This document discusses thrombocytopenia, defining it as a platelet count below 150,000. It outlines three pathophysiological mechanisms: decreased platelet production, increased platelet destruction, and splenic sequestration. Splenic sequestration is the primary determinant of thrombocytopenia. Treatment options discussed include splenectomy, embolization of the splenic artery, and pharmacological therapies. Invasive procedures are only recommended when the platelet count is above 50,000.

2. Objetivos
1. DEFINICION DE TROMBOCITOPENIA
2. MECANISMOS FISIOPATOLÓGICOS
3. OPCIONES DE TRATAMIENTO
1. CUANDO TRANSFUNDIR

3. DEFINICION
< 150,000
100,000 – 150,000
50,000 – 100,000
<50,000
LEVE
MODERADA
SEVERA
Moore A. Thrombocitpenya in Cirrhosis: A review a phatophysiology and management options. CliniCal liver Disease, vOl 14, nO 5, november 2019

4. FISIOPATOLOGIA
Existen tres mecanismos fisiopatológicos de
la trombocitopenia:
1. DISMINUCION DE LA PRODUCCION DE
PLAQUETAS
2. AUMENTO DE LA DESTRUCCION DE
PLAQUETAS
3. SECUESTRO ESPLÉNICO
Gallo P, et al. Thrombocytopenia in chronic liver disease: Physiopathology and new therapeutic strategies before invasive
procedures. World J Gastroenterol 2022 August 14; 28(30): 4061-4074

5. Disminución de producción plaquetria
Trombopoyetina

6. • Destrucción de
plaquetas mediada
inmunológicamente
• Disminución ADAMS-13
Disminución de producción plaquetaria

7. Principal determinante
de trombocitopenia
Secuestro esplénico
Gallo P, et al. Thrombocytopenia in chronic liver disease: Physiopathology and new therapeutic strategies before invasive
procedures. World J Gastroenterol 2022 August 14; 28(30): 4061-4074

8. Gallo P, et al. Thrombocytopenia in chronic liver disease: Physiopathology and new therapeutic strategies before invasive procedures. World J Gastroenterol 2022 August 14; 28(30): 4061-4074

10. EMBOLIZACION DE ARTERIA ESPLENICA
INVASIVOS
ESPLENECTOMIA
Gallo P, et al. Thrombocytopenia in chronic liver disease: Physiopathology and new therapeutic
strategies before invasive procedures. World J Gastroenterol 2022 August 14; 28(30): 4061-4074

11. FARMACOLOGICOS
Gallo P, et al. Thrombocytopenia in chronic liver disease: Physiopathology and new therapeutic strategies before invasive
procedures. World J Gastroenterol 2022 August 14; 28(30): 4061-4074

12. FARMACOLOGICOS
Gallo P, et al. Thrombocytopenia in chronic liver disease: Physiopathology
and new therapeutic strategies before invasive procedures. World J
Gastroenterol 2022 August 14; 28(30): 4061-4074

14. BIBLIOGRAFIAS
Moore A. Thrombocitpenya in Cirrhosis: A review a phatophysiology and management options. CliniCal liver
Disease, vOl 14, nO 5, november 2019
Gallo P, et al. Thrombocytopenia in chronic liver disease: Physiopathology and new therapeutic strategies before
invasive procedures. World J Gastroenterol 2022 August 14; 28(30): 4061-4074