3. RECURRENTABDOMINAL PAIN
3 main features:
Three or more episodes of pain
over at least three months
Interfere with normal activities
Represents a description and not a diagnosis
4. CHRONIC ABDOMINAL PAIN
Intermittent or constant abdominal pain for a minimum
duration of 2 months.
Causes:
Organic 15 %
Functional 70-80%
Psychogenic <5 %
5. FUNCTIONAL GIT DISORDERS INTRODUCTION
Prevalence remains between 10 and 30 % [1, 2]
Functional gastrointestinal disorders (FGIDs) common all age
groups
Are Conditions related to GIT, cannot be attributed to structural
or biochemical abnormalities(lacking objective evidence for
organic pathology.)
Diagnosed according to the symptom-based Rome criteria.
9. INFANT COLIC
OldWessel et al.’s ‘rule of threes’
crying more than 3 h a day,
for more than 3 days a week,
for more than 3 weeks in a row
New criteria includes prolonged, hard-to-soothe, and
unexplained nature of the crying behavior.
No evidence of infant failure to thrive, fever or illness
10. MANAGEMENT OF IC
No consensus on the definition, diagnostic methods and management
algorithms.
Adequate breastfeeding
Soothers and relaxing and distracting massages
Pharmacotherapy
If human milk cannot be supplied, it is recommended to replace it with
casein hydrolysates
Role of Semethicone..?
Dicyclomine is C/I
16. FUNCTIONAL OR NON-ULCER
DYSPEPSIA
Abdominal Pain Associated with Symptoms of Dyspepsia
1 or more symptoms at least 4 days per month (atleast 2
months):
1. Postprandial fullness
2. Early satiation
3. Epigastric pain or burning not associated with defecation
4. Cannot be fully explained by another medical condition.
17. WITHIN FD,THE FOLLOWING SUBTYPES
Postprandial distress syndrome
Epigastric pain syndrome
Pathophysiology : Hypotheses include abnormalities of
gastric motor function
18. INDICATION OF UPPER GI
ENDOSCOPY IN FD
Family history of peptic ulcer or H pylori infection
Older than 10 years of age
Symptoms persist for >6 months
Symptoms affect daily activities, including sleep
Red flag symptoms
Night Pain
Pain radiating to back
21. IRRITABLE BOWEL SYNDROME
Abdominal pain at least once a week for the past 2 months
Has two out of three associated features:
Onset associated with a change in form of stool
Onset associated with a change in stool frequency
Relieved with defecation
Supportive symptoms- abnormal stool frequency or type, passage of mucus
and bloating/distension.
Exacerbation of symptoms with stressors
No structural or metabolic abnormalities
Pain interferes with normal activities
22. Subtypes reflecting the predominant stool pattern
IBS with constipation
IBS with diarrhea
IBS with constipation and diarrhea
Unspecified IBS
24. ABDOMINAL MIGRAINE
Include all of the following occurring at least twice (for at least 6 months):
1. Paroxysmal abdominal pain lasting 1 hour or more (should be the most
severe and distressing symptom)
2. Episodes separated by weeks to months.
3. Pain is incapacitating
4. Stereotypical pattern
5. Pain is associated with 2 or more of
Anorexia/ Nausea/Vomiting/ Headache/ Photophobia/ Pallor
25. PATHOPHYSIOLOGY
Common in Abdominal migraine, CVS, and migraine headache
(episodic, self-limited, and stereotypical, and with symptom-
free intervals)
Similar triggers, Associated symptoms, Relieving factors
Abdominal migraine and CVS can evolve into migraine
headaches in adulthood.
27. FUNCTIONAL ABDOMINAL PAIN-NOS
At least 4 times per month (2months) Episodic or continuous
abdominal pain.
About 35% to 38% of elementary school children report
abdominal pain weekly, Only 1/3rd meet Rome criteria of any
FAPD
28. APPROACH
HISTORY
Pain (site, intensity, character, timing, relationship to food intake,
aggravating or relieving factors
Headaches frequently associated.
