Mitochondrial myopathy is a group of neuromuscular diseases caused by damage to the mitochondria in nerve and muscle cells. Symptoms include muscle weakness, exercise intolerance, heart problems, movement disorders, and seizures. Most cases occur in people under 20 years old and begin with exercise intolerance or muscle weakness. While prognoses vary, these are progressive diseases that can lead to death. There is no cure, but physical therapy, vitamins, and supplements may provide relief from some symptoms.