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Management of acute asthma The British Thoracic Society  Scottish Intercollegiate Guidelines Network Management of acute asthma. Thorax 2003; 58 (Suppl I): i1-i92
Patients at risk of developing near fatal or fatal asthma Management of acute asthma. Thorax 2003; 58 (Suppl I): i1-i92 and Recognised by combination of: Severe asthma Adverse behavioural or psychosocial features
Patients at risk of developing near fatal or fatal asthma Management of acute asthma. Thorax 2003; 58 (Suppl I): i1-i92 and Recognised by combination of: Adverse behavioural or psychosocial features ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Severe asthma
Patients at risk of developing near fatal or fatal asthma Management of acute asthma. Thorax 2003; 58 (Suppl I): i1-i92 and Recognised by combination of: Severe asthma ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Adverse behavioural or psychosocial features
Lessons learnt from studies of asthma deaths Management of acute asthma. Thorax 2003; 58 (Suppl I): i1-i92 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Health care professionals must be aware that patients with severe asthma and one or more adverse psychosocial factors are at risk of death B Respiratory specialist should follow up patients admitted with severe asthma for at least a year after admission  Keep patients who have had near fatal asthma or brittle asthma under specialist supervision indefinitely 
Levels of severity of acute asthma exacerbations Management of acute asthma. Thorax 2003; 58 (Suppl I): i1-i92 Raised PaCO 2  and/or requiring mechanical ventilation with raised inflation pressures Near fatal asthma
Levels of severity of acute asthma exacerbations Management of acute asthma. Thorax 2003; 58 (Suppl I): i1-i92 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Any one of the following in a patient with severe asthma: Life threatening asthma ,[object Object],[object Object],[object Object],[object Object],Raised PaCO 2  and/or requiring mechanical ventilation with raised inflation pressures Near fatal asthma
Levels of severity of acute asthma exacerbations Management of acute asthma. Thorax 2003; 58 (Suppl I): i1-i92 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Any one of: Acute severe asthma ,[object Object],[object Object],[object Object],Any one of the following in a patient with severe asthma: Life threatening asthma ,[object Object],[object Object],[object Object],[object Object],Raised PaCO 2  and/or requiring mechanical ventilation with raised inflation pressures Near fatal asthma
Levels of severity of acute asthma exacerbations Management of acute asthma. Thorax 2003; 58 (Suppl I): i1-i92 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Any one of: Acute severe asthma ,[object Object],[object Object],[object Object],Any one of the following in a patient with severe asthma: Life threatening asthma ,[object Object],[object Object],Moderate asthma exacerbation ,[object Object],[object Object],[object Object],[object Object],Raised PaCO 2  and/or requiring mechanical ventilation with raised inflation pressures Near fatal asthma
Levels of severity of acute asthma exacerbations Management of acute asthma. Thorax 2003; 58 (Suppl I): i1-i92 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Any one of: Acute severe asthma ,[object Object],[object Object],[object Object],Any one of the following in a patient with severe asthma: Life threatening asthma ,[object Object],[object Object],Brittle asthma ,[object Object],[object Object],Moderate asthma exacerbation ,[object Object],[object Object],[object Object],[object Object],Raised PaCO 2  and/or requiring mechanical ventilation with raised inflation pressures Near fatal asthma
Initial assessment – the role of symptoms, signs and measurements Management of acute asthma. Thorax 2003; 58 (Suppl I): i1-i92 Clinical features, symptoms and respiratory and cardiovascular signs helpful in recognising severe asthma, but none specific, and their absence does not exclude a severe attack Clinical features
Initial assessment – the role of symptoms, signs and measurements Management of acute asthma. Thorax 2003; 58 (Suppl I): i1-i92 Measurements of airway calibre improve recognition of severity and guide hospital or at home management decisions.  PEF is more convenient and cheaper than FEV 1 .  PEF as % previous best value or % predicted most useful PEF or FEV 1 Clinical features, symptoms and respiratory and cardiovascular signs helpful in recognising severe asthma, but none specific, and their absence does not exclude a severe attack Clinical features
