This document summarizes a webinar on fertility presented by Dr. Gary Levy, Chief Medical Officer of Fertility Cloud. It discusses that approximately 15% of US couples are affected by infertility, with common causes being ovulation disorders, fallopian tube issues, low ovarian reserve, and sperm-related factors. It outlines treatment options including lifestyle changes, oral or injectable medications, surgery, and in-vitro fertilization (IVF). IVF success rates decline with female age but it has higher success rates than other options for certain diagnoses. Less invasive options include medications which have cumulative pregnancy rates around 40-60% depending on the diagnosis. Fertility Cloud offers online consultations and personalized treatment plans using medications

1. Amy Beckley Dr. Gary Levy
CEO, MFB Fertility
PhD in Pharmacology
Board Certified Reproductive
Endocrinologist
Associate Professor of Obstetrics
and Gynecology
Chief Medical Officer, Fertility Cloud
Free fertility webinar for Proov customers
Trying to Conceive? Hear from an Experienced Fertility Doctor

2. (с) Fertility Cloud 2020
Trouble Getting Pregnant?
Get A Second Opinion
Dr. Gary Levy,
Chief Medical Officer, Fertility Cloud
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3. Changing the way infertility is diagnosed
• Chief Executive Officer, MFB Fertility
(Proov Trademark)
• PhD in Pharmacology
• Infertility and recurrent miscarriage
veteran, one child by IVF, second
naturally conceived
Amy Beckley, PhD
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4. 20 years, 2,000+ healthy babies born
• Board Certified Reproductive
Endocrinologist
• Associate Professor of Obstetrics and
Gynecology
• Chief Medical Officer, Fertility Cloud
Dr. Gary Levy
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5. Treatment 3-6 months + Medical Support
Fertility Cloud is an Online Clinic
following established fertility treatment protocols
Online
consultation
Test kits shipped to
your home
Medications
prescribed online
Shipped to the patient
Positive
pregnancy test
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6. Your Participation Is Requested
before, during and after the webinar
Some of you sent questions
before when registered
Dr. Levy will answer them in the
end
You will be asked several
questions during the webinar
Anonymous results will be
summarized on the screen to
guide the discussion
After the webinar
You will receive a followup email
with details
• Data references are available upon request
• Some numbers are rounded up for better comprehension
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7. Today’s Discussion
• How to optimize your fertility | What is Infertility ?
• Common Causes of infertility
• Options for treatment, costs and efficacy
• Natural
• Procedure-based treatment
• Medical-based treatment
• Q&A
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8. Poll #1
Your concern
Are you currently concerned about your reproductive
status or reproductive potential?
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9. Do You Really Have a Problem?
If you cannot conceive:
Age For
-35 12 months You may have
an infertility
issue
Seek a
reproductive
endocrinologist
(REI)35+ 6 months
9
American Society for Reproductive Medicine. Optimizing Natural Fertility. 2015

10. When Should I Talk
to a reproductive endocrinologist (REI) immediately?
Women
Irregular/absent menses
Negative ovulation kits
History of pelvic infections
Prior history of infertility
Men
Known medical problems with
genitalia
Abnormal sexual functioning
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American Society for Reproductive Medicine. Optimizing Natural Fertility. 2015

11. 15% of US Couples Affected by Infertility
in line with the global trend
Delaying childbearing:
increasing infertility in
men and women
Treatment is
expensive | Plans may
lack coverate
Fertility doctors
are geographically
isolated
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12. Chances Decrease with Aging
for both men and women
American Society for Reproductive Medicine. Optimizing Natural Fertility. 2015
www.sofainfertility.com
Permonthchanceofconception
0 %
6 %
13 %
19 %
25 %
Age in years
22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48
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13. during the webinar
• Ask questions in the Q&A section
• Go to Chat to exchange messages with other participants, but we don’t
answer questions there
• In Q&A you can also ask private and anonymous questions
Ask Your Questions
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14. Poll #2
Your attitude to natural fertility
Do you think lifestyle changes are effective to helping
you conceive?
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15. What Is The Fertile Window?
It’s just a few days in a month
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16. How Can I Improve My Chances Naturally?
depends on many factors
• How often should I have intercourse?
• What sexual practices can improve the chances of conceiving?
• How does diet affect male and female fertility?
• How does lifestyle affect fertility?
• The Internet is maybe of little help
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17. Poll #3
Your search for solutions
Have you inquired about fertility care or treatment on
the Internet?
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18. 70%of fertility patients believe the information they receive is
incomplete or biased
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19. Poll #4
What is your diagnosis?
Have you been diagnosed with either infertility or
subfertility by a reproductive health professional?
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20. 4 Major Causes of Infertility
explain most cases
Causes of
Infertility
Men
Low ovarian
reserve 10%
Ovulation
40%
Age dependent
Sperm
30%
Fallopian tubes
obstruction 20%
Undiagnosed
25-30%
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Women