Nausea
Hallmark of FAP is School absenteeism
Rarely remain in bed instead lying on the couch watching television
Pain may delay the onset of sleep but seldom awakens them
34. ALARM FEATURES
Family history of inflammatory bowel disease, celiac disease, or peptic
ulcer disease
Persistent right upper or right lower quadrant pain
Dysphagia
Odynophagia
Persistent vomiting
Gastrointestinal blood loss
Oral aphthous ulcers
Skin changes
35. …ALARM FEATURES
Chronic Diarrhoea, Nocturnal diarrhoea
Arthritis
Perirectal disease
Weight loss
Deceleration of linear growth
Delayed puberty
Unexplained fever
Urinary Symptoms
Back pain
37. EXAMINATION
Prolonged, disabling symptoms who looks well and is thriving.
Assessment of growth, anemia, clubbing, oral ulceration, and
perianal disease.
39. INVESTIGATIONS
Level II (If Red flag signs +):
CRP/Blood sugar/amylase/lipase/SGPT,SGOT
Screening for Celiac Disease
Epigastric pain: UGI Endoscopy, Inv. H.pylori
LLQ pain/altered bowel habits, bleeding PR: Colonoscopy
Small bowel pathology: Barium studies/CECT abdomen.
Hepatobiliary/pancreatic disease: CECT abdomen, MRCP.
40. • Majority of children were girls (n=62, 56.4%, n=110)
• Most of them belonged to age group 6-12yrs (52.7%).
• 28 (42.3%) children with FD had some abnormality
• Rapid UreaseTest for H Pylori was positive in 30(51.7%) of children with FD, while
only 1 in FAP NOS (p<0.001).
41. MANAGEMENT
Goal- return to normal function (ie, rehabilitation) rather than complete
elimination of pain
Individualized
Interventions
Therapeutic relationship
Patient education
Behavior modification
Improve pain tolerance and coping
Avoidance of triggers
Symptomatic management
42. PATIENT EDUCATION
FAPDs are common
Pain is real
Could be triggered or exacerbated external factors
Pain not life-threatening.
Treatment focuses on return to normal activity despite discomfort
Realistic Goals
Return to school
44. HOW A CHILD AND HIS/HER FAMILY COPES WITH
PAIN INFLUENCES OUTCOMES OF FAPDS
45. MANAGEMENT OF SYMPTOMS
Abdominal pain
Probiotics (eg, Lactobacillus rhamnosus, Lactobacillus reuteri
Water-soluble fiber (eg, psyllium/ispaghula husk), dose of 1.5 to
12.5 grams per day
Peppermint oil
Dyspepsia (Avoid NSAIDs, Foods aggravating symptoms, Acid
blockada, Prokinetics, Antidepressant)
46. FOLLOW-UP
Regular follow-up to
Maintain the therapeutic relationship
continued education and reassurance
Monitor the response to intervention
Monitor the development of alarm findings
47. PROGNOSIS
30 % – persist as adult
30-50 % - cured, mostly within in 2-6 weeks after diagnosis
Remaining – some other form of pain
Poor prognosis : Age < 5 years, male sex, pain prone family ( maternal
anxiety) symptoms > 6 months, parents resistant to ‘non organic’
diagnosis
Long term FU ( 5-7 years)- only 2 % develop organic disease
50. ..AT LAST LETS ALSO DISCUSS
FUNCTIONAL CONSTIPATION
No included In ROME IV of FAP
Common cause chronic Abd pain.
Include 2 or more at least once per week for a minimum of 1 month
(insufficient criteria for a diagnosis of irritable bowel syndrome):
2 or fewer defecations in the toilet per week.
At least 1 episode of fecal incontinence per week
History of retentive posturing or excessive volitional stool retention
History of painful or hard bowel movements
Presence of a large fecal mass in the rectum
History of large diameter stools
51. ALARM FEATURES IN CONSTIPATION
Passage of meconium >48 h in a
term newborn
Constipation starting in the first
month of life
Family history of Hirschsprung’s
disease
Blood in the stools in the
absence of anal fissures
Failure to thrive
Severe abdominal distension
Abnormal thyroid gland
Abnormal position of the anus
Absent anal or cremasteric reflex
Decreased lower extremity
strength/tone/reflex
Tuft of hair on spine
Bilious vomiting
52. MANAGEMENT
Disimpaction: Polyethylene glycol (PEG) in a dose of 1.5 g/kg/
day for 3-4 days
Maintenance (promote regular stooling and prevent
reimpaction): lactulose (1-3 ml/kg/day) and PEG (0.8-1.0
g/kg/day)
ex Movicol Pediatric 6.9 gm sachet
54. 2. Organic causes account for ………% of FAPD
A. 10%
B. 15%
C. 30%
D. <2%
55. 3. Latest Rome Criteria is:
A. ROME IV (2016)
B. ROMEV (2018)
C. ROME III (2010)
D. ROMEVI (2019)
56. 4. Correctly match the following according to
ROME IV
A. H2a I. IBS
B. H2b II. Abdominal Migraine
C. H3c III. FD
D. H3d IV. FAD-NOS
57. 5.Wessel et al’s rule of threes was used for
diagnosis of
A. IBS
B. FD
C. IC
D. Rumination
58. 6. Which is false regarding FAP
A. Chronic Pain abdomen ≥2months
B. No anatomic defect
C. Stool positive for occult blood
D. Prevelance 10-30%
59. 7.Precentage of children diagnosed as FAP which
are cured, mostly within in 2-6 weeks after
diagnosis..?
