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Mental Health Wearables
April 21, 2015
Craig A. DeLarge, Shana L. Washington, Cheryl DeLarge
The Digital Mental Health Project, WiseWorking, LLC
Copyright, 2015, WiseWorking, LLC
+
Agenda
 What is the The Digital Mental Health Project?
 What are Mental Health Wearables (MHW)?
 Who are the Players in this Space?
 Some Conclusions & Insights?
 What Can You Do To Help?
Copyright, 2015, WiseWorking, LLC
2
+ The Digital Mental Health
Project
Copyright, 2015, WiseWorking, LLC 3
+
What is The Digital Mental Health
Project?
 My Sabbatical Project in late 2014!
 An exploration of the ways digital technology is being used to
preserve or recover mental health
 A collection of ongoing of projects: research, publications and
events to educate, curate and connect “digital mental health”
“interesteds” to nurture responsible scale-up of this space
 A call to address the “shadow elements” & barriers to scale up: 1)
stigma/discrimination, 2) privacy concerns, 3) measurement
accuracy & 4) digital divides
Copyright, 2015, WiseWorking, LLC
4
+
Copyright, 2015, WiseWorking, LLC
5
The Digital Mental Health Project is a
portfolio of current & pending projects
EventsPublicationsResearch
Awareness & Use
Survey
Landscape Maps
Social Media
Listen. Analysis
Podcast Series
Peer-Reviewed
Articles
CME Course
#mMentalHealth
LI/TweetChat
Mental Health
Digital Innovation
Challenge
Mental Health
Wearables Talk
DataBase
+
Why this Research?
 Mental health is generally in
decline around the world
 Digital technology adoption
growing
 Digital adoption for mental
health is early stage & needing
attention, influence &
responsible scale up
 This space is full of
opportunity & risk which must
be managed well
Copyright, 2015, WiseWorking, LLC
6
“There is no
health without
mental health.”
Richard Carmona,
US Surgeon General, 2002-6
+ Digital Mental Health Applications across
the Care Continuum
Copyright, 2015, WiseWorking, LLC
Prevention Diagnosis Treatment Maintenance
• Social
communities for
education &
stigma reduction
• Mobile apps &
sensors for diet,
exercise, sleep &
good
relationships
• MRI of the
mentally well/ill
brain
• Predictive data
algorithms for
onset alerts
• TelePsych for
remote diagnosis
• Social
communities for
support &
education,
• Therapy mobile
apps for PE & CBT
• Compliance
app/sensor
combinations
• TelePsych for
remote
treatment
• Virtual &
Augmented
Reality
• Care
coordination
platforms to
optimize
interventions
• TeleCare for
remote
interventions
• Realtime data
algorithms for
onset alerts
• Compliance
app/sensor
combinations
Source: The Digital Mental Health Project
+ What are Mental Health
Wearables?
Copyright, 2015, WiseWorking, LLC 8
+
What are Mental Health Wearables?
 The subcategory of wearables
developed expressly to aid the
preservation or recover of
mental health.
 A subset of a $400B annual
global sector of energy or
relaxation inducing products &
services1
Copyright, 2015, WiseWorking, LLC 1 – Source: Thync
9
+ Mental Health Wearable Applications across
the Care Continuum
Copyright, 2015, WiseWorking, LLC
Prevention Diagnosis Treatment Maintenance
• Mobile apps &
sensors for diet,
exercise, sleep &
good
relationships
• EEG of the
mentally well/ill
brain
• Predictive data
algorithms for
onset alerts
• Virtual &
Augmented
Reality
• Compliance
app/sensor
combinations
Source: The Digital Mental Health Project
+
Who are the Players?
Copyright, 2015, WiseWorking, LLC 11
+
MUSE
The brain sensing headband
Description: A brain fitness tool that uses EEG to teach users
how to focus and sustain their attention through meditation
based exercises with real-time feedback.
Application(s)
 Reduce stress
 Boost attention
 Learn to meditate
 Measure brain activity for various brain-computer interface
applications; open app development platform
Effectiveness: Several randomized clinical trials underway in
different population groups at tier 1 universities; first results
mid-2015.
Level of Adoption: Unknown
Anxiety.org Accessed 3/29/15
+
Thync
Wearable Mood Modification
Description: 1st consumer wearable using
neurosignaling algorithms to shift people’s state
of mind in areas related to energy, calm, and
focus.