21. Ovulation (40%): Complex Endocrine System
is not working properly
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22. What Has Changed in the Past 5 Years?
New home testing kits now available
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23. Fallopian Tube Obstruction (20%):
healthy eggs are blocked on the way
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24. Low Ovarian Reserve (10%):
Lower number and decreased quality of eggs – decrease pregnancy chances
FollicleNumber
1 000
10 000
100 000
1 000 000
0 18 31 37 41 45 51
Optimal Fertility
Decreased Fertility
Irregular Cycles
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Menopause

25. What Has Changed in the Past 5 Years?
New home blood and urine tests are available
At home same day testing
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26. Sperm (30%):
too little, too slow, etc. : more abnormalities = lower chances of pregnancy
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27. What Has Changed in the Past 5 Years?
New home sperm tests are available
At home same day testing
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28. Poll #5
Your treatment status
Have you thought or received reproductive care from a
healthcare professional?
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29. Reproductive Endocrinologists (REIs)
are specially trained to treat reproductive disorders
Reproductive
Endocrinologist
Focus on both men and women Yes
More experience in solving infertility issues Yes
Creates more individualized plan Yes
Can help you if: Yes
You are over 35 and has been trying to conceive for over 12 months Yes
You have been diagnosed with any kind of infertility Yes
29

30. Poll #6
Have you been recommended an IVF?
Have you undergone an evaluation and/or treatment
for infertility and your physician recommended In-Vitro
Fertilization (IVF)?
30

31. 80%of health plans lack any coverage for infertility treatment
31

32. $35,000The average successful patient spends on IVF
32

33. In-Vitro Fertilization
How does it work?
• Ovarian Stimulation
• Egg Retrieval
• Egg Fertilization
• Embryo Culture
• Embryo Transfer | Embryo
Freezing
• Genetic Testing
• Frozen Embryo Transfer
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34. How Effective Is IVF?
Compared to medication and other treatments
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Age of woman
<35 35-37 38-40 41-42
Singleton Births 50 % 31 % 19 % 11 %
Live Births 52 % 33 % 21 % 14 %
Singleton (percentage of live births) 97 % 95 % 89 % 78 %

35. When Should I Definitely Go for IVF?
as the final resort
• Confirmed Obstructed Fallopian Tubes
• Genetic mutation with desire for elimination from offspring
• Desire for genetic testing or family balancing
• Using an egg donor or adopted embryos
• Severe male factor infertility
• Failed initial treatment with Clomiphene, Letrozole, Gonadotropins
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36. What Are The Options to Avoid IVF?
when you are not in IVF-only group
• Lifestyle interventions to improve
fertility
• Diet
• Exercise
• Tobacco
• Alcohol
• Sugar
• Anti-oxidants
• Supplements
• Medications for ovarian
stimulation /
• Continuing with treatment
• Hormones to support early
pregnancy
• Surgery
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37. $1,500
The average successful patient spends on a complete medical
treatment*
* Including evaluation, tests and medications (no hidden costs)
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38. Fertility Cloud Personalized Treatment Plans
monitored by doctor at each stage
Evaluation
Doctor
Consultation
Medical
History
Bloodwork &
Sperm Test
Treatment
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39. How Effective Is Medical Treatment?
Fertility Cloud offers a high chance with cost effective treatment
Diagnosis Chance Treatment
Cumulative Pregnancy Rate
three months single agent
treatment
3 Months 6 Months
Single Agent Double Agent
Oligoovulation 35 % Ovulation Induction 45% 60%
Unexplained 15 %
Superovulation | Ovarian
Stimulation
39% 45%
Endometriosis 20 % 30% 45%
Mild Male Factor 20 % 21% 42%
Presumed Tubal 10 % 27% 40%
Total 100 %
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Kamphuis EI, Bhattacharya S, van der Veen F, Mol BW, Templeton A. Are we overusing IVF? BMJ 2014;348:g252-g252
Misso ML, Wong JL, Teede HJ, et al. Aromatase inhibitors for PCOS: a systematic review and meta-analysis. Hum Reprod Update 2012;18:301-312

40. Skip the clinic, skip the needle
www.MyFertilityCloud.com
707-361-6339
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41. Q&A
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42. Screen Sharing
OFF
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