3. Case 8
6 yo patient with recently received a BMT and
has a rash of face and trunk.
4.
5.
6.
7. GVHD
SX: diarrhea, cramping, fever, n/v
“ribbon bowel”-SB fold effacement with
tubular appearance, loss of haustra, spasm,
edema, ulceration, granular mucosa in colon
”SB cast”-prolonged coating of abnormal
bowel for hours to days
Fatal in up to 15% due to opportunistic infix.
TX: steroids, cyclosporine
DDX: super infection with enterovirus
11. High resolution CT (HRCT) of a patient with
systemic graft versus host disease (GVHD)
HRCT shows mild bronchial dilatation,
bronchial wall thickening, peripheral vascular
pruning and areas of patchy lung attenuation
with air trapping. Appearances suggest
obliterative bronchiolitis in GVHD.
12. 54-year-old woman with calcinosis cutis and
sclerodermatous graft versus host disease. Radiographs of
the right lower leg (A), left lower leg (B), and left hip
13. Calcinosis cutis is a condition characterized by
calcium deposits in the dermis or hypodermis [1].
There are four types of calcinosis cutis based on
etiology: dystrophic, metastatic, idiopathic, and
iatrogenic. Dystrophic calcinosis cutis is the most
common form and occurs in abnormal tissue with
normal serum calcium and phosphate levels. The
exact mechanism of calcification is unknown.
Dystrophic calcinosis is associated with connective
tissue disease such as systemic lupus erythematosis,
dermatomyositis, and systemic sclerosis as well as
devitalized tissue from trauma or infection.
14. Case 9
H/O: A 40 years patient presented with PUO
and abdominal pain.
15.
16. Ultrasound of thickened bowel. Relatively hypoechoic thick
walls (arrowed) with echogenic lumen. Appearances are non-
specific - in this case, Crohn's disease of the ileum.
17. Small bowel non-Hodgkin's lymphoma. (a) Enteroclysis examination demonstrates
a segment of ileum in the right iliac fossa with wall thickening, destruction of the
normal fold pattern and aneurysmal ulceration (arrowed) and mass effect; (b) CT
demonstrates marked wall thickening and aneurismal luminal dilatation,
containing contrast.
27. Figure 11A. Celiac disease (sprue) with reversal of jejunal-ileal fold
pattern on CT. (A) Axial contrast-enhanced image shows loops of
proximal jejunum (arrowheads) with effaced, atrophic folds. (B) Loops of
ileum show fold thickening and increased number of folds (arrows).
28. Small Bowel Dilatation Sprue
Features:
Jejunal dilitation and wall/ fold thickening leads to
ilealization jejunum (<3 folds/ inch). Compensatory
increase number of folds in ileum.
losses of villi leads to Moulage sign (featureless
folds). Malabsorption/ excess fluid leads to
flocculation of barium.
Complications: intussusceptions, lymphadenopathy,
ascites, hepatic steatosis from malabsorption,
malignancy (lymphoma> adenocarcinoma, SCC)
30. Duke DDX Dilated SB Loops With Normal Folds
Obstruction
Intrinsic – stricture-> tumor, crohn, XRT, ischemia, infection
intussusceptions-> tumor, Meckel’s, duplication, adhesions,
lymphoid hyperplasia in children
malrotation with paraduodenal hernia/ volvulus
Extrinsic – adhesions (60%), hernia, closed loop obstruction,
masses
Ilues
Sprue
Scleroderma – commonset cause of intestinal pseudo
obstruction
On to the Folds
Evaluation of SBFT
31. You need to ask yourself the following
questions when evaluating a SBFT.
1-Describe the folds (this is the biggest clue)
Are the folds thickened?
If so, is it focal or diffuse?
Are they regular or irregular?
Regular – hemorrhage and edema
Irregular – inflammatory or neoplastic
Are the folds too close together? “Hidebound”
Are the folds dilated?
Are the folds absent or displaced?
32.
33. Case 11
H/O: Adult female with abdominal pain,
hepatomegaly, diarrhea, and multiple
episodes of pseudoobstruction
34.
35. Scleroderma of the bowel - note reflux into slightly dilated
distal esophagus and dilatation of small bowel with "stack-of-
coins" appearance. On the right, a stack-of-coins.