Application(s)
 Reduces the brain’s response to stress
 Helps people monitor their mood at will
 Helps to achieve certain mental states without
stimulators
Effectiveness: 82 volunteers experienced
significant stress reduction and 97% of these,
greater relaxation vs placebo
Level of Adoption:
 Trialed in over 3,000 people
 Launch scheduled in 2015
 Substitute for procedures, drugs & chemicals
1 The Daily Dot “Thync prepares to launch a mood-altering wearable” October 24, 2014
Images of the device not
available.
+
Spire
Wearable Breath Tracker
Description: A wearable that measures
breathing patterns throughout the day and
notifies users when tense
Application(s)
 Tracks the frequency & magnitude of
breathing
 Notifies users when tense
 Tracks steps and activity
 Provides breathing retraining guidance
Effectiveness: Currently planning clinical studies
with Stanford, UC Davis, Alliant University, and
Harvard University among others.
Level of Adoption:
 Began shipping January 2015
1 The Daily Dot “Thync prepares to launch a mood-altering wearable” October 24, 2014
+
IMEC
Wearable Health Monitor
Description: Neurological
electroencephalographic (EEG) headsets
Application(s):
 Stress reduction
 Sleep Apnea detection
Effectiveness: N/A
Level of Adoption: N/A
1http://vandrico.com/wearables/device/imec-eeg-headset
+
Neurosky Mindwave
NeuroFeedback EcoSystem
Description: A headset that measures the
brainwaves & provides feedback
Application(s)
 Gameplay based on focus & calmness
(Crooked Tree Studios)
 Aiding study attention & focus (Nervanix)
 Stress reduction & mindfulness (ZenZone)
Clinical Effectiveness: Research institutions have
attested to the quality and effectiveness of
NeuroSky's technology1
Level of Adoption:
 UK’s National Health Service (ZenZone)
+
PSIOUS
Virtual Reality Psychotherapy
Description: A virtual reality tool that
administers prolonged exposure therapy
Application(s)
 Exposes patient to anxiety ridden scenarios,
i.e. flying, needles, driving, bugs, public
speaking, tight spaces, public spaces,
heights
 Allows therapist to witness & coach
patient’s experience
Effectiveness: VR has 90% success rate. Psious
has similar effectiveness in 2 pilots w 6 BII Phobia
patients over 8 weekly sessions. Stanford
University, University of lllinois & UNAM are
currently running studies.
Level of Adoption: 90+ private clinicians + top
institutions such as Stanford & USC using it.
+
Conclusion & Insights
Copyright, 2015, WiseWorking, LLC 18
+
Applications are Broad & Promising!
Copyright, 2015, WiseWorking, LLC
Prevention Diagnosis Treatment Maintenance
• Mobile apps &
sensors for diet,
exercise, sleep &
good
relationships
• EEG of the
mentally well/ill
brain
• Predictive data
algorithms for
onset alerts
• Virtual &
Augmented
Reality
• Compliance
app/sensor
combinations
Source: The Digital Mental Health Project
+
Business Model Potentials Go
Significantly Beyond Device Revenue
Device $ X X X X X X
In-app $ X X X
Software
License
X
Data Algo. X X X X X X
Research
Methods
X X X X X X
App Stores X
Copyright, 2015, WiseWorking, LLC
20
+
More Efficacy than I Thought; in Very Early
Adoption Stage and Broad Payer Prospects
Efficacy Y? Y Y? ? Y? Y
Adoption ? Y ? ? Y Y
Who
Paying?
C
P?
C C
E
A A
C
P
TD
HCP
A
Copyright, 2015, WiseWorking, LLC
21
C – Consumer
P – Payor
E – Employer
HCP – Healthcare Professionals
TD – Tech Developers
A – Academia
+
Chief Barriers for Continued Work
Socio-Cultural-Legal
 stigma & discrimination
 measurement accuracy
 privacy concerns
 affordability
 funding
Technical
data integration &
insights
desirable form factors
lack of apps
battery life
+
How We Can Contribute to this Space’s
Progression?
Work to Address Barriers
Continue to Efficacy Evidence
Envision & forge partnerships integrating into
present prevention & treatment platforms &
regimens
Copyright, 2015, WiseWorking, LLC
24
Now for Questions & Hopefully Answers!