Initial assessment – the role of symptoms, signs and measurements Management of acute asthma. Thorax 2003; 58 (Suppl I): i1-i92 Necessary to determine adequacy of oxygen therapy and need for arterial blood gas measurement. Aim of oxygen therapy is to maintain SpO 2    92% Pulse oximetry Measurements of airway calibre improve recognition of severity and guide hospital or at home management decisions.  PEF is more convenient and cheaper than FEV 1 .  PEF as % previous best value or % predicted most useful PEF or FEV 1 Clinical features, symptoms and respiratory and cardiovascular signs helpful in recognising severe asthma, but none specific, and their absence does not exclude a severe attack Clinical features
Initial assessment – the role of symptoms, signs and measurements Management of acute asthma. Thorax 2003; 58 (Suppl I): i1-i92 Necessary for patients with SpO 2  <92% or other features of life threatening asthma Blood gases (ABG) Necessary to determine adequacy of oxygen therapy and need for arterial blood gas measurement. Aim of oxygen therapy is to maintain SpO 2    92% Pulse oximetry Measurements of airway calibre improve recognition of severity and guide hospital or at home management decisions.  PEF is more convenient and cheaper than FEV 1 .  PEF as % previous best value or % predicted most useful PEF or FEV 1 Clinical features, symptoms and respiratory and cardiovascular signs helpful in recognising severe asthma, but none specific, and their absence does not exclude a severe attack Clinical features
Initial assessment – the role of symptoms, signs and measurements Management of acute asthma. Thorax 2003; 58 (Suppl I): i1-i92 ,[object Object],[object Object],Not routinely recommended in patients in the absence of: Chest X-ray ,[object Object],[object Object],[object Object],Necessary for patients with SpO 2  <92% or other features of life threatening asthma Blood gases (ABG) Necessary to determine adequacy of oxygen therapy and need for arterial blood gas measurement. Aim of oxygen therapy is to maintain SpO 2    92% Pulse oximetry Measurements of airway calibre improve recognition of severity and guide hospital or at home management decisions.  PEF is more convenient and cheaper than FEV 1 .  PEF as % previous best value or % predicted most useful PEF or FEV 1 Clinical features, symptoms and respiratory and cardiovascular signs helpful in recognising severe asthma, but none specific, and their absence does not exclude a severe attack Clinical features
Initial assessment – the role of symptoms, signs and measurements Management of acute asthma. Thorax 2003; 58 (Suppl I): i1-i92 ,[object Object],[object Object],Not routinely recommended in patients in the absence of: Chest X-ray ,[object Object],[object Object],[object Object],Necessary for patients with SpO 2  <92% or other features of life threatening asthma Blood gases (ABG) Necessary to determine adequacy of oxygen therapy and need for arterial blood gas measurement. Aim of oxygen therapy is to maintain SpO 2    92% Pulse oximetry Measurements of airway calibre improve recognition of severity and guide hospital or at home management decisions.  PEF is more convenient and cheaper than FEV 1 .  PEF as % previous best value or % predicted most useful PEF or FEV 1 Abandoned as an indicator of the severity of an attack Systolic paradox Clinical features, symptoms and respiratory and cardiovascular signs helpful in recognising severe asthma, but none specific, and their absence does not exclude a severe attack Clinical features
Management of acute severe asthma in adults in A&E: assessment of PEF Management of acute asthma. Thorax 2003; 58 (Suppl I): i1-i92
Management of acute severe asthma in adults in A&E: PEF >75% predicted Management of acute asthma. Thorax 2003; 58 (Suppl I): i1-i92 60 min 15-30 min Clinically stable AND PEF >75% Give usual bronchodilator 5 min PEF >75% best or predicted: mild POTENTIAL DISCHARGE 120 min Measure PEF and arterial saturations Time
Management of acute severe asthma in adults in A&E: PEF 33-75% predicted Management of acute asthma. Thorax 2003; 58 (Suppl I): i1-i92 features of severe asthma ,[object Object],[object Object],[object Object],[object Object],Life threatening features OR PEF <50% Clinically stable AND PEF <75% No life threatening features AND PEF 50-75% 15-30 min Clinically stable AND PEF >75% Give salbutamol 5mg by oxygen-driven nebuliser 5 min PEF 33-75% best/predicted:   moderate/severe Measure PEF and arterial saturations Time ,[object Object],[object Object],[object Object],IMMEDIATE MANAGEMENT
