2. • Merck Sharp & Dohme (MSD) outside the United States and
Canada, is an American pharmaceutical company and one of the
largest pharmaceutical companies in the world.
• The company was established in 1891 as the United States
subsidiary of the German company Merck, which was founded in
1668 by the Merck family.
• Merck & Co. was nationalized by the US government during World
War I and subsequently established as an independent American
company in 1917.
• While it operates as Merck & Co. in North America, the original
Merck based in Darmstadt holds the rights to the Merck name
everywhere else.
• Merck & Co. is the world's seventh largest pharmaceutical
company by market capitalization and revenue. Its headquarters is
located in Kenilworth, New Jersey.
3. History
• In 1891, family member George (Georg) Merck
emigrated to the United States and set up Merck &
Co. in New York as the US subsidiary of the family
company.
• Until the end of World War II, the company was led
by George W. Merck. Merck & Co. hold the
trademark rights to the "Merck" name in North
America, while its former parent company retains
the rights in the rest of the world.
• In 1929, H. K. Mulford Company merged with Sharpe
and Dohme, Inc. This company brought to the future
Merck & Co, Inc vaccine technology, including
immunization of cavalry horses in World War I and
delivery of a diphtheria antitoxin in 1925.
4. MSD in India
MSD operates its human health business in India through three separate legal
entities:
MSD Pharmaceuticals Private Limited,
Organon (India) Private Limited, and
Fulford (India) Limited.
Since its existence in India, the company has moved quickly in laying the
foundation for a business that is differentiated by its focus through launching
innovative products relevant to India. MSD in India also has presence in Animal
Health via MSD Animal Health with its vaccines facility located in Pune,
Maharashtra.
Key therapeutic areas
MSD in India currently operates in various therapeutic areas in human health,
including Metabolics, Cardiovascular, Vaccines, Critical Care, Immunology,
Virology, Oncology, Women's Health, Dermatology, Respiratory,
Musculoskeletal and Primary Care, and offers a strong and diversified product
portfolio of over 60 brands in total.
5. Commitment to India
• MSD has a long term commitment to India both in terms of bringing best in class
products and also making necessary investments to serve the Indian patients.
• In addition to setting up a sales and marketing structure to market best in class
products in India, MSD is also coordinating research projects with clinical
investigators in India's leading hospitals and universities, for development of new
drugs to address unmet medical needs for Indian patients.
Caring for the society we serve
• MSD embraces a commitment to its stakeholders, employees, neighbors, and
others in the global communities where it lives and works.
• Its commitment is demonstrated by its work in more than 140 countries
worldwide through its philanthropic initiatives and ethical business practices.
• In India as well, the Company has a number of Corporate Social Responsibility,
Disease Management programs and Capacity building initiatives in order to better
serve the interest of patients and communities.
6. Our Vision
• To make a difference in the lives of people globally through our innovative
medicines, vaccines, biologic therapies, and animal health products. We
aspire to be the best healthcare company in the world and are dedicated
to providing leading innovations and solutions for tomorrow.
Our Mission
• To discover, develop and provide innovative products and services that
save and improve lives around the world.
What We Stand for
• Excellence in science and healthcare innovation, with an emphasis on
addressing unmet medical needs
• Focus on patients and anticipating customers' needs
• Comitments to expand access to our medicines and vaccines, and to
improve global health
7. Views and Positions
• We support public policies that advance the interests of patients, improve
public health and promote access to medicines and innovation.
• We work to achieve our business objectives responsibly and respond to
our many stakeholders' needs and concerns. We support policies that
promote the discovery of innovative medicines and vaccines and make
these products available to all who need them.
TO ADVANCE THIS OBJECTIVE, WE:
• develop policy positions that guide our activities and advocacy on a range
of issues;
• seek opportunities to adopt industry-leading standards in several areas;
• strive to communicate clearly and transparently about our positions; and
• work closely with the many groups and individuals who are also trying to
address the complex healthcare challenges that confront us.
8. Critical Care
Cancidas_ Caspofungin(50 Mg)
Uses- Gastric acid reduction during anaesthesia, peritonitis.
How it works
• Caspofungin inhibits the synthesis of beta-(1,3)-D-glucan,
an essential component of the cell wall of Aspergillus
species and Candida species, beta-(1,3)-D-glucan is not
present in mammalian cells.
Common side effects
• Vomiting, Nausea, Abdominal pain, Fever, Flushing,
Headache, Itching, Rash
Competetors- CASPOGIN 50 MG INJECTION, CASPERCID 50MG
INJECTION, CASPORAN 50MG INJECTION
9. Ethyol®
ETHYOL 500MG INJECTION -Amifostine(500 mg)
Uses
• Amifostine is used to reduce the toxicity to kidneys associated with cisplatin
therapy in patients with advanced ovarian cancer, and in prevention of dry
mouth (xerostomia) during radiotherapy for head and neck cancer.
How it works
• Amifostine is a cytoprotectant. It protects the normal cells against the harmful
effects of chemotherapy medications and radiation treatment by producing a
chemical ‘thiol’ that binds to and detoxifies the harmful compounds produced
by cisplatin. Amifostine does not interfere with the action of cisplatin.