For further discussion, reach me at:
215-530-1411
craig@wiseworking.com

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Mental Health Wearables Talk (for Distribution) 5 4 15

  • 1. + Mental Health Wearables April 21, 2015 Craig A. DeLarge, Shana L. Washington, Cheryl DeLarge The Digital Mental Health Project, WiseWorking, LLC Copyright, 2015, WiseWorking, LLC
  • 2. + Agenda  What is the The Digital Mental Health Project?  What are Mental Health Wearables (MHW)?  Who are the Players in this Space?  Some Conclusions & Insights?  What Can You Do To Help? Copyright, 2015, WiseWorking, LLC 2
  • 3. + The Digital Mental Health Project Copyright, 2015, WiseWorking, LLC 3
  • 4. + What is The Digital Mental Health Project?  My Sabbatical Project in late 2014!  An exploration of the ways digital technology is being used to preserve or recover mental health  A collection of ongoing of projects: research, publications and events to educate, curate and connect “digital mental health” “interesteds” to nurture responsible scale-up of this space  A call to address the “shadow elements” & barriers to scale up: 1) stigma/discrimination, 2) privacy concerns, 3) measurement accuracy & 4) digital divides Copyright, 2015, WiseWorking, LLC 4
  • 5. + Copyright, 2015, WiseWorking, LLC 5 The Digital Mental Health Project is a portfolio of current & pending projects EventsPublicationsResearch Awareness & Use Survey Landscape Maps Social Media Listen. Analysis Podcast Series Peer-Reviewed Articles CME Course #mMentalHealth LI/TweetChat Mental Health Digital Innovation Challenge Mental Health Wearables Talk DataBase
  • 6. + Why this Research?  Mental health is generally in decline around the world  Digital technology adoption growing  Digital adoption for mental health is early stage & needing attention, influence & responsible scale up  This space is full of opportunity & risk which must be managed well Copyright, 2015, WiseWorking, LLC 6 “There is no health without mental health.” Richard Carmona, US Surgeon General, 2002-6
  • 7. + Digital Mental Health Applications across the Care Continuum Copyright, 2015, WiseWorking, LLC Prevention Diagnosis Treatment Maintenance • Social communities for education & stigma reduction • Mobile apps & sensors for diet, exercise, sleep & good relationships • MRI of the mentally well/ill brain • Predictive data algorithms for onset alerts • TelePsych for remote diagnosis • Social communities for support & education, • Therapy mobile apps for PE & CBT • Compliance app/sensor combinations • TelePsych for remote treatment • Virtual & Augmented Reality • Care coordination platforms to optimize interventions • TeleCare for remote interventions • Realtime data algorithms for onset alerts • Compliance app/sensor combinations Source: The Digital Mental Health Project
  • 8. + What are Mental Health Wearables? Copyright, 2015, WiseWorking, LLC 8
  • 9. + What are Mental Health Wearables?  The subcategory of wearables developed expressly to aid the preservation or recover of mental health.  A subset of a $400B annual global sector of energy or relaxation inducing products & services1 Copyright, 2015, WiseWorking, LLC 1 – Source: Thync 9
  • 10. + Mental Health Wearable Applications across the Care Continuum Copyright, 2015, WiseWorking, LLC Prevention Diagnosis Treatment Maintenance • Mobile apps & sensors for diet, exercise, sleep & good relationships • EEG of the mentally well/ill brain • Predictive data algorithms for onset alerts • Virtual & Augmented Reality • Compliance app/sensor combinations Source: The Digital Mental Health Project
  • 11. + Who are the Players? Copyright, 2015, WiseWorking, LLC 11
  • 12. + MUSE The brain sensing headband Description: A brain fitness tool that uses EEG to teach users how to focus and sustain their attention through meditation based exercises with real-time feedback. Application(s)  Reduce stress  Boost attention  Learn to meditate  Measure brain activity for various brain-computer interface applications; open app development platform Effectiveness: Several randomized clinical trials underway in different population groups at tier 1 universities; first results mid-2015. Level of Adoption: Unknown Anxiety.org Accessed 3/29/15
  • 13. + Thync Wearable Mood Modification Description: 1st consumer wearable using neurosignaling algorithms to shift people’s state of mind in areas related to energy, calm, and focus. Application(s)  Reduces the brain’s response to stress  Helps people monitor their mood at will  Helps to achieve certain mental states without stimulators Effectiveness: 82 volunteers experienced significant stress reduction and 97% of these, greater relaxation vs placebo Level of Adoption:  Trialed in over 3,000 people  Launch scheduled in 2015  Substitute for procedures, drugs & chemicals 1 The Daily Dot “Thync prepares to launch a mood-altering wearable” October 24, 2014 Images of the device not available.