36. Scleroderma
Systemic disorder with Skeletal, renal,
pulmonary and gastrointestinal
manifestations
SB: Hidebound(stacked coins) – normal
thickness/tightly packed within dilated
segment Pseudodivertuculi messenteric
border from scarring. Pneumatosis coli
intestinalis
37. Hidebound or stacked coin pattern with
pseudodiverticula of antimessenteric border
Duke Notes SB Diverticuli
Diverticulosis – messenteric border, acquired
outpouchings ie colon with same string of
associations
Meckel’s diverticulum – remnant of
omphalomessentric duct, arises in distal ileum,
antimessentric, rule of 2’s(w/l 2 ft IC valve, length 2
in., present age<2), 1/3 contain gastric mucosa, 2/3
symptomatic contain gastric mucosa
Pseudodiverticuli/sacculations – cinching on
antimessenteric border from chronic inflammatory
disease with fibrosis(Crohns) and muscle
atrophy(Scleroderma)
43. Rectal contrasted CT demonstrating inverted
Meckel’s diverticulum with intussusception.
Notice the central fat and soft tissue filling
defect
44.
45. Small bowel barium examination,
demonstrates numerous bariumfilled
messenteric
border diverticuli. Notice the absence of
hidebound pattern seen in Scleroderma and
strictures/fistula seen in Crohn’s.
46. Case 12
20 yo man with tender scrotum (left side).
47.
48.
49.
50.
51.
52. . On the coronal dynamic contrast-enhanced subtraction 3D fast field-echo MR images
shows early and strong increase in homogeneous contrast enhancement relative to the right
testis, while the right testis shows gradual and progressive increase in contrast enhancement.
Note that the left epididymis (arrowheads) shows early and intense enhancement.
53. Clinically proved acute mumps epididymo-
orchitis in a 41-year-old man. The MR
imaging examination was performed 5 days
after the onset of left scrotal pain and
swelling. (a) Coronal fat-saturated T2-
weighted fast spin-echo MR image
(1,800/100) of the left testis (arrow) shows
lower signal intensity relative to that of the
right testis. On the coronal dynamic contrast-
enhanced subtraction 3D fast field-echo MR
images (10.2/4.1; flip angle, 35°) obtained (b)
30 and (c) 360 seconds after injection of
54. Epididymoorchitis
Epididymoorchitis
Results from retrograde spread of organisms
from bladder or prostate via the vas deferens.
Common pathogens:
Gonococcus
Pyogenic (E. coli, Pseudomonas)
Mumps
TB
55. Radiographic features:
Epididymis and spermatic cord enlargement
Decreased echogenicity of epididymis cord
Focal orchitis: peripheral hypoechoic region; all
hypoechoic testicular lesions need to be followed by
US until resolution; 10% of patients with testicular
tumors present with orchitis.
Reactive hydrocele or pyocele
Thickening of the skin
Calcification in chronic inflammation
Color Doppler: hypervascularity in affected
epididymis and/ or testis.
58. Antenatal USG at 18 weeks showing bilateral enlarged
echogenic kidney with oligohydramnios!! suggestive of
autosomal recessive polycystic kidneys!!!
59. Urogram (X-ray) of the abdomen in a 32 year old patient, showing
polycystic kidney disease affecting both kidneys (at upper left and right,
bilateral). Polycystic kidney disease is one of the most common causes of
chronic kidney failure in adults.
69. US of 65 years old male presented to emergency room with bilateral flank pain,
nausea and vomiting for the past 1 week. He had an ultrasound in a peripheral
hospital, which identified hydronephrosis on the right side, and percutaneous
nephrostomy tube was placed. His left kidney showed hydronephrosis with renal
stone (upper picture). This scan shows small-scarred right kidney (middle picture),
pigtail catheter could be identified (arrow) and a proximal ureteric stone could
also be seen (lower picture).
70.
71. Hypoplastic Right Kidney
Incomplete development resulting in a
smaller (<50%) kidney with fewer calyces and
papillae (usually < 5) but normal function
Not to be confused with dysplasia, which
results from collecting system obstruction and
creates a bizarre appearance of the kidney.
Hypoplastic kidneys are smooth with short
infundibulae and sometimes have clubbed
calyces
72. Segmental hypoplasia (Ask-Upmark kidney):
usually upper pole with deep transverse
groove. Associated with severe hypertension.
Etiology is controversial (congenital vs.
