Vitamin D deficiency in Uttar Pradesh:An observational study, per-Ph.D presentation. Role of sunlight in vitamin D, role of latitude in vitamin D,role of skin exposure in sunlight for vitamin D formation.

1. Pre-PhD Presentation

2. Status of Vitamin D deficiency in Uttar
Pradesh : an observational study
Presenter: Samreen

3. Introduction
• Vitamin D is very critical nutritional deficiency in India yet it has been
widely undiagnosed and untreated.[1]
• Since the discovery of Vitamin D and its chemical structure in last
century, its role in calcium metabolism and in the prevention of
rickets and osteomalacia has been thought of as the main physiological
function.
• Research shows that insufficient levels of vitamin D are associated
with elevated risk of developing numerous skeletal and non-skeletal
diseases like type-1 diabetes mellitus, Multiple sclerosis, Depression,
Schizophrenia, Cardiovascular diseases, Obesity and various other
diseases.

4. Problem Statement
• Prevalence of vitamin-D reported worldwide.
• Community-based Indian studies on apparently heathy persons
reported prevalence ranging from 50% to 94%.[2]
• Hospital based Indian studies showed prevalence ranging from 37% to
99%.[3]
• An school based study in kullu district of himachal Pradesh showed
prevalence of 80%.[4]

5. System-wise problems of Vitamin-D deficiency

7. Sunlight-Best Vitamin-D generator
About 90% of required vitamin D is synthesized in the skin under sun exposure.[5]

8. [9]

9. Effect of Latitude, weather in different regions of India
Latitude of Uttar Pradesh-26.8467° N, 80.9462° E
Latitude exposure to sunlight between the hours of 11 a.m. and
2 p.m. will promote vitamin-D production in the skin year
round.
A review article containing 26 studies from various regions of India also have similar results
regarding latitude and weather for sun exposure and vitamin-D production.

10. Does we expose enough skin?

11. Vitamin-D Rich Foods

12. Review of Literature
• In last decade 18 community based prominent studies were done in
India in various states.
• In last decade 16 Hospital based prominent studies were done in
India in various states.

15. Aims and Objectives
• To conduct an ecological study on a representative sample of the
population of Uttar Pradesh.
• Observing serum Vitamin-D status across age groups, Gender,
Occupation, Mode of work, Education, socioeconomic status.
• To know the proportion of patients having Vitamin D deficiency in
our set up.

16. Study Design
• Place of study
The proposed study is a hospital based study centred
in King George Medical University Lucknow and GSVM Medical
College Kanpur.
• Type of study
Prospective observational study
• Duration of study
2 years

17. Sampling Method
• All the patients visited to the department of Neurology and department
of Medicine, KGMU and department of Medicine GSVM Medical
College Kanpur over a period of 2 years [2022-2024] will be subjected
for study.
• Subjects will be instructed regarding overnight fasting (8 hour) 1 day
before the sample collection.
• Venous blood samples will be collected by trained phlebotomist.
• Blood samples were transported to the central pathology lab of the
institutes.
• 25(OH)D concentration will be measured with an antibody
competitive immunoassay.

18. Diagnostic criteria for Vitamin-D deficiency [7]

19. Inclusion Criteria
• All the patients admitted with various diseases to the
department of Neurology and department of Medicine,
KGMU and department of Medicine GSVM Medical
College Kanpur.
Age ≥ 18 years.

20. Exclusion Criteria
1) Patients with age ≤18 years.
2) Mentally unstable patient
3) Sick patients needing ICU care.
4) Pregnant woman
5) Patients/ attendants refusing consent

23. • Informed consent will be taken from Patient/Relatives.
• For Ethical committee clearance proposal to be submitted to
institutional ethics committee.

24. References
1. Aparna P, Muthathal S, Nongkynrih B, Gupta SK. Vitamin D deficiency in India. J Family Med
Prim Care 2018;7:324-30
2. Suryanarayana P, Arlappa N, Sai Santosh V, Balakrishna N, Lakshmi Rajkumar P, Prasad U, et
al. Prevalence of vitamin D deficiency and its associated factors among urban elderly population
in hyederabad metropolitan city, South india. Ann Hum Biol 2018;45:133-9
3. Angurana SK, Angurana RS, Mahajan G, Kumar N, Mahajan V. Prevalence of vitamin D
deficiency in apparently healthy children in North India. J Pediatr Endocrinol Metab
2014;27:1151-6
4. Kapil U, Pandey RM, Goswami R, Sharma B, Sharma N, Ramkrishnan L, et al. Prevalence of
vitamin D deficiency and associated reisk factors among children residing at high altitude in
Shimla District, Himachal Pradesh, India. Indian J Endocrinol Metab 2017;21:178-83
5. Holick MF. Vitamin D: a Millenium Perspective. J Cell Biochem 2003;88:296-307
6. www.landesbioscience.com/journals/dermatoendocrinology/article/23873
7. Sadat-Ali M, Al-Elq A, Al-Turki H, Al-Mulhim F, Al-Ali a. Vitamin D level in healthy men in
eastern Saudi arabia. Ann Saudi Med 2009;29:378-82.

25. THANK YOU

26. Bell shaped curve