Management of acute severe asthma in adults in A&E: PEF 33-75% predicted Management of acute asthma. Thorax 2003; 58 (Suppl I): i1-i92 PEF 33-75% best/predicted: moderate/severe Measure PEF and arterial saturations Time Patient recovering AND PEF >75% No signs of severe asthma AND PEF 50-70% Repeat  salbutamol 5mg nebuliser Give prednisolone 40-50mg orally Signs of severe asthma OR PEF <50% Life threatening features OR PEF <50% Clinically stable AND PEF <75% No life threatening features AND PEF 50-75% 60 min 15-30 min Clinically stable AND PEF >75% IMMEDIATE MANAGEMENT ,[object Object],[object Object],[object Object],[object Object],[object Object]
Management of acute asthma. Thorax 2003; 58 (Suppl I): i1-i92 Management of acute severe asthma in adults in A&E: PEF 33-75% predicted ,[object Object],[object Object],[object Object],[object Object],[object Object],ADMIT Patient should be accompanied by a nurse or doctor at all times Signs of severe asthma OR PEF <50% Patient stable AND PEF >50% OBSERVE monitor SpO 2 , heart rate and respiratory rate Patient recovering AND PEF >75% No signs of severe asthma AND PEF 50-70% Signs of severe asthma OR PEF <50% 60 min 15-30 min Clinically stable AND PEF >75% POTENTIAL DISCHARGE 120 min PEF 33-75% best/predicted: moderate/severe Measure PEF and arterial saturations Time
Management of acute severe asthma in adults in A&E: PEF <33% predicted Management of acute asthma. Thorax 2003; 58 (Suppl I): i1-i92 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Obtain senior/ICU help now if any life-threatening features are present 5 min 15-30 min ,[object Object],[object Object],[object Object],[object Object],Measure arterial blood gases Markers of severity: IMMEDIATE MANAGEMENT ,[object Object],60 min PEF <33% best or predicted  OR  any   life threatening features : ADMIT – Patient should be accompanied by a nurse or doctor at all times 120 min ,[object Object],[object Object],Measure PEF and arterial saturations Time
Management of acute severe asthma in adults in A&E: potential discharge Management of acute asthma. Thorax 2003; 58 (Suppl I): i1-i92 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Management of acute asthma. Thorax 2003; 58 (Suppl I): i1-i92 Management of acute severe asthma in adults in hospital: assessment of PEF
Management of acute asthma. Thorax 2003; 58 (Suppl I): i1-i92 Management of acute severe asthma in adults in hospital Caution:  Patients with severe attacks may not be distressed and may not have all these abnormalities.  The presence of any should alert the doctor. FEATURES OF ACUTE SEVERE ASTHMA ,[object Object],[object Object],[object Object],[object Object]
Management of acute asthma. Thorax 2003; 58 (Suppl I): i1-i92 Management of acute severe asthma in adults in hospital Caution:  Patients with life threatening attacks may not be distressed and may not have all these abnormalities.  The presence of any should alert the doctor. LIFE THREATENING FEATURES ,[object Object],[object Object],[object Object],[object Object],[object Object]
Management of acute asthma. Thorax 2003; 58 (Suppl I): i1-i92 Management of acute severe asthma in adults in hospital BLOOD GAS MARKERS OF A LIFE THREATENING ATTACK ,[object Object],[object Object],[object Object],[object Object],If a patient has any life threatening feature, measure arterial blood gases.  No other investigations are needed for immediate management
Management of acute asthma. Thorax 2003; 58 (Suppl I): i1-i92 Management of acute severe asthma in adults in hospital ,[object Object],[object Object],NEAR FATAL ASTHMA
Management of acute severe asthma in adults in hospital Management of acute asthma. Thorax 2003; 58 (Suppl I): i1-i92 ,[object Object],[object Object],[object Object],IF LIFE THREATENING FEATURES ARE PRESENT: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],IMMEDIATE TREATMENT
Management of acute severe asthma in adults in hospital Management of acute asthma. Thorax 2003; 58 (Suppl I): i1-i92 IF PATIENT IS STILL NOT IMPROVING: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],IF PATIENT NOT IMPROVING AFTER 15-30 MINUTES: ,[object Object],[object Object],[object Object],IF PATIENT IS IMPROVING continue: SUBSEQUENT MANAGEMENT IMMEDIATE TREATMENT
