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PET CT. Shabnam.pptx-positron emission tomography scan
- 1. PET-CT By: Seyedeh Shabnam Mousavi Gezafroodi Medical Physics M.Sc.
- 2. Outline • Nuclear Medicine • PET o Principles o Radiopharmaceuticals o Crystals • PET/CT o Imaging technique o Clinical applications o Radiation exposure o Coincidence o Resolution o Limitations & advantages Shabnam Mousavi, Medical Physicis
- 3. What is nuclear medicine? • Biodistribution map of Radiopharmaceutical in Body • Diagnostic (Gamma radiation) & Treatment (Beta radiation) • Nuclear medicine imaging includes: 1. Radioisotopes (Generator, Baby cyclotron) 2. Radiopharmaceuticals (Hot Lab) 3. Instruments (PET & SPECT) 4. Data processing Shabnam Mousavi, Medical Physicis
- 4. PET imaging • Detecting (indirectly) positrron emission via the detection of both annihilation photons (511 keV) that occur and hit opposite detector simultaneously β⁺ emission β⁺ annihilates to 2 photons Photons are detected Lies on a line At a point determind by time of flight • Positron imaging idea • William H Sweet (Suggestion for using annihilation radiation) First clinical positron imaging device 1953 Shabnam Mousavi, Medical Physicis
- 5. Basics of Positron Emission Tomography Shabnam Mousavi, Medical Physicis
- 6. Principles of PET Shabnam Mousavi, Medical Physicis
- 7. FDG Shabnam Mousavi, Medical Physicis
- 8. PET radiopharmaceutical Shabnam Mousavi, Medical Physicis
- 9. Crystals used in PET Shabnam Mousavi, Medical Physicis
- 10. Designs for PET • NaI PET system • Coincidence Gamma Camera (PET/SPECT) • Dedicated PET • Hybrid PET/CT Scanner • Small animal PET • Portable PET Shabnam Mousavi, Medical Physicis
- 11. PET/CT • Was invented by Dr. Ron Nutt and Dr. David Townsend in 1998 • Medical inventions of the year 2000 by time magazine • Commercially available in 2001 Shabnam Mousavi, Medical Physicis
- 12. PET/CT Shabnam Mousavi, Medical Physicis
- 13. Shabnam Mousavi, Medical Physicis
- 14. Imaging technique Shabnam Mousavi, Medical Physicis
- 15. SUV Shabnam Mousavi, Medical Physicis
- 16. Display of PET-CT Shabnam Mousavi, Medical Physicis
- 17. PET-CT clinical application • Oncology • Neurology • Cardiology Shabnam Mousavi, Medical Physicis
- 18. FDG-PET false negative Shabnam Mousavi, Medical Physicis
- 19. FDG-PET false positive Shabnam Mousavi, Medical Physicis
- 20. Conclusion Shabnam Mousavi, Medical Physicis
- 21. Radiation exposure from PET/CT Shabnam Mousavi, Medical Physicis
- 22. PET imaging: Ideal case Shabnam Mousavi, Medical Physicis
- 23. Data arrangment Shabnam Mousavi, Medical Physicis
- 24. Deviations from ideal case – scatter events Shabnam Mousavi, Medical Physicis
- 25. Deviations from ideal case – random counts Shabnam Mousavi, Medical Physicis
- 26. Type of coincidence may be detected (at a glance) Shabnam Mousavi, Medical Physicis
- 27. Resolution Shabnam Mousavi, Medical Physicis
- 28. Limitations & artifacts of PET-CT Shabnam Mousavi, Medical Physicis
- 29. Advantages of PET-CT Shabnam Mousavi, Medical Physicis
- 30. Advantages of PET/MRI over PET/CT Shabnam Mousavi, Medical Physicis
- 31. Shabnam Mousavi, Medical Physicis
Editor's Notes
- درمانی: آلفا-بتا-دلتا تشخیصی: اکس و گاما
- Spatial resoulution ̴ 4-5 mm FWHM
- Analog of glucose Transported by facilitated diffusion Phosphorylated within the cell to [18F] FDG –6-phosphate Phosphorylated FDG can not exit cell
- Speciefic activity: High Half life: Few minutes Short: not enough time for examination Long: High dose to the patients & Waste disposal
- NaI NaI detectors thickness (up to 30 mm) Large area rather than a block configuration Six such crystals in hexagonal arrangement Suited to steady-state imaging Due count rate limitations, are less suitable for performing kinetic studies -------------------------------------------------- Coincidence camera Dual-head NaI-based gamma-cameras Crystal thickness is 15 mm Signal processing techniques improves poor coincidence count rate capability ------------------------------------- Dedicated One or more complete rings of block detectors Small ring diameter (60 cm) for brain imaging Larger ring diameter (100 cm) for whole body imaging Axial field of view depends on the number of rings Relatively high count rate capability Suitable for kinetic studies -------------------------- animal PET is Noninvasive Flexible in chemistry Very attractive in the study of laboratory animals and measuring biological process Several dedicated PET with spatial resolution of 1-2 mm have been developed for mice and rat
- عکس 5 فلدر 1
- عکس 14 فولدر 1
- عکس 14 فولدر 1