sequelae of pyelonephritis)
78. Prostate Cancer
Represents 18% of all cancers in the US
Second most common cause of cancer death in men
in the US (According to the Primer, 3rd )
Incidence increases with age
BPH does not predispose to cancer
Origin: Most occur in outer gland (posterior and
peripheral) 70% Inner gland tumors are 30%
Prostate Specific Antigen: elevated in cancer. Normal
is 2-4 Units
79. Prostate Cancer, Staging (Jewett
System)
Stage A: non palpable tumor at biopsy
(radical prostatectomy), A1=well
differentiated, A2=poorly differentiated
Stage B: palpable tumor, confined to prostate
(radical prostatectomy)
Stage C: extension through prostatic capsule
but no mets (radiation tx)
Stage D: metastases (hormonal therapy, rad
tx, chemotherapy)
80. Other tx: Brachytherapy (Radiation Seed
Placement)
Used for localized prostate cancer. Can be
performed as an alternative to External Beam
Radiation Therapy or prostatectomy
Multiple types of implants can be used
including: Ir-192, Cs-137, I-125, Pd-103
Contraindications: TURP, public arch
interference, Obstructive symptoms, Morbid
Obesity
89. Pelvic Lipomatosis
Abnormal amount of fatty tissue in the pelvis
compressing normal structures. Unrelated to
obesity or race
Features:
Elongation and narrowing of urinary bladder
(pear shape)
Elongation and narrowing of rectosigmoid
Large amount of fat in the pelvis
90. Teardrop or Pear-Shaped Bladder
Results from circumferential extrinsic
compression
Physiological: Normal Variant, IIIiopsoas
hypertrophy
Fluid: Hematoma (usually from pelvic
fracture), abscess
Masses: Pelvic lymphoma, Pelvic lipomatosis,
Retroperitoneal fibrosis
91. Case 17
30 year old male presents for IVP. Develops
SOB, urticaria, drop in blood pressure
94. Shock Kidney
Findings: One minute film demonstrates normal kidneys. Ten
minute film demonstrates persistently dense nephrograms with
regression and disappearance of the pyelogram phase
Almost always seen in association with a severe adverse
reaction to the administration of contrast. Hypotension leads to
(and hypotension from any cause can cause this appearance)
When arterial perfusion pressure to the kidneys drops below the
minimum level required for glomerular filtration, tubular stasis
occurs. Any contrast that has been excreted into the kidney
stagnates
Once Shock Kidney develops, Nephrographic desity will persist
and become progressively denser. The most dramatic finding is
regression or disappearance of the pyelogram phase. These
findings indicate a potentially life threatening hypotension as a
result of contrast reaction
95. Case 18
2 years old was an unrestrained passenger in
a motor vehicle accident
96.
97.
98. Hypoperfusion complex
Hypoperfusion complex (aka, Shock Complex)
Typically demonstrates intense enhancement of
bowel wall, kidneys, aorta, and enhancement of
bowel wall, kidneys, aorta, and infeeerior vena cava
Bowel loops are dilated and fluid filled and the aorta
and IVC demonstrate a diminished caliber
Hypoperfusion complex suggests tenuous
hemodynamic stability and associated with high
mortality rate (85%)
99.
100.
101.
102.
103.
104.
105.
106.
107.
108.
109.
110. Scleroderma
• Affects esophagus, small bowel and colon,
sparing the stomach
• Atrophy of the muscular layers and
replacement with fibrous tissue
• Associated with malabsorption
X-ray
• Whole small bowel is usually dilated with
close approximation of the valvulae (hide-
bound appearance) (stack-of-coins)
111. • Dilatation of esophagus
Upon standing, esophagus empties (DDX
from Achalsia which does not empty on
standing)
• Does not have increased secretions in
small bowel as does sprue
• May be associated with pneumatosis
intestinales
112. Sprue
• 3 diseases: Celiac Disease of Children, Nontropical sprue and
Tropical Sprue
• Celiac disease and Nontropical sprue improve on gluten-free diet
• Tropical sprue improves with antibiotics and folic acid
X-ray
• The hallmark features are: dilatation and dilution, especially
in jeunum
• Segmentation of the barium column occurs because it moves
more slowly through areas of excessive fluid and separates from the
rest of the column-not commonly seen with newer barium mixtures
• Fragmentation is an exaggerated example of the irregular
stippling of residual barium in the proximal bowel (which is normal)
• Intussusception is not uncommon but is usually not obstructive; sprue
has increased risk of ca and lymphoma
• Moulage sign is caused by dilated loop with effaced folds looking like
tube into which wax has been poured
113. Whipple’s Disease
• Glycoprotein in the lamina propia of the small
bowel is Sudan-negative, PAS-positive
• Clinically: arthralgia, abdominal pain, diarrhea and
weight loss
• Treated with long term antibiotics-penicillin
• Very rare
X-ray
• The hallmarks of the disease are nodules and
a markedly thickened bowel wall (picket-fence)
• Small bowel may or may not be dilated
• Affects jejunum mostly
114. Lymphoma
• Most commonly involves terminal ileum
• Bowel wall becomes markedly thickened
and submucosa infiltrated (picket-fence)
• “Thumb-printing“ may be seen
• Loops are widely separated and there may
be mass effect
• Another form may have a large ulceration
which is confined and produces so called
“aneurysmal dilatation” of the bowel