower

RESILIENT GROWTH WITH NATUGRO
NATUGRO, NATURAL GROWING
A SYSTEM THAT CONSISTS OF:
▪ Beneficial micro-organisms
– Fungi
– Bacteria
▪ Biostimulants
– Amino- acids
– Alga
– Botanicals
▪ Analysis
▪ Professional advice

KOPPERT AT/SERVICE – SOFTWARE
Koppert SmartScout App
▪ Digital database for collecting data from all different
sources, e.g. Remote Sensing, UAV Sensing, soil life
sensors etc. (input from external – Koppert’s output)
- pest and disease detection
-soil life monitoring
▪ Analyzing data by Koppert’s models – DSS (Decision
Support Systems)
▪ Scouting and monitoring pests and diseases by smart
phone

CROP PROTECTION & PRODUCTIVITY (YIELD IMPROVEMENT)
▪ Increased production when intensive use of
chemical pesticides is stopped.
▪ Plant growth promoting (PGP) effect of
micro-organisms
▪ Reduction of use of chemical fertilizers by
applying micro-organisms and biostimulants
▪ Protection against abiotic stress by using
micro-organisms.
▪ IPM+INM+ITM= ICM ( yield increase
starting with seed)

WHAT IS BIOLOGICAL CROP PROTECTION FOR KOPPERT?
TOTAL PLANT VITALITY
.
Advice
Pollination
Biological control
Healthy soil life

THANK YOU FOR
YOUR INTEREST!
CONTACT:
Koppert B.V. The Netherlands
Phone: +31 (0)10 5140444
info@koppert.com
CLOSING AND QUESTIONS?

By Menno Kok
June 14, 2018
EIT Health: the challenges of
prevention

The major challenge may well be in finding new ways to
influence behavior and lifestyle.

“Are we allowed to have some fun?”
Some of the innovation hurdles:
Who pays and who collects?
Willingness to pay
Evidence based care
User comfort:
consumer centered design and plug & play
Standardisation
Acceptation of (new) technology:
consumer (market-) pull
Privacy, safety
Standardisation
Standardisation

Its about making choices…….

And its about realism!
Obesitas and diabetes in some European countries (2014)

Empirical (genetic) data changes the way individuals perceive themselves and
their families, and change the way others see them
(Taylor, 2008)
The participative perspective (Hood & Friend, 2011)
Self management: personalized health shifts
the responsibility for good health from
government and collectives to the individual,
who becomes responsible for his/her own
health or disease
(Savond, 2013)
Personalised Medicine and Personalised Health

Inclusive innovation: European citizen 2.0
Inclusive innovation: fostering health,
performance and engagement of the European citizen.
Building on: social capital in European countries and regions

Traffic accidents(NL)
1970: 3181 deaths in traffic
There are good examples...
Numbers not normalised for the number of vehicles

Omni-approachable for the professional, interactive, standardized, useful for
the empowered citizen, safe, accepted, open to scientific approaches,….
Health care provider Self management

Smooth introduction of technology
Information Coaching Telemedicine

New approches to lifestyle interventions
• Involve the citizen
• Distribute responsibilities (self-management)
• Make it affordable (payment models)
• Facilitate access to tools (data)
• Capitalize on human resources
• Provide support
• Make it attractive and provide evidence
• Start now and...
• Stick to your plan

Performance with purpose
By Imran Afzal (PepsiCo)
VISIT THE WEBSITE HERE

The next generation of growing ………
The next generation of ultra nutritious fresh food …….
Ard Reijtenbagh
Chief Partnership Officer

Increasing Nutritional Values of crops
through Fully Controlled Growing
Environments

The next generation of growing
Unlock crops’ full potential
in a fully controlled environment
offering a new window of opportunities

About PlantLab, who we are …
• Since early ’90ties, prototype 2005, incorporated in 2010
• The Netherlands, ‘s-Hertogenbosch (+ office in USA)
• Multidisciplinary company:
• Plant Science
• Technology
• Production
• Supply chain
• Marketing & Food design