  • 14. + Spire Wearable Breath Tracker Description: A wearable that measures breathing patterns throughout the day and notifies users when tense Application(s)  Tracks the frequency & magnitude of breathing  Notifies users when tense  Tracks steps and activity  Provides breathing retraining guidance Effectiveness: Currently planning clinical studies with Stanford, UC Davis, Alliant University, and Harvard University among others. Level of Adoption:  Began shipping January 2015 1 The Daily Dot “Thync prepares to launch a mood-altering wearable” October 24, 2014
  • 15. + IMEC Wearable Health Monitor Description: Neurological electroencephalographic (EEG) headsets Application(s):  Stress reduction  Sleep Apnea detection Effectiveness: N/A Level of Adoption: N/A 1http://vandrico.com/wearables/device/imec-eeg-headset
  • 16. + Neurosky Mindwave NeuroFeedback EcoSystem Description: A headset that measures the brainwaves & provides feedback Application(s)  Gameplay based on focus & calmness (Crooked Tree Studios)  Aiding study attention & focus (Nervanix)  Stress reduction & mindfulness (ZenZone) Clinical Effectiveness: Research institutions have attested to the quality and effectiveness of NeuroSky's technology1 Level of Adoption:  UK’s National Health Service (ZenZone)
  • 17. + PSIOUS Virtual Reality Psychotherapy Description: A virtual reality tool that administers prolonged exposure therapy Application(s)  Exposes patient to anxiety ridden scenarios, i.e. flying, needles, driving, bugs, public speaking, tight spaces, public spaces, heights  Allows therapist to witness & coach patient’s experience Effectiveness: VR has 90% success rate. Psious has similar effectiveness in 2 pilots w 6 BII Phobia patients over 8 weekly sessions. Stanford University, University of lllinois & UNAM are currently running studies. Level of Adoption: 90+ private clinicians + top institutions such as Stanford & USC using it.
  • 18. + Conclusion & Insights Copyright, 2015, WiseWorking, LLC 18
  • 19. + Applications are Broad & Promising! Copyright, 2015, WiseWorking, LLC Prevention Diagnosis Treatment Maintenance • Mobile apps & sensors for diet, exercise, sleep & good relationships • EEG of the mentally well/ill brain • Predictive data algorithms for onset alerts • Virtual & Augmented Reality • Compliance app/sensor combinations Source: The Digital Mental Health Project
  • 20. + Business Model Potentials Go Significantly Beyond Device Revenue Device $ X X X X X X In-app $ X X X Software License X Data Algo. X X X X X X Research Methods X X X X X X App Stores X Copyright, 2015, WiseWorking, LLC 20
  • 21. + More Efficacy than I Thought; in Very Early Adoption Stage and Broad Payer Prospects Efficacy Y? Y Y? ? Y? Y Adoption ? Y ? ? Y Y Who Paying? C P? C C E A A C P TD HCP A Copyright, 2015, WiseWorking, LLC 21 C – Consumer P – Payor E – Employer HCP – Healthcare Professionals TD – Tech Developers A – Academia
  • 22. + Chief Barriers for Continued Work Socio-Cultural-Legal  stigma & discrimination  measurement accuracy  privacy concerns  affordability  funding Technical data integration & insights desirable form factors lack of apps battery life
  • 23. + How We Can Contribute to this Space’s Progression? Work to Address Barriers Continue to Efficacy Evidence Envision & forge partnerships integrating into present prevention & treatment platforms & regimens
  • 24. Copyright, 2015, WiseWorking, LLC 24 Now for Questions & Hopefully Answers! For further discussion, reach me at: 215-530-1411 craig@wiseworking.com

Editor's Notes

  1. Description: MUSE is a sleek plastic band embedded with seven electroencephalography (EEG) sensors that monitor your brain activity and can send real-time information to any compatible device over Bluetooth. Applications: Reduce stress, boost concentration, focus users minds by guiding them through a series of focused-attention exercises with the Calm app. Muse uses 7 sensors to detect and measure brain activity. This activity is converted into information that users can track on their phone or tablet. 1 Clinical Effectiveness: According to Dr. Alexander Bystritsky, Director of Anxiety Disorders Clinic at UCLA are no randomized controlled clinical trials of this type
  2. Study Reports Significant Reduction in Stress via Electrical Neurosignaling LOS GATOS, Calif. – February 12, 2015 Thync today announced results from a study published via bioRxiv that show electrical neurosignaling delivered by its consumer wearable device reduces the brain’s response to stress in a chemical-free manner. Thync uses electrical waveforms targeted to specific neural pathways to reduce the brain’s response to stress. The study, conducted on 82 volunteers in the Boston area, revealed that a 14-minute session using Thync’s electrical waveforms resulted in significant stress reduction, with 97 percent of the subjects stating the effects induced greater relaxation than the sham treatment. “Our results show that electrical neurosignaling can significantly reduce sympathetic nervous system activity in the face of stressful conditions. After several years of R&D we found a way to tap directly into noradrenergic systems and the locus coeruleus, parts of the brain that regulate physiological and cognitive arousal in response to environmental stress such as the ‘fight or flight’ response. If you ask most