A. 2-5%
B. 5-10%
C. 10-30%
D. 30-50%
Editor's Notes
Biopsychosocial model proposes that the pain is the child’s response to biological factors, governed by an interaction between the child’s temperament and the family and school environments.
The Rome criteria for FGIDs were first established in 1990, and these were only applicable in adults. In 1999, with the launch of the Rome II criteria, criteria were established for FGIDs in children.
Need of rome: t there are no biochemical markers or structural abnormalities that can be used to objectively diagnose or monitor progression of these disorders. Diagnoses are based on medical history and physical examination. It is essential that these symptom-based diagnostic criteria are accurate, clear, and unambiguous. Uniform diagnostic criteria are also necessary to conduct reliable, reproducible research on the epidemiology, pathophysiology and management of FGIDs in children.
divided into three main groups: functional nausea and vomiting disorders, functional abdominal pain disorders and functional defecation disorders.
diagnosis can only be made if ‘after appropriate medical evaluation, the symptoms cannot be attributed to another medical condition.’
This wording substitutes the previous statement that there had to be ‘absence of inflammatory, anatomic, metabolic, or neoplastic process that explains the subject’s symptoms.’
New criteria, now focused on symptoms shown to cause distress in parents, i.e. the
training to parents on behaviors to respond to crying
and feeding patterns for nursing mothers; this proved to be more
effective for handling IC than hydrolyzed formulas.
Breastfeeding provided on demand and completely emptying
the mammary gland adequately balances the milk content and
the percentage distribution of the macronutrients,
Lactobacillus reuteri, because of their adequate
safety spectrum and therapeutic properties. immunomodulatory effect on the intestines regulating the fermentation
of carbohydrates, positively impacting the symptomatology..
dicyclomine hydrochloride is the only drug that improves the frequency and severity of IC compared to
placebos in more than 53% of cases due to its anticholinergic activity.
However, it has side effects such as apnea, syncope and dissociative seizures,
pharmacological surfactants such as simethicone
—whose function is to reduce the surface tension of gases— have not
shown greater therapeutic effect than other drugs. There is insufficient
evidence to opt for surfactants to treat IC
A study(267infants) partially hydrolyzed with oligosacc(carbohydrates) > standard formula with simethicone…reduced colic episodes..
Lactase supplementation…. No adverse effects in any study..
Soy based milk….reduced crying time..but not recommended..thry can impact hormones in baby…
Cohrane..acc to availavle evidence no current dietary modification.
Functional Nausea
include all of the following fulfilled for the last 2 months:
nausea early in the morning, and observe that when they “sleep late,” that is, past the usual time when they would experience nausea
One or more episodes of vomiting per week
for minimum 2 months.
patients with chronic nausea commonly report mild vomiting with varying frequency. The presence of severe vomiting in addition to nausea presents a different situation in which central nervous system disease, GI anatomic abnormalities (eg, malrotation), gastroparesis, and intestinal pseudo-obstruction should be excluded.
. Biochemical testing may include measurement of serum electrolytes, calcium, cortisol, and thyroid hormone levels. Intestinal obstruction and motility disorders (eg, gastroparesis, intestinal pseudoobstruction) should be considered and excluded in the presence of recurrent vomiting.
Cyclic vomiting syndrome
2 or more periods of intense, unremitting nausea and paroxysmal vomiting, lasting hours to days within a 6-month period.
Episodes are separated by weeks to months with return to baseline health between episodes
. If the predominant feature is abdominal pain, then abdominal migraine should be considered.