Common side effects
• Flushing or feeling of warmth, Headache and tiredness, Nausea and vomiting,
Chills or shivering, Fever, Hiccups, Drowsiness, Sneezing
COMPETITORS- NATFOST 500 MG INJECTION, AMIPHOS 500MG INJECTION,
AMFOS 500MG INJECTION
10. Invanz®
Ertapenem(1 gm)
Uses
• Ertapenem is used to treat various bacterial infections in the body. These include
gynecologic and abdominal infections, pneumonia, skin and underlying tissue
infections due to diabetes (e.g. diabetic foot). It is also used to prevent infection
after certain types of surgeries.
How it works
• Ertapenem is an antibiotic of the beta-lactam group, which works by killing the
infection causing bacteria.
Common side effects
• Vomiting, Nausea, Application site burning, Application site redness of skin,
Application site irritation, Confusion, Cough, Dizziness, Vagina dryness, Headache,
Insomnia, Stomach pain, Irritation in urethra, Vaginal burning sensation, Vaginal
itching, Irritation in vagina, Pain in vagina, Pain in urethra, Burning sensation in
urethra, Constipation, Diarrhoea, Chills, Fever
• ZIVATOR 1 GM INJECTION, GERTA 1GM INJECTION, ALERTA 1 GM INJECTION
11. Maxalt®
Rizatriptan(10 mg)
Uses
• Rizatriptan is used in adults to treat the acute headache phase of the migraine
attack (pulsating headaches, often on one side of the head) with or without aura
(visual disturbances usually in the form of geometric patterns or flashing,
shimmering lights that one experiences just before a migraine attack).
How it works
• Rizatriptan belongs to the class of drugs called selective serotonin 5-HT1B/1D
receptor agonists. It acts by reducing swelling of blood vessels around the brain
and also controlling release of certain chemicals in the body that can trigger
headache pain, nausea, sensitivity to light and sound, and other migraine
symptoms.
Common side effects
• Nausea, Neck pain, Numbness, Abdominal bloating, Chest pain, Abdominal pain,
Decreased mental acuity, Diarrhoea, Dry mouth, Flushing, Headache, Indigestion,
Insomnia, Stiffness, Tachycardia, Heart rate irregular, Throat disorder, Tingling
sensation, Vomiting
12. Noxafil®
• Posaconazole(40 mg)
• Posaconazole is used for prophylaxis of
invasive Aspergillus and Candida infections in
patients who are at high risk of developing
these infections due to being severely
immunocompromised.
• It is also used for treatment of oropharyngeal
candidiasis (OPC), including OPC refractory
(rOPC) to itraconazole and/or fluconazole.
13. Temodal®
• Temozolomide(100 mg)
• Temozolomide is used in adults and in children
above 3 years of age to treat certain specific
types of brain tumor such as glioblastoma
multiforme (malignant grade IV brain tumor) or
anaplastic astrocytoma (grade III brain tumor).
• It is usually used together with radiotherapy or
other medications and is generally given after
other cancer medicines have been tried without
success.
14. DINMEK™
• Lamivudine(300 mg),Tenofovir(300 mg)
Uses
• Lamivudine indicated as part of antiretroviral combination
therapy for the treatment of Human Immunodeficiency
Virus (HIV) infected adults and children and also used in the
treatment of Hepatitis B virus infection.
Esmeron®-Rocuronium(50 mg)
Uses
• Adjunct to anesthesia, Muscle relaxation (intermediate
duration) during intensive care, Muscle relaxation
(intermediate duration) for surgery or intubation, Muscular
spasm.
15. Chronic Care
• Axeten™- Telmisartan
Uses
• Telmisartan belongs to a class of medicines
known as angiotensin II receptor blockers.
• It is used to treat high blood pressure, prevention
and treatment of heart attack (myocardial
Infarction) and heart failure; when heart is unable
to pump sufficient blood.
• It is also used for kidney failure in patients with
diabetes.
16. INTERIGLIN 0.75MG INFUSION
• Eptifibatide(0.75 mg
Uses
• Eptifibatide is used in combination with other medications
to treat severe coronary insufficiency (insufficient blood
flow through the blood vessels carrying blood to the heart
muscle) and to prevent heart attack.
• Janumet®
• Sitagliptin(50 mg),Metformin(500 mg)
• Sitagliptin is used to control blood sugar levels in patients
with type 2 diabetes mellitus.
• Metformin is an antidiabetic medicine that helps to control
blood sugar in people with type 2 diabetes mellitus.
17. Januvia®
• Sitagliptin(100 mg)
• Sitagliptin is used to control blood sugar levels in patients with t
How it works
• Sitagliptin belongs to class of medications called dipeptidyl
peptidase-4 (DPP-4) inhibitors.This medicine helps to improve the
levels of insulin after a meal and decreases the amount of sugar
made by the body. It works by increasing the amounts of certain
natural substances that lower blood sugar when it is high.
Common side effects
• Nausea, Diarrhoea, Acne-like rash, Hormone imbalance, Allergic
reaction, Slow growth in children and teenagers, Joint pain,
Headache, Loss of appetite, Running nose, Nasal congestion, Sore
throat
• Type 2 diabetes mellitus.