About PlantLab, what we do ……
• Develop plant growth recipes
• Develop integrated technology solution (hard- & software)
• Build and operate indoor vertical farms → production
• Partnerships

Plant ParadisePlant Paradise
3%

’90ties: nature = mathematics
Light
CO2
Water
Nutrients
Leaves
Maintenance
Sinks
Speed

Global challenges & Indoor farming
Food security Sustainability
Indoor farming
Anywhere
Footprint
Food waste
Recycling
No chemicals
Water use
CO2 Foot print

Growing recipes – tailor made

Steering levels of compounds → taste & nutrition

Basil
PPU vs Greenhouse
0
1000
2000
3000
4000
5000
Rosie A1 Rosie A2 Rosie A3 Rosie
Control 1
Rosie
Control 2
Rosie
Control 3
Rosie
Control 4
Geraniol
0
50000
100000
150000
Control 1
Rosie
Control 2
Rosie
Control 3
Rosie
Control 4
Linalool
0
2000
4000
6000
Control 1
Rosie
Control 2
Rosie
Control 3
Rosie
Control 4
Eugenol

Typical values 100 grams
contains
A typical
serving
Energy 60 kJ (14kCal) 48kJ (11kCal)
Protein 0,7g 0,6g
Carbohydrate 1,9g 1,5g
Sugars 1,9 1,5g
Fat 0,3g 0,2g
Saturates <0,1g <0,1g
Fibre 0,6g 0,5g
Salt 0,0g 0,0g
Iceberg lettuce
Romaine lettuce
Nutritional value

Plant ParadisePlant Paradise
Fresh & healthy food is top of mind

Plant Paradise
Personalized fresh
food
Functional
fresh food
Food = Medicine

How ecological thinking can improve agro-
food- and pharma-systems
On the potential applications of controlling harmful species by their
extracellular self-DNA
Prof. Stefano Mazzoleni
Laboratory of Applied Ecology and System Dynamics Modelling
Dept. Agricultural Sciences – University of Napoli Federico II
www.ecoap.unina.it
European Institute of Innovation & Technology (EIT) Food
Cross-KIC event with EIT Health
Rotterdam
14 June 2018

Why plants in arid environments form rings?

Bonanomi et al. 2005. Plant Ecology
Scirpus holoschoenus

Plant-soil negative feedback CENTRAL
DIE-BACK
Other species
establishment

Negative plant-soil feedback
and tropical forest diversity
Mangan et al. 2010, Nature

131
Why seedlings die under their mother plant?
?
… and why other species do not?

Direction of tussock spread
Living tillers
A)
Living
fine roots
Direction of tussock spread
Living tillers
Dead tillers,
rhizomes
and roots
B)
Living
fine roots

β=2.5
t = 10 t = 25 t = 50
β=5β=10
y
xxx
y
y
Simulation results
time
toxicityeffect
Modelling ring forming plants
Journal of Theoretical Biology 2012

Simulation results
tim
e
toxicity
effect
Modelling ring forming plants
Journal of Theoretical Biology 2012