Effortless repetitive regurgitation, reswallowing, and/or spitting within minutes of starting a meal define rumination. Rumination caused by increase in intragastric pressure- opening of the lower esophageal sphincter, leading to the return of gastric content into the esophagus
Earlier called ‘adolescent’ rumination syndrome.
Now…not…because children who are younger may also suffer from this condition.
The elimination of “painless” from the description of the regurgitation is justified by the fact that often patients have another FAPD and by the fact that the act of regurgitation is often triggered by a sensation of discomfort (pressure, pain, burning) in the abdomen that is relieved by regurgitation
eliminated the requirement that symptoms do not respond to gastroesophageal reflux disease treatment, as it is not compulsory to treat for gastroesophageal reflux disease before diagnosis of rumination.
Func nausea and vomiting….s also experience autonomic symptoms, such as sweating, dizziness, pallor, and tachycardia
Abdominal distention due to intraluminal air which increases during the day
air swallowing is excessive, gas fills the GI lumen, resulting in excessive belching, abdominal distention, flatus, and pain, presumably as a consequence of luminal distention
Is considered a disorder of the brain-gut axis
Visceral hypersensitivity may relate to the child’s psychological distress (anxiety, depression, impulsiveness, anger). Increased mucosal proinflammatory cytokines have been demonstrated and may be induced as a consequence of an acute infectious gastroenteritis (postinfectious IBS)..
Impaired gastric accommodation, as determined by a decreased ability of the stomach to relax in response to a meal, has been demonstrated.23 Using electrogastrogram and gastric emptying studies
Noxious early life events (eg, surgery) have been associated with a higher risk for developing FAPDs in childhood,
Visceral Hypersensitivity in the Context
of Physiological Peristalsis..
the contraction of the GI tract follows two patterns:
rhythmic phasic contractions (continuously) and giant
migrating contractions (several times a day). These peristaltic
mechanisms should not generally cause pain.
In patients with FAP, increased levels of substance P and other nociceptive
transmitters lower the threshold for the child’s perception
of pain .. causing visceral hypersensitivity and intestinal dysmotility
[28]. The presence of physical and psychological stressors
exacerbate this ‘visceral’ hypersensitivity
(A) neither RPC rhythmic phasic contractions
or GMC giant
migrating contractions pierce the nociceptive threshold to cause pain.
However, in a
child with gastroenteritis (child B) the GMCs are of greater amplitude,
breaking the nociceptive threshold, and causing pain.
Infection can be
a stressor for RAP, for example 1/3 of patients after a bout of gastroenteritis
develop IBS, with evidence of mucosal lymphocytic infiltration
on biopsies.
In a child with FAP (child C): the visceral hypersensitivity
has lowered the nociceptive threshold, causing a perception of pain.
The aim iswill return to normal (D). RPC retrograde peristaltic contractions
GMC giant migrating contractions.
No relief from defecation
or associated with change in bowel pattern (i.e. not IBS).
Persistent or recurrent epigastric pain (ulcer like)
Once a week for the past 2 months
No relief from defecation
in the new diagnostic criteria rome IV, the previous sentence ‘‘no evidence for organic disease’’ is replaced with the new ‘‘after appropriate medical evaluation the symptoms cannot be attributed to another medical condition’’
Pain interferes with normal activities
Postprandial distress syndrome includes bothersome postprandial fullness or early satiation that prevents finishing a regular meal. Supportive features include upper abdominal bloating, postprandial nausea, or excessive belching
pain or burning localized to the epigastrium. The pain is not generalized or localized to other abdominal or chest regions and is not relieved by defecation or passage of flatus. Supportive criteria can include (a) burning quality of the pain but without a retrosternal component and
Hypotheses include abnormalities of gastric motor function, genetic predisposition.
Impaired gastric accommodation, as determined by a decreased ability of the stomach to relax in response to a meal, has been demonstrated.23 Using electrogastrogram and gastric emptying studies
(eg, caffeine containing, spicy, fatty)
Acid blockade with histamine receptor antagonists and proton pump inhibitors can be offered for pain predominant symptoms
omeprazole is superior to ranitidine, famotidine, and cimetidine.