people, they would say that directly modulating this part of the brain in such a way can only be accomplished with invasive procedures, drugs, or chemicals, but we show that is not true. We identified and targeted neural pathways that naturally communicate directly with this part of the brain,” said Jamie Tyler, CSO and co-founder of Thync. “Our brains already have the power to combat stress and achieve a calm state. We found a way to invoke these mechanisms on demand using approaches described in our recent report. For neuroscience, and for us, this is a big deal.” In the study, researchers experimentally induced stress in subjects by exposing them to various environmental stimuli causing fear or cognitive pressure. When Thync scientists examined stress biomarkers in the saliva of subjects at different time points throughout the study, they observed something interesting. They found the levels of salivary α-amylase, an enzyme that increases with stress, as well as noradrenergic and sympathetic activity, significantly dropped for the subjects that received electrical neurosignaling compared to the subjects that received the sham. “This particular observation was a breakthrough for us because it showed that we can suppress one of the body’s primary biochemical responses to acute stress by tapping into specific neural pathways,” said Tyler. The subjects that received Thync electrical neurosignaling also had significantly greater self-reported relaxation, as well as reduced heart-rate variability and galvanic skin responses. The Thync device also made no difference, as compared to the sham, on cognitive performance or executive processing reaction times. “The potential impact of our findings becomes rather evident when we study how the ability to decrease stress on demand affects people in more natural contexts – in their everyday life at home or work,” said Sumon Pal, Ph.D. neuroscientist and Executive Director of Thync. “We find that people just feel better when they can instantly relax when they want. The program only takes about 10 minutes to run, but the acute effects last from 30 minutes to an hour. People describe the sense of calm as similar to meditating or having a couple of drinks without being lethargic. We feel this can be a game changing approach to managing the daily stress we all experience day in and day out.” The full paper is available via bioRxiv and provides a scientific description of how transdermal electrical neurosignaling significantly reduced the brain’s response to stress by acting on central noradrenergic systems. The neurosignaling approach used in the study was a culmination of a three-year R&D venture combining Ph.D. neuroscientists with experienced technology engineers. Those interested in hearing more about Thync or becoming part of the Thync community can visit www.thync.com.     About Thync Founded in 2011 by entrepreneur and investor Isy Goldwasser and Dr. Jamie Tyler, Associate Professor of Biological and Health Systems Engineering at Arizona State University, Thync is dedicated to giving people access to the power of their minds. Since inception, the company has raised $13 million in funding. Thync is headquartered in Silicon Valley, with an office in Boston. Thync board members include Goldwasser, Tyler, Blake Krikorian and Samir Kaul. More information is available at www.thync.com. Media Contact: Kathy Johnson at Consort Partners for Thync (415) 823-9566 pr@thync.com All Press Releases end layout-widget-wrapper end widget-span end row end row-wrapper end widget-span end row end row-wrapper end layout-widget-wrapper end widget-span end row end row-wrapper end body end body wrapper Home About us Science & Tech Resources Products Contact Participate Blog Privacy Policy Copyright 2015 Thync end layout-widget-wrapper end widget-span end row end row-wrapper end footer end footer wrapper Start of Async HubSpot Analytics Code End of Async HubSpot Analytics Code Google Tag Manager <iframe src="//www.googletagmanager.com/ns.html?id=GTM-K5Z6KH" height="0" width="0" style="display:none;visibility:hidden"></iframe> End Google Tag Manager <img height="1" width="1" alt="" style="display:none" src="https://www.facebook.com/tr?id=1488577711362791&ev=PixelInitialized"> <iframe src="http://20647161p.rfihub.com/ca.html?rb=17409&ca=20647161&ra=%n" style="display:none;padding:0;margin:0" width="0" height="0"></iframe> Generated by the HubSpot Template Builder - template version 1.03 end coded_template: id:2413573765 path:generated_layouts/2413573755.html  
  3. Imec is looking at partnering their extensive knowledge of health monitoring with other OEM manufacturers.
  4. 1 According to NeuroSky website
  5. Description: MUSE is a sleek plastic band embedded with seven electroencephalography (EEG) sensors that monitor your brain activity and can send real-time information to any compatible device over Bluetooth. Applications: Reduce stress, boost concentration, focus users minds by guiding them through a series of focused-attention exercises with the Calm app. Muse uses 7 sensors to detect and measure brain activity. This activity is converted into information that users can track on their phone or tablet. 1 Clinical Effectiveness: According to Dr. Alexander Bystritsky, Director of Anxiety Disorders Clinic at UCLA are no randomized controlled clinical trials of this type