Grasses - Sedges
Forbs
N - Fixing
Woody
SpeciesVegetation type Plant material Decomposition
(5) Junkus effusus L. Leaf - Root Aerobic / Anaerobic
(2) Carex distachya Desf. Leaf - Root Aerobic
(7) Phragmites australis (Cav.) Trin. Leaf - Root Aerobic / Anaerobic
(4) Festuca drymeia M. et K. Leaf Aerobic / Anaerobic / Litterbag
(8) Coronilla emerus L. Leaf Aerobic / Anaerobic / Litterbag
(13) Cistus monspeliensis L. Leaf Aerobic / Anaerobic
(12) Cistus incanus L. Leaf Aerobic
(16) Quercus ilex L. Leaf Aerobic / Anaerobic / Litterbag
(25) Typha latifolia L. Leaf - Root Aerobic / Anaerobic
(19) Hedera helix L. Leaf Aerobic / Anaerobic / Litterbag
(6) Phleum subulatum (Savi) Asch et Gr. Leaf Aerobic
(1) Ammophila littoralis (Beauv.) Rothm. Leaf Aerobic
(3) Dactylis hispanica Roth Leaf - Root Aerobic
(9) Medicago marina L. Leaf Aerobic
(10) Medicago minima L. Leaf - Root Aerobic
(11) Melilotus neapolitana Ten. Leaf - Root Aerobic
(17) Rosmarinus officinalis L. Leaf Aerobic
(15) Pinus pinea L. Leaf Aerobic
(14) Fraxinus ornus L. Leaf Aerobic
(23) Teucrium chamaedrys L. Leaf - Root Aerobic
(24) Teucrium polium L. Leaf - Root Aerobic
(21) Petrorhagia saxifraga L. Leaf - Root Aerobic
(22) Petrorhagia velutina Guss Leaf - Root Aerobic
(20) Lobularia maritima L. Leaf - Root Aerobic
(18) Bellis perennis L. Leaf - Root Aerobic
Functional group
Wetland
Grassland
Wetland
Woodland
Grassland
Mobile sand dune
Grassland
Woodland
Mobile sand dune
Grassland
Grassland
Shrubland
Shrubland
Woodland
Shrubland
Woodland
Woodland
Wetland
Woodland
Grassland
Grassland
Grassland
Grassland
Grassland
Grassland
Bonanomi et al. (2005)

AC +
AC -
Control Quercus ilex
0Decomposition
days
120 0 120
Heterospecific ConspecificLITTER
Toxicity experiment

Nutrient cycling
Model idea
Inhibitory effect by
extracellular SELF-DNA

DNA concentration
Fresh litter Decomposed litter Agarose gel

DNA release by litter
decomposition and
root turnover
extracellular DNA
degradation
interactions with minerals
and organic matter
uptake
Enhance
pathogen
attack
inhibit root
functionality
inhibit cell
functionality
Inhibitory effect of extracellular SELF-DNA as mechanism of NF

149
Jantzen-Connel distribution of seedlings is explained

Discovery (1)
> 30 plant species
Results published in: New Phytologist 2015 a
+ Heterologous DNA + Self DNA

Inhibitory effect not only for plants: it is a general biological phenomenon!
Discovery (2) Results published in: New Phytologist 2015 b
+ SELF-DNA

Inhibitory effect not only for plants: it is a general biological phenomenon!
Discovery (2) Results published in: New Phytologist 2015 b
+ SELF-DNA
X
Animalia: Sarchophaga carnaria
+ SELF-DNA+ Heterologous DNA

Innovative concept
Harmful organisms can be controlled by the exposure to their own DNA

Spodoptora
Plodia
Soil nematodes
Varroa
Snails
Weeds
AGRO applications

DNA
extraction
Specific
nematode
inhibitor
Synthetic
pesticide
(
(
Pesticide
application
Self-DNA
application
PARASITE/PATHOGEN ATTACK
Imagine if:
NEW SCENARIO FOR BIOCONTROL
Traditional approach

Synthetic
herbicide
DNA
extraction
Specific
weed
inhibitor
(
(
WEEDS INFESTATION

15years(averageresearchtime)
• Random screening long and
expensive
• Low or No specificity of action
• Toxicity for humans
• Environmental contamination
• Pathogen resistance problem
Problems!
Traditional phytochemical and pharmaceutical approach

15years(averageresearchtime)
NEW NOSELF METHOD
1year
DNA
extraction
TARGET
BIOLOGICAL
SYSTEM
DNA fragmentation
Traditional phytochemical and pharmaceutical approach
• No random screening
• High specificity of action
• No toxicity for humans
• No environmental contamination
• No pathogen resistance problem
Imagine if:

COMPARATIVE ANALYSIS
Traditional
approach
No Self
Technology
High ENVIRONMENTAL POLLUTION None
High ONSET OF RESISTANCE None
Low SPECIFICITY OF ACTION Maximal
High HUMAN HEALTH HAZARD None
High R&D COSTS Low
Years R&D DURATION Months

controlling harmful species in agriculture with their own DNA
as nature does
AND
Biopharma
:)

The benefits of biologicals for food & health industries

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