Nausea, bloating, and early satiety are more difficult to treat, and prokinetics such as cisapride and domperidone
low-dose tricyclic antidepressant therapy with agents such as amitriptyline and imipramine is often considered in difficult cases
description of exacerbation
of symptoms with stressors (physical/psychological),
for example with exams/performances
family history of IBS is common
In children with constipation, the pain does not resolve with resolution of the constipation (children in whom the pain resolves have functional constipation, not irritable bowel syndrome
Greater the number of alarm symptoms present, the greater the likelihood of an organic disease
Determination of fecal calprotectin is increasingly being utilized as a noninvasive screen for intestinal mucosal inflammation and appears to be superior to standard testing such as C-reactive protein
elimination diet reducing intake of fermentable oligosaccharides, disaccharides, monosaccharides, and polyols.5
Paroxysmal episodes of intense, acute periumbilical, midline or diffuse abdominal pain lasting 1 hour or more (should be the most severe and distressing symptom)
6. cannot be fully explained by another medical condition.
t similar triggers (eg, stress, fatigue, and travel), associated symptoms (eg, anorexia, nausea, and vomiting), and relieving factors (eg, rest and sleep)
A double-blind, placebo-controlled, crossover trial in 14 children found a prophylactic benefit of oral pizotifen, a drug with antiserotonin and antihistamine effects
Prophylaxis with drugs such as amitriptyline,61 propranolol, and cyproheptadine62 has been successful.
substitutes for the Rome III terms functional abdominal pain and FAPS
continuous abdominal pain that does not occur solely during physiologic events (eg, eating, menses)
best diagnostic tool is a detailed history both from the patient and the family
Pain…mostly periumbilical, On morning wakening, improves in the afternoon and becomes severe again prior to bedtime suggests FAP)
Night---GERD,
Vomiting, gastrointestinal bleeding, weight loss, or diarrhoea suggest an organic cause.
Parents may emphasise the severity of pain and associated pallor and lethargy in response to any suggestion of non-organic aetiology.
conscientious, obsessional, sensitive, insecure, anxious, and prone to peer relationship problems.3.. Garralda ME
J Child Psychol Psychiatry. 1996 Jan; 37(1):13-33.
Inquire about parental illness, bereavement in close family members ..
worry about their parents mortality, financial problems, unemployment, and marital disharmony. Parents often fail to appreciate that children as young as 6–8 years are aware of and worry about such issues.
With predominant symptom of dyspepsia
presence of ‘red flag signs’ such as vomiting, weight loss, poor height gain, fever, hematemesis bleeding per rectum, rash, and arthralgia may indicate an organic pain
Persistent right upper ..hepatobiliary dis
Rt lower quad..appendicitis.
Dysphagia, Odynophagia –esophagitis, achalasia
Persistent vomiting –CVS, PEPTIC ACID DIS, BOWEL OBSTRUCTION, HEPATOBILIARY DISEASE,
Oral aphthous ulcers..ibd
Skin changes
(rash eczema)…ibd, celiac disease, food allergy
Chronic Diarrhoea, Nocturnal diarrhoea (enteric infection, celiac disease, IBD, IMMUNE DEFICINCY
Bloody diarrhoea..ibd
Perirectal disease (skin tag, rash)..IBD
Deceleration of linear growth…ibd, celiac disease
Unexplained fever INFECTION, INFLAMM
Urinary Symptoms recurrent uti
Back pain…referred, chr pancreatitis
Level I investigations sufficient if pain has the characteristics of functional pain described earlier, and no Red Flag signs or symptoms are present
Complete blood counts including peripheral smear is a simple screening method to identify anemia, leukemia, lead poisoning and sickle cell disease.
Urine and stool microscopy should always be included in the evaluation of CAP.
Albuminuria, pyuria or hematuria will be a quick test to check problems of the urinary tract.
The presence of ova and trophozoites in stool is diagnostic of parasitic infestation such as giardiasis and
the presence of occult blood denotes mucosal lesions such as IBD or tuberculosis.
When alarm or warning signs are present few more investigations are included.
CRP an acute phase reactant is valuable in checking inflammatory disease.
Blood sugar should be included in the protocol as diabetic ketoacidosis may present with abdominal pain.
X-ray chest and Mantoux test are done for those children with a contact history or symptoms suggestive of Tuberculosis.
X-ray abdomen is useful when there is a suspicion of renal or pancreatic disease. The presence of pancreatic calculi or calculi in the kidney, ureters or in the urinary bladder may clinch the cause of pain.