Management of acute severe asthma in adults in hospital Management of acute asthma. Thorax 2003; 58 (Suppl I): i1-i92 ,[object Object],[object Object],[object Object],Transfer to ICU accompanied by a doctor prepared to intubate if: ,[object Object],[object Object],[object Object],[object Object],MONITORING SUBSEQUENT MANAGEMENT IMMEDIATE TREATMENT
Management of acute severe asthma in adults in hospital Management of acute asthma. Thorax 2003; 58 (Suppl I): i1-i92 ,[object Object],[object Object],MONITORING Patients with severe asthma  (indicated by need for admission)  and adverse behavioural or psychosocial features are at risk of further severe or fatal attacks ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],When discharged from hospital, patients should have: DISCHARGE SUBSEQUENT MANAGEMENT IMMEDIATE TREATMENT
Management of acute asthma. Thorax 2003; 58 (Suppl I): i1-i92 Referral and admission of adults with acute asthma Admit patients with any feature of a life threatening or near fatal attack, or severe attack persisting after initial treatment B ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],C Refer to hospital any patients with features of acute severe or life threatening asthma D Discharge from A&E patients with PEF >75% best or predicted 1 hour after initial treatment, unless:
Oxygen treatment for acute asthma in adults Management of acute asthma. Thorax 2003; 58 (Suppl I): i1-i92 Give high flow oxygen to all patients with acute severe asthma C Whilst supplemental oxygen is recommended, its absence should not prevent nebulised therapy being given if indicated C ,[object Object],[object Object],A
ß 2 -agonist bronchodilators for acute asthma in adults Management of acute asthma. Thorax 2003; 58 (Suppl I): i1-i92 In severe/poorly responsive asthma, consider continuous nebulisation A Use high dose inhaled   2  agonists first line in acute asthma given as early as possible, with IV   2  agonists if inhaled therapy cannot be used reliably A Use oxygen driven nebuliser in acute life threatening asthma 
Steroids  and other therapy for acute asthma in adults Management of acute asthma. Thorax 2003; 58 (Suppl I): i1-i92 Routine prescription of antibiotics is not indicated for acute asthma B IV magnesium sulphate (1.2-2 g IV infusion over 20 minutes) and IV aminophylline should only be used following consultation with senior medical staff  Consider IV magnesium sulphate for patients with poorly responding acute severe or life threatening asthma A Nebulised ipratropium bromide (0.5mg 4-6 hourly) should be added to   2  agonist treatment if poor response to   2  agonist therapy A Give steroid tablets in adequate doses in all cases of acute asthma A Continue prednisolone 40-50mg daily for at least 5 days or until recovery 
Monitoring of adults with acute asthma Management of acute asthma. Thorax 2003; 58 (Suppl I): i1-i92 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],
Management of acute asthma. Thorax 2003; 58 (Suppl I): i1-i92 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Referral of adults with acute asthma to intensive care All patients transferred to intensive care units should be accompanied by a doctor suitably equipped and skilled to intubate if necessary C
Hospital discharge and follow up after acute asthma Management of acute asthma. Thorax 2003; 58 (Suppl I): i1-i92 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],The patient’s primary care practice must be informed (by fax/ e-mail) within 24 hours of discharge from A&E/hospital after asthma exacerbation, ideally directly with named individual responsible for asthma care 
Overview: Management of acute asthma Management of acute asthma. Thorax 2003; 58 (Suppl I): i1-i92 ,[object Object],[object Object],[object Object],[object Object],[object Object]

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Management Of Acute Asthma

  • 1. Management of acute asthma The British Thoracic Society Scottish Intercollegiate Guidelines Network Management of acute asthma. Thorax 2003; 58 (Suppl I): i1-i92
  • 2. Patients at risk of developing near fatal or fatal asthma Management of acute asthma. Thorax 2003; 58 (Suppl I): i1-i92 and Recognised by combination of: Severe asthma Adverse behavioural or psychosocial features
  • 3.
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  • 6. Levels of severity of acute asthma exacerbations Management of acute asthma. Thorax 2003; 58 (Suppl I): i1-i92 Raised PaCO 2 and/or requiring mechanical ventilation with raised inflation pressures Near fatal asthma
  • 7.
