In today’s era of digitization, libraries across Africa are gradually shifting from piles of books to becoming digital, making it more effective, efficient, usable, accessible, quality and ensuring user satisfaction. Electronic library is a digital setting that keeps and organizes electronic books and their associated documents. Electronic libraries present a new and better platform for providing 24/7 access to latest and updated library materials, improving research and sharing knowledge. In well- developed economies, virtual library is the main source for preserving information and disseminating knowledge. In Ghana, the government through its agency, Ghana Library Authority has setup a digital library contents where students, including those in the health sector can read, watch and listen to eBook, video and audiobook collections aimed at optimizing responsible use of time for children whilst ensuring quality education. Nevertheless, some traditional librarians are of the view that electronic library has challenges which could limit its services, including intermittent power supply, limited access to internet services, poor and sufficient bandwidth. This paper therefore determines the impact of e- library on the performance of health students in institutions of higher education in Africa.