Ultrasound (US) of abdomen is probably one of the most widely used non-invasive investigation in the work up for CAP and rates over other radiological investigations because of the absence of radiation.
screening for celiac is recommended in places where the prevalence is high.
Determination of fecal calprotectin is increasingly being utilized as a noninvasive screen for intestinal mucosal inflammation and appears to be superior to standard testing such as C-reactive protein
Presence of alarm symptoms and the clinical suspicion of organic pain necessitate further workup.
Persistent dyspepsia, vomiting and epigastric pain would merit an Upper GI Endoscopy (UGIE).C
olonoscopy is done if there is bleeding PR
management is individualized according to child and family behaviors, triggers, and symptoms.
Therapeutic relationship
: reassured by the clinician's acknowledging that the pain is real and has affected important activities in the child's or adolescent's life.
The patient and family should be assured that the clinician will initiate a treatment plan and continue to follow up with the patient on a regular basis
alliance may be strengthened by focusing on the shared goal of return to normal function – for both the child and family.
The child's or adolescent's pain may have become a focal point of the family's life, creating stress for other members.
FAPDs are common, occurring in approximately 10 to 20 percent of children.
Pain is real, thought to be caused by a heightened sensitivity to the normal function of the stomach and bowel.
Could be triggered or exacerbated external factors environmental (eg, gastrointestinal infection, medications) and psychosocial factors, including stress, anxiety, and social reinforcement (eg, attention, staying home from school.. responses to stress or anxiety include headaches, churning of the stomach before a test, and nausea when given bad news.
Goals for management should be realistic (eg, maintenance of normal activities, increased tolerance of symptoms
Return to school — A plan for return to school is crucial. School absenteeism adds to family stress and can interfere with the child or adolescent's school performance and social functioning
Reinforcement of non pain (healthy or adaptive) behaviors and avoiding/stopping reinforcement of pain behaviors
..by :Providing attention to the pain (eg, asking about symptoms, by allowing the child to stay home from school or leave school, excusing the child from completing his or her homework, Allowing the child who stays home from school to watch television
Praising/rewarding the child for attending school or extracurricular activities
Coping is defined as voluntary efforts to regulate emotion, thought, behavior, physiology, and the environment in response to stressful events or circumstances .. Psychosocial therapies that may improve the ability to cope include relaxation( deep breathing exercises to be performed at least twice a da), distraction (Distraction techniques include conversation, games)
The judgemnet of any pain episode experienced by a child may have significant impact on the child’s ability to cope effectively and accommodate to the pain, and consequently his or her normal function and development. In the presence of risk factors or when protective factors are less effective, the child may develop a maladaptive response leading to a state of chronic pain. From Walker et al
Alterations to commensal bacterial populations have been implicated in dysmotility, visceral hypersensitivity, abnormal colonic fermentation, and immunologic activation.
Probiotics may improve gastrointestinal symptoms by restoring the microbial balance in the gut through metabolic competition with pathogens, by enhancing the intestine's mucosal barrier, or by altering the intestinal inflammatory response
probiotic be tried for four to six weeks before reassessment of symptoms of abdominal pain and/or abnormal bowel movements..
2017 systematic review and meta-analysis of seven randomized trials that compared probiotics with placebo in 722 children with recurrent abdominal pain/functional gastrointestinal disorders (FGIDs) found moderate quality evidence that probiotics improve pain at zero to three months..
Rome iv The committee recommends that patients with constipation and abdominal pain initially be treated for constipation only. If abdominal pain resolves with constipation treatment, patient has functional constipation. If pain does not resolve with appropriate constipation treatment alone, the patient likely has IBS with constipation. I
Fibre.. altered composition of stool and gas, and/or accelerated gastrointestinal transit … . A reasonable target for total dietary fiber intake is the child's age in years plus 5 to 10 grams per day. 2017 systematic review concluded that there was no evidence to support the use of fiber supplementation for treatment of recurrent abdominal pain/FGIDs in children
peppermint oil is thought to decrease smooth muscle spasms in the gastrointestinal tract .
A 2011 meta-analysis of randomized trials in patients >12 years of age concluded that peppermint oil was effective in the treatment of IBS
whose diarrhea consists of ≥3 loose or watery stools per day for more than two weeks (which is an alarm symptom) require evaluation for organic disease