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  • 10.
  • 11. Initial assessment – the role of symptoms, signs and measurements Management of acute asthma. Thorax 2003; 58 (Suppl I): i1-i92 Clinical features, symptoms and respiratory and cardiovascular signs helpful in recognising severe asthma, but none specific, and their absence does not exclude a severe attack Clinical features
  • 12. Initial assessment – the role of symptoms, signs and measurements Management of acute asthma. Thorax 2003; 58 (Suppl I): i1-i92 Measurements of airway calibre improve recognition of severity and guide hospital or at home management decisions. PEF is more convenient and cheaper than FEV 1 . PEF as % previous best value or % predicted most useful PEF or FEV 1 Clinical features, symptoms and respiratory and cardiovascular signs helpful in recognising severe asthma, but none specific, and their absence does not exclude a severe attack Clinical features
  • 13. Initial assessment – the role of symptoms, signs and measurements Management of acute asthma. Thorax 2003; 58 (Suppl I): i1-i92 Necessary to determine adequacy of oxygen therapy and need for arterial blood gas measurement. Aim of oxygen therapy is to maintain SpO 2  92% Pulse oximetry Measurements of airway calibre improve recognition of severity and guide hospital or at home management decisions. PEF is more convenient and cheaper than FEV 1 . PEF as % previous best value or % predicted most useful PEF or FEV 1 Clinical features, symptoms and respiratory and cardiovascular signs helpful in recognising severe asthma, but none specific, and their absence does not exclude a severe attack Clinical features
  • 14. Initial assessment – the role of symptoms, signs and measurements Management of acute asthma. Thorax 2003; 58 (Suppl I): i1-i92 Necessary for patients with SpO 2 <92% or other features of life threatening asthma Blood gases (ABG) Necessary to determine adequacy of oxygen therapy and need for arterial blood gas measurement. Aim of oxygen therapy is to maintain SpO 2  92% Pulse oximetry Measurements of airway calibre improve recognition of severity and guide hospital or at home management decisions. PEF is more convenient and cheaper than FEV 1 . PEF as % previous best value or % predicted most useful PEF or FEV 1 Clinical features, symptoms and respiratory and cardiovascular signs helpful in recognising severe asthma, but none specific, and their absence does not exclude a severe attack Clinical features
  • 15.
  • 16.
  • 17. Management of acute severe asthma in adults in A&E: assessment of PEF Management of acute asthma. Thorax 2003; 58 (Suppl I): i1-i92
  • 18. Management of acute severe asthma in adults in A&E: PEF >75% predicted Management of acute asthma. Thorax 2003; 58 (Suppl I): i1-i92 60 min 15-30 min Clinically stable AND PEF >75% Give usual bronchodilator 5 min PEF >75% best or predicted: mild POTENTIAL DISCHARGE 120 min Measure PEF and arterial saturations Time
  • 19.
  • 20.
  • 21.
  • 22.
  • 23.
  • 24. Management of acute asthma. Thorax 2003; 58 (Suppl I): i1-i92 Management of acute severe asthma in adults in hospital: assessment of PEF
  • 25.
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  • 34.
  • 35. ß 2 -agonist bronchodilators for acute asthma in adults Management of acute asthma. Thorax 2003; 58 (Suppl I): i1-i92 In severe/poorly responsive asthma, consider continuous nebulisation A Use high dose inhaled  2 agonists first line in acute asthma given as early as possible, with IV  2 agonists if inhaled therapy cannot be used reliably A Use oxygen driven nebuliser in acute life threatening asthma 
  • 36. Steroids and other therapy for acute asthma in adults Management of acute asthma. Thorax 2003; 58 (Suppl I): i1-i92 Routine prescription of antibiotics is not indicated for acute asthma B IV magnesium sulphate (1.2-2 g IV infusion over 20 minutes) and IV aminophylline should only be used following consultation with senior medical staff  Consider IV magnesium sulphate for patients with poorly responding acute severe or life threatening asthma A Nebulised ipratropium bromide (0.5mg 4-6 hourly) should be added to  2 agonist treatment if poor response to  2 agonist therapy A Give steroid tablets in adequate doses in all cases of acute asthma A Continue prednisolone 40-50mg daily for at least 5 days or until recovery 
  • 37.
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  • 40.